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Personalized Therapy For Multiple Myeloma
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Book Synopsis Personalized Therapy for Multiple Myeloma by : Saad Z. Usmani
Download or read book Personalized Therapy for Multiple Myeloma written by Saad Z. Usmani and published by Springer. This book was released on 2017-10-30 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the clinician with concise, practical guidance on risk stratification and therapeutic decision making in patients with multiple myeloma. In addition, the available clinical trial and research data are summarized into meaningful reviews and evidence-based recommendations for treatment are presented. The coverage encompasses all phases and forms of disease, including high-risk myeloma. Over recent decades, greater understanding of the biology of myeloma has fostered the development of new, more effective drugs, leading to remarkable improvements in survival. To continue this momentum, several recent prospective trials have aimed to identify further potential therapeutic targets or to evaluate various combinations of anti-myeloma agents. The increasing abundance of management options makes the decision making complex in different phases of the disease. This book will offer the clinician valuable assistance in the choice and sequencing of therapies, highlighting the need for a personalized approach that reflects the growing recognition that myeloma is not one uniform disease.
Book Synopsis Towards Individualized Therapy for Multiple Myeloma by : Gerrard Teoh
Download or read book Towards Individualized Therapy for Multiple Myeloma written by Gerrard Teoh and published by World Scientific. This book was released on 2009 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This very provocative book takes the reader on a ?think-out-of-the-box? journey through the development of a treatment regimen for multiple myeloma called ?dtZ?. It is a firsthand account of how more than 50 patients with myeloma were given a non-toxic, precisely-targeted, anti-cancer treatment that was specifically adapted to their individual cancers. These Individualized Anti-Cancer Targeted Therapies (smart bombs) have produced amongst the best responses as well as survival rates for myeloma. Accordingly, the author argues that some patients might even have been ?cured? of their cancers.The concepts and logic behind ?dtZ? are carefully presented in simple language so that both doctors and patients can easily understand them. Numerous tables and figures are provided, together with clear and simple explanations. This book is a valuable resource for all patients with myeloma who want to get the most out of their treatment by individualizing treatment to suit their needs, particularly for patients who have just been diagnosed with myeloma and who are taking that very important first step in their treatment. It is also a useful guide for doctors, nurses and researchers who treat and/or study myeloma.
Book Synopsis Advancing Microfluidic Assays Toward Personalized Multiple Myeloma Cancer Therapy Selection by : Thomas Allen Moore
Download or read book Advancing Microfluidic Assays Toward Personalized Multiple Myeloma Cancer Therapy Selection written by Thomas Allen Moore and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer treatment selection is hindered by a lack of personalized data, relying instead on empirical evidence to justify treatment selection. For multiple myeloma (MM), a hematologic cancer, treatment selection is complicated by the occurrence of drug resistance, and patients have been observed to respond in an unpredictable fashion. To address these challenges, there is a need for more personalized treatment selection methods. Since the 1950's, tools and assays for testing individual patient samples with a variety of drug treatments, called chemosensitivity and resistance assays (CSRAs), have been under development. There are currently no CSRAs approved for clinical use due to a lack of data supporting improved clinical outcomes compared to current empirical methods. A lack of improved clinical outcomes has been linked to limitations associated with the tools and methods used to perform these assays, as they require higher quantities of patient sample than some patients can provide, and they do not sufficiently mimic in vivo conditions. To address these limitations, my objective was to produce several individual advances for a platform previously developed to study MM. Using microfabrication and device material characterization, poly(dimethylsiloxane) (PDMS) drug absorption and its impact on cytotoxicity assays was studied. Diffusion modelling and analysis was performed alongside physical experiments to confirm near-uniform soluble factor diffusion across microsystems. Cell population heterogeneity measures were used to study the effects of varying cell population to assess the feasibility of reducing cell seeding populations. Finally, the importance of accurately mimicking in vivo drug treatment concentrations was assessed by comparing two approaches for analyzing cytotoxicity assay data. The combination of these advancements positions the platform for further application in clinical studies, and to further our basic understanding of MM, with a specific focus on disease progression and drug resistance.
