Oxyradicals in Medical Biology

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Publisher : Elsevier
ISBN 13 : 0080877109
Total Pages : 201 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Oxyradicals in Medical Biology by : J.M. McCord

Download or read book Oxyradicals in Medical Biology written by J.M. McCord and published by Elsevier. This book was released on 1998-04-23 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid expansion of the area of free radical biology in the last 25 years has occurred within a framework of assumptions and preconceived notions that has at times directed the course of this movement. The most dominant of these notions has been the view that free radical production is without exception a bad thing, and that the more efficient our elimination of these toxic substances, the better off we will be. The very important observation by Bernard Babior and colleagues in 1973 that activated phagocytes produce superoxide in order to kill micro organisms, served to illustrate that constructive roles are possible for free radicals. For many in the field, however, this merely underscored the deadly nature of oxygen-derived radicals, both from the microbe's point of view and from the host's as well. (Phagocyte-produced superoxide is responsible in part for the tissue injury manifested as inflammation. See Harris and Granger, Chapter 5, and Leff, Hybertson and Repine, Chapter 6.) Mother Nature, however, has a penchant for being able to make a silk purse from a sow's ear. If one is dealt a bad hand, one must simply make the best of it. After two decades of focusing on the destructive side of free radicals, the last few years have begun to reveal a new and finer perspective on free radical metabolism - a role in regulation of cellular function (see Schulze-Osthoff and Baeuerle, Chapter 2). Evidence from a number of sources suggests that an increase in the oxidative status of cell encourages that cell to grow and divide. Increasing the expression of mangnese superoxide dismutase can suppress the malignant phenotype of melanon cells (see Oberley and Oberley, Chapter 3). Oxidative stress beyond a certain poitosis (from the Greek, literally "to fall apart"). Is this suicide response an evolutionary fail-safe device to curtail tumorogenesis? Does oxidative stress-induced apoptosis account for the loss of immune cells in AIDS (see Flores and McCor Chapter 4)? This volume attempts to present the spectrum of roles, both good and bad played by active oxygen species as understood at this point in the evolution of this field of free radical biology.

Oxygen Radicals in Biology and Medicine

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468455680
Total Pages : 1064 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Oxygen Radicals in Biology and Medicine by : Michael Simic

Download or read book Oxygen Radicals in Biology and Medicine written by Michael Simic and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Oxy-Radicals in Molecular Biology and Pathology

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Author :
Publisher : Wiley-Liss
ISBN 13 : 9780471501886
Total Pages : 606 pages
Book Rating : 4.5/5 (18 download)

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Book Synopsis Oxy-Radicals in Molecular Biology and Pathology by : Peter A. Cerutti

Download or read book Oxy-Radicals in Molecular Biology and Pathology written by Peter A. Cerutti and published by Wiley-Liss. This book was released on 1988-09-22 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides in-depth coverage of recent advances in oxy-radical biology and medicine. Examines the deleterious effects of oxy-radicals at the tissue, cellular, and molecular levels; and application of ESR and spin-trapping to in vivo detection and identification of free radicals. Also covers biological sources of O2-, superoxide dismutases, the defensive role of glutathione peroxidase against oxygen toxicity, regulation of the GSHPx gene, and much more.

Oxy-radicals in Molecular Biology and Pathology

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Publisher :
ISBN 13 :
Total Pages : 616 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Oxy-radicals in Molecular Biology and Pathology by : Upjohn Company

Download or read book Oxy-radicals in Molecular Biology and Pathology written by Upjohn Company and published by . This book was released on 1988 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Excited States and Free Radicals in Biology and Medicine

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Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Excited States and Free Radicals in Biology and Medicine by : R. V. Bensasson

Download or read book Excited States and Free Radicals in Biology and Medicine written by R. V. Bensasson and published by . This book was released on 1993 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excited states and free radicals are involved in the normal physiology of living systems, in pathological processes (including lipid peroxidation, inflammation, Parkinson's disease, cancer, and aging), in the mechanisms of drug action, and in the photochemotherapies such as the PUVA therapy for skin diseases and PDT for cancer. This text introduces the reader to this rapidly expanding field, one that lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine. The authors explore in particular how time-resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems. Topics include the nature of excited states and free radicals and the techniques for their study, activated oxygen species, DNA, proteins, carotenoids and photosynthetic reaction centers, photodermatology and melanogenesis, and aspects of cancer related to radio-, chemo-, and photodynamic therapy. Researchers and graduate students in photochemistry, photobiology, photomedicine, radiation chemistry and biology, and cancer therapies will find this book to be of very significant interest.

Reactive Oxygen Species in Chemistry, Biology, and Medicine

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Author :
Publisher : Springer
ISBN 13 : 9781475704181
Total Pages : 232 pages
Book Rating : 4.7/5 (41 download)

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Book Synopsis Reactive Oxygen Species in Chemistry, Biology, and Medicine by : A. Quintanilha

Download or read book Reactive Oxygen Species in Chemistry, Biology, and Medicine written by A. Quintanilha and published by Springer. This book was released on 2013-04-17 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NATO Advanced Study Institute on "Oxygen Radicals in Biological Systems: Recent Progress and New Methods of Study" was held in Braga, Portugal between Sep tember 1 and September 14, 1985, in order to consider the basic chemistry and biochem istry of activated oxygen (both radical and non-radical species) and their effect in biolog ical systems. This book summarizes the main lectures given at this meeting. While there is no attempt to cover all the major topics in the expanding subject of oxidative mechanisms in biology, an effort has been made to provide overviews on some key aspects of this field. The authors have attempted to convey a clear picture of both what is known and what remains unclear in their respective subjects. Not only are some of the techniques used for detecting activated oxygen species described, but also their strengths and limi tations. The chemistry of many of these species is discussed and the biological and/or pathological implications are carefully reviewed. The medical and therapeutic aspects of some of the well established pathways of damage and protection are analyzed. It is our hope that the material included in this book might be useful for both researchers and teachers at the graduate level. The success of this meeting was to a large extent due to the tireless committment of Professor Alberto Amaral and Dr. Concei~a:o Rangel; without their outstanding efforts in dealing with all the aspects of the organization, this summer school would not have been possible.

Reactive Oxygen Species in Chemistry, Biology, and Medicine

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Publisher : Springer Science & Business Media
ISBN 13 : 1475704178
Total Pages : 233 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Reactive Oxygen Species in Chemistry, Biology, and Medicine by : A. Quintanilha

Download or read book Reactive Oxygen Species in Chemistry, Biology, and Medicine written by A. Quintanilha and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NATO Advanced Study Institute on "Oxygen Radicals in Biological Systems: Recent Progress and New Methods of Study" was held in Braga, Portugal between Sep tember 1 and September 14, 1985, in order to consider the basic chemistry and biochem istry of activated oxygen (both radical and non-radical species) and their effect in biolog ical systems. This book summarizes the main lectures given at this meeting. While there is no attempt to cover all the major topics in the expanding subject of oxidative mechanisms in biology, an effort has been made to provide overviews on some key aspects of this field. The authors have attempted to convey a clear picture of both what is known and what remains unclear in their respective subjects. Not only are some of the techniques used for detecting activated oxygen species described, but also their strengths and limi tations. The chemistry of many of these species is discussed and the biological and/or pathological implications are carefully reviewed. The medical and therapeutic aspects of some of the well established pathways of damage and protection are analyzed. It is our hope that the material included in this book might be useful for both researchers and teachers at the graduate level. The success of this meeting was to a large extent due to the tireless committment of Professor Alberto Amaral and Dr. Concei~a:o Rangel; without their outstanding efforts in dealing with all the aspects of the organization, this summer school would not have been possible.

Physiology of Inflammation

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Publisher : Springer
ISBN 13 : 1461475120
Total Pages : 558 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Physiology of Inflammation by : Klaus Ley

Download or read book Physiology of Inflammation written by Klaus Ley and published by Springer. This book was released on 2013-05-27 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the physiological processes relevant to inflammation. It centers on the recruitment of leukocytes to sites of injury and infection, their function in the tissue and the eventual resolution of inflammation.

Current Catalog

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Publisher :
ISBN 13 :
Total Pages : 1144 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Current Catalog by : National Library of Medicine (U.S.)

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Reactive Oxygen Species in Biology and Human Health

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Publisher : CRC Press
ISBN 13 : 1315352648
Total Pages : 782 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Reactive Oxygen Species in Biology and Human Health by : Shamim I. Ahmad

Download or read book Reactive Oxygen Species in Biology and Human Health written by Shamim I. Ahmad and published by CRC Press. This book was released on 2017-12-19 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unlike other narrowly focused books, Reactive Oxygen Species in Biology and Human Health provides a comprehensive overview of ROS. It covers the current status of research and provides pointers to future research goals. Additionally, it authoritatively reviews the impact of reactive oxygen species with respect to various human diseases and discusses antioxidants and other compounds that counteract oxidative stress. Comprised of seven sections, the first section describes the introduction, detection, and production of ROS, emphasizing phenolic compounds and vitamin E for their abilities to act as antioxidants. This section also highlights the role of lipoprotein-associated oxidative stress. Section two addresses the importance of iron accumulation in the brain resulting in the development of a group of neurodegenerative disorders (NDs) and identifies several causative genes for neurodegeneration with brain iron accumulation (NBIA) associated with Parkinsonism-related disorders. The third section discusses a number of NDs, including amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). Section four addresses autoimmune diseases caused by ROS, including asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. Section five analyzes a number of different cancers, including lung cancer, breast cancer, and melanoma, along with possible treatment regimens. Section six discusses cardiovascular diseases (CVDs) induced by ROS, presents the ROS-associated complex biochemical processes inducing inflammation as an important cause of CVDs, and explains the roles carotenoids play in preventing CVDs. The final section addresses other human diseases induced by oxidative stress, including sickle cell disease, nonalcoholic steatohepatitis, retinopathy, fibromyalgia, chronic obstructive pulmonary disease, asthma, pulmonary hypertension, infertility, and aging of human skin.

Energy Research Abstracts

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Publisher :
ISBN 13 :
Total Pages : 524 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Energy Research Abstracts by :

Download or read book Energy Research Abstracts written by and published by . This book was released on 1985 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Basis of Detoxication

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Publisher : Elsevier
ISBN 13 : 0323150101
Total Pages : 444 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Biological Basis of Detoxication by : John Caldwell

Download or read book Biological Basis of Detoxication written by John Caldwell and published by Elsevier. This book was released on 2012-12-02 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Basis of Detoxication focuses on the biological processes involved in detoxication, with emphasis on the biochemistry of the removal of xenobiotics from an organism. Topics range from the formation of toxic metabolites and compounds that are not metabolized at all to the tissue distribution and nutritional considerations, the kinetics and mechanisms of the metabolic and excretory processes, and the integration of xenobiotic metabolism in the activation and detoxication of carcinogens. Organized into 14 chapters, this book begins with an overview of the enzymatic basis for the metabolic activation of foreign compounds in forming reactive chemical intermediates. The first few chapters discuss the identification of reactive electrophiles derived from xenobiotics, intratissue distribution of activating and detoxicating enzymes, enzymatic and non-enzymatic modes of xenobiotic metabolism, and unmetabolized compounds. The middle chapters explore the biological basis of detoxication of oxygen free radicals, physiologic and kinetic aspects of the fate of xenobiotics, excretion of xenobiotics, and effects of nutrition on detoxication. The remaining chapters look at the relationships between the enzymes of detoxication and host defense mechanisms, metabolic basis of target organ toxicity, the enzymatic factor in selective toxicity, and intraindividual and interindividual variations in rates of hepatic metabolism of exogenous chemicals. Pharmacologists, toxicologists, and biochemists will find this book highly informative.

Breakthrough in Cell-Defense

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Publisher : GOLDENeight Publishing
ISBN 13 : 9781890412869
Total Pages : 300 pages
Book Rating : 4.4/5 (128 download)

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Book Synopsis Breakthrough in Cell-Defense by : Dr Allan C Somersall, Ph.D., M.D.

Download or read book Breakthrough in Cell-Defense written by Dr Allan C Somersall, Ph.D., M.D. and published by GOLDENeight Publishing. This book was released on 1999 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like Fleming's discovery of Penicillin, Dr. Gustavo Bounous looked to nature, where answers to complex medical problems are waiting to be found. After immigrating to the US to complete his medical residency, Bounous moved to Canada in 1963 and began a career that led him to dietary therapy research. His work earned him the medal of the Royal College of Physicians and Surgeons of Canada, awarded in 1965. In 1978, now a leading scientific and medical expert in nutrition research, Bounos joined with a colleague and isolated a protein in milk whey that strengthens the human immune system. The resultant product, Immunocal "RM," is being used as a complement to treatments for AIDS, cancer, ALS, chronic fatigue syndrome and in conjunction with chemotherapy treatments. Breakthrough in Cell-Defense provides accessible medical insight into how the human immune system and Bounous' treatment work. But it is also the story of an immigrant doctor who fought the odds to revolutionize medicine and patient treatment. If you or anyone you know is coping with a chronic disease, Breakthrough in Cell-Defense will give you a sense of where your treatment came from, or where it should be going.

Free Radicals: from Basic Science to Medicine

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Publisher : Birkhäuser
ISBN 13 : 3034891164
Total Pages : 540 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Free Radicals: from Basic Science to Medicine by : POLI

Download or read book Free Radicals: from Basic Science to Medicine written by POLI and published by Birkhäuser. This book was released on 2013-03-11 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.

Noble Metals and Biological Systems

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Publisher : CRC Press
ISBN 13 : 9780849361647
Total Pages : 426 pages
Book Rating : 4.3/5 (616 download)

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Book Synopsis Noble Metals and Biological Systems by : Robert R. Brooks

Download or read book Noble Metals and Biological Systems written by Robert R. Brooks and published by CRC Press. This book was released on 1992-04-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Noble Metals and Biological Systems examines the relationship between noble metals (gold, silver, and platinum group metals) and biological systems. The book is divided into three parts. Part 1 is concerned with the analytical chemistry of noble metals and includes a description of the latest methods of analysis. Part 2 describes such topics as ecology and environmental science of noble metals as they pertain to biogeochemical exploration, noble metals in hair, the environmental geochemistry of palladium, microorganisms and noble metals, animals and noble metals, and a general survey of noble metals in the environment. Coverage is comprehensive and includes information regarding the use of dogs and termites as field assistants in mineral prospecting, as well as the fascinating story of the "gold bug", a microorganism that plates itself with gold. Part 3 is devoted entirely to noble metals in the treatment of disease and includes chapters describing the use of osmium and gold for arthritis treatment, silver as a bactericide, and platinum and ruthenium as anticancer agents. Noble Metals and Biological Systems will provide fascinating reading for applied geochemists, environmentalists, public health specialists, ecologists, microbiologists, clinical biochemists, oncologists, and specialists in rheumatic diseases.

Annual Report

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Publisher :
ISBN 13 :
Total Pages : 708 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Annual Report by : National Institute on Aging

Download or read book Annual Report written by National Institute on Aging and published by . This book was released on 1988 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mechanism for Oxygen Regulation Escherichia Coli Transcription Factor FNR

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Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Mechanism for Oxygen Regulation Escherichia Coli Transcription Factor FNR by : Beth A. Lazazzera

Download or read book Mechanism for Oxygen Regulation Escherichia Coli Transcription Factor FNR written by Beth A. Lazazzera and published by . This book was released on 1995 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: