Pathways For Cytolysis

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Pathways for Cytolysis

Author : Gillian M. Griffiths
Publisher : Springer Science & Business Media
ISBN 13 : 3642794149
Total Pages : 231 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Pathways for Cytolysis by : Gillian M. Griffiths

Download or read book Pathways for Cytolysis written by Gillian M. Griffiths and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring or generated by gene targeting. It is now clear that there are two predominant pathways which act hand in hand and lead to efficienttarget cell destruction.

Pathways for Cytolysis

Author : Gillian M. Griffiths
Publisher : Springer
ISBN 13 : 9783642794162
Total Pages : 224 pages
Book Rating : 4.7/5 (941 download)

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Book Synopsis Pathways for Cytolysis by : Gillian M. Griffiths

Download or read book Pathways for Cytolysis written by Gillian M. Griffiths and published by Springer. This book was released on 2011-12-25 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: At first glance the destruction of a target cell by a killer cell seems to be a simple endeavor. A closer look, however, reveals the complex mechanisms underlying this task. Killer cells are able to specifically recognize altered or infected cells. A transient contract with target cells has to be established to allow the delivery of lethal molecules or signals. The killer cell then disengages from the damaged cell and moves away to kill other target cells. After the eradication of the target cells, the number or activity of activated killer cells has to be reduced to avoid nonspecific killing of innocent cells. In 1992, Herman Eisen concluded, in his introductory remarks in the most recent volume on lymphocyte cytotoxicity (EISEN 1993): "Given the immense amount of effort made in the past decade to understand these (lytic) mechanisms, it seems surprising that a consensus about the principal mechanisms has not been reached." Since that time, advances made in the field of cell-mediated cytolysis are so significant that our knowledge regarding the lytic mechanisms has been considerably augmented. Much of this is due to studies with transfectants and mutants-either naturally occurring or generated by gene targeting. It is now clear that there are two predominant pathways which act hand in hand and lead to efficienttarget cell destruction.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Immunology, Immunopathology, and Immunity

Author : Stewart Sell
Publisher : HarperCollins Publishers
ISBN 13 :
Total Pages : 410 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunology, Immunopathology, and Immunity by : Stewart Sell

Download or read book Immunology, Immunopathology, and Immunity written by Stewart Sell and published by HarperCollins Publishers. This book was released on 1975 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sixth edition of this best-selling textbook presents a systematic account of the effects, both good and bad, of the immune system. Special emphasis is placed on what the immune system actually does in causing and preventing disease. Divided into two parts, the sixth edition discusses inflammation, the fundamentals of the immune system and how it is activated, the seven immune effector mechanisms, and how these effector mechanisms act not only to protect against infection and cancer but also to cause diseases. Valuable reading for physicians, medical students, graduate students, nurse practitioners, physician assistants, teachers of immunology, and advanced courses in immunology.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Eosinophils in Health and Disease

Author : James J. Lee
Publisher : Academic Press
ISBN 13 : 012394385X
Total Pages : 679 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Eosinophils in Health and Disease by : James J. Lee

Download or read book Eosinophils in Health and Disease written by James J. Lee and published by Academic Press. This book was released on 2012-11-02 with total page 679 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.

Cytokine Storm Syndrome

Author : Randy Q. Cron
Publisher : Springer Nature
ISBN 13 : 3031598156
Total Pages : 609 pages
Book Rating : 4.0/5 (315 download)

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Book Synopsis Cytokine Storm Syndrome by : Randy Q. Cron

Download or read book Cytokine Storm Syndrome written by Randy Q. Cron and published by Springer Nature. This book was released on with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Signaling Mechanisms Regulating T Cell Diversity and Function

Author : Jonathan Soboloff
Publisher : CRC Press
ISBN 13 : 149870509X
Total Pages : 258 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Signaling Mechanisms Regulating T Cell Diversity and Function by : Jonathan Soboloff

Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Adverse Effects of Vaccines

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309214351
Total Pages : 894 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Adverse Effects of Vaccines by : Institute of Medicine

Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Cytolytic Lymphocytes and Complement Effectors of the Immune System

Author : Eckhard R. Podack
Publisher : CRC Press
ISBN 13 : 1351088203
Total Pages : 400 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Cytolytic Lymphocytes and Complement Effectors of the Immune System by : Eckhard R. Podack

Download or read book Cytolytic Lymphocytes and Complement Effectors of the Immune System written by Eckhard R. Podack and published by CRC Press. This book was released on 2018-01-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes, Cytolytic Lymphocytes and Complement: Effectors of the Immune System, originate from the realization that pathways of recognition and killings of foreign targets follow similar routes in the humoral and cellular part of the immune system. In particular, the homology of immunoglobins with the T-cell-MHC-antigen receptor at the beginning of the recognition sequence and the homology of complement component C9 with lymphocyte perforin 1 (P1) as pore formers at the end of the effector sequence are striking examples.

Targeting the Broadly Pathogenic Kynurenine Pathway

Author : Sandeep Mittal
Publisher : Springer
ISBN 13 : 3319118706
Total Pages : 422 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Targeting the Broadly Pathogenic Kynurenine Pathway by : Sandeep Mittal

Download or read book Targeting the Broadly Pathogenic Kynurenine Pathway written by Sandeep Mittal and published by Springer. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tryptophan metabolism via kynurenine pathway plays a critical role in both health and a variety of human diseases. This book highlights the known associations between kynurenine pathway and various disease states, as well as examines the current status of drug development and clinical trials of compounds known to alter tryptophan metabolism. The research plays a critical role in molecular targeted therapies directed at altering the kynurenine pathway of tryptophan metabolism. The initial and rate-limiting step of tryptophan metabolism is mediated by one of two enzymes, tryptophan-2,3-dioxygenase (TDO; predominantly in the liver, but also in the brain) and indoleamine-2,3-dioxygenase (IDO; in a host of tissues in response to immune activation). Targeting the enzymes IDO and TDO, as well as other downstream effectors would therefore be likely to generate novel treatment options that would be helpful in a wide variety of clinical settings. This book provides a unique bridge between basic mechanistic understanding of the role of the kynurenine pathway with translational applications and clinical relevance. It will explore the indications that tryptophan metabolism is a potential biomarker of disease activity, can contribute to local and possibly systemic immune suppression in cancer, and is an attractive target for which a variety of inhibitors are readily available.

Lactogenesis

Author : Monica Reynolds
Publisher : University of Pennsylvania Press
ISBN 13 : 1512806056
Total Pages : 284 pages
Book Rating : 4.5/5 (128 download)

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Book Synopsis Lactogenesis by : Monica Reynolds

Download or read book Lactogenesis written by Monica Reynolds and published by University of Pennsylvania Press. This book was released on 2016-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a symposium, satellite to the 24th International Congress of Physiological Sciences, University of Pennsylvania.

Molecular Diagnostics

Author : Wayne W. Grody
Publisher : Academic Press
ISBN 13 : 0080919049
Total Pages : 518 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Molecular Diagnostics by : Wayne W. Grody

Download or read book Molecular Diagnostics written by Wayne W. Grody and published by Academic Press. This book was released on 2009-11-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genomic and proteomic profiling of disease have transformed the field of molecular diagnostics, thus leading the way for a major revolution in clinical practice. While the range of tests for disease detection and staging is rapidly expanding, many physicians lack the knowledge required to determine which tests to order and how to interpret results. Molecular Diagnostics provides a complete guide to the use and interpretation of molecular testing in the clinical arena. No other available resource offers this emphasis, comprehensive scope, and practical utility in the clinical setting. - Serves as the definitivereference for molecular pathologists worldwide - Covers a variety of molecular techniques including next generation sequencing, tumor somatic cell genotyping, infectious and genetic disease tecting, and pharmacogenetics - Discusses in the detail issues concerning quality assurance, regulation, ethics, and future directions for the science

Unifying Microbial Mechanisms

Author : Michael F. Cole
Publisher : Garland Science
ISBN 13 : 0429557833
Total Pages : 350 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Unifying Microbial Mechanisms by : Michael F. Cole

Download or read book Unifying Microbial Mechanisms written by Michael F. Cole and published by Garland Science. This book was released on 2019-09-09 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial pathogenesis is the study of the mechanisms by which microbes (bacteria, viruses, protozoa, and multicellular parasites) cause infectious disease and make their hosts (humans) ill. Bacterial infections we thought were easily treatable are again a huge cause for concern with the well-publicized rise of antibiotic resistance. There are very few effective antiviral drugs and we live with the threat of epidemics such as bird flu and the outbreaks of viruses such the recent (and ongoing) Ebola crisis. Parasitic diseases such as malaria continue to pose a heavy burden in the developing world and with climate change could spread into the developed world. There is therefore an urgent need to understand microbial mechanisms, with research programmes and university courses dedicated to the subject.

International Review of Cytology

Author :
Publisher : Academic Press
ISBN 13 : 0080857213
Total Pages : 321 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis International Review of Cytology by :

Download or read book International Review of Cytology written by and published by Academic Press. This book was released on 1998-04-18 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. - Acetabularia - The Role of the Dynactin Complex in Intracellular Motility - Dual Mechanisms of Apoptosis Induction by Cytotoxic Lymphocytes - Drought-Induced Responses in Plant Cells - Peptidergic Control of the Corpus Cardiacum-Copora Allata Complex of Locusts

Apoptosis: Biology and Mechanisms

Author : Sharad Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 3540691847
Total Pages : 242 pages
Book Rating : 4.5/5 (46 download)

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Book Synopsis Apoptosis: Biology and Mechanisms by : Sharad Kumar

Download or read book Apoptosis: Biology and Mechanisms written by Sharad Kumar and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis is currently one of the fastest moving fields in biology with spectacular progress made over the past few years in delineating the molecular It is now indisputable that apoptosis mechanisms which underlie this process. plays an essential role in normal cell physiology and that aberrant apoptosis can manifest itself in a variety of human disorders. Published in two parts (Volumes 23 and 24 of the series entitled Results and Problems in Cell Differen tiation), this is an attempt to bring together many different aspects of apoptosis. Given that this is such a vast and rapidly expanding field, it is almost impossible to cover everything that is now known about apoptosis in two short books, but 1 hope these volumes prove to be a guidepost, providing basic essential information on the biology and molecular mechanisms of apoptosis and its implications in some human diseases. As a significant am o unt of new information on apoptosis is emerging every week, it is unrealistic to expect that by the time these two books are published, all the articles will deliver up-to-date information. Nevertheless, 1 believe that the fundamentals of the apoptotic phenomenon are now firmly in place and are discussed at length in various chapters. Readers may find a small degree of overlap between some chapters. This was unavoidable since closely related areas of apoptosis research have been covered by more than one author.

Microbiology and Parasitology PMFU - E-BooK

Author : B. S. Nagoba
Publisher : Elsevier Health Sciences
ISBN 13 : 8131244288
Total Pages : 847 pages
Book Rating : 4.1/5 (312 download)

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Book Synopsis Microbiology and Parasitology PMFU - E-BooK by : B. S. Nagoba

Download or read book Microbiology and Parasitology PMFU - E-BooK written by B. S. Nagoba and published by Elsevier Health Sciences. This book was released on 2016-05-27 with total page 847 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition of the book is thoroughly updated and presented in new four-colour format. It highlights the important aspects of Medical Microbiology and Parasitology. It presents a concise exam-oriented text as per the guidelines of Medical Council of India and health universities across the country, and nearby countries. Designed specifically to meet the needs of the students pursuing undergraduate courses in Medical, Dental, Physiotherapy, Nursing, Pharmacy and Science. - Maintained the basic pattern, followed for text in question–answer format which helps the students in quick learning and revision - Newer developments and revisions to keep up the text with the latest changes as per the undergraduates' curriculum. - More emphasis on systemetic presentation of information, helps to recollect the things easily New to this Edition - Merged Parasitolgy section with Microbiology section within same page range in single book - Addition of many new coloured figures to facilitate greater retention of knowledge. Also replacement of earlier figures with newer coloured figures to make understanding better