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Pharmaceutical Applications Of Raman Spectroscopy
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Book Synopsis Pharmaceutical Applications of Raman Spectroscopy by : Slobodan Sasic
Download or read book Pharmaceutical Applications of Raman Spectroscopy written by Slobodan Sasic and published by John Wiley & Sons. This book was released on 2007-10-23 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raman spectroscopy has advanced in recent years with increasing use both in industry and academia. This is due largely to steady improvements in instrumentation, decreasing cost, and the availability of chemometrics to assist in the analysis of data. Pharmaceutical applications of Raman spectroscopy have developed similarly and this book will focus on those applications. Carefully organized with an emphasis on industry issues, Pharmaceutical Applications of Raman Spectroscopy, provides the basic theory of Raman effect and instrumentation, and then addresses a wide range of pharmaceutical applications. Current applications that are routinely used as well as those with promising potential are covered. Applications cover a broad range from discovery to manufacturing in the pharmaceutical industry and include identifying polymorphs, monitoring real-time processes, imaging solid dosage formulations, imaging active pharmaceutical ingredients in cells, and diagnostics.
Book Synopsis Pharmaceutical Applications of Raman Spectroscopy by : Slobodan Sasic
Download or read book Pharmaceutical Applications of Raman Spectroscopy written by Slobodan Sasic and published by Wiley-Interscience. This book was released on 2007-11-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raman spectroscopy has advanced in recent years with increasing use both in industry and academia. This is due largely to steady improvements in instrumentation, decreasing cost, and the availability of chemometrics to assist in the analysis of data. Pharmaceutical applications of Raman spectroscopy have developed similarly and this book will focus on those applications. Carefully organized with an emphasis on industry issues, Pharmaceutical Applications of Raman Spectroscopy, provides the basic theory of Raman effect and instrumentation, and then addresses a wide range of pharmaceutical applications. Current applications that are routinely used as well as those with promising potential are covered. Applications cover a broad range from discovery to manufacturing in the pharmaceutical industry and include identifying polymorphs, monitoring real-time processes, imaging solid dosage formulations, imaging active pharmaceutical ingredients in cells, and diagnostics.
Book Synopsis Application of Raman Spectroscopy in Pharmaceuticals by : Anna Zarow
Download or read book Application of Raman Spectroscopy in Pharmaceuticals written by Anna Zarow and published by . This book was released on 2011 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental research on the use of Raman spectroscopy as an in- and on-line sensing tool and a complementary characterization technique for pharmaceutical applications is presented in this thesis. In the first chapter following a broad overview, the use of Raman spectroscopy, together with x-ray powder diffraction, scanning electron microscopy (SEM) and differential scanning calorimetry, for multilevel characterization of cryomilled powders, and the melt-grown amorphous phase of griseofulvin, a model active pharmaceutical ingredient (API), is presented and discussed in detail. A key feature was the observation of a broad inelastic background superimposed on the Raman spectra of cryomilled powders, which is attributed to lattice disorder and Mie scattering generated by mechanical processing and sub-micron particle interfaces. In the following chapter, polymorphs of another model API, acetaminophen (APAP), were studied by Raman spectroscopy with supporting information obtained from x-ray diffraction, SEM images and intrinsic dissolution profiles. An important result was the stabilization and characterization of the metastable type II orthorhombic phase of APAP which is highly desired for its unique tabletting properties which are important for pharmaceutical manufacturing. Stabilization of metastable type II APAP was achieved by micronizing or nanocoating stable monoclinic crystallites of type I APAP. In addition, as an Appendix to the thesis, micro-Raman spectroscopy of single crystal APAP as a function of crystal orientation and of temperature was measured to provide an understanding of the lattice properties of APAP for input into models to predict its behavior under mechanical milling conditions widely used in pharmaceutical processing. Molecular behavior obtained from the above studies guided simulated in-line and off-line characterization of griseofulvin as thin gel films made from micronized powders and nanosuspensions. By employing complementary near infrared and Raman imaging for newly developed films, it was possible to extract valuable information on the spatial distribution and crystallinity of the embedded particles in a polymeric matrix at different scales of scrutiny. Chemometrics processing of spectroscopic data for films and nanosuspensions allowed for qualitative and quantitative particle size determinations of the API’s in the films and nanosuspensions. In the final chapter a photonic crystal substrate for surface enhanced Raman spectroscopic (SERS) sensing was employed to detect and study griseofulvin and APAP down to 10-8 M levels with enhancement factors approaching 1099. Detection sensitivities of the aromatic griseofulvin and APAP molecules were also compared with those of less aromatic and non-aromatic energetic molecules in order to understand the Raman enhancement process.
