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Author : Robert R. Maronpot
Publisher :
ISBN 13 : 9781889899022
Total Pages : 699 pages
Book Rating : 4.8/5 (99 download)
Download or read book Pathology of the Mouse written by Robert R. Maronpot and published by . This book was released on 1999-01-01 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cheryl L. Scudamore
Publisher : John Wiley & Sons
ISBN 13 : 1119941202
Total Pages : 258 pages
Book Rating : 4.1/5 (199 download)
Download or read book A Practical Guide to the Histology of the Mouse written by Cheryl L. Scudamore and published by John Wiley & Sons. This book was released on 2014-02-10 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation
Author : Stephen W. Barthold
Publisher : John Wiley & Sons
ISBN 13 : 1118924037
Total Pages : 385 pages
Book Rating : 4.1/5 (189 download)
Download or read book Pathology of Laboratory Rodents and Rabbits written by Stephen W. Barthold and published by John Wiley & Sons. This book was released on 2016-01-04 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fourth edition, Pathology of Laboratory Rodents and Rabbits has become a standard text for veterinary pathologists, laboratory animal veterinarians, students, and others interested in these species. • The standard reference on the pathogenesis and cardinal diagnostic features of diseases of mice, rats, hamsters, gerbils, guinea pigs, and rabbits • Expanded coverage of rabbit disease, normal anatomic features, and biology • Over 450 color photographs illustrating gross and microscopic pathology • Companion website offering images from the text in PowerPoint
Author : Brad Bolon
Publisher : CRC Press
ISBN 13 : 1420070096
Total Pages : 446 pages
Book Rating : 4.4/5 (2 download)
Download or read book Pathology of the Developing Mouse written by Brad Bolon and published by CRC Press. This book was released on 2015-04-24 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology expe
Author : Richard S. Smith
Publisher : CRC Press
ISBN 13 : 1420041606
Total Pages : 383 pages
Book Rating : 4.4/5 (2 download)
Download or read book Systematic Evaluation of the Mouse Eye written by Richard S. Smith and published by CRC Press. This book was released on 2001-12-20 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the first phase of the Human Genome Project has presented scientists with a mountain of new information. The availability of all human genes and their locations is exciting, but their mechanisms of action and interaction with other genes are often unknown. Certain variations in the environment and characteristics of human genes make i
Author : Piper M. Treuting
Publisher : Academic Press
ISBN 13 : 0123813611
Total Pages : 475 pages
Book Rating : 4.1/5 (238 download)
Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2012 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.
Author : Piper M. Treuting
Publisher : Academic Press
ISBN 13 : 0128029196
Total Pages : 573 pages
Book Rating : 4.1/5 (28 download)
Download or read book Comparative Anatomy and Histology written by Piper M. Treuting and published by Academic Press. This book was released on 2017-08-29 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. - Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work - Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence - Teaches biomedical researchers to examine the histologic changes in their model rodents - Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images
Author : Elizabeth Fiona McInnes
Publisher : Elsevier Health Sciences
ISBN 13 : 0702049247
Total Pages : 141 pages
Book Rating : 4.7/5 (2 download)
Download or read book Background Lesions in Laboratory Animals E-Book written by Elizabeth Fiona McInnes and published by Elsevier Health Sciences. This book was released on 2011-10-24 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Lesions in Laboratory Animals will be an invaluable aid to pathologists needing to recognize background and incidental lesions while examining slides taken from laboratory animals in acute and chronic toxicity studies, or while examining exotic species in a diagnostic laboratory. It gives clear descriptions and illustrations of the majority of background lesions likely to be encountered. Many of the lesions covered are unusual and can be mistaken for treatment-related findings in preclinical toxicity studies. The Atlas has been prepared with contributions from experienced toxicological pathologists who are specialists in each of the laboratory animal species covered and who have published extensively in these areas. - over 600 high-definition, top-quality color photographs of background lesions found in rats, mice, dogs, minipigs, non-human primates, hamsters, guinea pigs and rabbits - a separate chapter on lesions in the reproductive systems of all laboratory animals written by Dr Dianne Creasy, a world expert on testicular lesions in laboratory animals - a chapter on common artifacts that may be observed in histological glass slides - extensive references to each lesion described - aging lesions encountered in all laboratory animal species, particularly in rats in mice which are used for carcinogenicity studies
Author : John P. Sundberg
Publisher : John Wiley & Sons
ISBN 13 : 1119624576
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)
Download or read book Pathology of Genetically Engineered and Other Mutant Mice written by John P. Sundberg and published by John Wiley & Sons. This book was released on 2022-01-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.
Author : William D. Gude
Publisher : Springer
ISBN 13 : 1461517435
Total Pages : 150 pages
Book Rating : 4.4/5 (615 download)
Download or read book Histological Atlas of the Laboratory Mouse written by William D. Gude and published by Springer. This book was released on 2012-12-06 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Biology Division of the Oak Ridge National Laboratory ducted with very large numbers of mice, and mice proved to was organized in 1946 for the purpose of studying the imme be especially suitable for cancer induction studies. diate and long-term implications of man's exposure to ioniz As this work progressed, we became convinced that a ing radiation. The program that developed concentrated on strong histology department was needed to prepare the tis the basic mechanism of the effects in biological organisms sues in a uniform manner and also to examine and interpret from the genetic, biochemical, biophysical, and molecular bio them. With the support of Dr. Furth at that time, we secured physical points of view. the services of William D. Gude, who organized this section Most of its activities at the beginning concentrated on of the Biology Division and whose dedicated management nonmammalian work (bacteria, fungi, Drosophzla, plants, etc. ) developed it into a central information source for histology since no facilities to perform mammalian studies were availa work, not only for our Biology Division but also for this area ble at that time. It became most obvious that specimens more of Tennessee, thus establishing its excellent reputation. closely related to mammalian tissue would likely yield more I am most pleased to see that Mr. Gude has assembled this conclusive data to extrapolate these effects upon man. work into a detailed atlas of the laboratory mouse.
Author : Hans Hedrich
Publisher : Academic Press
ISBN 13 : 012382009X
Total Pages : 869 pages
Book Rating : 4.1/5 (238 download)
Download or read book The Laboratory Mouse written by Hans Hedrich and published by Academic Press. This book was released on 2012-06-14 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Laboratory Mouse, Second Edition is a comprehensive book written by international experts. With inclusions of the newly revised European standards on laboratory animals, this will be the most current, global authority on the care of mice in laboratory research. This well-illustrated edition offers new and updated chapters including immunology, viruses and parasites, behavior, enrichment and care standards of laboratory mice across the life sciences, medical and veterinary fields. - Features four-color illustrations with complete instruction on mouse surgery, anatomy, behavior and care of the mouse in laboratory research - Offers additional chapters on new mouse strains, phenotyping of strains, bacteria and parasites, and immunology - Includes the newly revised EU standards on care, as well as, comparisons to standards and regulations in the US and other countries
Author : Ulrich Mohr
Publisher : Springer Science & Business Media
ISBN 13 : 3662079739
Total Pages : 487 pages
Book Rating : 4.6/5 (62 download)
Download or read book International Classification of Rodent Tumors. The Mouse written by Ulrich Mohr and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists from both academia and industry in many countries have closely cooperated to arrive at a consensus on the descriptions of all the types of tumour and preneoplastic lesions encountered in laboratory mice. The series of fascicles should provide information and guidelines especially adapted for international use in practical toxicologic pathology. Images showing the typical appearance of the discussed lesions and references to the most recently published papers complete the information presented here.
Author : Jesus Ruberte
Publisher : Elsevier
ISBN 13 : 0128128771
Total Pages : 602 pages
Book Rating : 4.1/5 (281 download)
Download or read book Morphological Mouse Phenotyping written by Jesus Ruberte and published by Elsevier. This book was released on 2017-01-27 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. - Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organs - Includes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona) - Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images - Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology
Author : Jennifer Johnson
Publisher : CRC Press
ISBN 13 : 0429615353
Total Pages : 100 pages
Book Rating : 4.4/5 (296 download)
Download or read book The Laboratory Mouse written by Jennifer Johnson and published by CRC Press. This book was released on 2019-03-18 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Key features: High quality full color photographs and descriptive texts on the location and removal of the organs from the mouse Instructive methods and clear visuals for trimming and orienting the organs for paraffin histology to obtain the best possible sections for analysis Full color photomicrographs of the resulting section for each organ stained with hematoxylin and eosin demonstrating important features and landmarks for the histologist to ensure the optimal area for analysis is achieved All in one, easy to use guide organized by individual organs of the laboratory mouse Spiralbound for easy reference in the lab This "one-stop" guide offers an essential resource for any academic, research or development operation where mouse necropsy and/or histology are performed. Connecting the reader ‘from the mouse to the microscope’, it provides a detailed guide for locating, trimming, orientating and embedding of the most frequently investigated tissues collected in the laboratory mouse. It shows where the organs reside in the mouse, how to trim and embed them as well as the resulting optimal sections. This guide brings together the wealth of scattered information into one high-quality text, the emphasis is on providing knowledge that will help histologists and scientists get better results in any downstream assays where ideal sections are needed.
Author : Thomas C. Jones
Publisher : Springer Science & Business Media
ISBN 13 : 3642803350
Total Pages : 496 pages
Book Rating : 4.6/5 (428 download)
Download or read book Urinary System written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete update on the safety testing of foods, drugs, and chemicals in laboratory animals, featuring: - a thorough review of each subject area with extensive revision in line with new information and concepts - electron micrographs in exquisite detail to illustrate results of recent research - the effects of many carcinogens described succinctly and illustrated in detail - neoplasms described in detail and compared with natural and induced tumours in other species - standardised nomenclature. Of interest to those interested in the many applications to human patients, Urinary System: - facilitates uniform interpretation of bioassay results world-wide - provides a basis for understanding mechanisms involved in the functions and malfunctions of the most minute, but important structures of the kidneys - explains the functional significance of details by identifying the composition of structures at the molecular level. Forming a solid basis for understanding the causes and effects of disease of the urinary system, this is essential reading for pathologists, toxicologists, regulatory agencies, and all those involved in carcinogenicity and toxicity studies.
Author : Pritam S. Sahota
Publisher : CRC Press
ISBN 13 : 0429658060
Total Pages : 691 pages
Book Rating : 4.4/5 (296 download)
Download or read book The Illustrated Dictionary of Toxicologic Pathology and Safety Science written by Pritam S. Sahota and published by CRC Press. This book was released on 2019-04-26 with total page 691 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a growing interest in toxicologic pathology, especially as related to its impact on the safety assessment of pharmaceuticals and chemicals, and in drug development. Thus, there is a growing need for an Illustrated Dictionary of Toxicology Pathology and Safety Science (IDTP) that this dictionary aims to fill. The language of toxicologic pathology may be less familiar to a broad range of safety scientists, especially those involved in the safety evaluation of pharmaceuticals and chemicals. The IDTP format provides the brevity and clarity that the user is not likely to receive in a textbook, even if adequately indexed. With the inclusion of descriptions for terms used in toxicology, drug metabolism/pharmacokinetics, and regulatory science, the scope of the IDTP is considerably broadened and decidedly unique in its appeal to all safety scientists. With over 800 photos and illustrations to provide visual context,* an important aim of the IDTP is to present pathological changes as reference examples for terminology, nomenclature, and term descriptions for the entry entry-level as well as seasoned toxicologic pathologist. It will also aid students and non-pathology specialists such as study directors, senior toxicology report reviewers, scientific management of contract research organizations, regulatory agencies, and drug development companies to better understand the biological significance of tissue changes. The IDTP provides a single reference volume for these users to further their understanding and appreciation of biologically significant pathology findings. The IDTP consists of four major areas: 1. A-Z Dictionary of Pathology encompassing all organ systems, together with relevant non-pathology terms supported by references in "For Further Reading" sections. 2. Appendix 1: An Overviews of Drug Development, Nonclinical Safety & Toxicologic Pathology, and Important/Special Topics. 3. Appendix 2: Diagnostic Criteria of for Proliferative Proliferative Lesions in Rodents (Rat and Mouse) and Selected Non-Rodent Laboratory Species containing illustrations with detailed references and links to source material. 4) Appendix 3: Mini-Atlas of Organ System Anatomy and Histology to help re-acquaint the non-pathologist safety scientist with many normal anatomical structures. The editors and contributing scientists (board-certified veterinary pathologists, board-certified toxicologists, allied health safety scientists, health regulatory representatives) have experience from bench-level pathology and toxicology to managing global preclinical safety units in leading pharmaceutical companies. They have considerable experience mentoring pharmaceutical industry project team members, interacting with industry clinicians and representatives of decision-making bodies within the industry, as well as with global health authorities, such as the FDA and EMA. These activities convinced them of the necessity for and usefulness of the IDTP. As experts in their field, they have undertaken the hard work of writing and compiling the information, making the IDTP an exceptional, go-to reference. *Illustrations Editor: Gregory Argentieri
Author : Qingbo Xu
Publisher : John Wiley & Sons
ISBN 13 : 0470028785
Total Pages : 402 pages
Book Rating : 4.4/5 (7 download)
Download or read book A Handbook of Mouse Models of Cardiovascular Disease written by Qingbo Xu and published by John Wiley & Sons. This book was released on 2006-08-04 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The availability of well-defined genetic strains and the ability to create transgenic and knockout mice makes mouse models extremely valuable biomedical tools. Their suitability as an experimental system for cardiovascular research depends on the individual investigator’s ability to manipulate the mice surgically. Many mouse models require microsurgical techniques, which hitherto could not be performed without practical training. This comprehensive handbook enables scientists to develop these models in their own laboratories. A Handbook of Mouse Models of Cardiovascular Disease is the first book to address pathology in mouse models of heart disease, providing the reader with essential information on technical assays in artificially created models. It includes background information on individual cardiovascular diseases, describes detailed methods and materials used for establishing each mouse model, discusses the problems that may appear in the experiments, and provides examples of applications of the model. A Handbook of Mouse Models of Cardiovascular Disease: Describes mouse models of all important cardiovascular diseases, including atherosclerosis, atrial fibrillation and thrombosis Features videos of key experimental procedures on the accompanying CD, allowing researchers to learn the techniques by directly watching the whole operational procedure Describes how to establish each experimental model with detailed protocols and tips on dealing with common operational problems Highlights potential applications of each model in areas such as pathogenesis, gene transfer, therapy and pathophysiology This handbook is an invaluable resource for researchers in cardiovascular disease, pathology, physiology, interested in the mechanism of vascular disorders and therapeutic approaches. It is also relevant to clinicians seeking to understand the pathology of cardiovascular disease and the rationale for interventions, and of interest to the pharmaceutical industry and all those involved in drug discovery/development for cardiovascular disease.
