Phagocytosis Of Dying Cells

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Phagocytosis of Dying Cells

Author : Dmitri V. Krysko
Publisher : Springer Science & Business Media
ISBN 13 : 1402092938
Total Pages : 449 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Phagocytosis of Dying Cells by : Dmitri V. Krysko

Download or read book Phagocytosis of Dying Cells written by Dmitri V. Krysko and published by Springer Science & Business Media. This book was released on 2009-03-10 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytosis has been at the forefront of cell biology for more than a century. Initially, phagocytosis, which comes from Greek words meaning “devouring cells,” was discovered in the late 19th century by Ilya Metchnikoff, who was awarded, together with Paul Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 “in recognition of their work on immunity.” At that time Metchnikoff had already identified a function for phagocytes not only in host defense but also as scavengers of degenerating host cells during metamorphosis of tadpoles, thus providing one of the first descriptions of apoptotic cell clearance by macrophages (Kaufmann 2008). Since then, much has been learned about phagocytosis, and the previous several decades have witnessed outstanding progress in understanding the functions and the molecular mechanisms of phagocytosis. Two main types of targets are cleared by phagocytosis: microbial pathogens and dying cells. Rapid recognition and clearance of dying cells by phagocytes plays a pivotal role in development, maintenance of tissue homeostasis, control of immune responses, and resolution of inflammation. Clearance of dying cells can be divided into several stages, including sensing, r- ognition, binding and signaling, internalization, and immunological responses. In this book, our contributors address these different stages of dead cell cle- ance and examine how impaired clearance of dying cells may lead to human d- eases. We have attempted to provide sufficient cross-referencing and indexing to enable the reader to easily locate the ideas elaborated in the different chapters.

Phagocytosis of Dying Cells

Author : Regina E. Cocco
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Phagocytosis of Dying Cells by : Regina E. Cocco

Download or read book Phagocytosis of Dying Cells written by Regina E. Cocco and published by . This book was released on 2000 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy

Author : Christopher D. Gregory
Publisher : Springer
ISBN 13 : 3319394061
Total Pages : 260 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy by : Christopher D. Gregory

Download or read book Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy written by Christopher D. Gregory and published by Springer. This book was released on 2016-08-24 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses properties of apoptosis and other cell death modalities in cancer pathogenesis and treatment. Its nine chapters discuss modulation of anti-tumor inflammatory and immune responses, effects on the tumor microenvironment, to strategies for improving pro-apoptotic therapies, mechanisms and implications for disease pathogenesis, axl and mer receptor tyrosine kinases, immunogenic apoptotic cell death and anti-cancer immunity and cancer cell death-inducing radiotherapy. This book places the onco-biology of apoptosis in clear and objective perspective through an expertly synthesized series of reviews. Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy is a deft and thorough exploration of cutting-edge research in apoptosis and anti-cancer mechanisms from basic biology to oncology. It highlights a rapidly growing field within cancer research and is essential reading for oncologists, biochemists and advanced graduate students alike.

Recognition and Phagocytosis of Dying Cells

Author : Ulrich Hirt
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (248 download)

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Book Synopsis Recognition and Phagocytosis of Dying Cells by : Ulrich Hirt

Download or read book Recognition and Phagocytosis of Dying Cells written by Ulrich Hirt and published by . This book was released on 2001 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phagocytosis: Molecular Mechanisms and Physiological Implications

Author : Esther M. Lafuente
Publisher : Frontiers Media SA
ISBN 13 : 2889661474
Total Pages : 251 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Phagocytosis: Molecular Mechanisms and Physiological Implications by : Esther M. Lafuente

Download or read book Phagocytosis: Molecular Mechanisms and Physiological Implications written by Esther M. Lafuente and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Apoptotic Cell Clearance in Health and Disease

Author : Estee Kurant
Publisher : Frontiers Media SA
ISBN 13 : 2889456889
Total Pages : 294 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Apoptotic Cell Clearance in Health and Disease by : Estee Kurant

Download or read book Apoptotic Cell Clearance in Health and Disease written by Estee Kurant and published by Frontiers Media SA. This book was released on 2018-12-27 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.

Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464904316
Total Pages : 64 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition by :

Download or read book Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Phagocytosis in a concise format. The editors have built Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phagocytosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phagocytosis: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Apoptosis

Author : C. S. Potten
Publisher : Cambridge University Press
ISBN 13 : 9780521626798
Total Pages : 240 pages
Book Rating : 4.6/5 (267 download)

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Book Synopsis Apoptosis by : C. S. Potten

Download or read book Apoptosis written by C. S. Potten and published by Cambridge University Press. This book was released on 2004-08-16 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of programmed cell death, or apoptosis, has exploded into a major scientific field of interest for cell biologists, oncologists, and many other biomedical researchers. Apoptosis occurs throughout the lifetime of most multicellular organisms. During development, for example, the selective death of cells is vital to remove tissue between the digits to produce fingers and toes. Apoptosis is also necessary to destroy cells that represent a threat to the integrity of the organism, for example cells infected by a virus. In many cancers the genes regulating apoptosis are defective, producing immortal, continuously proliferating cells. This book discusses the philosophical and technical difficulties in defining the moment of death for a cell, as well as the biological implications and significance of programmed cell death. Recent developments in the genetic control and interacting gene networks associated with apoptosis are presented. The book is written for advanced undergraduate and postgraduate students, and is highly illustrated to aid understanding.

Efferocytosis

Author : Namasivayam Nalini
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (139 download)

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Book Synopsis Efferocytosis by : Namasivayam Nalini

Download or read book Efferocytosis written by Namasivayam Nalini and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several cell death modes, each with a unique feature and mode of inducing cell death have been established. Cell death occurring under physiological conditions is primarily caused by apoptosis, which is a non-inflammatory or silent process, whereas necroptosis or pyroptosis is triggered by pathogen invasion, which stimulates the immune system and induces inflammation. In physiology, clearing dead cells and associated cellular debris is necessary since billions of cells die during mammalian embryogenesis and every day in adult organisms. For degradation, dead cells produced by apoptosis are quickly engulfed by macrophages. This chapter will present a description of the phagocytosis of dead and dying cells, by a process known as efferocytosis. Macrophages and, to a lesser degree, other ,Äòprofessional,Äô phagocytes (such as monocytes and dendritic cells) and ,Äònon-professional,Äô phagocytes, such as epithelial cells, conduct efferocytosis. Recent discoveries have shed light on this mechanism and how it works to preserve homeostasis of tissue, repair of tissue and health of the organism. Caspases are a large family of proteases of cysteine acting in cascades. A cascade leading to activation of caspase 3 mediates apoptosis and is responsible for killing cells, hiring macrophages, and presenting a ,Äúeat me,Äù signal(s). If macrophages do not effectively engulf apoptotic cells, they undergo secondary necrosis and release intracellular materials that reflect a molecular pattern associated with injury, which can lead to autoimmune diseases. Here, the processes of efferocytosis are illustrated and the pathophysiological effects that which occur when this phase is abrogated are highlighted.

Necrotic Cell Death

Author : Han-Ming Shen
Publisher : Springer Science & Business Media
ISBN 13 : 1461482208
Total Pages : 402 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Necrotic Cell Death by : Han-Ming Shen

Download or read book Necrotic Cell Death written by Han-Ming Shen and published by Springer Science & Business Media. This book was released on 2014-03-29 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

How are Dying Cells Recognized by Their Phagocytes?

Author : Victor Venegas
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (694 download)

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Book Synopsis How are Dying Cells Recognized by Their Phagocytes? by : Victor Venegas

Download or read book How are Dying Cells Recognized by Their Phagocytes? written by Victor Venegas and published by . This book was released on 2009 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell Apoptosis

Author : Lawrence B. Shultz
Publisher : Nova Publishers
ISBN 13 : 9781600215087
Total Pages : 228 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis Cell Apoptosis by : Lawrence B. Shultz

Download or read book Cell Apoptosis written by Lawrence B. Shultz and published by Nova Publishers. This book was released on 2007 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is the regulated form of cell death. It is a complex process defined by a set of characteristic morphological and biochemical features that involves the active participation of affected cells in a self-destruction cascade. This programmed cell death plays a critical role in physiological functions such as cell deletion during embryonic development, balancing cell number in continuously renewing tissues and immune system development. Additionally, a dysregulation of apoptosis is underlying in numerous pathological situations such as Parkinson, Alzheimer's disease and cancer.A number of studies have pointed out an association between consumption of fruits and vegetables, and certain beverages such as tea and wine, which are rich in polyphenols, with reduced risk of chronic diseases, including cancer. Apoptosis is also the regulatory mechanism involved in the removal of unnecessary cells during development and in tissue homeostasis in a wide range of organisms from insects to mammals. This book deals with cell apoptosis regulation and environmental factors.

