Peptide And Protein Vaccines

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Delivery Technologies for Biopharmaceuticals

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Author : Lene Jorgensen
Publisher : John Wiley & Sons
ISBN 13 : 0470688408
Total Pages : 442 pages
Book Rating : 4.4/5 (76 download)

Book Synopsis Delivery Technologies for Biopharmaceuticals by : Lene Jorgensen

Download or read book Delivery Technologies for Biopharmaceuticals written by Lene Jorgensen and published by John Wiley & Sons. This book was released on 2009-10-23 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Peptide Antibodies

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Author : Gunnar Houen
Publisher : Humana
ISBN 13 : 9781493929986
Total Pages : 0 pages
Book Rating : 4.9/5 (299 download)

Book Synopsis Peptide Antibodies by : Gunnar Houen

Download or read book Peptide Antibodies written by Gunnar Houen and published by Humana. This book was released on 2015-10-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This extensive volume covers basic and advanced aspects of peptide antibody production, characterization and uses. Although peptide antibodies have been available for many years, they continue to be a field of active research and method development. For example, peptide antibodies which are dependent on specific posttranslational modifications are of great interest, such as phosphorylation, citrullination and others, while different forms of recombinant peptide antibodies are gaining interest, notably nanobodies, single chain antibodies, TCR-like antibodies, among others. Within this volume, those areas are covered, as well as several technical and scientific advances: solid phase peptide synthesis, peptide carrier conjugation and immunization, genomics, transcriptomics, proteomics and elucidation of the molecular basis of antigen presentation and recognition by dendritic cells, macrophages, B cells and T cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, Peptide Antibodies: Methods and Protocols serves as an ideal reference for researchers exploring this vital and expansive area of study.

Immunoinformatics

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Author : Christian Schönbach
Publisher : Springer Science & Business Media
ISBN 13 : 0387729682
Total Pages : 216 pages
Book Rating : 4.3/5 (877 download)

Book Synopsis Immunoinformatics by : Christian Schönbach

Download or read book Immunoinformatics written by Christian Schönbach and published by Springer Science & Business Media. This book was released on 2007-11-21 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to existing books on immunoinformatics, this volume presents a cross-section of immunoinformatics research. The contributions highlight the interdisciplinary nature of the field and how collaborative efforts among bioinformaticians and bench scientists result in innovative strategies for understanding the immune system. Immunoinformatics is ideal for scientists and students in immunology, bioinformatics, microbiology, and many other disciplines.

Nanostructures for Oral Medicine

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Author : Ecaterina Andronescu
Publisher : Elsevier
ISBN 13 : 0323477216
Total Pages : 1036 pages
Book Rating : 4.3/5 (234 download)

Book Synopsis Nanostructures for Oral Medicine by : Ecaterina Andronescu

Download or read book Nanostructures for Oral Medicine written by Ecaterina Andronescu and published by Elsevier. This book was released on 2017-04-11 with total page 1036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. - Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied - Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine - Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices

Pharmaceutical Biotechnology

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Author : Daan J. A. Crommelin
Publisher : CRC Press
ISBN 13 : 9780415285018
Total Pages : 456 pages
Book Rating : 4.2/5 (85 download)

Book Synopsis Pharmaceutical Biotechnology by : Daan J. A. Crommelin

Download or read book Pharmaceutical Biotechnology written by Daan J. A. Crommelin and published by CRC Press. This book was released on 2002-11-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.

Omics Technologies and Bio-engineering

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Author : Debmalya Barh
Publisher : Academic Press
ISBN 13 : 0128047496
Total Pages : 645 pages
Book Rating : 4.1/5 (28 download)

Book Synopsis Omics Technologies and Bio-engineering by : Debmalya Barh

Download or read book Omics Technologies and Bio-engineering written by Debmalya Barh and published by Academic Press. This book was released on 2017-12-01 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Omics Technologies and Bio-Engineering: Towards Improving Quality of Life, Volume 1 is a unique reference that brings together multiple perspectives on omics research, providing in-depth analysis and insights from an international team of authors. The book delivers pivotal information that will inform and improve medical and biological research by helping readers gain more direct access to analytic data, an increased understanding on data evaluation, and a comprehensive picture on how to use omics data in molecular biology, biotechnology and human health care. - Covers various aspects of biotechnology and bio-engineering using omics technologies - Focuses on the latest developments in the field, including biofuel technologies - Provides key insights into omics approaches in personalized and precision medicine - Provides a complete picture on how one can utilize omics data in molecular biology, biotechnology and human health care

Peptide and Protein Vaccines

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Author : Rossen Donev
Publisher : Academic Press
ISBN 13 : 0128028696
Total Pages : 192 pages
Book Rating : 4.1/5 (28 download)

Book Synopsis Peptide and Protein Vaccines by : Rossen Donev

Download or read book Peptide and Protein Vaccines written by Rossen Donev and published by Academic Press. This book was released on 2015-06-08 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. - Describes advances in application of powerful techniques in a wide bioscience area - Chapters are written by authorities in their field - Targeted to a wide audience of researchers, specialists, and students - The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables

Harnessing the Power of Viruses

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Author : Boriana Marintcheva
Publisher : Academic Press
ISBN 13 : 0128105151
Total Pages : 298 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Harnessing the Power of Viruses by : Boriana Marintcheva

Download or read book Harnessing the Power of Viruses written by Boriana Marintcheva and published by Academic Press. This book was released on 2017-11-13 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Harnessing the Power of Viruses explores the application of scientific knowledge about viruses and their lives to solve practical challenges and further advance molecular sciences, medicine and agriculture. The book contains virus-based tools and approaches in the fields of: i) DNA manipulations in vitro and in vivo; ii) Protein expression and characterization; and iii) Virus- Host interactions as a platform for therapy and biocontrol are discussed. It steers away from traditional views of viruses and technology, focusing instead on viral molecules and molecular processes that enable science to better understand life and offer means for addressing complex biological phenomena that positively influence everyday life. The book is written at an intermediate level and is accessible to novices who are willing to acquire a basic level of understanding of key principles in molecular biology, but is also ideal for advanced readers interested in expanding their biological knowledge to include practical applications of molecular tools derived from viruses. - Explores virus-based tools and approaches in DNA manipulation, protein expression and characterization and virus-host interactions - Provides a dedicated focus on viral molecules and molecular processes that enable science to better understand life and address complex biological phenomena - Includes an overview of modern technologies in biology that were developed using viral components/elements and knowledge about viral processes

Vaccine Development and Manufacturing

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Author : Emily P. Wen
Publisher : John Wiley & Sons
ISBN 13 : 1118870905
Total Pages : 452 pages
Book Rating : 4.1/5 (188 download)

Book Synopsis Vaccine Development and Manufacturing by : Emily P. Wen

Download or read book Vaccine Development and Manufacturing written by Emily P. Wen and published by John Wiley & Sons. This book was released on 2014-10-06 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vaccine Manufacturing and Production is an invaluable reference on how to produce a vaccine - from beginning to end - addressing all classes of vaccines from a processing, production, and regulatory viewpoint. It will provide comprehensive information on the various fields involved in the production of vaccines, from fermentation, purification, formulation, to regulatory filing and facility designs. In recent years, there have been tremendous advances in all aspects of vaccine manufacturing. Improved technology and growth media have been developed for the production of cell culture with high cell density or fermentation. Vaccine Manufacturing and Production will serve as a reference on all aspects of vaccine production by providing an in-depth description of the available technologies for making different types of vaccines and the current thinking in facility designs and supply issues. This book will provide insight to the issues scientists face when producing a vaccine, the steps that are involved, and will serve as a reference tool regarding state-of-the-art vaccine manufacturing technologies and facility set-up. Highlights include: Comprehensive coverage of vaccine production : from a process point of view- fermentation to purification to formulation developments; from a production point of view - from facility design to manufacturing; and from a regulatory point of view - requirements from government agencies Authors from different major pharmaceutical and biotechnology companies Describes the challenges and issues involved in vaccine production and manufacturing of the different classes of vaccines, an area not covered by other books currently on the market

Oncoimmunology

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Author : Laurence Zitvogel
Publisher : Springer
ISBN 13 : 3319624318
Total Pages : 700 pages
Book Rating : 4.3/5 (196 download)

Book Synopsis Oncoimmunology by : Laurence Zitvogel

Download or read book Oncoimmunology written by Laurence Zitvogel and published by Springer. This book was released on 2017-12-13 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.

