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Opioid Induced Hyperalgesia
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Book Synopsis Opioid-Induced Hyperalgesia by : Jianren Mao
Download or read book Opioid-Induced Hyperalgesia written by Jianren Mao and published by CRC Press. This book was released on 2016-04-19 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first clinically focused text dedicated to the newly emerging area of pain medicine known as opioid-induced hyperalgesia (OIH), Opioid-Induced Hyperalgesia provides pain specialists, anesthesiologists, and neurologists with the most current, cutting-edge research and therapeutic options for treating OIH patients. It supplies best practice guide
Book Synopsis Pain Models by : Hermann O. Handwerker
Download or read book Pain Models written by Hermann O. Handwerker and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neurobiology and mechanisms discovered in animals often do not translate to patients with a chronic pain condition. To help researchers and clinicians develop and use models that can help translate data from animals into humans, this book presents experimental animal models, with a focus on how they may translate into humans human experimental pain models, including details about pain induction and assessment human surrogate pain models clinical applications of pain models models that may link mechanisms of pain and pruritus Pain Models contains 29 chapters by internationally recognized experts. It is a comprehensive survey of pain models at different levels, and commentaries by clinicians directly address clinical perspectives. This unique book is unprecedented in its content. It's a quick reminder of the hard work needed to investigate the complex issue of pain perception. With the advent of increasingly sensitive noninvasive investigational tools, the authors want readers to know that basic research is still needed to help develop new drugs. This book will enrich anyone who wishes to know all that goes into conducting pain research with a lab-based pain model.
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309459575 Total Pages :483 pages Book Rating :4.3/5 (94 download)
Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine
Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.
Book Synopsis Opioid-related Side-effects and Opioid-induced Hyperalgesia by : Ruth Jayne Isherwood
Download or read book Opioid-related Side-effects and Opioid-induced Hyperalgesia written by Ruth Jayne Isherwood and published by . This book was released on 2015 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacology of Pain by : Pierre Beaulieu
Download or read book Pharmacology of Pain written by Pierre Beaulieu and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees
Book Synopsis The Essence of Analgesia and Analgesics by : Raymond S. Sinatra
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Book Synopsis The Dilemma of Opioid-Induced Hyperalgesia and Tolerance in Chronic Opioid Therapy by : Qutaiba Amir Tawfic
Download or read book The Dilemma of Opioid-Induced Hyperalgesia and Tolerance in Chronic Opioid Therapy written by Qutaiba Amir Tawfic and published by . This book was released on 2013 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Acute Pain Management by : Raymond S. Sinatra
Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.
Book Synopsis Opioid-induced Hyperalgesia: Underlying Mechanisms and Clinical Relevance by : Anna Vardanyan
Download or read book Opioid-induced Hyperalgesia: Underlying Mechanisms and Clinical Relevance written by Anna Vardanyan and published by . This book was released on 2007 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastatic bone cancer causes severe pain that is primarily treated with opioids. A recently developed model of bone cancer painwas used to evaluate the effects of sustained morphine treatment. In cancer-treated mice, morphine enhanced spontaneous and evoked pain; these effects were dose-dependent and naloxone-sensitive. SP and CGRP positive DRG cells did not differ between sarcoma or control mice, but were increased following morphine in both groups. Morphine increased ATF-3 expression only in DRG cells of sarcoma mice. Morphine did not alter tumor growth in vitro or in vivo but increased sarcoma-induced bone destruction and incidence of spontaneous fracture in a dose- and naloxone-sensitive manner. Morphine increased osteoclast activity suggesting enhancement of sarcoma-induced osteolysis. Thus, morphine treatment may"add-on"additional mechanisms of pain beyond those induced by sarcoma. Despite the potential clinical significance, the exact mechanisms of opioid-induced hypersensitivity remain unknown. The vanilloid 1 receptor (TRPV1) is a molecular integrator of noxious stimuli. Sustained morphine elicited thermal and tactile hypersensitivity in WT, but not TRPV1 KO mice. Sustained morphine enhanced capsaicin-induced flinching and plasma extravasation in rats, indicating increased activity of these receptors in the periphery. Immunohistochemical studies indicate increase in TRPV1 expression in DRG and sciatic nerve, but not spinal cord, suggesting increased trafficking of TRPV1 channel to the periphery. Possible mechanisms of this enhanced expression and function of TRPV1 channels is activation of p38 MAPK. Sustained intrathecal infusion of p38 MAPK inhibitor prevents morphine-induced hypersensitivity and enhanced capsaicin-induced flinching, indicating the role of p38MAPK in the development of morphine-induced pain, possibly through sensitization of TRPV1 receptors. Acute administration of p38 MAPK inhibitor reversed morphine-induced pain suggesting the importance of p38 MAPK in the maintenance of morphine-induced hypersensitivity, likely through activation of TRPV1 channel. Sustained morphine also up-regulates NGF contentin skin, which is then transported to DRG neurons where phosporilation of p38MAPK takes place. Single injection of anti-NGF peptibody blocked the development of morphine-induced hypersensitivity, enhanced capsaicin-induced flinching and plasma extravasation. Co-treatment with these compounds blocks the development of morphine-induced hyperalgesia and may optimize treatment of chronic pain states, like bone cancer pain.
Book Synopsis Acute Pain Management by : Pamela E. Macintyre
Download or read book Acute Pain Management written by Pamela E. Macintyre and published by CRC Press. This book was released on 2021-06-20 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a focus on practical acute pain management in adults in the hospital setting, this book provides health professionals with simple and practical information to help them manage patients with acute pain safely and effectively. • Combines evidence-based information with practical guidelines and protocols • Covers the pharmacology of opioids, local anesthetics, and nonopioid and adjuvant analgesic agents • Discusses management of acute pain in both surgical and nonsurgical acute pain settings including in patients with spinal cord or burns injuries and selected medical illnesses • Includes evidence-based information about management of acute pain in some specific patient groups , including the older patient, opioid-tolerant patients, and those with addiction disorders, pregnant or lactating patients and patients with obstructive sleep apnea or who have renal or hepatic impairment • Considers the role of acute pain management in the context of the current opioid epidemic and identifies possible strategies to minimise the risks. This resource will be helpful to a variety of professionals in assessing and managing acute pain.
Book Synopsis Cancer Pain Relief by : World Health Organization
Download or read book Cancer Pain Relief written by World Health Organization and published by World Health Organization. This book was released on 1996 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of a guide, which introduced a simple, yet highly effective method for the relief of cancer pain. Thoroughly revised and updated, the new edition further refines the WHO method, which advocates the use of a small number of relatively inexpensive drugs, including morphine. Revisions draw on experiences with millions of patients around the world as well as new knowledge about the specific pain syndromes unique to cancer. Completely new are chapters describing the international system by which morphine and other opioids are made available for medical purposes. The book has two parts. Part one provides a practical guide to the relief of cancer pain, concentrating on drug treatment as the mainstay of pain management. The most extensive section sets out detailed guidelines for the selection and prescribing of non-opioid analgesics, opioid analgesics, drugs for neuropathic pain, and adjuvant drugs for the treatment of adverse effects, the enhancement of pain relief and the management of concomitant psychological disturbances. Information ranges from explanations of how specific drugs work, through the precautions to take in the presence of certain disorders, to a list of factors that influence the effectiveness of opioids. Concerning the use of opioids, readers are reminded that psychological dependence does not occur in cancer patients and that the only correct dose of morphine is the one that relieves the pain. Part two provides a guide to opioid availability. A discussion of the reasons why opioids continue to be underprescribed or difficult to obtain is followed by an explanation of the Single Convention on Narcotic Drugs.
Book Synopsis Cancer Pain Management by : Deborah B. McGuire
Download or read book Cancer Pain Management written by Deborah B. McGuire and published by Jones & Bartlett Learning. This book was released on 1995 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Pain Management, Second Edition will substantially advance pain education. The unique combination of authors -- an educator, a leading practitioner and administrator, and a research scientist -- provides comprehensive, authoritative coverage in addressing this important aspect of cancer care. The contributors, acknowledged experts in their areas, address a wide scope of issues. Educating health care providers to better assess and manage pain and improve patientsrsquo; and familiesrsquo; coping strategies are primary goals of this book. Developing research-based clinical guidelines and increasing funding for research is also covered. Ethical issues surrounding pain management and health policy implications are also explored.
Book Synopsis Stress-induced Analgesia by : M. D. Tricklebank
Download or read book Stress-induced Analgesia written by M. D. Tricklebank and published by John Wiley & Sons. This book was released on 1984 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Behavioral and Psychopharmacologic Pain Management by : Michael H. Ebert
Download or read book Behavioral and Psychopharmacologic Pain Management written by Michael H. Ebert and published by Cambridge University Press. This book was released on 2010-11-25 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is the most common symptom bringing a patient to a physician's attention. Physicians training in pain medicine may originate from different disciplines and approach the field with varying backgrounds and experience. This book captures the theory and evidence-based practice of behavioral, psychotherapeutic and psychopharmacological treatments in modern pain medicine. The book's contributors span the fields of psychiatry, psychology, anesthesia, neurology, physical medicine and rehabilitation, and nursing. Thus the structure and content of the book convey the interdisciplinary approach that is the current standard for the successful practice of pain management. The book is designed to be used as a text for training fellowships in pain medicine, as well as graduate courses in psychology, nursing, and other health professions.
Book Synopsis Opioids and Their Receptors by : Mariana Spetea
Download or read book Opioids and Their Receptors written by Mariana Spetea and published by MDPI. This book was released on 2020-12-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
Book Synopsis Acute Pain Management by : Pamela E. Macintyre
Download or read book Acute Pain Management written by Pamela E. Macintyre and published by . This book was released on 2010-01-01 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Landmark Papers in Pain by : Paul Farquhar-Smith
Download or read book Landmark Papers in Pain written by Paul Farquhar-Smith and published by Oxford University Press. This book was released on 2018-08-10 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Medicine, a relatively new specialty, has proven increasingly relevant to medical practitioners in every field. The specialism of pain has emerged over the past 50 years, largely due to the persistence of experts and new medical evidence that points to its necessity. Today, it is a distinct and integral part of global medical practice. Landmark Papers in Pain offers a comprehensive inventory of over 80 key studies in pain medicine from the last 100 years. Each paper is accompanied by a concise commentary on the significance of the original findings written by an expert in pain. The reviews discuss how the paper influenced the development of the speciality, and how the findings have advanced our global comprehension of pain. Together, the selected papers and reviews chart the growth of an embryonic field into the modern speciality of pain medicine. Complied by leading specialists in the field, the papers included in this book are significant for any student, researcher, clinical practitioner, or medical historian interested in pain medicine. Organised into eight distinct topics and cross-referenced by topics and author of original paper, the book is comprehensive in its coverage and easy to use. A review of the contemporary and historical research that shaped the speciality of pain, Landmark Papers in Pain is essential reading for all medical practitioners with an interest in pain medicine.
