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Passive Experience Dependent Plasticity In Mouse Primary Visual Cortex
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Book Synopsis Passive Experience-dependent Plasticity in Mouse Primary Visual Cortex by : Dustin Jared Hayden
Download or read book Passive Experience-dependent Plasticity in Mouse Primary Visual Cortex written by Dustin Jared Hayden and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimulus-selective response plasticity (SRP) is a form of experience-dependent plasticity readily measured in primary visual cortex (V1) of mice. Chronic local field potential (LFP) recordings in layer 4 (L4) of V1 allow for the tracking of visually evoked potentials (VEPs) in response to phase-reversing sinusoidal grating stimuli. As a given visual stimulus becomes familiar to the mouse, the VEP magnitude increases. This increase in VEP magnitude is highly selective to stimulus features, such as the orientation, spatial frequency, and contrast of the grating. Previous work has shown that SRP requires synaptic mechanisms that are not only hallmarks of Hebbian synaptic plasticity, but also the engagement of parvalbumin-positive (PV+) inhibitory interneurons. Herein we build upon this foundational work and show that SRP expression can be explained as the engagement of two different interneuron subclasses: somatostatin-positive (SOM+) and PV+ cells. Familiar visual stimuli induce an increase in low-frequency (10-30 Hz) oscillations and an increase in SOM+ cell activity in L4. Conversely, novel visual stimuli induce an increase in high-frequency (60-80 Hz) oscillations and an increase in PV+ cell activity in L4. These differences in oscillations and cell activities to familiar and novel stimuli emerge in the seconds after the start of a block of stimuli. Finally, we show using laminar recordings in V1 that familiar stimuli cause elevated peak firing throughout most layers compared to novel stimuli, but reduced overall activity due to quick attenuation of the evoked signal. Together, these data further develop our understanding of experience-dependent plasticity.
Book Synopsis Experience-dependent Plasticity in Mouse Visual Cortex by : Mikhail Y. Frenkel
Download or read book Experience-dependent Plasticity in Mouse Visual Cortex written by Mikhail Y. Frenkel and published by . This book was released on 2006 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Understanding Experience-dependent Plasticity of Cellular and Network Activity in the Mouse Primary Visual Cortex by : Taekeun Kim (Ph. D.)
Download or read book Understanding Experience-dependent Plasticity of Cellular and Network Activity in the Mouse Primary Visual Cortex written by Taekeun Kim (Ph. D.) and published by . This book was released on 2019 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensory experiences in daily life modulates corresponding primary sensory cortices and eventually alter our behavior in a befitting manner. One of the most impactful sensory modules is vision. Primary visual cortex (V1) in mammals is particularly malleable during a juvenile critical period, but this plasticity lasts even in adulthood. A representative form of visual cortical plasticity is ocular dominance (OD) plasticity following temporary monocular deprivation (MD). Here, we used a mouse model of amblyopia and revealed that juvenile OD plasticity, which manifests as depression of response to the deprived eye, requires expression of an immediate early gene, Arc. Also, the juvenile OD shift requires the activity of N-methyl-D-aspartate (NMDA) receptors in layer 4 excitatory principal neurons in V1. Another simple but powerful phenomenon of an adult form of visual cortical plasticity is stimulus-selective response potentiation (SRP). SRP is induced simply through experience to the same gratings visual stimulus over days, resulting in potentiation of visually-evoked potentials (VEPs) in layer 4 of V1. Due to the lack of studies regarding the cellular and network activity changes coincident with the induction of SRP, we have used calcium indicator expressing mice to visualize cellular activity across days of SRP training. Using two-photon calcium imaging, we found that there is indeed no significant net change in the population of active neurons during presentation of the familiar (trained) visual stimulus. Follow-up endoscopic calcium imaging revealed that rather, there is a significant reduction of somatic calcium responses selectively for the familiar visual stimulus on the test day following 5 days of SRP induction. Interestingly, the cellular calcium response to the first presentation of the familiar visual stimulus in each block was substantially similar to the response to those of a novel, yet unseen visual stimulus. However, calcium responses to the familiar visual stimulus dramatically decreased as stimulation was repeated in each presentation block within, and across days of SRP training, whereas the response to the novel visual stimulus on the test day was maintained. The findings that short-latency VEP responses are potentiated, while the slower responses revealed by calcium imaging are depressed suggest that feedback inhibition in V1 is strongly recruited by visual recognition of familiar stimulus. A number of previous studies have suggested that deficits in experience-dependent sensory cortical plasticity and perceptual learning are associated with neuropsychiatric disorders such as autism spectrum disorder (ASD), Rett syndrome and schizophrenia. Our results, therefore, may contribute to our understanding of the underlying mechanisms of these disorders and may help inform ways of intervention and treatments.
Book Synopsis Neuronal Circuits of Experience-dependent Plasticity in the Primary Visual Cortex by : Evelyn Dylda
Download or read book Neuronal Circuits of Experience-dependent Plasticity in the Primary Visual Cortex written by Evelyn Dylda and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structural Mechanisms of Experience-dependent Synaptic Plasticity in the Mouse Visual Cortex by : Rachel W. Schecter
Download or read book Structural Mechanisms of Experience-dependent Synaptic Plasticity in the Mouse Visual Cortex written by Rachel W. Schecter and published by . This book was released on 2016 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Changes in the sensory experience of an animal shapes behavior through synaptic plasticity. Modification in the strength of synaptic drive can result from adjustments in the strength of existing synapses, creation of new synapses, or removal of existing ones and involves presynaptic, postsynaptic, and extra-synaptic mechanisms. Ocular dominance (OD) plasticity following brief periods of monocular deprivation (MD) is a classic example of experience-dependent change, which leads to a rapid weakening of cortical responsiveness to the deprived eye and a strengthening of responsiveness to the non-deprived eye. Though there is clear anatomical reorganization following long periods of lid suture, only recently has brief periods (3 days) of MD has been shown to drive structural plasticity of thalamic input to binocular visual cortex. The exact molecular and synaptic mechanisms responsible for rapid OD shifts remain unclear. In my thesis work, I address the requirement of proper microglial functioning via the fractalkine receptor (CX3CR1) in OD plasticity following 3 days of MD. I first identify increased lysosomal content in microglia within layer 4 (L4) of binocular visual cortex following MD, which suggests microglia participate in this structural rearrangement. As it is currently believed that a major axis of communication between neurons and microglia occurs via fractalkine and its specific receptor CX3CR1, I investigated OD plasticity within the CX3CR1 KO mouse. My experiments reveal increased lysosomal content, structural plasticity of thalamocortical synapses, and OD shifts measured with visually evoked potentials (VEPs) all occur normally in this mutant mouse as a result of 3 days of MD with only subtle differences when compared to WT mice. I conclude that, while microglia may have a role in the anatomical and functional experience-dependent cortical plasticity driven by brief lid suture, it does not require CX3CR1.
Book Synopsis Cellular and Biochemical Mechanisms of Experience-dependent Plasticity in the Rodent Visual Cortex by : Nathaniel B. Sawtell
Download or read book Cellular and Biochemical Mechanisms of Experience-dependent Plasticity in the Rodent Visual Cortex written by Nathaniel B. Sawtell and published by . This book was released on 2003 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Ocular Dominance Plasticity in the Juvenile and Adult Mouse Visual Cortex by : Lena A. Khibnik
Download or read book Mechanisms of Ocular Dominance Plasticity in the Juvenile and Adult Mouse Visual Cortex written by Lena A. Khibnik and published by . This book was released on 2011 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular dominance (OD) plasticity is a classic example of bidirectional experience-dependent plasticity in the primary visual cortex. This form of plasticity is most robust during early postnatal development (termed the "critical period"), when monocular deprivation (MD) leads to a rapid weakening of responses evoked through the deprived eye followed by a delayed strengthening of non-deprived eye inputs. It has been proposed that these bidirectional changes occur as a three-stage process: first, degradation of patterned visual input weakens deprived-eye responses via homosynaptic long-term depression (LTD); this is accompanied by a shift in the plasticity modification threshold (0m) that determines the direction of synaptic plasticity, such that synaptic strengthening is favored over synaptic weakening; finally, weak open-eye responses are strengthened via the mechanisms of homosynaptic long-term potentiation (LTP). Despite the growing evidence supporting this model of experience-dependent synaptic modification, the exact molecular and synaptic mechanisms that are responsible for these processes remain controversial. In my thesis work, I address three questions. First, I attempt to parse the relative contribution of excitatory and inhibitory processes to expression of the OD shift in order to understand how deprived-eye depression is expressed in the cortex. To address this, I first induce a shift in OD with 3 days of MD and then use several pharmacological methods to shut off cortical inhibitory synaptic transmission. I demonstrate that rapid deprived-eye depression is strongly expressed at excitatory thalamocortical synapses without any influences of polysynaptic intracortical inhibition. In the second part of my work, I try to resolve the nature/identity of the molecular mechanism that underlies the regulation of [theta]m. Using a transgenic mouse model, I find that a reduction in the NR2A/B subunit ratio of the N-methyl-d-aspartate (NMDA) receptor during MD alters the qualities of OD plasticity by impairing weakening of deprived-eye inputs and enhancing strengthening of open-eye inputs. These findings suggest that NMDAR subunit composition may specify the value and the rate of adjustment of synaptic 0m, which in turn determines the bidirectional cortical response to MD. The final portion of my thesis addresses the factors that limit OD plasticity beyond the critical period. I test the hypothesis that the developmental increase in intracortical GABAergic inhibitory synaptic transmission is a fundamental restricting factor for adult cortical plasticity and demonstrate that parvalbumin-expressing fast-spiking basket cells are specifically implicated in the absence of juvenile-like deprived-eye depression in adult mice.
Book Synopsis Visual Cortical Plasticity by : Eitan S. Kaplan
Download or read book Visual Cortical Plasticity written by Eitan S. Kaplan and published by . This book was released on 2016 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The roles played by cortical inhibitory neurons in experience-dependent plasticity and learning are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult mice: ocular dominance (OD) plasticity resulting from monocular deprivation and stimulus-selective response potentiation (SRP) resulting from supplemental visual experience. These two forms of plasticity are triggered by different events but lead to a similar increase in visual cortical response. Both also require the NMDA class of glutamate receptor (NMDAR). However, we find that PV+ inhibitory neurons in V1 play a critical role in the expression of SRP and its behavioral correlate of familiarity recognition, but not in the expression of OD plasticity. Furthermore, NMDARs expressed within PV+ cells play a critical role in SRP, but not in the induction or expression of adult OD plasticity. We also explore the use of visual cortical plasticity paradigms to better understand the function of proteins implicated in autism spectrum disorders (ASDs) and schizophrenia. We find that NMDAR-dependent long-term depression (LTD) and deprived-eye depression in layer 4 of V1 require metabotropic glutamate receptor 5 (mGluR5) signaling during postnatal development. Additionally, schizophrenia-associated protein neurogranin overexpression in V1 disrupts juvenile ocular dominance plasticity. Finally, we evaluate SRP in two models of ASDs associated with excitatory/ inhibitory imbalance: Rett syndrome (RTT) and tuberous sclerosis complex (TSC). Surprisingly, mouse models of RTT and TSC exhibit abnormal SRP phenotypes, but in opposite directions.
Book Synopsis Mechanisms of Homeostatic Plasticity in the Mouse Visual Cortex by : Rosanna Sammons
Download or read book Mechanisms of Homeostatic Plasticity in the Mouse Visual Cortex written by Rosanna Sammons and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: During development, newly established cortical circuits are undergoing a period of experience dependent refinement. Visual deprivation during this time leads to the induction of plasticity mechanisms, including homeostatic plasticity measures. These are a distinct set of plasticity mechanisms thought to play a role in maintaining stability within networks, and preventing large perturbations in overall activity levels. Homeostatic plasticity mechanisms can be divided into synaptic and intrinsic mechanisms. While details of individual mechanisms are reasonably well understood, details of how these different mechanisms are linked to one another are much less clear. In this thesis, I investigate the relationship between structural and functional forms of synaptic and intrinsic plasticity in layer 2/3 neurons in the monocular visual cortex, before and after induction of plasticity via monocular enucleation. I find that while axon initial segment (AIS) plasticity takes place following deprivation, in both pyramidal neurons, and a subset of inhibitory neurons, it does not correlate with functional measures of excitability. However, in control conditions, I do find a relationship between the synaptic inputs of a neuron, and its intrinsic excitability. Following deprivation, this relationship is altered. Specifically, I find that the activity status of the neuron affects the level of intrinsic excitability, and to some extent, the synaptic input to the cell. Putatively inactive neurons show increased excitability, and trend towards stronger synaptic input in comparison to their active counterparts. These differences between active and inactive cells may reflect the engagement of homeostatic mechanisms in inactive cells, in order to restore their activity levels.
Book Synopsis The Maturation and Experience-dependent Plasticity of the Developing Visual Cortex by : Kevin R. Duffy
Download or read book The Maturation and Experience-dependent Plasticity of the Developing Visual Cortex written by Kevin R. Duffy and published by . This book was released on 2001 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Experience-dependent Plasticity in the Mouse Barrel Cortex by : Nathalie Johnston-Wenger
Download or read book Experience-dependent Plasticity in the Mouse Barrel Cortex written by Nathalie Johnston-Wenger and published by . This book was released on 2010 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Kevin R. Duffy Publisher :National Library of Canada = Bibliothèque nationale du Canada ISBN 13 : Total Pages :292 pages Book Rating :4.:/5 (769 download)
Book Synopsis The Maturation and Experience-dependent Plasticity of the Developing Visual Cortex [microform] by : Kevin R. Duffy
Download or read book The Maturation and Experience-dependent Plasticity of the Developing Visual Cortex [microform] written by Kevin R. Duffy and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2001 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Experience-dependent Spatial Expectations in Mouse Visual Cortex by : Aris Fiser
Download or read book Experience-dependent Spatial Expectations in Mouse Visual Cortex written by Aris Fiser and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Experience-dependent Induction of Homeostatic Plasticity in Developing Visual Cortex by : Mary E. Lambo
Download or read book Experience-dependent Induction of Homeostatic Plasticity in Developing Visual Cortex written by Mary E. Lambo and published by . This book was released on 2012 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development and Plasticity of Visual Cortex by : Takao Kurt Hensch
Download or read book Development and Plasticity of Visual Cortex written by Takao Kurt Hensch and published by . This book was released on 1996 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inhibitory Synaptic Plasticity by : Melanie A. Woodin
Download or read book Inhibitory Synaptic Plasticity written by Melanie A. Woodin and published by Springer Science & Business Media. This book was released on 2010-11-02 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.
Book Synopsis The Role of Visual Experience in Shaping Synaptic Plasticity from Two Pathways Onto Common Cells on the Primary Visual Cortex of Mice by :
Download or read book The Role of Visual Experience in Shaping Synaptic Plasticity from Two Pathways Onto Common Cells on the Primary Visual Cortex of Mice written by and published by . This book was released on 2015 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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