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Author : Kevin Brown
Publisher : The History Press
ISBN 13 : 0750953470
Total Pages : 472 pages
Book Rating : 4.7/5 (59 download)
Download or read book Penicillin Man written by Kevin Brown and published by The History Press. This book was released on 2005-09-15 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The history of penicillin.
Author : Eric Lax
Publisher : Macmillan
ISBN 13 : 9780805077780
Total Pages : 336 pages
Book Rating : 4.0/5 (777 download)
Download or read book The Mold in Dr. Florey's Coat written by Eric Lax and published by Macmillan. This book was released on 2005-02 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eric Lax's The Mold in Dr. Florey's Coat is the dramatic, untold story of the discovery of the first wonder drug, the men who led the way, and how it changed the modern world
Author : Norman George Heatley
Publisher :
ISBN 13 : 9780954862701
Total Pages : 11 pages
Book Rating : 4.8/5 (627 download)
Download or read book Penicillin and Luck written by Norman George Heatley and published by . This book was released on 2004 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert W. Winters
Publisher : Simon and Schuster
ISBN 13 : 151071247X
Total Pages : 349 pages
Book Rating : 4.5/5 (17 download)
Download or read book Accidental Medical Discoveries written by Robert W. Winters and published by Simon and Schuster. This book was released on 2016-11-22 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many of the world’s most important and life-saving devices and techniques were often discovered purely by accident. Serendipity, timing, and luck played a part in the discovery of unintentional cures and breakthroughs: A plastic shard in an RAF pilot’s eye leads to the use of plastic for contact lenses. The inability to remove a titanium chamber from rabbit’s bone leads to dental implants. Viagra was discovered by a group of chemists, working in the lab to find a new drug to alleviate the pain of angina pectoris. A stretch of five weeks of unusually warm weather in 1928 played a role in assisting Dr. Alexander Fleming in his analysis of bacterial growth and the discovery of penicillin. After studying the effects of the venom injected by the bite of a deadly pit viper snake, chemists developed a groundbreaking drug that works to control blood pressure. Accidental Medical Discoveries is an entertaining and enlightening look at the creation of 25 medical inventions that have changed the world – unintentionally. The book is presented in a lively and engaging way, and will appeal to a wide variety of readers, from history buffs to trivia fanatics to those in the medical profession.
Author : William Rosen
Publisher : Penguin
ISBN 13 : 0698184106
Total Pages : 370 pages
Book Rating : 4.6/5 (981 download)
Download or read book Miracle Cure written by William Rosen and published by Penguin. This book was released on 2017-05-09 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epic history of how antibiotics were born, saving millions of lives and creating a vast new industry known as Big Pharma. As late as the 1930s, virtually no drug intended for sickness did any good; doctors could set bones, deliver babies, and offer palliative care. That all changed in less than a generation with the discovery and development of a new category of medicine known as antibiotics. By 1955, the age-old evolutionary relationship between humans and microbes had been transformed, trivializing once-deadly infections. William Rosen captures this revolution with all its false starts, lucky surprises, and eccentric characters. He explains why, given the complex nature of bacteria—and their ability to rapidly evolve into new forms—the only way to locate and test potential antibiotic strains is by large-scale, systematic, trial-and-error experimentation. Organizing that research needs large, well-funded organizations and businesses, and so our entire scientific-industrial complex, built around the pharmaceutical company, was born. Timely, engrossing, and eye-opening, Miracle Cure is a must-read science narrative—a drama of enormous range, combining science, technology, politics, and economics to illuminate the reasons behind one of the most dramatic changes in humanity’s relationship with nature since the invention of agriculture ten thousand years ago.
Author : Jens Nielsen
Publisher : World Scientific
ISBN 13 : 9789810227654
Total Pages : 290 pages
Book Rating : 4.2/5 (276 download)
Download or read book Physiological Engineering Aspects of Penicillium Chrysogenum written by Jens Nielsen and published by World Scientific. This book was released on 1997 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gives a review of penicillin production by Penicillium chrysogenum, and also deals with a number of general aspects of fungal cultivations, e.g. primary metabolism of filamentous fungi, morphology, monitoring of fungal cultivations, and bioreactor performance (more than 750 references).The first two chapters give an introduction to the area of penicillin production; with a review of the history and a survey of the present status of this industrially very important process in the first chapter. In the second chapter is given an introduction to the microorganism, i.e. its nutritional requirements, its taxonomy, and an overview of different strain development programmes.Chapter 3 gives an introduction to the concept of Physiological Engineering. This is followed by a review of various monitoring techniques and different theoretical techniques for analysis of cultivation processes, e.g. mathematic modeling, metabolic flux analysis, and metabolic control analysis.Chapter 4 and 5 give a review of the metabolism, with the primary metabolism being the topic of Chapter 4 and the secondary metabolism, i.e. penicillin biosynthesis, being the topic of Chapter 5. The review of the penicillin biosynthetic pathway is followed by a description of a number of results obtained using metabolic flux and metabolic control analysis.Chapter 6 is devoted to the morphology of the fungus, and it gives a detailed description of the growth mechanisms of filamentous fungi.Chapter 7 deals with the bioreactor performance during fungal cultivations, i.e. medium rheology, gas-liquid mass transfer, and mixing.Finally is the fed-batch process applied for penicillin production described in Chapter 8. It gives an overview of the most important factors influencing penicillin production.
Author : Robert Bud
Publisher : OUP Oxford
ISBN 13 : 0199254060
Total Pages : 342 pages
Book Rating : 4.1/5 (992 download)
Download or read book Penicillin written by Robert Bud and published by OUP Oxford. This book was released on 2007 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: The author sets the discovery and use of penicillin in the broader context of social and cultural changes across the world. He examines the drug's contributions to medicine and agriculture, and investigates the global spread of resistant bacteria as antibiotic use continues to rise.
Author : Christian Busch
Publisher : Penguin
ISBN 13 : 0593086023
Total Pages : 386 pages
Book Rating : 4.5/5 (93 download)
Download or read book The Serendipity Mindset written by Christian Busch and published by Penguin. This book was released on 2020-06-09 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Good luck isn’t just chance—it can be learned and leveraged—and The Serendipity Mindset explains how you can use serendipity to make life better at work, at home—everywhere. Many of us believe that the great turning points and opportunities in our lives happen by chance, that they’re out of our control. Often we think that successful people—and successful companies and organizations—are simply luckier than the rest of us. Good fortune—serendipity—just seems to happen to them. Is that true? Or are some people better at creating the conditions for coincidences to arise and taking advantage of them when they do? How can we connect the dots of seemingly random events to improve our lives? In The Serendipity Mindset, Christian Busch explains that serendipity isn’t about luck in the sense of simple randomness. It’s about seeing links that others don’t, combining these observations in unexpected and strategic ways, and learning how to detect the moments when apparently random or unconnected ideas merge to form new opportunities. Busch explores serendipity from a rational and scientific perspective and argues that there are identifiable approaches we can use to foster the conditions to let serendipity grow. Drawing from biology, chemistry, management, and information systems, and using examples of people from all walks of life, Busch illustrates how serendipity works and explains how we can train our own serendipity muscle and use it to turn the unexpected into opportunity. Once we understand serendipity, Busch says, we become curators of it, and luck becomes something that no longer just happens to us—it becomes a force that we can grasp, shape, and hone. Full of exciting ideas and strategies, The Serendipity Mindset offers a clear blueprint for how we can cultivate serendipity to increase innovation, influence, and opportunity in every aspect of our lives.
Author : Gwyn Macfarlane
Publisher : Vintage
ISBN 13 :
Total Pages : 340 pages
Book Rating : 4.3/5 (91 download)
Download or read book Alexander Fleming written by Gwyn Macfarlane and published by Vintage. This book was released on 1984 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Morton A. Meyers
Publisher : Skyhorse Publishing Inc.
ISBN 13 : 1611451620
Total Pages : 466 pages
Book Rating : 4.6/5 (114 download)
Download or read book Happy Accidents written by Morton A. Meyers and published by Skyhorse Publishing Inc.. This book was released on 2011-09 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Afascinating and highly accessible look at the surprising role serendipity has played in some of the most important medical discoveries in the twentieth...
Author : Thomas J. Dougherty
Publisher : Springer Science & Business Media
ISBN 13 : 1461414008
Total Pages : 1119 pages
Book Rating : 4.4/5 (614 download)
Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.
Author : Stuart B. Levy
Publisher : Springer
ISBN 13 : 1489960422
Total Pages : 284 pages
Book Rating : 4.4/5 (899 download)
Download or read book The Antibiotic Paradox written by Stuart B. Levy and published by Springer. This book was released on 2013-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of antibiotics heralded medicine's triumph over previously fatal diseases that once destroyed entire civilizations - thus earning their reputation as miracle drugs. But today, the terrifying reality of antibiotic-resistant bacteria resulting from our widespread misuse of antibiotics forewarns us that the miracle may be coming to an end. The seemingly innocent consumer who demands antibiotics to treat nonbacterial diseases such as the common cold or plays doctor by saving old prescriptions for later use is paving the way for a future of antibiotic failure. "What harm can it do?" is a popular refrain of people worldwide as they pop another antibiotic pill. Dr. Stuart Levy - the leading international expert on hazards of antibiotic misuse - reveals how this cavalier and naive attitude about the power of antibiotics can have deadly consequences. He explains that we are presently witnessing a massive evolutionary change in bacteria. This build-up of new antibiotic-resistant bacteria in individuals and the environment worldwide is an insidious and silent process. Thus, unwittingly consumers encounter resistant bacteria in their meat, poultry, fish, and vegetables. Unregulated dispensing of antibiotics in poorer countries breeds countless more resistant strains. Since bacteria recognize no geographical boundaries, resistant forms can travel the globe. If this trend continues to grow unchecked, we may someday find that all of our antibiotics are obsolete. Today doctors can no longer expect that their first choice of antibiotic for women's urinary tract infections or children's ear infections will work. Similarly, cancer therapy is rendered useless if patients are unable to fight infections that are sometimes resistant to eight to ten different drugs. In developing countries, people are now dying of previously treatable diseases that are no longer responsive to traditional antibiotics. These problems are just a harbinger of what will come if we do not act now. Dr. Levy, recognized by The New Yorker for his superb contributions to this field, is sending out an urgent message that the world cannot afford to ignore any longer. The goal of this unprecedented investigation into the dangers of antibiotic misuse is to protect the world community from resistant infections and ensure the success of antibiotics for generations to come
Author : Donald R. Kirsch
Publisher : Simon and Schuster
ISBN 13 : 1628727195
Total Pages : 298 pages
Book Rating : 4.6/5 (287 download)
Download or read book The Drug Hunters written by Donald R. Kirsch and published by Simon and Schuster. This book was released on 2016-12-13 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.
Author : Vladimir Marko
Publisher : Springer Nature
ISBN 13 : 3030442861
Total Pages : 288 pages
Book Rating : 4.0/5 (34 download)
Download or read book From Aspirin to Viagra written by Vladimir Marko and published by Springer Nature. This book was released on 2020-07-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Aspirin to Viagra, insulin to penicillin, and vaccines to vitamin supplements, drugs have become part of our everyday lives. This staggering global industry wasn’t born overnight; advancements in pharmaceutical science have been happening for a long while, over the course of decades and even centuries. This book tells the history of ten prominent substances and how they came to be common household names. It shows how the creation of such influential drugs often began with the right person at the exactly right—or wrong!— time. The chapters tell the stories of geniuses and charlatans; scholars and amateurs; advances won through hard work or pure luck; and ultimately, the handful of resounding successes that revolutionized a global industry. Beyond the pioneers of the most famous drugs in our culture, the book analyzes how our perspective on medical treatment has shifted over the decades. Modern standards for testing and administering substances have created a new set of advantages, setbacks, and stigmas, all of which are discussed herein.
Author : James H. Austin
Publisher : MIT Press
ISBN 13 : 9780262250108
Total Pages : 278 pages
Book Rating : 4.2/5 (51 download)
Download or read book Chase, Chance, and Creativity written by James H. Austin and published by MIT Press. This book was released on 2003-08-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: A personal story of the ways in which persistence, chance, and creativity interact in biomedical research. This first book by the author of Zen and the Brain examines the role of chance in the creative process. James Austin tells a personal story of the ways in which persistence, chance, and creativity interact in biomedical research; the conclusions he reaches shed light on the creative process in any field. Austin shows how, in his own investigations, unpredictable events shaped the outcome of his research and brought about novel results. He then goes beyond this story of serendipity to propose a new classification of the varieties of chance, drawing on his own research and examples from the history of science—including the famous accidents that led Fleming to the discovery of penicillin. Finally, he explores the nature of the creative process, considering not only the environmental and neurophysiological correlates of creativity but also the role of intuition in both scientific discoveries and spiritual quests. This updated MIT Press paperback edition includes a new introduction and recent material on medical research, creativity, and spirituality.
Author : Jay S. Cohen
Publisher : Square One Publishers, Inc.
ISBN 13 : 0757054692
Total Pages : 205 pages
Book Rating : 4.7/5 (57 download)
Download or read book What You Must Know About the Hidden Dangers of Antibiotics written by Jay S. Cohen and published by Square One Publishers, Inc.. This book was released on 2018-06-13 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the news about taking too many antibiotics is now common knowledge, there is another underlying danger that the public is not aware of. As beneficial as this class of drugs are, there is a widely prescribed family of antibiotics that is highly destructive. Called fluoroquinolones, they are better known under the names Cipro and Levaquin (as well as four others). What You Must Know About the Hidden Dangers of Antibiotics, has two main goals. The first is to expose the truly destructive capability of these drugs to cause serious, sometimes long term and permanent injuries. The capacity of these drugs for such damage has been attested to by the government’s own watchdog agency, the FDA. Hundreds of patients, many of whom are quoted in this book, have confirmed their long-lasting injuries to the book’s author, Dr. Jay Cohen, while many hundreds more have been ignored or dismissed by their own physicians. As this book will show, being brushed off and dismissed as simple side effects essentially allows these manufactures to hide these problems from public view. The second goal of this book is to provide other safer and effective remedies, solutions, and considerations that may help end the suffering experienced by patients suffering from these dangerous side effects--that can affect many human systems including the musculoskeletal, nervous, psychiatric, gastrointestinal, and others. To do this we explain how these dangerous antibiotics work, and particularly how they injure. By understanding the underlying problems, the alternatives offered in this book can help people potentially reduce their pain reduction, clear up persistent antibiotic-based health issues, and just as important, give them hope. Because so many doctors do not carefully read the FDA’s dire warnings about the risks these specific antibiotics pose, there is little likely patients will be know why they are having such serious reactions. With What You Must Know About the Hidden Dangers of Antibiotics, they may have the answer they are looking for.
Author : Graeme Donald
Publisher : Michael O'Mara Books
ISBN 13 : 1782430997
Total Pages : 182 pages
Book Rating : 4.7/5 (824 download)
Download or read book The Accidental Scientist written by Graeme Donald and published by Michael O'Mara Books. This book was released on 2013-10-30 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Accidental Scientist explores the role of chance and error in scientific, medical and commercial innovation, outlining exactly how some of the most well-known products, gadgets and useful gizmos came to be.
