Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic

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Publisher : Frontiers Media SA
ISBN 13 : 2889453170
Total Pages : 222 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic by : Daniela Andres

Download or read book Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic written by Daniela Andres and published by Frontiers Media SA. This book was released on 2017-10-31 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.

Compendium of in Vivo Monitoring in Real-time Molecular Neuroscience

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Author :
Publisher : World Scientific
ISBN 13 : 9811206236
Total Pages : 397 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Compendium of in Vivo Monitoring in Real-time Molecular Neuroscience by : Adrian C. Michael

Download or read book Compendium of in Vivo Monitoring in Real-time Molecular Neuroscience written by Adrian C. Michael and published by World Scientific. This book was released on 2019 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is the third in a series entitled, Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience. Its purpose is to provide a cross-section of research addressing monitoring in the rodent, and in some cases, the human brain. Detailed understanding of the neurobiology of the brain is demanding and involves increasingly wider scope of talent ranging from physicists, neurobiologists, chemists, molecular biologists and bioengineers. Coming from varied backgrounds, they do not necessarily understand how to formulate functional issues in a mutually understandable way. This aim of this book is to provide information which can serve as a starting point for understanding such a complex topic. The authors provide "tutorial" writing for specialists, as well as material understandable to a wide audience including neuroscientists, those interested in drug discovery, and those using such measurements for diagnosis purposes."-

Neuroscience and the Problem of Dual Use

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Publisher : Springer Nature
ISBN 13 : 3030537900
Total Pages : 210 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Neuroscience and the Problem of Dual Use by : Malcolm R. Dando

Download or read book Neuroscience and the Problem of Dual Use written by Malcolm R. Dando and published by Springer Nature. This book was released on 2020-08-20 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state’s chemical and biological non-proliferation regime’s during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.

A New Understanding of Mental Disorders

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Publisher : MIT Press
ISBN 13 : 0262036894
Total Pages : 225 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis A New Understanding of Mental Disorders by : Andreas Heinz

Download or read book A New Understanding of Mental Disorders written by Andreas Heinz and published by MIT Press. This book was released on 2017-10-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new computational and dimensional approach to understanding and classifying mental disorders: modeling key learning and decision-making mechanisms across different mental disorders. Even as researchers look for neurobiological correlates of mental disorders, many of these disorders are still classified solely according to the manifestation of clinical symptoms. Neurobiological findings rarely help diagnose a specific disease or predict its outcome. Although current diagnostic categories are questionable (sometimes labeling common states of human suffering as disorders), traditional neuroimaging approaches are not sophisticated enough to capture the neurobiological markers of mental disorder. In this book, Andreas Heinz proposes a computational and dimensional approach to understanding and classifying mental disorders: modeling key learning and decision-making mechanisms across different mental disorders. Such an approach focuses on the malleability and diversity of human behavior and its biological underpinnings. Heinz explains basic learning mechanisms and their effects on human behavior, focusing not on single disorders but on how such mechanisms work in a multitude of mental states. For example, he traces alterations in dopamine-reinforcement learning in psychotic, affective, and addictive disorders. He investigates to what extent these basic dimensions of mental disorders can account for such syndromes as craving and loss of control in addiction, positive and negative mood states in affective disorders, and the altered experience of self and world associated with psychotic states. Finally, Heinz explores the clinical and therapeutic implications of such accounts. He argues that a focus on learning mechanisms, with its emphasis on human creativity and resilience, should help reduce the stigma of mental disorder.

Clinical Management of Sensorimotor Speech Disorders

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Publisher : Thieme
ISBN 13 : 1588906434
Total Pages : 452 pages
Book Rating : 4.5/5 (889 download)

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Book Synopsis Clinical Management of Sensorimotor Speech Disorders by : Malcolm R. McNeil

Download or read book Clinical Management of Sensorimotor Speech Disorders written by Malcolm R. McNeil and published by Thieme. This book was released on 2011-01-01 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive reference for managing sensorimotor speech disorders Bringing together the expertise of leading research practitioners in the field, the second edition of Clinical Management of Sensorimotor Speech Disorders is an up-to-date reference for the underlying theory and the basic principles of assessment and treatment. This book provides a solid foundation in the conceptual framework essential for classifying and differentiating disorders according to clinical categories. It covers the theory underlying measurement strategies including acoustic, kinematic, aerodynamic, and electromyographic techniques, and guides the reader through treatments for each disorder. New in this edition is a comprehensive section with in-depth coverage of the diseases, syndromes, and pathologic conditions which are accompanied by sensorimotor speech disorders. These chapters provide concise descriptions of the disease and its signs and symptoms, neuropathology, epidemiology, and etiology. Each chapter goes on to present the speech impairment associated with the disorder and its signs and symptoms, etiology, neuropathology, associated cognitive, linguistic, and communicative signs and symptoms, special diagnostic considerations, treatment, and key references. Features: Clear articulation of theoretical issues provides a strong foundation for the clinical management of the dysarthrias, apraxia, and speech problems secondary to hearing loss New chapter on neurogenic fluency disorders Extensive discussion of neuropathologic conditions that cause sensorimotor speech disorders Authoritative and comprehensive, this expanded edition will prove to be the reference of choice for students in speech-language pathology programs as well as clinicians and researchers.

