Author : Ye Yang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (116 download)
Book Synopsis On the Interplay of Gold Nanoparticles and Small Molecules by : Ye Yang
Download or read book On the Interplay of Gold Nanoparticles and Small Molecules written by Ye Yang and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold nanoparticles (AuNPs) have been widely used in optical, catalytic, chemical and biomedical applications due to their distinct physicochemical properties. Molecular recognition and the binding of chemical and biological entities have attracted particular research interest for the relevance in drug delivery and diagnostics. By addressing material design as well as advanced characterisation methods, this thesis aims to shed light on fundamental aspects of AuNPs, including the synthesis, functionalisation and implications for relevant applications. A versatile AuNP synthesis enabled the decoupling of core size refinement and ligand shell variation in sub-10 nm thiol-capped AuNPs, thus providing a novel solution of comparative fine-tuning of the ligand shell composition. The analysis of AuNP size distribution was addressed with a comparative study employing single particle analysis (electron microscopy imaging) and ensemble methods (X-ray scattering and analytical ultracentrifugation). Subsequently, nanoscale colloidal stability and molecular interaction with small molecules were investigated both in solution by small-angle X-ray scattering and on a surface by quartz crystal microbalance with dissipation monitoring. This work establishes a versatile platform for AuNP engineering with target size and surface functionality and provides a powerful toolbox for systematic studies on colloidal behaviour as well as ligand-shell mediated nanoparticle-stimuli interactions for biomedical applications.