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Overcoming Physiologic Barriers To Treatments For Hematologic Malignancies By Molecularly Targeting The Tumor Microenvironment
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Book Synopsis Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment by : Qin Wang
Download or read book Overcoming Physiologic Barriers to Treatments for Hematologic Malignancies by Molecularly Targeting the Tumor Microenvironment written by Qin Wang and published by Frontiers Media SA. This book was released on 2024-01-29 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematologic malignancies (HMs) represent a group of hematologic cancers originating from bone marrow or lymphoid organs. Currently, leukaemia, lymphoma, and multiple myeloma are the most common HMs. Conventional treatments for HMs include bone marrow transplantation, radiotherapy, chemotherapy, and immunotherapy. Despite the significant achievements obtained over the past decade in the drug therapy of HMs, tumor metastasis and relapse in patients often occurred after an initial response, indicating the generation of drug resistance to current therapies. Moreover, many clinically used therapeutic drugs are often associated with dose-related side effects and a lack of specificity to tumor tissues. The tumor microenvironment (TME) in HMs consists of a complicated network of cellular interactions and signaling cross-talking within the bone marrow cavity, and it plays an essential role in the progression and metastasis of HM. Furthermore, the TME in HMs has formed physiologic barriers such as immunosuppressive microenvironment, upregulated anti-apoptotic system, drug resistance, etc. to facilitate drug resistance and relapse of HMs. It has become widely accepted that effective treatment against HMs may require targeting both the cancer cell and TME.
Book Synopsis Sarcoma Oncology by : Raphael E. Pollock, MD, PhD
Download or read book Sarcoma Oncology written by Raphael E. Pollock, MD, PhD and published by PMPH USA. This book was released on 2019-05-16 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sarcoma Oncology: A Multidisciplinary Approach is a comprehensive textbook that addresses the entire spectrum of the subject from epidemiology to laboratory research in the biology of sarcomas. Chapters contributed by an international group of highly regarded specialists cover the epidemiology and pathology of sarcomas; diagnostic imaging and biopsy techniques; staging and prognosis: surgery of sarcomas in extremity soft tissue, abdominal wall and trunk, and skeletal bone; hyperthermia in sarcoma treatment; isolated limb perfusion; surgery for metastases; reconstructive surgery; radiation therapy; systemic chemotherapy; multidisciplinary care; treatment-induced sarcoma; pain management in sarcoma; and basic research including molecular biology and mouse models.
Book Synopsis Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications by : Qingxin Mu
Download or read book Nanoparticles in Cancer Therapy: Novel Concepts, Mechanisms and Applications written by Qingxin Mu and published by Frontiers Media SA. This book was released on 2019-04-03 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the invention of nanomedicine decades ago, considerable progresses have been made, especially with cancer as a target. Nanoparticles have been proven to be powerful imaging tools or potent agents for cancer diagnosis, treatment and prevention. Active research spread from fundamental research to clinical investigations. This topic intends to cover several important aspects in this field including nanocarrier development, gene delivery, intrinsically active nanoparticles, tumor microenvironment, immunology, and toxicity.
Book Synopsis Stem Cells and Cancer by : Rebecca G. Bagley
Download or read book Stem Cells and Cancer written by Rebecca G. Bagley and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significance of Stem Cells to Tumor Development Cancer stem cells remain a controversial topic and the criteria that define cancer stem cells are continuing to evolve. A recent surge in stem cell research has ignited a field of discovery into many human diseases including diabetes, neuropathologies, and cancer. By replacing specific differentiated cells that have either been lost or died, stem cell therapy proves to be a very promising approach to the treatment of many debilitating diseases. Though stem cells may provide therapeutic benefit under certain conditions, they are also often implicated in the initiation, progression, and therapeutic resistance of malignant disease. This first edition of Stem Cells and Cancer is intended to give a current perspective on the role of stem cells in cancer and strategies for novel therapies directed toward tumor stem cells. The current cancer stem cell hypothesis is presented in several chapters with distinctions made between the hierarchical and stochastic models of tumor cell development. "Stemness," self-renewal, pluripotency, clonality, and tumorigenicity are important concepts applied towards defining cancer stem cells. Signaling pathways such as Wnt, Sonic Hedgehog, Notch, and Bmi-1 that are involved in differentiation, proliferation, and survival are implicated in the malignant process. Additional chapters address the identification of cancer stem cell populations through the evaluation of molecular markers such as CD133, CD44, and CD24, for example, or by Hoescht dye exclusion to recognize ‘side populations.’ Mesenchymal and hematopoietic stem cells are described as well as mouse models that are employed to elucidate the properties and functionality of stem cells in cancer and the stem cell niche. This book encompasses a wide variety of human cancers that include but are not limited to leukemia, gliomas, breast, and prostate cancers. Resistance to conventional therapies, genetic versus epigenetic changes that affect therapeutic response and strategies to prevent disease recurrence are challenges have been incorporated into this volume. Stem Cells and Cancer represents a compendium of cutting edge research by experts in the field and will be instrumental in the study of this intriguing line of investigation for many years to come. Rebecca Bagley is a senior scientist at Genzyme Corporation and has worked in the biotechnology industry for 20 years with degrees in biology from Wellesley College and Harvard University. Her expertise in drug development spans a wide range of approaches including immunotherapies, gene and protein therapies, and small molecule delivery with publications in journals such as Molecular Cancer Therapeutics, Cancer Research, and Microvascular Research . Her current research focuses on stem cells, tumor vasculature, and target validation. Dr. Beverly A. Teicher is Vice President of Oncology Research at Genzyme Corporation. Dr. Teicher completed a PhD in Bioorganic Chemistry at the Johns Hopkins University and postdoctoral training at Yale University School of Medicine. Dr. Teicher joined Dana-Farber Cancer Institute as an Assistant Professor of Pathology and rose to Associate Professor of Medicine and Radiation Therapy, Harvard Medical School at Dana-Farber Cancer Institute and Joint Center for Radiation Therapy. Dr. Teicher is an active member of the international scientific community having authored or co-authored more than 400 scientific publications. She has edited eight books, is senior editor for the journal Clinical Cancer Research and is series editor for the Cancer Drug Discovery and Development book series.
Book Synopsis Mass Transport of Nanocarriers by : Rita Elena Serda
Download or read book Mass Transport of Nanocarriers written by Rita Elena Serda and published by CRC Press. This book was released on 2012-12-17 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes barriers from the macro to the nanoscale, starting with endothelial and mucosal barriers, and ending with cellular organelles. Experimental approaches to track nanoparticles in vitro and in vivo are presented, as well as the ability to tailor-make nanoparticles for specific functions. Several model types of nanoparticles are presented, as well the impact of particle attributes on biological transport.
Book Synopsis Advanced Drug Formulation Design to Optimize Therapeutic Outcomes by : Robert O. Williams
Download or read book Advanced Drug Formulation Design to Optimize Therapeutic Outcomes written by Robert O. Williams and published by CRC Press. This book was released on 2007-09-25 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title demonstrates how advanced formulation designs and delivery technologies can be used to improve drug efficacy and treatment outcomes in particular therapeutic categories or disease states. It discusses nanoparticle systems for cancer treatments, and also presents cutting edge immono-regulation agents for transplantation and the local targ
Book Synopsis Radiation-induced effects and the immune system by : Gabriele Multhoff
Download or read book Radiation-induced effects and the immune system written by Gabriele Multhoff and published by Frontiers E-books. This book was released on with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous developments in molecular biology have led to an explosive growth in the knowledge underlying mechanisms of carcinogenesis, cell signalling, tumor progression and development of metastasis. However, cure of cancer is still hampered by the inherited capacity of tumors to become resistant to standard therapies, to metastasize from their initial location and to proliferate in other tissue compartments. Radiotherapy is one of the main treatment modalities to achieve locoregional tumor control. However, the treatment of distant metastases further remains to be a challenge. In this special topic we are interested to elucidate immunological aspects which are initiated and affected by radiotherapy. We also aim to describe the development of innovative immunological strategies from a preclinical stage to clinical application which could be combined with standard radiotherapeutic approaches. A special interest will also deal with the effects of radiotherapy on tumor initiating cells as well as on the tumor microenvironment. Last but not least the effects of different irradiation sources and qualities such as photones, protones and heavy ions will be analyzed with respect to immunological outcome.
Book Synopsis Biomaterials Science by : Yitzhak Rosen
Download or read book Biomaterials Science written by Yitzhak Rosen and published by CRC Press. This book was released on 2012-06-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book is essential when designing, developing and studying biomedical materials. provides an excellent review-from a patient, disease, and even genetic point of view-of materials engineering for the biomedical field. This well presented book strongly insists on how the materials can influence patients' needs, the ultimate drive for biomedic
Book Synopsis Nanotechnology by : Bhaskar Mazumder
Download or read book Nanotechnology written by Bhaskar Mazumder and published by CRC Press. This book was released on 2019-03-18 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today we find the applications of nanotechnology in all spheres of life. Nanotechnology: Therapeutic, Nutraceutical and Cosmetic Advances discusses recent advances in the field, particularly with therapeutics, nutraceuticals and cosmetic sciences. Therapeutics is an area which has perhaps benefitted the most, although nanoscience and technology have quietly entered the realms of food science and are playing pivotal roles in the efficient utilization of nutraceuticals. Finally, even before therapeutics came cosmetics and companies started marketing unique products embedding the beneficial and advanced properties enabled by the use of nanostructures. This book highlights trends and applications of this wonderful new technology.
Book Synopsis Biological and Pharmaceutical Applications of Nanomaterials by : Polina Prokopovich
Download or read book Biological and Pharmaceutical Applications of Nanomaterials written by Polina Prokopovich and published by CRC Press. This book was released on 2015-06-26 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and Pharmaceutical Applications of Nanomaterials presents the findings of cutting-edge research activities in the field of nanomaterials, with a particular emphasis on biological and pharmaceutical applications. Divided into four sections-nanomaterials for drug delivery, antimicrobial nanomaterials, nanomaterials in biosensors, and safet
Book Synopsis Biomedical Application of Nanoparticles by : Bertrand Henri Rihn
Download or read book Biomedical Application of Nanoparticles written by Bertrand Henri Rihn and published by CRC Press. This book was released on 2017-09-05 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Application of Nanoparticles explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune system and targeted cells. Risk assessment of nanoparticles for human is described, including: cellular paradigms, transcriptomics and toxicogenomics. Finally, the applications of nanoparticles in medicine and antioxidant regenerative therapeutics are presented in several chapters with emphasis on how nanoparticles enhance transport of drugs across biological membrane barriers and therefore may enhance drug bioavailability.
Book Synopsis Combinatorial Approaches to Enhance Anti-Tumor Immunity: Focus on Immune Checkpoint Blockade Therapy by : Patrik Andersson
Download or read book Combinatorial Approaches to Enhance Anti-Tumor Immunity: Focus on Immune Checkpoint Blockade Therapy written by Patrik Andersson and published by Frontiers Media SA. This book was released on 2019-12-27 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system harbors great potential for controlling and eliminating tumors. Recent developments in the field of immuno-oncology has led to unprecedented clinical benefits for a broad spectrum of solid tumors. However, immunotherapy (IT) approaches currently have several limitations including (i) low response rate; (ii) development of resistance and (iii) causing severe immune-related adverse effects (IrAEs), which underline the importance of adequate patient selection. Importantly, IT holds promising synergistic potential when combined with standard-of-care chemotherapy, radiotherapy (RT) and anti-angiogenic therapy (AAT) as part of multi-modal oncologic treatment regimes. Published data suggest that there are potential synergy between RT and AAT, which ultimately could help potentiate the response to IT. However, the complex interactions between RT and IT and/or AAT remain poorly understood. Many research questions including optimal timing, scheduling and dosing, as well as patient selection and side effects of combined therapy approaches, remain to be addressed. This Research Topic aims to give a comprehensive overview of the current field with particular emphasis on the future outlook of RT and AAT as complementary approaches to improve IT in solid tumors.
Book Synopsis NanoBioEngineering by : Bhupinder Singh
Download or read book NanoBioEngineering written by Bhupinder Singh and published by CRC Press. This book was released on 2018-11-02 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to provide the fundamental comprehension of a broad range of topics in an integrated volume such that readership hailing from diverse disciplines can rapidly acquire the necessary background for applying it in pertinent research and development field.
Book Synopsis Harnessing Oncolytic Virus-mediated Antitumor Immunity by : Philippe Fournier
Download or read book Harnessing Oncolytic Virus-mediated Antitumor Immunity written by Philippe Fournier and published by Frontiers Media SA. This book was released on 2015-03-02 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncolytic viruses (OVs) have emerged as a promising anticancer treatment. OVs selectively infect, replicate in, and kill tumor cells. Oncolytic viral therapy occurs in two phases: an initial phase where the virus mediates direct oncolysis of tumor cells, and a second phase where an induced post-oncolytic immune response continues to mediate tumor destruction and retards progression of the disease. For a long time, the therapeutic efficacy was thought to depend mainly on the direct viral oncolysis based on their tumor selective replication and killing activities. But the post-oncolytic anti-tumor activity induced by the OV therapy is also a key factor for an efficient therapeutic activity. The topic adresses various strategies how to optimize OVs anti-tumor activity.
Book Synopsis Drug Delivery in Oncology by : Felix Kratz
Download or read book Drug Delivery in Oncology written by Felix Kratz and published by John Wiley & Sons. This book was released on 2013-09-30 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this first authoritative overview on modern cancer chemotherapy 121 international specialists have contributed their experience and recent data for what is likely to become the gold standard in the field. The authors summarize knowledge gained over the past decade, from basic concepts to successful applications in the clinic, covering active and passive targeting strategies as well as tissue-specific approaches. All current and future targeted delivery systems are discussed, from ligand-based to antibody-based polymer-based systems, right up to micro- and nanoparticulate systems. A special section covers the delivery of nucleic acid therapeutics, such as siRNA, miRNA and antisense nucleotides. In each case, a description of the basic technique is followed by a discussion of the latest preclinical and clinical developments in the field. By virtue of its clear and didactic structure, rich illustrative material and summary chapters, this handbook and ready reference enables the efficient transfer of knowledge between different disciplines, from basic research to the clinician and vice versa. It is equally well suited for professionals, researchers and students in medical oncology and cancer biology, and is also excellent for teaching medical students the foundations of 21st century cancer chemotherapy.
Book Synopsis The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies by : Michael Molls
Download or read book The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies written by Michael Molls and published by Springer Science & Business Media. This book was released on 2009-03-25 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Te rapidly changing concepts in radiation oncology with the development of more precise - strumentation for delivery of radiation therapy and a greater emphasis on hypofractionation technologies require a very intimate knowledge of tumor biology and the infuence of various biologic factors on dose distribution within the tumor in terms of homogeneity as well as prev- tion of any late efects on normal tissue surrounding the tumor itself. Not only are these major factors in clinical practice but also the known factors of inhomogeneity of cancer cells, the impact of microenvironment in terms of radiation efect, and host factors make it mandatory to design therapeutic strategies to improve the outcome and to diminish any potential short-term or lo- term risks from the radiation therapy. Te authors have developed an outstanding text that deals with these strategies and how they would impact on established and emerging new technologies and treatment. Te context of the presentations within a multidisciplinary combined modality therapy program is incredibly - portant. In this volume, various topics are reviewed including tumor genesis, cell proliferation, - giogenesis, the physiologic characteristics of malignant tissues, invasion and adhesion, the route and role pursued in the development of metastasis, and the role of the human immune system in cancer prevention and development.
Book Synopsis Drug Delivery Approaches and Nanosystems, Volume 2 by : Raj K. Keservani
Download or read book Drug Delivery Approaches and Nanosystems, Volume 2 written by Raj K. Keservani and published by CRC Press. This book was released on 2017-11-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a thorough presentation of the state-of-the-art research and developments in drug delivery systems using nanotechnology and its applications. The second of this two-volume set, it addresses the applications of nanotechnology or nano-sized materials in the medical field and the real-world challenges and complexities of current drug delivery methodologies and techniques. This volume includes 11 chapters that focus on the targeting facet of drug delivery systems. Targeting is a focused maneuver to achieve the specified goals, including achieving the desired result and reaching the specific location. Targeting has now been successfully achieved for several diseases/disorders; however, its role is noteworthy in cancer treatment where chemotherapy is a main course of approach. Nanotechnology-based products have great potential by virtue of their inherent features. This edited book provides a detailed application of nanotechnology in drug delivery systems in health care. The book discusses general principles of drug targeting, material of construction and technological concerns of nanoparticles, and different drug delivery systems and their preparation. Taken together, the informative chapters will provide researchers and scientists as well as faculty and students with valuable research on the effective use of new approaches in advanced drug delivery nanosystems. Volume 1 of the two-volume series is subtitled Novel Drug Carriers. The volumes are available separately or as a set.