Book Synopsis Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences by : Andrei A. Bunaciu
Download or read book Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences written by Andrei A. Bunaciu and published by Elsevier. This book was released on 2020-07-26 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vibrational Spectroscopy Applications in Biomedical, Pharmaceutical and Food Sciences synthesizes the latest research on the applications of vibrational spectroscopy in biomedical, pharmaceutical and food analysis. Suitable for graduate-level students as well as experienced researchers in academia and industry, this book is organized into five distinct sections. The first deals with the fundamentals of vibrational spectroscopy, with the second presenting the most important sampling methodology used for infrared and Raman spectroscopy in various fields of interest. Since spectroscopy is the study of the interaction of electromagnetic radiation with matter, this section deals with the characteristics, properties and absorption of electromagnetic radiation. Final sections describe the analytical studies performed all over the world in biomedical, pharmaceutical and in the food sciences. Presents a critical discussion of many of the applications of vibrational spectroscopy Covers details of the analytical methodologies used in pharmaceutical and biomedical applications Discusses the latest developments in pharmaceutical and biomedical analysis of both small and large molecules
Book Synopsis Raman and SERS Investigations of Pharmaceuticals by : Monica Baia
Download or read book Raman and SERS Investigations of Pharmaceuticals written by Monica Baia and published by Springer Science & Business Media. This book was released on 2008-06-11 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last several years it has become apparent to most researchers that interdisciplinary research is the key to success in the sciences’ future. The present book exemplifies such interdisciplinary work. Thus, some new derivatives have been prepared by chemists and consecutively analyzed by physicists in order to better understand their physical-chemical properties for future tests to be performed by pharmacists. The book consists of an introductory section and other eight chapters. First, the fundamentals of infrared, Raman and surface-enhanced Raman spectroscopy and those of the theoretical methods employed for the vibrational prediction modes are highlighted. The SERS investigations illustrated in the following chapters are focused on different kinds of drugs: tranquilizers and sedatives, anti-inflammatory drugs, vitamins, drugs with anti-bacterial properties, etc. Since there is an increased interest in designing highly effective and controllable SERS-active substrates, a few newly developed substrates that could contribute to a deeper understanding and knowledge of the adsorption behavior of various types of molecules of pharmaceutical and medical interest are also presented.
Book Synopsis Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields by : Pavel Matousek
Download or read book Emerging Raman Applications and Techniques in Biomedical and Pharmaceutical Fields written by Pavel Matousek and published by Springer Science & Business Media. This book was released on 2010-01-20 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest technological advances in Raman spectroscopy that are presently redrawing the landscape of many fields of biomedical and pharmaceutical R&D. Numerous examples are given to illustrate the application of the new methods.
