Percutaneous Absorption

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Percutaneous Absorption

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Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 9781420000948
Total Pages : 992 pages
Book Rating : 4.0/5 (9 download)

Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 1999-05-28 with total page 992 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since publication of the Second Edition in 1989, numerous innovations have occurred that affect the way scientists look at issues in the field of percutaneous absorption. Focusing on recent advances as well as updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption, Third Edition provides thorough coverage of the skin's role as an important portal of entry for chemicals into the body. Assembles the work of nearly 80 experts-30 more than the Second Edition-into a unified, comprehensive volume that contains the latest ideas and research! Complete with nearly 600 drawings, photographs, equations, and tables and more than 1600 bibliographic citations of pertinent literature, Percutaneous Absorption, Third Edition details the applied biology of percutaneous penetration factors that affect skin permeation, such as age, vehicles, metabolism, hydration of skin, and chemical structure in vivo and in vitro techniques for measuring absorption, examining factors influencing methodology such as animal models, volatility of test compound, multiple dosage, and artificial membranes procedures for use in transdermal delivery, exploring topics such as effects of penetration enhancers on absorption, optimizing absorption, and the topical delivery of drugs to muscle tissue And presents new chapters on mathematical models cutaneous metabolism prediction of percutaneous absorption in vitro absorption methodology dermal decontamination concentration of chemicals in skin transdermal drug delivery mechanisms of absorption safety evaluation of cosmetics absorption of drugs and cosmetic ingredients nail penetration Emphasizes human applications-particularly useful for pharmacists, pharmacologists, dermatologists, cosmetic scientists, biochemists, toxicologists, public health officials, manufacturers of cosmetic and toiletry products, and graduate students in these disciplines! An invaluable reference source for readers who need to keep up with the latest developments in the field, Percutaneous Absorption, Third Edition is also an excellent experimental guide for laboratory personnel.

Skin Barrier

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Author : Hans Schaefer
Publisher : S. Karger AG (Switzerland)
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Skin Barrier by : Hans Schaefer

Download or read book Skin Barrier written by Hans Schaefer and published by S. Karger AG (Switzerland). This book was released on 1996 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Skin Barrier is the first book to be written exclusively by researchers for researchers as a convenient desktop reference. It focuses on several key aspects of the skin barrier including composition and structure and a description of the properties governing the diffusion of compounds across the skin. Although there has been a large number of laboratories involved in measuring percutaneous absorption over the past 15 to 20 years, it is only recently that there has been a general consensus in the scientific community regarding the development of standard protocols. Recognizing the importance of this, the authors have included two chapters detailing the protocol used in measuring and predicting percutaneous absorption and a discussion on the practical application of these techniques to solve associated problems. In order to provide the researcher and especially the student with access to more detailed information, the book features a comprehensive listing of references published over the past 10 years. Skin Barrier is the only desktop reference for dermatologists, cosmetologists, biochemists, biologists, and those in the pharmaceutics industry, who need detailed and accurate information about the skin barrier on a daily basis. No R & D department should be without a copy.

Percutaneous Absorption

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Author : Nina Dragićević
Publisher : CRC Press
ISBN 13 : 0429511566
Total Pages : 1008 pages
Book Rating : 4.4/5 (295 download)

Book Synopsis Percutaneous Absorption by : Nina Dragićević

Download or read book Percutaneous Absorption written by Nina Dragićević and published by CRC Press. This book was released on 2021-07-30 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updating and expanding the scope of topics covered in the previous edition, Percutaneous Absorption: Drugs, Cosmetics, Mechanisms, Methods, Fifth Edition supplies new chapters on topics currently impacting the field including cutaneous metabolism, skin contamination, exposure to protein allergens, in vitro absorption methodology and the percutaneous absorption of chemical mixtures. Complete with studies on the role of the skin as a key portal of entry for chemicals into the body, this book serves as a detailed reference source for recent advances in the field, as well as an experimental guide for laboratory personnel. Key Features: Details in vivo and in vitro methods for measuring absorption, dermal decontamination, mechanisms of transdermal delivery, and the relationship of transepidermal water loss to percutaneous absorption Considers a range of mathematical models, the safety evaluation of cosmetic ingredients, the absorption of hair dyes, nanoparticles for drug delivery, and other novel methods of drug delivery Discusses topics including skin metabolism, the skin reservoir, and the effects of desquamation on absorption

Percutaneous Absorption

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Author : Robert L. Bronaugh
Publisher :
ISBN 13 :
Total Pages : 688 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by . This book was released on 1989 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt:

In Vitro Percutaneous Absorption

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Author : Robert L. Bronaugh
Publisher : CRC Press
ISBN 13 : 1000946622
Total Pages : 290 pages
Book Rating : 4.0/5 (9 download)

Book Synopsis In Vitro Percutaneous Absorption by : Robert L. Bronaugh

Download or read book In Vitro Percutaneous Absorption written by Robert L. Bronaugh and published by CRC Press. This book was released on 2023-06-14 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.

Dermal Absorption and Toxicity Assessment

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Author : Michael S. Roberts
Publisher : CRC Press
ISBN 13 : 0849375924
Total Pages : 704 pages
Book Rating : 4.8/5 (493 download)

Book Synopsis Dermal Absorption and Toxicity Assessment by : Michael S. Roberts

Download or read book Dermal Absorption and Toxicity Assessment written by Michael S. Roberts and published by CRC Press. This book was released on 2007-12-14 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin ab

Methods for Skin Absorption

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Author : Barbara W. Kemppainen
Publisher : CRC Press
ISBN 13 : 9780849346514
Total Pages : 244 pages
Book Rating : 4.3/5 (465 download)

Book Synopsis Methods for Skin Absorption by : Barbara W. Kemppainen

Download or read book Methods for Skin Absorption written by Barbara W. Kemppainen and published by CRC Press. This book was released on 1990-06-13 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date volume describes the wide variety of available methods concerning percutaneous absorption of drugs and toxins. It discusses in detail the advantages and disadvantages of each method. This unique publication provides a clear, systematic presentation of each aspect which must be considered when designing and performing skin penetration experiments and when interpreting results. It includes specific information regarding necessary supplies and equipment, along with commercial sources for these items. This state-of-the-art book is an ideal instructional manual for investigators uninitiated in performing percutaneous absorption and metabolism studies. Those involved with investigative dermatology, dermatological research, toxicology, and pharmacology will find this reference interesting and indispensable.

Predictive Methods in Percutaneous Absorption

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Author : Gary P. Moss
Publisher : Springer
ISBN 13 : 3662473712
Total Pages : 206 pages
Book Rating : 4.6/5 (624 download)

Book Synopsis Predictive Methods in Percutaneous Absorption by : Gary P. Moss

Download or read book Predictive Methods in Percutaneous Absorption written by Gary P. Moss and published by Springer. This book was released on 2015-07-01 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products

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Author : Zacarías León González
Publisher : Springer
ISBN 13 : 9783319346977
Total Pages : 0 pages
Book Rating : 4.3/5 (469 download)

Book Synopsis Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products by : Zacarías León González

Download or read book Percutaneous Absorption of UV Filters Contained in Sunscreen Cosmetic Products written by Zacarías León González and published by Springer. This book was released on 2016-08-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zacarías León's thesis describes the development and validation of analytical methods to estimate the processes set in motion by percutaneous absorption of UV filters in sunscreen cosmetic products. León describes these methods in both in vitro and non-invasive in vivo methodologies. Currently dermatologists recommend the use of sunscreen products not only under conditions of extreme exposure to the sun but also in daily situations. However the chemical compounds in these products contain may lead to undesired processes and cause induced toxicity, estrogenic effects and endocrine activity. León establishes methods to investigate these effects and provides valuable information on the undesired side effects associated with the use of UV filters found in sunscreen products. The work in this thesis has led to a number of publications in renowned analytical chemistry journals.

Topical Drug Bioavailability, Bioequivalence, and Penetration

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Author : Vinod P. Shah
Publisher : Springer
ISBN 13 : 1493912895
Total Pages : 393 pages
Book Rating : 4.4/5 (939 download)

Book Synopsis Topical Drug Bioavailability, Bioequivalence, and Penetration by : Vinod P. Shah

Download or read book Topical Drug Bioavailability, Bioequivalence, and Penetration written by Vinod P. Shah and published by Springer. This book was released on 2015-01-30 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.

Percutaneous Penetration Enhancers

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Author : Eric Wane Smith
Publisher : CRC Press
ISBN 13 : 1420039202
Total Pages : 448 pages
Book Rating : 4.4/5 (2 download)

Book Synopsis Percutaneous Penetration Enhancers by : Eric Wane Smith

Download or read book Percutaneous Penetration Enhancers written by Eric Wane Smith and published by CRC Press. This book was released on 2005-11-02 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thoroughly updated, this second edition is the most comprehensive reference on the methods available for the enhancement of percutaneous penetration. The book examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed is, arguably, unsurpassed anywhere in the literature. This edition contains comprehensive descriptions of the latest techniques and several chapters cover the modern analytical techniques adapted to assess and measure penetration enhancement. New to this volume are chapters addressing penetration retardation, important for substances such as sunscreen agents, for which skin penetration is not desirable.

Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

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Author : Nina Dragicevic
Publisher : Springer
ISBN 13 : 3662478625
Total Pages : 387 pages
Book Rating : 4.6/5 (624 download)

Book Synopsis Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement by : Nina Dragicevic

Download or read book Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement written by Nina Dragicevic and published by Springer. This book was released on 2016-01-05 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered and the latest findings are provided on skin structure and function, mathematics in skin permeation and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners and also students.

Dermal Absorption

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Author : J. Kielhorn
Publisher : World Health Organization
ISBN 13 : 9241572353
Total Pages : 217 pages
Book Rating : 4.2/5 (415 download)

Book Synopsis Dermal Absorption by : J. Kielhorn

Download or read book Dermal Absorption written by J. Kielhorn and published by World Health Organization. This book was released on 2006 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction and definitions -- Skin structure and function -- Skin transport mechanisms and theoretical concepts -- Metabolism in the skin -- In vitro tests for dermal absorption -- In vivo tests for dermal absorption -- Comparative studies -- Data collections -- Estimation/prediction of dermal penetration -- Use of dermal penetration studies in risk assessment -- Controversial topics in the assessment of dermal absorption -- Conclusions and recommendations.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method

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Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264071067
Total Pages : 8 pages
Book Rating : 4.2/5 (64 download)

Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 427: Skin Absorption: In Vivo Method written by OECD and published by OECD Publishing. This book was released on 2004-11-23 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...

Percutaneous Absorption

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Author : Robert L. Bronaugh
Publisher :
ISBN 13 :
Total Pages : 878 pages
Book Rating : 4.:/5 (16 download)

Book Synopsis Percutaneous Absorption by : Robert L. Bronaugh

Download or read book Percutaneous Absorption written by Robert L. Bronaugh and published by . This book was released on 2010 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Quantitative Study of Percutaneous Absorption

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Author : R. Kenneth Loeffler
Publisher :
ISBN 13 :
Total Pages : 38 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis A Quantitative Study of Percutaneous Absorption by : R. Kenneth Loeffler

Download or read book A Quantitative Study of Percutaneous Absorption written by R. Kenneth Loeffler and published by . This book was released on 1951 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt:

PERCUTANEOUS ABSORPTION.

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Author : Richard B. Stoughton
Publisher :
ISBN 13 :
Total Pages : 15 pages
Book Rating : 4.:/5 (227 download)

Book Synopsis PERCUTANEOUS ABSORPTION. by : Richard B. Stoughton

Download or read book PERCUTANEOUS ABSORPTION. written by Richard B. Stoughton and published by . This book was released on 1963 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: A summary is given of studies concerning various aspects of the absorption of biologically active substances through the human skin.