Cell death in biology and pathology

Author : I. Bowen
Publisher : Springer Science & Business Media
ISBN 13 : 9401169217
Total Pages : 499 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Cell death in biology and pathology by : I. Bowen

Download or read book Cell death in biology and pathology written by I. Bowen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is clear that lysosomal enzymes often play a role in the destruction of the cytoplasm, but very few authorities feel that they initiate the process (Chapters 1, 2, 3, 5 -8, 12, 13). The cells show many forms of damage, and sometimes even complete destruction, before Iysosomes become a dominant part of the environ ment. What initiates the process is still unclear, although in several instances it appears that the death of a cell may arise from anyone of several pathways (Chapters, 10, II). It is rather interesting that evolution has chosen to achieve the same goal by different means. Apparently no one point is exceptionally or pre ferentially vulnerable, though a common pathway, such as permeability of the plasma membrane to calcium (Chapter 7), might currently be too subtle for routine identification. Factors which affect membrane stability and which induce mem brane bending can lead to blebing, cell fragmentation and death. Thus, more work on the changing chemistry of the plasma membrane in relation to environmental fluctuations would be welcomed. Space requirements and the major orientation of the book forced the exclusion of several very interesting topics: an evolutionary treatment of the advantages of cell death as a means of eliminating vestigial organs or embryonic scaffolding; or consider ation of the merits of body sculpting by cell death rather than cell growth.

Mechanisms of Cell Death

Author : Zahra Zakeri
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Mechanisms of Cell Death by : Zahra Zakeri

Download or read book Mechanisms of Cell Death written by Zahra Zakeri and published by . This book was released on 1999 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

Autophagy

Author : Gizem Ayna
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128069198
Total Pages : 32 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy by : Gizem Ayna

Download or read book Autophagy written by Gizem Ayna and published by Elsevier Inc. Chapters. This book was released on 2013-07-29 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the natural functions of the immune system is to find and eradicate neoplastic and dysplastic cells in tissues. This immune surveillance can be impaired due to the unpredictable immune escape strategies of cancer cells. Induction of apoptotic cell death by chemotherapy is applied to kill malignant cells in patients with cancer even though it has many weak points, such as the fact that apoptotic cells are usually ignored by the immune system since they are immunologically silent and even suppress inflammation. Inducing immunogenic cell death can promote efficient clearance of cancerous cells before they become aggressive and lethal. Unlike the generally anti-inflammatory apoptotic cells, clearance of immunogenic apoptotic, necrotic, and autophagic dying cells often triggers an innate immune response through inflammasome activation with subsequent release of IL-1β and IL-18 from immune-competent cells. These immunogenic dying cells can expose or release danger-associated molecular pattern molecules (DAMPs), which are the inducers of inflammasome components’ expression and/or assembly of the inflammasome to activate caspase-1 for the formation of active cytokines. In this chapter, we discuss which inflammasome-stimulant DAMPs have been recognized so far, and how immunogenic apoptotic, necrotic, and particularly autophagic dying cells may provoke inflammasome induction and/or activation.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

When Cells Die II

Author : Richard A. Lockshin
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 578 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis When Cells Die II by : Richard A. Lockshin

Download or read book When Cells Die II written by Richard A. Lockshin and published by Wiley-Liss. This book was released on 2004 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers the most thorough, cutting-edge coverage of the field of cell death since publication of the first edition. Leading international researchers present an up-to-date yet accessible survey ranging from the history of cell death science to its modern methodology. Extensively revised, this new edition features relavant discussions of: the impact of genomics and proteomics; gene therapy and pharmacogenetics; the role of mitochondria; caspase-independent and non-apoptotic cell death; and evolution of mechanisms.