Book Synopsis Raman Spectroscopy for Chemical Analysis by : Richard L. McCreery
Download or read book Raman Spectroscopy for Chemical Analysis written by Richard L. McCreery and published by John Wiley & Sons. This book was released on 2005-02-25 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Minimaler Aufwand bei der Probenvorbereitung, hoher Informationsgehalt des Spektrums und die Möglichkeit, mit festen Proben zu arbeiten, machen die Raman-Spektroskopie zunehmend attraktiv. Wie man diese Methode mit modernster Ausrüstung effizient anwendet, zeigt Ihnen das vorliegende Buch. Im Mittelpunkt stehen neue Entwicklungen wie CCDs, Diodenlaser und Fourier-Transform-Techniken. Behandelt werden auch quantitative Analysen, die in der bisher vorhandenen Literatur häufig zu kurz kamen. (08/00)
Book Synopsis Several Pharmaceutical Applications of Fourier-transform Raman Spectroscopy by : Clare Louise Armstrong
Download or read book Several Pharmaceutical Applications of Fourier-transform Raman Spectroscopy written by Clare Louise Armstrong and published by . This book was released on 1995 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: FT-Raman spectroscopy has been applied in the analysis of various pharmaceutical systems. Spectra were acquired using the macroscopic, microscopic and mapping facilities of the FT-Raman spectrometer and the environmental chamber attachment. All spectra were obtained at a resolution of 4 cm-l. Investigations of polyethylene glycol in aqueous systems showed that the polymer is stable with no major alterations to inherent bands. However, the technique was proved to be valuable in analysing the interactions between the water molecules and polyethylene glycol. Thermal behaviour of polyethylene glycol was also investigated with molecular modes altering through melting and re-solidification of the material. Polyvinylpyrrolidone was examined with the Raman technique following exposure to high humidity and interactions between water and polyvinylpyrrolidone were observed. Topical preparations (a hormone replacement therapy patch and a cream formulation) were examined. A crystal inclusion in the patch was shown to be solid oestradiol using microscopic FT-Raman spectroscopy. Minor differences in the lattice modes of this inclusion were noted as compared with the modes in a pure oestradiol sample. The inhomogeneity of oestradiol distribution in the patch was examined using a mapping facility on the microscope; drug distribution was shown to vary within the patch as a result of crystallisation of some of the drug. The stability of the cream formulation was examined over a two week period followed by an accelerated stability study equivalent to one months exposure to light. After two weeks, distinct phases were seen, one of which degraded further with time. A broad range of bacterial species were examined in this project. Attempts to probe the molecular basis for penicillin interactions with bacterial cell walls were unsuccessful. However, good quality FT-Raman spectra were obtained for seven different bacteria. No clear indication for cell wall groupings (Gram-positive or Gram- negative) could be seen from the spectra. Differences between some of the species could be ascribed to pigmentation in the cells. Overall these studies have shown the value, and some of the limitations, of FT-Raman spectroscopy for examining some complex pharmaceutically relevant.
Book Synopsis Introductory Raman Spectroscopy by : John R. Ferraro
Download or read book Introductory Raman Spectroscopy written by John R. Ferraro and published by Academic Press. This book was released on 2012-12-02 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for Introductory Raman Spectroscopy Highlights basic theory, which is treated in an introductory fashion Presents state-of-the-art instrumentation Discusses new applications of Raman spectroscopy in industry and research
Book Synopsis Handbook of Raman Spectroscopy by : Ian R. Lewis
Download or read book Handbook of Raman Spectroscopy written by Ian R. Lewis and published by CRC Press. This book was released on 2001-08-08 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers principles of Raman theory, analysis, instrumentation, and measurement, specifying up-to-the-minute benefits of Raman spectroscopy in a variety of industrial and academic fields, and how to cultivate growth in new disciplines. It contains case studies that illustrate current techniques in data extraction and analysis, as well as over 500 drawings and photographs that clarify and reinforce critical text material. The authors discuss Raman spectra of gases; Raman spectroscopy applied to crystals, applications to gemology, in vivo Raman spectroscopy, applications in forensic science, and collectivity of vibrational modes, among many other topics.
Book Synopsis Micro-Raman Spectroscopy by : Jürgen Popp
Download or read book Micro-Raman Spectroscopy written by Jürgen Popp and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-02-10 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Micro-Raman Spectroscopy introduces readers to the theory and application of Raman microscopy. Raman microscopy is used to study the chemical signature of samples with little preperation in a non-destructive manner. An easy to use technique with ever increasing technological advances, Micro-Raman has significant application for researchers in the fields of materials science, medicine, pharmaceuticals, and chemistry.
Book Synopsis Infrared and Raman Spectroscopic Imaging by : Reiner Salzer
Download or read book Infrared and Raman Spectroscopic Imaging written by Reiner Salzer and published by John Wiley & Sons. This book was released on 2014-08-07 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of the successful ready reference is updated and revised with approximately 30% new content to reflect the numerous instrumental developments and improvements, as well as the significant expansion of this rapidly developing field. For example, the combination of IR imaging with AFM has enhanced the achievable lateral resolution by an order of magnitude down to a few hundred nanometers, thus launching a multiplicity of new applications in material science. Furthermore, Raman and IR spectroscopic imaging have become key technologies for the life sciences and today contribute tremendously to a better and more detailed understanding of numerous biological and medical research topics. The topical structure of this new edition is now subdivided into four parts. The first treats the fundamentals of the instrumentation for infrared and Raman imaging and mapping and an overview on the chemometric tools for image analysis. The second part describes a wide varie-ty of applications ranging from biomedical via food, agriculture and plants to polymers and pharmaceuticals. This is followed by a description of imaging techniques operating beyond the diffraction limit, while the final part covers special methodical developments and their utility in specific fields. With its many valuable practical tips, this is a must-have overview for researchers in academic and industrial laboratories wishing to obtain reliable results with this method.
Book Synopsis Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development by : Don E. Pivonka
Download or read book Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development written by Don E. Pivonka and published by Wiley-Blackwell. This book was released on 2008-04-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Solid State Development and Processing of Pharmaceutical Molecules by : Michael Gruss
Download or read book Solid State Development and Processing of Pharmaceutical Molecules written by Michael Gruss and published by John Wiley & Sons. This book was released on 2021-11-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.
Book Synopsis Applications of Raman Spectroscopy and Multivariate Data Analysis in Food and Pharmaceutical Sciences by : Lotte Bøge Lyndgaard
Download or read book Applications of Raman Spectroscopy and Multivariate Data Analysis in Food and Pharmaceutical Sciences written by Lotte Bøge Lyndgaard and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy by : Emil W. Ciurczak
Download or read book Pharmaceutical and Medical Applications of Near-Infrared Spectroscopy written by Emil W. Ciurczak and published by CRC Press. This book was released on 2002-02-08 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the theory, instrumentation, validation, and implementation of near-infrared spectroscopy for pharmaceutical and medical applications. It showcases a diverse range of contemporary methods for the production, screening, and analysis of new drug products and pharmaceuticals. Presents current approaches in near-infrared spectroscop
Book Synopsis Modern Raman Spectroscopy by : Ewen Smith
Download or read book Modern Raman Spectroscopy written by Ewen Smith and published by John Wiley & Sons. This book was released on 2019-02-22 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second edition of the guide to the modern techniques that demonstrate the potential of Raman spectroscopy Completely revised and updated, the second edition of Modern Raman Spectroscopy presents the information needed for clear understanding and application of the technique of Raman Spectroscopy in a range of areas such as pharmaceuticals, forensics, and biology. The authors—noted experts on the topic—reveal how to make full use of the critical information presented and include a wealth of examples of the pitfalls that can be encountered. The text opens with a description of the basic theory to assist readers in making a practical interpretation of Raman Spectra. Chapters include the main equations that are used in order to highlight the theory’s meaning and relevance while avoiding a full mathematical treatment. Modern Raman Spectroscopy provides a firm grounding, combined with a variety of references, from which to approach a more comprehensive study of specific aspects of Raman Spectroscopy. This new edition: Includes instrumentation sections that now contain Spatially Offset Raman scattering and transmission Raman scattering Offers an updated SERS chapter that presents recent examples and Tip enhanced Raman scattering Contains updated information with an emphasis on pharmaceutical, forensic, and biological applications Introduces modern techniques in the imaging and mapping of biological samples and more advanced methods which are becoming easier to use Written for users of Raman Spectroscopy in industry, including non-analysts, researchers, and academics, the second edition of Modern Raman Spectroscopy clearly demonstrates the potential of using Raman Spectroscopy for a wide range of applications.