Non-human Primate Models of Psychiatric Disorders

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Publisher : Frontiers Media SA
ISBN 13 : 2889719847
Total Pages : 101 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Non-human Primate Models of Psychiatric Disorders by : Rafael S. Maior

Download or read book Non-human Primate Models of Psychiatric Disorders written by Rafael S. Maior and published by Frontiers Media SA. This book was released on 2022-01-06 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders

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Publisher : Frontiers Media SA
ISBN 13 : 2889455637
Total Pages : 247 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders by : Aasef G. Shaikh

Download or read book Ocular Motor and Vestibular Function in Neurometabolic, Neurogenetic, and Neurodegenerative Disorders written by Aasef G. Shaikh and published by Frontiers Media SA. This book was released on 2018-08-29 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.

Encyclopedia of the Neurological Sciences

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Publisher : Academic Press
ISBN 13 : 0123851580
Total Pages : 4744 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Encyclopedia of the Neurological Sciences by :

Download or read book Encyclopedia of the Neurological Sciences written by and published by Academic Press. This book was released on 2014-04-29 with total page 4744 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index

Cumulated Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1284 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1988 with total page 1284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of the Behavioral Neurobiology of Serotonin

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Author :
Publisher : Academic Press
ISBN 13 : 0444641262
Total Pages : 1044 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Handbook of the Behavioral Neurobiology of Serotonin by :

Download or read book Handbook of the Behavioral Neurobiology of Serotonin written by and published by Academic Press. This book was released on 2020-01-23 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Behavioral Neurobiology of Serotonin, Second Edition, builds on the success of the first edition by continuing to provide a detailed and comprehensive overview of the many facets of behavioral serotonin research. The text expands on the two key topics, behavioral control (sensory processing, ultrasonic vocalization, and melatonin and sleep control) and psychiatric disorders, including its role on psychostimulant abuse and addiction. The new edition includes two new sections on the serotonin systems interactions and the involvement of serotonin in neurological disorders and associated treatment. Serotonin is a major neurotransmitters in the serotonergic system which one of the best studied and understood transmitter systems. Both are critically involved in the organization of all behaviors and in the regulation of emotion and mood. - Features two new sections on serotonin systems interactions and serotonin in neurological disorders - Focuses on ionotropic and metabotropic 5-HT receptor involvement in behavior - Maps receptors and receptor signaling pathways to neurochemical and behavioral outcomes - Covers the interactions between serotonin, melatonin and kynurenine pathways

Parkinson's Disease and Movement Disorders

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781778817
Total Pages : 748 pages
Book Rating : 4.7/5 (788 download)

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Book Synopsis Parkinson's Disease and Movement Disorders by : Joseph Jankovic

Download or read book Parkinson's Disease and Movement Disorders written by Joseph Jankovic and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an international group of renowned experts, the Fifth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of all common and uncommon movement disorders. Coverage includes Parkinson's disease, other neurodegenerative diseases, tremors, dystonia, Tourette's syndrome, Huntington's disease, and ataxias. This edition features extensive updates on genetics, imaging, and therapeutics of Parkinson's disease, other parkinsonian disorders, and all hyperkinetic movement disorders. A bound-in CD-ROM, Video Atlas of Movement Disorders, demonstrates the movement and posture abnormalities and other disturbances associated with Parkinson's disease and other neurologic disorders.

Textbook of Neural Repair and Rehabilitation

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Publisher : Cambridge University Press
ISBN 13 : 110701168X
Total Pages : 749 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Textbook of Neural Repair and Rehabilitation by : Michael E. Selzer

Download or read book Textbook of Neural Repair and Rehabilitation written by Michael E. Selzer and published by Cambridge University Press. This book was released on 2014-04-24 with total page 749 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 2 of the Textbook of Neural Repair and Rehabilitation stands alone as a clinical handbook for neurorehabilitation.

Regeneration and Brain Repair

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Publisher : Frontiers Media SA
ISBN 13 : 2889710459
Total Pages : 140 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Regeneration and Brain Repair by : Daniella Rylander Ottosson

Download or read book Regeneration and Brain Repair written by Daniella Rylander Ottosson and published by Frontiers Media SA. This book was released on 2021-07-15 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Massachusetts General Hospital Comprehensive Clinical Psychiatry - E-BOOK

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Publisher : Elsevier Health Sciences
ISBN 13 : 0443118450
Total Pages : 1074 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Massachusetts General Hospital Comprehensive Clinical Psychiatry - E-BOOK by : Theodore A. Stern

Download or read book Massachusetts General Hospital Comprehensive Clinical Psychiatry - E-BOOK written by Theodore A. Stern and published by Elsevier Health Sciences. This book was released on 2024-03-06 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Massachusetts General Hospital is widely regarded as one of the world's premier psychiatric institutions. Massachusetts General Hospital Comprehensive Clinical Psychiatry, 3rd Edition, offers practical, informative, and hands-on advice from the staff of the esteemed MGH Department of Psychiatry, helping you put today's best practices to work for your patients. This authoritative reference covers a wide variety of clinical syndromes and settings, aided by superb graphics throughout. In one convenient volume, you'll have easy access to the answers you need to face and overcome any clinical challenge. - Uses a reader-friendly and highly templated format with abundant boxed summaries, bulleted points, case histories, algorithms, references, and suggested readings. - Contains new chapters on the Psychiatric Management of Patients with Cardiac, Renal, Pulmonary, and Gastrointestinal Disease; COVID-19 Infection; Burns, Trauma, and Intensive Care Unit Treatment; Care of LGBTQ Patients; and Mindfulness and Resilience. - Covers key areas, such as Substance Use Disorders; Mood, Anxiety, and Psychotic Disorders; Emergency Psychiatry; Functional Neuroanatomy and the Neurologic Examination; Psychological and Neuropsychological Assessment; Military Psychiatry; Psychiatric Manifestations of Traumatic Brain Injury; Legal and Ethical Issues in Psychiatry; End of Life Care; and Approaches to Collaborative Care and Primary Care Psychiatry. - Features key points for every chapter, updated DSM-5 criteria, and enhanced content on collaborative care and behavioral medicine, ensuring that your knowledge is thorough and up to date. - Corresponds to the companion review volume, Massachusetts General Hospital Study Guide for Psychiatry Exams, 2nd Edition (ISBN: 978-0-443-11983-5). - Any additional digital ancillary content may publish up to 6 weeks following the publication date.

The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy

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Author :
Publisher : Springer
ISBN 13 : 331919285X
Total Pages : 154 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy by : Udo Rüb

Download or read book The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy written by Udo Rüb and published by Springer. This book was released on 2015-09-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.

Neuropathology of Neurodegenerative Diseases

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Publisher : Cambridge University Press
ISBN 13 : 1316337650
Total Pages : 320 pages
Book Rating : 4.3/5 (163 download)

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Book Synopsis Neuropathology of Neurodegenerative Diseases by : Gabor G. Kovacs

Download or read book Neuropathology of Neurodegenerative Diseases written by Gabor G. Kovacs and published by Cambridge University Press. This book was released on 2017-12-13 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide to the diagnosis of neurodegenerative diseases discusses modern molecular techniques, morphological classification, fundamentals of clinical symptomology, diagnostic pitfalls and immunostaining protocols. It is based on the proteinopathy concept of neurodegenerative disease, which has influenced classification and provides new strategies for therapy. Numerous high-quality images, including histopathology photomicrographs and neuroradiology scans, accompany the description of morphologic alterations and interpretation of immunoreactivities. Diagnostic methods and criteria are placed within recent developments in neuropathology, including the now widespread application of immunohistochemistry. To aid daily practice, the guide includes diagnostic algorithms and offers personal insights from experienced experts in the field. Special focus is given to the way brain tissue should be handled during diagnosis. This is a must-have reference for medical specialists and specialist medical trainees in the fields of pathology, neuropathology and neurology working with neuropathologic features of neurodegenerative diseases.

Society for Neuroscience Abstracts

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Author :
Publisher :
ISBN 13 :
Total Pages : 1372 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Society for Neuroscience Abstracts by : Society for Neuroscience. Annual Meeting

Download or read book Society for Neuroscience Abstracts written by Society for Neuroscience. Annual Meeting and published by . This book was released on 1999 with total page 1372 pages. Available in PDF, EPUB and Kindle. Book excerpt: