Author : Bronaugh RL Ed
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Book Synopsis Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Revised and Expanded by : Bronaugh RL Ed
Download or read book Percutaneous Absorption : Mechanisms - Methodology - Drug Delivery , Revised and Expanded written by Bronaugh RL Ed and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The microscopic structure of the epidermis and its derivatives; Mathematical models of percutaneous absorption; Mechanism of percutaneous absorption from physicochemical evidence; Cutaneous metabolism of xenobiotics; Occlusion does not uniformly enhance penetration in vivo; Structure activity correlations in percutaneous absorption; Regional variation in percutaneous absorption; Cutaneous permeation of lipophilic molecules, effects of enhancers; Studies on the permeability of infant skin; Interaction of vehicles with model skin membranes in the permeation process; In vivo relationship between percutaneous absorption and transepidermal water loss; Skin contamination and absorption of chemicals from drinking water while bathing or swimming; Classification of percutaneous penetration enhancers, a conceptional diagram; In vivo methods for percutaneous absorption measurements; In vivo animal models for percutaneous absorption; Determination of percutaneous absorption by in vitro techniques; The influence of metabolism on percutaneous absorption; Localization of compounds in different skin layers and its use as an indicator of percutaneous absorption; Evaporation and penetration from skin; Dermal decontamination and percutaneous absorption; Interrelationships in the dose response of percutaneous absorption; Blood flow as a technology in percutaneous absorption, the assessment of the cutaneous microcirculation by laser doppler and photoplethysmographic techniques; Calculations of body exposure from percutaneous absorption data; Human skin sandwich flap model for percutaneous absorption; Stripping method for measuring percutaneous absorption in vivo; Noninvasive radioisotope counting on skin, surface or external counting; The human skin blanching assay as an indicator of topical corticosteroid bioavailability and potency, an update; Skin absorption from patch test systems, relevance to allergic contact dermatitis and transdermal delivery systems; In vitro systems for the assessment of drug release from topical formulations and transmembrane permeation; Percutaneous penetration as a method of delivery to muscle and other tissue; Optimizing percutaneous absorption; Facilitated percutaneous absorption of charged drugs; Action of penetration enhancers on human stratum corneum as assessed by differential scanning calorimetry; Ultrasound as a transdermal enhancer; Iontophoretic Drug Delivery, Effects of physicochemical factors on the skin uptake of drugs; In vivo percutaneous absorption, effect of repeated application versus single dose; In vitro testing of topical pharmaceutical formulations.