Pathophysiological Mechanisms Of Sarcopenia In Aging And In Muscular Dystrophy A Translational Approach

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Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Author : Luciano Merlini
Publisher : Frontiers Media SA
ISBN 13 : 2889196844
Total Pages : 250 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach by : Luciano Merlini

Download or read book Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach written by Luciano Merlini and published by Frontiers Media SA. This book was released on 2016-01-18 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention.

Osteosarcopenia: Bone, Muscle and Fat Interactions

Author : Gustavo Duque
Publisher : Springer Nature
ISBN 13 : 3030258904
Total Pages : 383 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Osteosarcopenia: Bone, Muscle and Fat Interactions by : Gustavo Duque

Download or read book Osteosarcopenia: Bone, Muscle and Fat Interactions written by Gustavo Duque and published by Springer Nature. This book was released on 2019-11-06 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Sarcopenia

Author : Kunihiro Sakuma
Publisher : Elsevier
ISBN 13 : 0128226579
Total Pages : 344 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Sarcopenia by : Kunihiro Sakuma

Download or read book Sarcopenia written by Kunihiro Sakuma and published by Elsevier. This book was released on 2021-07-22 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sarcopenia: Molecular Mechanism and Treatment Strategies provides answers and guidance on a disease that has serious health consequences in terms of fractures, frailty, disability and diminished quality of life. Written by experts around the world, this book is for all those that care for aging populations. As the global population ages, sarcopenia remains a therapeutic challenge and major public health concern. Difficulties in defining sarcopenia as a clinical phenotype remain and have hindered treatment. Covers physical, dietary and pharmacological strategies to maintain adequate muscle mass to ensure healthy aging Provides a complete and up-to-date reference on molecular mechanisms of sarcopenia Presents a clear definition of sarcopenia, along with the latest research in one volume

Muscle Atrophy

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811314357
Total Pages : 624 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Muscle Atrophy by : Junjie Xiao

Download or read book Muscle Atrophy written by Junjie Xiao and published by Springer. This book was released on 2018-11-02 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

Muscle Homeostasis and Regeneration

Author : Antonio Musarò
Publisher : MDPI
ISBN 13 : 3039434365
Total Pages : 500 pages
Book Rating : 4.0/5 (394 download)

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Book Synopsis Muscle Homeostasis and Regeneration by : Antonio Musarò

Download or read book Muscle Homeostasis and Regeneration written by Antonio Musarò and published by MDPI. This book was released on 2020-11-20 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a collection of original research and review articles addressing the intriguing field of the cellular and molecular players involved in muscle homeostasis and regeneration. One of the most ambitious aspirations of modern medical science is the possibility of regenerating any damaged part of the body, including skeletal muscle. This desire has prompted clinicians and researchers to search for innovative technologies aimed at replacing organs and tissues that are compromised. In this context, the papers, collected in this book, addressing a specific aspects of muscle homeostasis and regeneration under physiopathologic conditions, will help us to better understand the underlying mechanisms of muscle healing and will help to design more appropriate therapeutic approaches to improve muscle regeneration and to counteract muscle diseases.

Muscle Regeneration

Author : Alexander Mauro
Publisher : Raven Press (ID)
ISBN 13 :
Total Pages : 582 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Muscle Regeneration by : Alexander Mauro

Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Molecular Nutrition of Amino Acids and Proteins

Author : Dominique Dardevet
Publisher : Academic Press
ISBN 13 : 0128023759
Total Pages : 368 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Molecular Nutrition of Amino Acids and Proteins by : Dominique Dardevet

Download or read book The Molecular Nutrition of Amino Acids and Proteins written by Dominique Dardevet and published by Academic Press. This book was released on 2016-06-08 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Nutrition of Amino Acids and Proteins provides an in-depth look at the involvement and role of amino acids and proteins in molecular nutrition. Editor Dominique Dardevet has assembled a collection of chapters written by leading researchers and top professors that provide the reader with a comprehensive understanding of amino acids and proteins. The book provides an introduction to the fundamentals of amino acids and proteins as well as the composition of food. It then delves into the molecular biology of the cell and genetic machinery and its function. The Molecular Nutrition of Amino Acids and Proteins also features reference guides for terms and bullet-point summaries, making it readily accessible to novices while still providing the most up-to-date and detailed information that experienced researchers need. Provides a gentle introduction to the subject by first addressing nutritional information and then building in molecular aspects, clearly establishing fundamental information for the reader Facilitates reader comprehension by including succinct summary points in each chapter Contains a glossary of definitions that allows readers to easily reference terms Provides both a deep and broad understanding of the subject by containing overviews as well as detail-focused chapters

Mitochondrial Dysfunction in Ageing and Diseases

Author : Jaime M. Ross
Publisher : MDPI
ISBN 13 : 3038422517
Total Pages : 543 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Mitochondrial Dysfunction in Ageing and Diseases by : Jaime M. Ross

Download or read book Mitochondrial Dysfunction in Ageing and Diseases written by Jaime M. Ross and published by MDPI. This book was released on 2018-09-28 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Mitochondrial Dysfunction in Ageing and Diseases" that was published in IJMS

Muscle and Exercise Physiology

Author : Jerzy A. Zoladz
Publisher : Academic Press
ISBN 13 : 0128145943
Total Pages : 618 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Muscle and Exercise Physiology by : Jerzy A. Zoladz

Download or read book Muscle and Exercise Physiology written by Jerzy A. Zoladz and published by Academic Press. This book was released on 2018-11-05 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Muscle and Exercise Physiology is a comprehensive reference covering muscle and exercise physiology, from basic science to advanced knowledge, including muscle power generating capabilities, muscle energetics, fatigue, aging and the cardio-respiratory system in exercise performance. Topics presented include the clinical importance of body responses to physical exercise, including its impact on oxygen species production, body immune system, lipid and carbohydrate metabolism, cardiac energetics and its functional reserves, and the health-related effects of physical activity and inactivity. Novel topics like critical power, ROS and muscle, and heart muscle physiology are explored. This book is ideal for researchers and scientists interested in muscle and exercise physiology, as well as students in the biological sciences, including medicine, human movements and sport sciences. Contains basic and state-of-the-art knowledge on the most important issues of muscle and exercise physiology, including muscle and body adaptation to physical training, the impact of aging and physical activity/inactivity Provides both the basic and advanced knowledge required to understand mechanisms that limit physical capacity in both untrained people and top class athletes Covers advanced content on muscle power generating capabilities, muscle energetics, fatigue and aging

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems

Author : Wanda M. Haschek
Publisher : Elsevier
ISBN 13 : 032399282X
Total Pages : 910 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems by : Wanda M. Haschek

Download or read book Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 4: Toxicologic Pathology of Organ Systems written by Wanda M. Haschek and published by Elsevier. This book was released on 2024-05-02 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume Four: Toxicologic Pathology of Organ Systems is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Organ systems covered include cardiac, vascular and skeletal muscle systems and the endocrine, respiratory, reproductive, digestive and nervous systems. Completely revised with a new olfactory chapter, this new release is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Presents updated chapters on systems toxicologic pathology, including new chapter on olfactory Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions to highlight difficult concepts with clear illustrations

Background and Management of Muscular Atrophy

Author : Julianna Cseri
Publisher : BoD – Books on Demand
ISBN 13 : 1838807241
Total Pages : 190 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Background and Management of Muscular Atrophy by : Julianna Cseri

Download or read book Background and Management of Muscular Atrophy written by Julianna Cseri and published by BoD – Books on Demand. This book was released on 2021-03-03 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: A healthy skeletal musculature is necessary for a good quality of life and is important in sports. The loss of skeletal muscle mass leads to severe clinical complications and alters daily functioning. The aim of this book is to give an overview of skeletal muscle atrophy including pathomechanism, clinical characters, and the tools for prevention and treatment. Skeletal muscle atrophy can develop due to neurogenic or myogenic reasons, and frequently appears as an age-dependent disorder (sarcopenia). The studies of theoretical background give promising perspectives to prevent and treat muscle atrophy. The book is recommended to scientists, practitioners, students, sportsmen, and everybody who is interested in the normal and impaired function of the skeletal muscle.

Disorders of Voluntary Muscle

Author : George Karpati
Publisher : Cambridge University Press
ISBN 13 : 9780521650625
Total Pages : 800 pages
Book Rating : 4.6/5 (56 download)

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Book Synopsis Disorders of Voluntary Muscle by : George Karpati

Download or read book Disorders of Voluntary Muscle written by George Karpati and published by Cambridge University Press. This book was released on 2001-07-12 with total page 800 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Respiratory Muscle Training

Author : Alison McConnell
Publisher : Elsevier Health Sciences
ISBN 13 : 0702054550
Total Pages : 403 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Respiratory Muscle Training by : Alison McConnell

Download or read book Respiratory Muscle Training written by Alison McConnell and published by Elsevier Health Sciences. This book was released on 2013-04-18 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory Muscle Training: theory and practice is the world’s first book to provide an "everything-you-need-to-know" guide to respiratory muscle training (RMT). Authored by an internationally-acclaimed expert, it is an evidence-based resource, built upon current scientific knowledge, as well as experience at the cutting-edge of respiratory training in a wide range of settings. The aim of the book is to give readers: 1) an introduction to respiratory physiology and exercise physiology, as well as training theory; 2) an understanding of how disease affects the respiratory muscles and the mechanics of breathing; 3) an insight into the disease-specific, evidence-based benefits of RMT; 4) advice on the application of RMT as a standalone treatment, and as part of a rehabilitation programme; and finally, 5) guidance on the application of functional training techniques to RMT. The book is divided into two parts – theory and practice. Part I provides readers with access to the theoretical building blocks that support practice. It explores the evidence base for RMT as well as the different methods of training respiratory muscles and their respective efficacy. Part II guides the reader through the practical implementation of the most widely validated form of RMT, namely inspiratory muscle resistance training. Finally, over 150 "Functional" RMT exercises are described, which incorporate a stability and/or postural challenge – and address specific movements that provoke dyspnoea. Respiratory Muscle Training: theory and practice is supported by a dedicated website (www.physiobreathe.com), which provides access to the latest information on RMT, as well as video clips of all exercises described in the book. Purchasers will also receive a three-month free trial of the Physiotec software platform (via www.physiotec.ca), which allows clinicians to create bespoke training programmes (including video clips) that can be printed or emailed to patients. Introductory overviews of respiratory and exercise physiology, as well as training theory Comprehensive, up-to-date review of respiratory muscle function, breathing mechanics and RMT Analysis of the interaction between disease and respiratory mechanics, as well as their independent and combined influence upon exercise tolerance Analysis of the rationale and application of RMT to over 20 clinical conditions, e.g., COPD, heart failure, obesity, mechanical ventilation Evidence-based guidance on the implementation of inspiratory muscle resistance training Over 150 functional exercises that incorporate a breathing challenge www.physiobreathe.com - access up-to-date information, video clips of exercises and a three-month free trial of Physiotec’s RMT exercise module (via www.physiotec.ca)

The Unfolded Protein Response

Author : Roberto Pérez-Torrado
Publisher : Humana
ISBN 13 : 9781071617311
Total Pages : 332 pages
Book Rating : 4.6/5 (173 download)

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Book Synopsis The Unfolded Protein Response by : Roberto Pérez-Torrado

Download or read book The Unfolded Protein Response written by Roberto Pérez-Torrado and published by Humana. This book was released on 2022-01-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is divided in six section covering the most experimental approaches involved in the study of the unfolded protein response (UPR) pathway. Chapters detail determination of unfolded protein levels, methods to study UPR signal transmission, analysing the outcomes of the UPR pathway activation, UPR studies in mammalian models, UPR in alternative models, and UPR and disease. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Unfolded Protein Response: Methods and Protocols aims to describe key methods and approaches used in the study of the UPR pathway and its complex cellular implications. Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

The Women's Health and Aging Study

Author : Jack M. Guralnik
Publisher : DIANE Publishing
ISBN 13 : 0788131222
Total Pages : 407 pages
Book Rating : 4.7/5 (881 download)

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Book Synopsis The Women's Health and Aging Study by : Jack M. Guralnik

Download or read book The Women's Health and Aging Study written by Jack M. Guralnik and published by DIANE Publishing. This book was released on 1996-07 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to help in the understanding of the causes & course of disability in older women. Offers an excellent overview of diseases & disability & their impact on older women. Covers: adaptation to disability, physical performance measures, the daily lives of disabled older women, utilization of health services, mental health & general well-being, pulmonary diseases & conditions, musculoskeletal disease, neurological conditions, vision & hearing, medication use, instrumental & emotional support, adaptation to disability, & much more.

Inflammation, Advancing Age and Nutrition

Author : Irfan Rahman
Publisher : Academic Press
ISBN 13 : 0123978076
Total Pages : 394 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Inflammation, Advancing Age and Nutrition by : Irfan Rahman

Download or read book Inflammation, Advancing Age and Nutrition written by Irfan Rahman and published by Academic Press. This book was released on 2013-09-03 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field. Includes models of aging, including worm, mouse and human Explores the relationship of inflammation with diseases, including ocular health, Alzheimer's and Parkinson's disease, and muscle health Encompasses a variety of lifestyle impacts, including diet, exercise and nutrition Includes suggested nutritional interventions

Hormones, Metabolism and the Benefits of Exercise

Author : Bruce Spiegelman
Publisher : Springer
ISBN 13 : 3319727907
Total Pages : 108 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Hormones, Metabolism and the Benefits of Exercise by : Bruce Spiegelman

Download or read book Hormones, Metabolism and the Benefits of Exercise written by Bruce Spiegelman and published by Springer. This book was released on 2018-03-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.