Book Synopsis Contemporary Management of Multiple Myeloma by : Ravi Vij
Download or read book Contemporary Management of Multiple Myeloma written by Ravi Vij and published by JAYPEE BROTHERS MEDICAL PUBLISHERS PVT. LTD.. This book was released on 2012-12-15 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book "Contemporary Management of Multiple Myeloma" discusses in detail about the management of multiple myeloma. Multiple Myeloma is the second most common hematological malignancy in the United States. This book highlights the interplay between the malignant plasma cell and the microenvironment, and the role of genetic alterations, adhesion molecules and critical cytokines in this complex milieu. The first chapter of this book discusses epidemiology, etiology and pathogenesis of multiple myeloma. The clinical presentation of the common plasma cell dyscrasias and discuss the diagnostic and prognostic work-up with a highlighting on recent advances in chapters 3 and 4. Chapters from 5 to 9 focus on the therapeutic evolution that has occurred, and accumulate the landmark clinical trials that have changed clinical practice for up-front treatment of both transplant eligible and ineligible patients and for those with relapsed and refractory disease. These chapters also highlights on the important role of clinical research with stem cell transplantation, proteasome-inhibition and immunomodulatory drugs that form the backbone of our present day therapeutic armamentarium. Recommendations for response assessment and current understanding of the value of maximizing the depth of response in personalized therapy and patient segmentation are briefly explained in chapters 10 and 11. Chapter 12 and 13 discussed about adjunctive treatment modalities and novel therapeutic compounds in clinical trial and targets for future drug development. This book provides complete information about current landscape for multiple myeloma which is helpful in future aspects.
Book Synopsis Genetic Biomarkers for Personalized Treatment in Multiple Myeloma by : Ming Han
Download or read book Genetic Biomarkers for Personalized Treatment in Multiple Myeloma written by Ming Han and published by . This book was released on 2016 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is an incurable haematological cancer characterized by the accumulation of monoclonal plasma cells inside the bone marrow. Melphalan and Thalidomide are two drugs that have dramatically improved patient survival. However, a significant subpopulation of myeloma patients does not respond to these drugs; in addition, some patients are predisposed to drug-related toxicities, which remains unpredictable. Using samples from the MY.10 randomized clinical trial with an observation arm, the present study found several single nucleotide polymorphism (SNP) genetic biomarkers to be predictive of thalidomide treatment benefit and thalidomide related toxicity (peripheral neuropathy). In addition, the present study also confirmed previous findings where several SNPs were also found to be predictive of melphalan response. Lastly, novel SNPs were found to be associated with myeloma prognosis. These findings contribute to the growing body of evidence that genetic biomarkers can be useful in predicting drug response and prognosis in myeloma. Further studies are needed to confirm our findings.
Author :Karthik Ramasamy Publisher :Karger Medical and Scientific Publishers ISBN 13 :1910797332 Total Pages :162 pages Book Rating :4.9/5 (17 download)
Book Synopsis Fast Facts: Multiple Myeloma and Plasma Cell Dyscrasias by : Karthik Ramasamy
Download or read book Fast Facts: Multiple Myeloma and Plasma Cell Dyscrasias written by Karthik Ramasamy and published by Karger Medical and Scientific Publishers. This book was released on 2017-01-09 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of multiple myeloma (MM) is growing at a formidable pace, particularly in terms of risk factors and potential drug targets. Minimal residual disease (MRD) negativity is set to become the new benchmark in treatment, and cytogenetic analysis is now paving the way for personalized therapies. This second edition of 'Fast Facts: Multiple Myeloma and Plasma Cell Dyscrasias' includes: - the new IMWG SLiM CRAB criteria - the latest advances in diagnostic tests and imaging - cytogenetics and genetic profiling - induction therapy prior to SCT - new lenalidomide- and bortezomib-based regimens - second-generation proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies treatments. This Fast Facts handbook provides a comprehensive overview of MM and other plasma cell dyscrasias, from bench to bedside, presenting the pathogenesis, diagnosis and treatment in the context of daily clinical practice. Contents: • Epidemiology and etiology Predisposing conditions associated with MM • Pathophysiology of MM and MGUS • Diagnosis, staging and monitoring of multiple myeloma • Genetics and multiple myeloma • Treatment of newly diagnosed multiple myeloma • Stem cell transplantation in multiple myeloma • Relapsed and refractory multiple myeloma • Bone disease and renal complications • AL amyloidosis • Rare plasma cell dyscrasias • Supportive care
Book Synopsis Experimental and Conceptual Basis for Personalized and Risk-adapted Treatment of Multiple Myeloma by :
Download or read book Experimental and Conceptual Basis for Personalized and Risk-adapted Treatment of Multiple Myeloma written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The EBMT/EHA CAR-T Cell Handbook by : Nicolaus Kröger
Download or read book The EBMT/EHA CAR-T Cell Handbook written by Nicolaus Kröger and published by Springer Nature. This book was released on 2022-02-07 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first open access European CAR-T Handbook, co-promoted by the European Society for Blood and Marrow Transplantation (EBMT) and the European Hematology Association (EHA), covers several aspects of CAR-T cell treatments, including the underlying biology, indications, management of side-effects, access and manufacturing issues. This book, written by leading experts in the field to enhance readers’ knowledge and practice skills, provides an unparalleled overview of the CAR-T cell technology and its application in clinical care, to enhance readers’ knowledge and practice skills.
Book Synopsis Multiple Myeloma by : Morie A. Gertz
Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.
Book Synopsis Advances in Biology and Therapy of Multiple Myeloma by : Nikhil C. Munshi
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Book Synopsis Medifocus Guidebook on by : Medifocus.com, Inc
Download or read book Medifocus Guidebook on written by Medifocus.com, Inc and published by Medifocus_com Inc. This book was released on 2012-01-29 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The MediFocus Guidebook on Multiple Myeloma is the most comprehensive, up-to-date source of information available. You will get answers to your questions, including risk factors of Multiple Myeloma, standard and alternative treatment options, leading doctors, hospitals and medical centers that specialize in Multiple Myeloma, results of the latest clinical trials, support groups and additional resources, and promising new treatments on the horizon. This one of a kind Guidebook offers answers to your critical health questions including the latest treatments, clinical trials, and expert research; high quality, professional level information you can trust and understand culled from the latest peer-reviewed journals; and a unique resource to find leading experts, institutions, and support organizations including contact information and hyperlinks. This Guidebook was updated on January 29, 2012.
Download or read book Myeloma Therapy written by Sagar Lonial and published by Springer Science & Business Media. This book was released on 2009-01-01 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic options for patients with myeloma have dramatically changed over the past 10 years. Beginning with the advances in therapy resulting from the use of high-dose therapy and autologous bone marrow or stem cell tra- plant, we have more than doubled the median survival for patients as a whole, and have now have a wealth of different biology -based treatment approaches for our patients in all disease stages. This book represents state-of-the-art information from many of the leaders in the plasma cell disorders world. Sections focusing on disease pathogenesis and biology, chemotherapy-based approaches, immune -based therapies, currently approved novel agents, developing targets, supportive care, and other plasma cell disorders provides a comprehensive collection and an excellent resource in this time of rapid change in clinical and preclinical disease knowledge. It is important to realize that these changes did not occur in a vacuum. Partnerships between academic institutions, the pharmaceutical industry, patient advocacy groups, the National Cancer Institute, community onco- gists, and ultimately our patients worked closely together to realize these advances, and to effect the radical changes in therapy we have witnessed over the past few years. This book would not have been possible without contri- tions from each of the gifted scientists and clinicians who worked tirelessly to prepare their individual chapters all the while maintaining commitment to the scientific and clinical mission of advancing care.
Book Synopsis Advances in Biology and Therapy of Multiple Myeloma by : Nikhil C. Munshi
Download or read book Advances in Biology and Therapy of Multiple Myeloma written by Nikhil C. Munshi and published by Springer Science & Business Media. This book was released on 2012-11-15 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Download or read book Love, Olivia written by Dr. Tomer Mark and published by WestBow Press. This book was released on 2012-02-24 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: From diagnosis to discoveries and decisions, author Olivia Chin has had experiences that would make others give up, but she has faced them with optimism and a sense of style. She has had her share of ups and downs, but has managed to continue her journey with humor, grace, courage, humanity, and a smile on her beautiful face. Olivias story is synonymous with survivorship; it is a source of inspiration to her family, friends, the medical community, and hopefully to others in need. In this book, she speaks to the importance of finding answers, having a community of support, and always keeping hope alive!
Book Synopsis Multiple Myeloma by : Thomas Moehler
Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer. This book was released on 2011-04-22 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
Book Synopsis Multiple Myeloma by : Thomas Moehler
Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer. This book was released on 2013-05-30 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.
Book Synopsis Personalized Medicine in Oncology by : Ari VanderWalde
Download or read book Personalized Medicine in Oncology written by Ari VanderWalde and published by . This book was released on 2022 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
