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One Hundred Years Of Chromosome Research And What Remains To Be Learned
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Book Synopsis One Hundred Years of Chromosome Research and What Remains to be Learned by : A. Lima-de-Faria
Download or read book One Hundred Years of Chromosome Research and What Remains to be Learned written by A. Lima-de-Faria and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: One Hundred Years of Chromosome Research: What Remains to be Learned, offers the reader a critical analysis of the observations and experiments that shaped the last 100 years of chromosome research, as well as the ideas which prevailed during this period. Emphasis is placed on what remains to be learned, particularly in light of reality of the sequencing of DNA which leaves the previous era of chromosome research as a prehistoric event. It is at this turning point, that well formulated questions can be asked about many of the chromosome's properties, which remain to be unveiled. The author, Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund Unviersity, Sweden, previously Head of the Institute of Molecular Cytogenetics, Lund University.
Book Synopsis Heredity under the Microscope by : Soraya de Chadarevian
Download or read book Heredity under the Microscope written by Soraya de Chadarevian and published by University of Chicago Press. This book was released on 2020-07-02 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on chromosomes, Heredity under the Microscope offers a new history of postwar human genetics. Today chromosomes are understood as macromolecular assemblies and are analyzed with a variety of molecular techniques. Yet for much of the twentieth century, researchers studied chromosomes by looking through a microscope. Unlike any other technique, chromosome analysis offered a direct glimpse of the complete human genome, opening up seemingly endless possibilities for observation and intervention. Critics, however, countered that visual evidence was not enough and pointed to the need to understand the molecular mechanisms. Telling this history in full for the first time, Soraya de Chadarevian argues that the often bewildering variety of observations made under the microscope were central to the study of human genetics. Making space for microscope-based practices alongside molecular approaches, de Chadarevian analyzes the close connections between genetics and an array of scientific, medical, ethical, legal, and policy concerns in the atomic age. By exploring the visual evidence provided by chromosome research in the context of postwar biology and medicine, Heredity under the Microscope sheds new light on the cultural history of the human genome.
Book Synopsis Praise of Chromosome "folly" by : A. Lima-de-Faria
Download or read book Praise of Chromosome "folly" written by A. Lima-de-Faria and published by World Scientific. This book was released on 2008 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: When examined carefully at the molecular level, the chromosome turns out to have created its own private world full of tricks, back door exits and novel solutions. This OC follyOCO makes it an untamed innovator. Geneticists have been bewildered for decades. What kind of creature was actually the chromosome? Was it plastic, changing by innumerous rearrangements and mutations all the time; or was it a rigid structure which has preserved its basic organisation and functions since the dawn of the cell? It is this conflicting state that seems to be at the base of its OC follyOCO. Perplexed by this behavior, cell biologists have called it a junkyard and even the ultimate parasite. Moreover, the chromosome has been regarded as a passive cell organelle prone to random mutations and subjected to the mercy of selection.The latest molecular information discloses a radically different picture in which the chromosome appears as an independent molecular structure that follows its own path. It does not obey gravity, randomness, selection or magnetism.By anchoring the chromosome's contradictory behavior on molecular processes directed by atomic self-assembly, Lima-de-Faria expands a novel view of the chromosome with unexpected implications for genetics, evolution and physics.This timely book contains the latest information on the molecular organization of the chromosome. The information is original and is presented in an unorthodox way, while carefully chosen elucidating and attractive figures serve to add clarity to the subject treated. Thus, the book will add greatly to the general debate on the evolution of living organisms, and will be of particular interest to those in the biotechnological field.
Author :Antonio Lima-de-Faria Publisher :Springer Science & Business Media ISBN 13 :3642253016 Total Pages :171 pages Book Rating :4.6/5 (422 download)
Book Synopsis Molecular Geometry of Body Pattern in Birds by : Antonio Lima-de-Faria
Download or read book Molecular Geometry of Body Pattern in Birds written by Antonio Lima-de-Faria and published by Springer Science & Business Media. This book was released on 2012-03-19 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: After having read this book you will never see birds in the same way again. The unexpected patterns displayed by a bird’s body have been seen as bizarre events that demanded little attention or were described as ‘amazing curiosities’. None of these surprising features seem to be fortuitous. They appear to be an integral part of a rigid order and a coherent geometry, which is directed by simple gene interactions and molecular cascades occurring at various cellular levels, and at different times, during the organism’s development. A novel geometry unfolds in front of your eyes, giving the body configurations another meaning. Lima-de-Faria is Professor Emeritus of Molecular Cytogenetics at Lund University, Lund, Sweden. This is his sixth book dealing with the molecular organization of the chromosome and its implications for the understanding of the mechanisms responsible for biological evolution.
Book Synopsis New Research on Genomic Instability by : Eleanor J. Gloscow
Download or read book New Research on Genomic Instability written by Eleanor J. Gloscow and published by Nova Publishers. This book was released on 2007 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many cancer biologists now believe that genomic instability not only initiates carcinogenesis, but also allows the tumour cell to become metastatic and evade drug toxicity. The loss of stability of the genome is becoming accepted as one of the most important aspects of carcinogenesis. One of the hallmarks of the cancer cell is the inherent instability of its genome. This book presents important research in this exciting field.
Download or read book The Altenberg 16 written by Suzan Mazur and published by North Atlantic Books. This book was released on 2010 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new theory of evolution begins to emerge in the pages of The Altenberg 16: An Expos of the Evolution Industry. Written by Suzan Mazur--a print and television journalist whose reports have appeared in the Financial Times, The Economist, Archaeology, Omni, and many other publications--the book is a front row seat to the thinking of the great evolutionary science minds of our time about the need to reformulate the neo-Darwinian theory of evolution. We hear from world renowned scientists such as Richard Lewontin, Lynn Margulis, Niles Eldredge, Richard Dawkins, the "evo-devo" revolutionaries, NASA astrobiologists, and others. The book grew out of a story Mazur broke online in March 2008--titled "Altenberg The Woodstock of Evolution?"--about the now famous meeting at Konrad Lorenz Institute in Altenberg, Austria in July 2008, where 16 scientists discussed expanding evolutionary thinking beyond outdated hypotheses. (MIT will publish the proceedings in April 2010.) Science magazine noted that Mazur's reporting "reverberated throughout the evolutionary biology community." Mazur says she was punished for getting out in front of the story and banned from the symposium but realized the story was bigger than Altenberg (which covered events beginning 500 million years ago) and spoke to scientists who were not invited, including those investigating pre-biotic evolution. She came to the conclusion that evolutionary science suffers because many in the scientific establishment refuse to acknowledge that the old science has served its purpose and there is disagreement about what the new evolution paradigm is. She thinks the dam is now breaking because the public (who funds science) has become a party to the discourse via the Internet and seeks answers to fundamental questions about evolution that scientists so far can't definitively answer.
Book Synopsis David Paul von Hansemann: Contributions to Oncology by : Leon P. Bignold
Download or read book David Paul von Hansemann: Contributions to Oncology written by Leon P. Bignold and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the late nineteenth century, David Paul von Hansemann coined phrases that have remained the basis of descriptive terms concerning the microscopical appearances of tumors ever since, yet his work is rarely mentioned today. This book presents translations of all the relevant German texts and analyses the background and context of Hansemann's theories. It shows that some of Hansemann’s ideas may still be relevant to cancer research today.
Book Synopsis Cancer: Cell Structures, Carcinogens and Genomic Instability by : Leon P. Bignold
Download or read book Cancer: Cell Structures, Carcinogens and Genomic Instability written by Leon P. Bignold and published by Springer Science & Business Media. This book was released on 2006-01-27 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume began with an invitation from the publishers to edit a volume of EXS on Cancer. This invitation undoubtedly derived from my articles in Cellular and Molecular Life Sciences in 2002 and 2003 on the relationships between the morphology, aetiology and pathogenesis of tumours, especially in relation to genetic instability. After many years of teaching the theories of c- cer in undergraduate medical school courses, it seemed to me that the variably chaotic histopathologic features of tumours parallel in some way, the variably unstable genomes of tumour cells, which were being discovered in the 1990s. Thus the title of the volume has come to include morphology, carcinogenesis and genetic instability. The invitation came while I was working with Herrn Dr. med. Hubertus Jersmann (MD Düsseldorf, PhD, now Senior Lecturer in Medicine of the University of Adelaide) and Professor Brian Coghlan (Emeritus Professor of German, the University of Adelaide), on the work of the nineteenth century cancer pathologists, especially David Paul von Hansemann (1858–1920). With the delivery of the manuscripts from the authors of the chapters, it became obvious that a background chapter for the volume could include some of the material which we had “uncovered” together. Because of this, chapter 1 is authored by the three of us, and the “new” material figures prominently.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment by : Jessica Wapner
Download or read book The Philadelphia Chromosome: A Genetic Mystery, a Lethal Cancer, and the Improbable Invention of a Lifesaving Treatment written by Jessica Wapner and published by The Experiment, LLC. This book was released on 2014-04-08 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of The Wall Street Journal’s 10 Best Nonfiction Books of the Year Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.
Book Synopsis Bioinformatics and Functional Genomics by : Jonathan Pevsner
Download or read book Bioinformatics and Functional Genomics written by Jonathan Pevsner and published by John Wiley & Sons. This book was released on 2015-08-17 with total page 1168 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bestselling introduction to bioinformatics and genomics – now in its third edition Widely received in its previous editions, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded third edition, it continues to be the go-to source for students and professionals involved in biomedical research. This book provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: Extensive revisions and a slight reorder of chapters for a more effective organization A brand new chapter on next-generation sequencing An expanded companion website, also updated as and when new information becomes available Greater emphasis on a computational approach, with clear guidance of how software tools work and introductions to the use of command-line tools such as software for next-generation sequence analysis, the R programming language, and NCBI search utilities The book is complemented by lavish illustrations and more than 500 figures and tables - many newly-created for the third edition to enhance clarity and understanding. Each chapter includes learning objectives, a problem set, pitfalls section, boxes explaining key techniques and mathematics/statistics principles, a summary, recommended reading, and a list of freely available software. Readers may visit a related Web page for supplemental information such as PowerPoints and audiovisual files of lectures, and videocasts of how to perform many basic operations: www.wiley.com/go/pevsnerbioinformatics. Bioinformatics and Functional Genomics, Third Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.
Download or read book Anticancer Research written by and published by . This book was released on 1999 with total page 1188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The New Walford Guide to Reference Resources by : Ray Lester
Download or read book The New Walford Guide to Reference Resources written by Ray Lester and published by . This book was released on 2005 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Walford highlights the best resources to use when undertaking a search for accurate and relevant information, saving you precious time and effort. For those looking for a selective and evaluative reference resource that really delivers on its promise, look no further. In addition to print sources, The New Walford naturally covers an extensive range of e-reference sources such as digital databanks, digital reference services, electronic journal collections, meta-search engines, networked information services, open archives, resource discovery services and websites of premier organizations in both the public and private sectors. But rather than supplying a list of all available known resources as a web search engine might, The New Walford subject specialists have carefully selected and evaluated available resources to provide a definitive list of the most appropriate and useful. With an emphasis on quality and sustainability, the subject specialists have been careful to assess the differing ways that information is framed and communicated in different subject areas. As a result the resource evaluations in each subject area are prefaced by an introductory overview of the structure of the relevant literature. This ensures that The New Walford is clear, easy-to-use and intuitive. - Publisher.
Book Synopsis DNA and Chromosomes by : Ernest J. DuPraw
Download or read book DNA and Chromosomes written by Ernest J. DuPraw and published by . This book was released on 1970 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis What Remains to Be Discovered by : John Maddox
Download or read book What Remains to Be Discovered written by John Maddox and published by Free Press. This book was released on 1999-11-05 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: What wonders of science will the 21st century bring? John Maddox takes up this challenge by describing precisely what remains to be discovered. Building on twenty-three years' experience at the helm of the world's preeminent science magazine, Nature, Maddox identifies new areas of discovery in physics, biology, health, intelligence, and global catastrophe. As Maddox shows, the rate of scientific discovery will continue to accelerate, hurtling us toward ever more exciting discoveries in the next century.
Download or read book Choice written by and published by . This book was released on 2005 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Better Half by : Dr. Sharon Moalem, MD, PhD
Download or read book The Better Half written by Dr. Sharon Moalem, MD, PhD and published by Farrar, Straus and Giroux. This book was released on 2020-04-07 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Guardian Book of the Week Longlisted for the PEN / E. O. Wilson Literary Science Writing Award An award-winning physician and scientist makes the game-changing case that genetic females are stronger than males at every stage of life Here are some facts: Women live longer than men. They have stronger immune systems. They're better at fighting cancer and surviving famine, and even see the world in a wider variety of colors. They are simply stronger than men at every stage of life. Why is this? And why are we taught the opposite? To find out, Dr. Sharon Moalem drew on his own medical experiences - treating premature babies in the neonatal intensive care unit; recruiting the elderly for neurogenetic studies; tending to HIV-positive orphans in Thailand - and tried to understand why in every instance men were consistently less likely to thrive. The answer, he discovered, lies in our genetics: two X chromosomes offer a powerful survival advantage. With clear, captivating prose that weaves together eye-opening research, case studies, diverse examples ranging from the behavior of honeybees to American pioneers, as well as experiences from his personal life and his own patients, Moalem explains why genetic females triumph over males when it comes to resiliency, intellect, stamina, immunity and much more. He also calls for a reconsideration of our male-centric, one-size-fits-all view of medical studies and even how we prescribe medications - a view that still sees women through the lens of men. Revolutionary and yet utterly convincing, The Better Half will make you see humanity and the survival of our species anew.