Subunit Vaccine Delivery

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Author : Camilla Foged
Publisher : Springer
ISBN 13 : 1493914170
Total Pages : 433 pages
Book Rating : 4.4/5 (939 download)

Book Synopsis Subunit Vaccine Delivery by : Camilla Foged

Download or read book Subunit Vaccine Delivery written by Camilla Foged and published by Springer. This book was released on 2014-11-22 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Mucosal Vaccines

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Author : Hiroshi Kiyono
Publisher : Elsevier
ISBN 13 : 0080537057
Total Pages : 501 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis Mucosal Vaccines by : Hiroshi Kiyono

Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Translational Immunotherapy of Brain Tumors

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Author : John H. Sampson
Publisher : Academic Press
ISBN 13 : 0128026251
Total Pages : 406 pages
Book Rating : 4.1/5 (28 download)

Book Synopsis Translational Immunotherapy of Brain Tumors by : John H. Sampson

Download or read book Translational Immunotherapy of Brain Tumors written by John H. Sampson and published by Academic Press. This book was released on 2017-02-06 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. 2018 BMA Medical Book Awards Highly Commended in Oncology - Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas - Edited by a prominent neurosurgeon with contributions by leading researchers in the field - Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors

Vaccines for Cancer Immunotherapy

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Author : Nima Rezaei
Publisher : Academic Press
ISBN 13 : 0128140402
Total Pages : 200 pages
Book Rating : 4.1/5 (281 download)

Book Synopsis Vaccines for Cancer Immunotherapy by : Nima Rezaei

Download or read book Vaccines for Cancer Immunotherapy written by Nima Rezaei and published by Academic Press. This book was released on 2018-10-17 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic cancer vaccines represent a type of active cancer immunotherapy. Clinicians, scientists, and researchers working on cancer treatment require evidence-based and up-to-date resources relating to therapeutic cancer vaccines. Vaccines for Cancer Immunotherapy provides a reference for cancer treatment for clinicians and presents a well-organized resource for determining high-potential research areas. The book considers that this promising modality can be made more feasible as a treatment for cancer. Chapters cover cancer immunology, general approaches to cancer immunotherapy, vaccines, tumor antigens, the strategy of allogeneic and autologous cancer vaccines, personalized vaccines, whole-tumor antigen vaccines, protein and peptide vaccines, dendritic cell vaccines, genetic vaccines, candidate cancers for vaccination, obstacles to developing therapeutic cancer vaccines, combination therapy, future perspectives and concluding remarks on therapeutic cancer vaccines. - Introduces the feasible immunotherapeutic vaccines for patients with different types of cancer - Presents the status of past and current vaccines for cancer treatment - Considers advantages and disadvantages of different therapeutic cancer vaccines - Looks at the combination of vaccines and other modalities, including immunotherapeutic and conventional methods - Analyzes obstacles to development of therapeutic cancer vaccines - Gives a view on future perspectives in the application of therapeutic cancer vaccines

Carbohydrate-based Vaccines

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Author : René Roy
Publisher : ACS Symposium
ISBN 13 : 9780841239838
Total Pages : 0 pages
Book Rating : 4.2/5 (398 download)

Book Synopsis Carbohydrate-based Vaccines by : René Roy

Download or read book Carbohydrate-based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.

Surgical Foundations

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Author : Michael S. Sabel
Publisher : Mosby
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Surgical Foundations by : Michael S. Sabel

Download or read book Surgical Foundations written by Michael S. Sabel and published by Mosby. This book was released on 2007 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A "mini-textbook" that delivers practical, need-to-know information in surgical oncology in an economical and user-friendly format. Coverage progresses from key basic science knowledge, principles of oncology care and research, to general diagnostic and operative procedures for a variety of cancers. Each chapter begins with key poings, presents crucial facts in boxes, and offers abundant illustrations, photographs, and tables to clarify complex concepts.

Vaccine Design

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Author : Sunil Thomas
Publisher :
ISBN 13 : 9781493933877
Total Pages : 873 pages
Book Rating : 4.9/5 (338 download)

Book Synopsis Vaccine Design by : Sunil Thomas

Download or read book Vaccine Design written by Sunil Thomas and published by . This book was released on 2016 with total page 873 pages. Available in PDF, EPUB and Kindle. Book excerpt: