Author : Weimin Lin
Publisher : Frontiers Media SA
ISBN 13 : 2832541879
Total Pages : 106 pages
Book Rating : 4.8/5 (325 download)
Book Synopsis Perspectives in Genetic and Epigenetic Regulatory Mechanisms in Dental and Craniofacial Biology by : Weimin Lin
Download or read book Perspectives in Genetic and Epigenetic Regulatory Mechanisms in Dental and Craniofacial Biology written by Weimin Lin and published by Frontiers Media SA. This book was released on 2023-12-29 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic factors have been proved to be involved in almost all dental and craniomaxillofacial diseases. Typical dental and craniomaxillofacial hereditary diseases refer to hereditary diseases which occurs in the oral and maxillofacial area, as well as systemic or other system hereditary diseases accompanied by oral abnormality. The former includes enamel hypoplasia, dentin hypoplasia and cleft lip and palate, which mainly occur in the oral cavity. While the latter commonly includes cranial clavicle hypoplasia, congenital ectodermal hypoplasia, osteogenesis imperfecta, and osteosclerosis. In addition, common diseases that appear locally in the oral cavity, including caries, periodontitis, oral mucosal diseases and head and neck tumors, are also considered to be related to genetic variations. With the increase of large-scale genome-wide association analysis study (GWAS) during the last decade, common loci for many genetic diseases have been identified. To date, most evidence comes from GWAS of dental caries and periodontal disease, which have tested associations between millions of single nucleotide polymorphisms (SNPs) and typical binary phenotypes. However, genetic loci for other rare oral diseases remain to be studied due to their large variety and low incidence. Multi-omics sequencing technology provides a more powerful tool for identifying the pathogenic genes of dental and craniomaxillofacial hereditary diseases at genomic, transcriptomic and proteomic level. In addition, with the development of single-cell multi-omics technology, specific cell populations involved in the pathogenesis of dental and craniomaxillofacial hereditary disease can be more accurately identified at single-cell resolution.