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Download or read book Phage Display written by Carlos F. Barbas and published by CSHL Press. This book was released on 2001 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.
Book Synopsis Phage Therapy: A Practical Approach by : Andrzej Górski
Download or read book Phage Therapy: A Practical Approach written by Andrzej Górski and published by Springer Nature. This book was released on 2019-10-25 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a detailed yet clear insight into the current state of the art of the therapeutic application of bacteriophages in different conditions. The authors bring in their practical expertise within their respective fields of expertise and provide an excellent overview of the potential and actual use of phage therapy. Topics like economic feasibility compared to traditional antibiotics and also regulatory issues are discussed in far detail. This new volume is therefore a valuable resource for individuals engaged in the medical application of novel phage therapies.
Download or read book Bacteriophages written by David R. Harper and published by Springer Nature. This book was released on 2021-01-30 with total page 1376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first major reference work dedicated to the mannifold industrial and medical applications of bacteriophages provides both theoretical and practical insights into the emerging field of bacteriophage biotechnology. The book introduces to bacteriophage biology, ecology and history and reviews the latest technologies and tools in bacteriophage detection, strain optimization and nanotechnology. Usage of bacteriophages in food safety, agriculture, and different therapeutic areas is discussed in detail. This book serves as essential guide for researchers in applied microbiology, biotechnology and medicine coming from both academia and industry.
Book Synopsis The Perfect Predator by : Steffanie Strathdee
Download or read book The Perfect Predator written by Steffanie Strathdee and published by Hachette Books. This book was released on 2019-02-26 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: An electrifying memoir of one woman's extraordinary effort to save her husband's life-and the discovery of a forgotten cure that has the potential to save millions more. "A memoir that reads like a thriller." -New York Times Book Review "A fascinating and terrifying peek into the devastating outcomes of antibiotic misuse-and what happens when standard health care falls short." -Scientific American Epidemiologist Steffanie Strathdee and her husband, psychologist Tom Patterson, were vacationing in Egypt when Tom came down with a stomach bug. What at first seemed like a case of food poisoning quickly turned critical, and by the time Tom had been transferred via emergency medevac to the world-class medical center at UC San Diego, where both he and Steffanie worked, blood work revealed why modern medicine was failing: Tom was fighting one of the most dangerous, antibiotic-resistant bacteria in the world. Frantic, Steffanie combed through research old and new and came across phage therapy: the idea that the right virus, aka "the perfect predator," can kill even the most lethal bacteria. Phage treatment had fallen out of favor almost 100 years ago, after antibiotic use went mainstream. Now, with time running out, Steffanie appealed to phage researchers all over the world for help. She found allies at the FDA, researchers from Texas A&M, and a clandestine Navy biomedical center -- and together they resurrected a forgotten cure. A nail-biting medical mystery, The Perfect Predator is a story of love and survival against all odds, and the (re)discovery of a powerful new weapon in the global superbug crisis.
Book Synopsis Biocommunication of Phages by : Guenther Witzany
Download or read book Biocommunication of Phages written by Guenther Witzany and published by Springer Nature. This book was released on 2020-06-29 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to systemize all levels of communicative behavior of phages. Phages represent the most diverse inhabitants on this planet. Until today they are completely underestimated in their number, skills and competences and still remain the dark matter of biology. Phages have serious effects on global energy and nutrient cycles. Phages actively compete for host. They can distinguish between ‘self’ and ‘non-self’ (complement same, preclude others). They process and evaluate available information and then modify their behaviour accordingly. These diverse competences show us that this capacity to evaluate information is possible owing to communication processes within phages (intra-organismic), between the same, related and different phage species (interorganismic), and between phages and non-phage organisms (transorganismic). This is crucial in coordinating infection strategies (lytic vs. lysogenic) and recombination in phage genomes. In 22 chapters, expert contributors review current research into the varying forms of phage biocommunication and Phagetherapy. Biocommunication of Phages aims to assess the current state of research, to orient further investigations on how phages communicate with each other to coordinate their behavioral patterns, and to inspire further investigation of the role of non-phage viruses (non-lytic, non-prokaryotic) in these highly dynamic interactional networks.
Book Synopsis Life in Our Phage World by : Forest Rohwer
Download or read book Life in Our Phage World written by Forest Rohwer and published by . This book was released on 2014-12-01 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: We share the Earth with more than 10,000,000,000,000,000,000,000,000,000,000 phages. Everywhere they thrive, from well-fed guts to near-boiling acidic springs, from cryoconite holes to endolithic fissures. They travel from one microbial host to the next as virions, their genetic weapons packaged inside a protective protein shell. If you could lay all of these nanoscopic phage virions side-by-side, the line-up would stretch over 42 million light years. Through their daily shenanigans they kill or collaborate with their microbial hosts to spur microbial evolution and maintain ecosystem functioning. We have learned much about them since their discovery by Frederick Twort a century ago. They also taught us that DNA, not protein, is the hereditary material, unraveled the triplet genetic code, and offered their enzymes as indispensible tools for the molecular biology revolution. More contributions will be forthcoming since the vast majority of phages await discovery. Phage genomes harbor the world's largest cache of unexplored genetic diversity, and we now have the equipment needed to go prospecting. Although there are field guides to birds, insects, wild flowers, even Bacteria, there was no such handbook to guide the phage explorer. Forest Rohwer decided to correct this oversight, for novice and expert alike, and thus was born Life in Our Phage World. A diverse collection of 30 phages are featured. Each phage is characterized by its distinctive traits, including details about its genome, habitat, lifestyle, global range, and close relatives. The beauty of its intricate virion is captured in a pen-and-ink portrait by artist Benjamin Darby. Each phage also stars in a carefully researched action story relating how that phage encounters, exploits, kills, or otherwise manipulates its host. These behaviors are imaginatively illustrated by fine artist Leah L. Pantea. Eight researchers that work closely with phages also relate their experiences as inhabitants of the phage world. Rohwer has years of first-hand experience with the phage multitudes in ecosystems ranging from coral reefs to the human lung to arctic waters. He pioneered the key metagenomic methods now widely used to catalog and characterize Earth's microbial and viral life. Despite research advances, most people, many scientists included, remain unaware of the ongoing drama in our phage world. In anticipation of 2015, the centennial of phage discovery, Forest assembled a cadre of writers, artists, scientists, and a cartographer and set them to work. The result? This alluring field guide-a feast for the imagination and a celebration of phage diversity."
Book Synopsis Bacteriophages in Health and Disease by : Paul Hyman
Download or read book Bacteriophages in Health and Disease written by Paul Hyman and published by CABI. This book was released on 2012 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bacteriophages are viruses that infect bacteria; as such, they have many potential uses for promoting health and combating disease. This book covers the many facets of phage-bacterial-human interaction in three sections: the role and impact of phages on natural bacterial communities, the potential to develop phage-based therapeutics and other aspects in which phages can be used to combat disease, including bacterial detection, bacterial epidemiology, the tracing of fecal contamination of water and decontamination of foods.
Book Synopsis The Forgotten Cure by : Anna Kuchment
Download or read book The Forgotten Cure written by Anna Kuchment and published by Springer Science & Business Media. This book was released on 2011-12-09 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book fills a void. Never before has a comprehensive history of phage therapy—a once-neglected, now resurgent field—been written. Kuchment writes from the perspective of the eager student of history for the common reader.
Book Synopsis Phage and the Origins of Molecular Biology by : John Cairns
Download or read book Phage and the Origins of Molecular Biology written by John Cairns and published by CSHL Press. This book was released on 2007 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1966 as a 60th birthday tribute to Max Delbrck, this influential work is republished as "The Centennial Edition." The book was hailed as "[introducing] into the literature of science, for the first time, a self-conscious historical element in which the participants in scientific discovery engage in writing their own chronicle ("Journal of History of Biology").
Download or read book Phages written by Matthew K. Waldor and published by . This book was released on 2005 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: provides comprehensive and accessible information in following areas: phage-bacteria interactions including: lysogeny, lysogenic conversion, and phage directed host cell lysis; phage regulatory circuits that control virulence gene expression; evolutionary forces in selection and maintenance of phages bearing virulence genes; phage contributions to pathogenicity of E. coli, Salmonella, Mycobacteria, Vibrio, Bordetella, Corynebacterium, Staphylococcus, Streptococcus, Pneumococcus, Mycoplasma, and Listeria; applied phage technologies, including high frequency recombination and phage display; critical analysis of phage therapy.
Download or read book A Genetic Switch written by Mark Ptashne and published by CSHL Press. This book was released on 2004 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long–range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.
Book Synopsis Single-stranded RNA phages by : Paul Pumpens
Download or read book Single-stranded RNA phages written by Paul Pumpens and published by CRC Press. This book was released on 2020-02-03 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention is devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. Included is an overview of the generation of novel vaccines, gene therapy vectors, drug delivery, and diagnostic tools exploring the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols. Key Features Presents the first full guide to single-stranded RNA phages Reviews the history of molecular biology summarizing the role RNA phages in the development of the life sciences Demonstrates how RNA phage-derived products have resulted in nanotechnological applications Presents an up-to-date account of the role played by RNA phages in evolutionary and environmental studies
Book Synopsis The Bacteriophages by : Richard Calendar
Download or read book The Bacteriophages written by Richard Calendar and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been 10 years since Plenum included a series of reviews on bacte riophages, in Comprehensive Virology. Chapters in that series contained physical-genetic maps but very little DNA sequence information. Now the complete DNA sequence is known for some phages, and the se quences for others will soon follow. During the past 10 years two phages have come into common use as reagents: A phage for cloning single copies of genes, and Ml3 for cloning and DNA sequencing by the dideoxy termi nation method. Also during that period the use of alternative sigma fac tors by RNA polymerase has become established for SPOl and T4. This seems to be a widely used mechanism in bacteria, since it has been implicated in sporulation, heat shock response, and regulation of nitro gen metabolism. The control of transcription by the binding of A phage CII protein to the -35 region of the promoter is a recent finding, and it is not known how widespread this mechanism may be. This rapid progress made me eager to solicit a new series of reviews. These contributions are of two types. Each of the first type deals with an issue that is exemplified by many kinds of phages; chapters of this type should be useful in teaching advanced courses. Chapters of the second type provide comprehensive pictures of individual phage families and should provide valuable information for use in planning experiments.
Book Synopsis Bacteriophages by : Martha R.J. Clokie
Download or read book Bacteriophages written by Martha R.J. Clokie and published by Humana Press. This book was released on 2017-11-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book expands on the previous volumes with new chapters exploring emerging themes and methodologies in bacterial virus research. The chapters in this book are divided into 4 parts and cover topics such as: iron chloride flocculation of bacteriophages from seawater; encapsulation of Listeria phage A511 by alginate; examining genome termini of bacteriophage through high-throughput sequencing; genome sequencing of dsDNA-containing bacteriophages directly from a single plaque; characterizing bacteriophages by biology, taxonomy, and genome analysis; phage genome annotation using the RAST pipeline; and the use of RP4::mini-Mu for gene transfer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and authoritative, Bacteriophages: Methods and Protocols, Volume III is a valuable resource for both established and novice phage scientists.
Book Synopsis Viruses Vs. Superbugs by : T. Häusler
Download or read book Viruses Vs. Superbugs written by T. Häusler and published by Springer. This book was released on 2016-05-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year thousands of people die from bacteria resistant to antibiotics. Alternative drugs are urgently needed. A surprising ray of hope from the past are viruses that kill bacteria, but not us. Award-winning science journalist Thomas Häusler investigates how these long-forgotten cures may help sick people today.
Download or read book Phage Display written by Tim Clackson and published by OUP Oxford. This book was released on 2004-03-04 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book is designed to enable researchers to design and undertake all aspects of a phage display project, from designing an experimental strategy and constructing a library to performing selections and analyzing the results.All of the protocols and chapters are extensively cross-referenced, allowing readers to move beyond the specific examples provided in order to customize the procedures for their own protein or selection system of interest. Phage Display is an up-to-date, comprehensive and integrated experimental guide to the technique, which is essential reading for anyone currently using, or wishing to use the technique for basic research and drug discovery.
Download or read book Phage Therapy written by Jan Borysowski and published by Caister Academic Press Limited. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is an essential reference for anyone interested in phage therapy and a highly recommended book for everyone working in the areas of antibacterial resistance, antimicrobial development, bacteriophage research, biocontrol and biodetection.
