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Oecd Series On Testing And Assessment Guidance Document For The Use Of Adverse Outcome Pathways In Developing Integrated Approaches To Testing And Assessment Iata
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Book Synopsis OECD Series on Testing and Assessment Guidance Document for the Use of Adverse Outcome Pathways in Developing Integrated Approaches to Testing and Assessment (IATA) by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document for the Use of Adverse Outcome Pathways in Developing Integrated Approaches to Testing and Assessment (IATA) written by OECD and published by OECD Publishing. This book was released on 2017-03-10 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of Integrated Approaches for Testing and Assessment (IATA). However, there is a need for a systematic framework to characterise the individual biological and toxicological relevance of alternative methods in assessing chemicals in predicting toxicological endpoints.
Book Synopsis OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of ...
Book Synopsis OECD Series on Testing and Assessment Report of the Workshop on a Framework for the Development and Use Of Integrated Approaches to Testing and Assessment by : OECD
Download or read book OECD Series on Testing and Assessment Report of the Workshop on a Framework for the Development and Use Of Integrated Approaches to Testing and Assessment written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document is a report of the Workshop on a framework for the development and use of integrated approaches to testing and assessment which was held on 17-19 November 2014 in Crystal City VA, USA. This framework should provide guiding principles, and technical guidance on how results from ...
Book Synopsis OECD Series on Testing and Assessment Report on Considerations from Case Studies on Integrated Approaches for Testing and Assessment (IATA) - First Review Cycle (2015) Case Studies on Grouping Methods as a Part of IATA by : OECD
Download or read book OECD Series on Testing and Assessment Report on Considerations from Case Studies on Integrated Approaches for Testing and Assessment (IATA) - First Review Cycle (2015) Case Studies on Grouping Methods as a Part of IATA written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: OECD member countries have been making efforts to expand the use of alternative methods in assessing chemicals. The OECD has been developing guidance documents and tools for the use of alternative methods such as (Q)SAR, chemical categories and Adverse Outcome Pathways (AOPs) as a part of ...
Book Synopsis Alternatives to Animal Testing by : Hajime Kojima
Download or read book Alternatives to Animal Testing written by Hajime Kojima and published by Springer. This book was released on 2018-12-27 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book presents recent advances in the pure sciences that are of significance in the quest for alternatives to the use of animals in research and describes a variety of practical applications of the three key guiding principles for the more ethical use of animals in experiments – replacement, reduction, and refinement, collectively known as the 3Rs. Important examples from across the world of implementation of the 3Rs in the testing of cosmetics, chemicals, pesticides, and biologics, including vaccines, are described, with additional information on relevant regulations. The coverage also encompasses emerging approaches to alternative tests and the 3Rs. The book is based on the most informative contributions delivered at the Asian Congress 2016 on Alternatives and Animal Use in the Life Sciences. It will be of value for those working in R&D, for graduate students, and for educators in various fields, including the pharmaceutical and cosmetic sciences, pharmacology, toxicology, and animal welfare. The free, open access distribution of Alternatives to Animal Testing is enabled by the Creative Commons Attribution license in International version 4: CC BY 4.0.
Book Synopsis OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches and Individual Information Sources to be Used within Integrated Approaches to Testing and Assessment (IATA) for Skin Sensitisation by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches and Individual Information Sources to be Used within Integrated Approaches to Testing and Assessment (IATA) for Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2017-07-11 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing and assessment in the area of skin ...
Book Synopsis OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption by : OECD
Download or read book OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption written by OECD and published by OECD Publishing. This book was released on 2018-09-03 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Book Synopsis OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on Good In Vitro Method Practices (GIVIMP) written by OECD and published by OECD Publishing. This book was released on 2018-12-10 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past several decades, there has been a substantial increase in the availability of in vitro test methods for evaluating chemical safety in an international regulatory context. To foster confidence in in vitro alternatives to animal testing, the test methods and conditions under which ...
Book Synopsis OECD Series on Testing and Assessment Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Skin Corrosion and Irritation by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document on an Integrated Approach on Testing and Assessment (IATA) for Skin Corrosion and Irritation written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Guidance Document proposes an integrated approach on testing and assessment (IATA) for skin corrosion and irritation. It also provides consistent information on key characteristics of each of the individual information sources of the IATA, and relevant guidance on how to integrate ...
Book Synopsis Skin 3-D Models and Cosmetics Toxicity by : Aditya Bhushan Pant
Download or read book Skin 3-D Models and Cosmetics Toxicity written by Aditya Bhushan Pant and published by Springer Nature. This book was released on 2023-08-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Efforts are being made by research organizations and cosmetic industries worldwide to develop more precise and targeted 3D models that mimic humans for testing cosmetic and personal health care product ingredients, following a complete ban on animal testing. This book includes several subtopics dedicated to the progress made, challenges faced, roadblocks encountered, and future prospects in the development and validation of 3D models for testing these products. The book consist of an editorial and 14 themed chapters that will showcase the significant progress made so far, challenges encountered, and future prospects in the development of 3D reconstruct models.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Guideline No. 497: Defined Approaches on Skin Sensitisation written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Book Synopsis OECD Studies on Water Endocrine Disrupting Chemicals in Freshwater Monitoring and Regulating Water Quality by : OECD
Download or read book OECD Studies on Water Endocrine Disrupting Chemicals in Freshwater Monitoring and Regulating Water Quality written by OECD and published by OECD Publishing. This book was released on 2023-10-12 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine disrupting chemicals (EDCs) are contaminants of emerging environmental and health concern that have been detected in freshwater, wastewater and drinking water. They interfere with the endocrine system in humans and wildlife, and produce adverse effects such as developmental, reproductive, neurological and immune effects.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 442D: In Vitro Skin Sensitisation Assays addressing the Adverse Outcome Pathway Key Event on Keratinocyte activation written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline (TG) provides an in vitro procedure (the ARE-Nrf2 luciferase test method) used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS.
Book Synopsis OECD Series on Testing and Assessment Guidance Document for Describing Non-Guideline In Vitro Test Methods by : OECD
Download or read book OECD Series on Testing and Assessment Guidance Document for Describing Non-Guideline In Vitro Test Methods written by OECD and published by OECD Publishing. This book was released on 2017-04-13 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this guidance is to harmonise the way non-guideline in vitro methods are described and thereby facilitate an assessment of the relevance of test methods for biological activities and responses of interest, and an assessment of the quality of data produced, irrespective of whether ...
Book Synopsis The History of Alternative Test Methods in Toxicology by :
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Book Synopsis WHO human health risk assessment toolkit by : World Health Organization
Download or read book WHO human health risk assessment toolkit written by World Health Organization and published by World Health Organization. This book was released on 2021-09-30 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis OECD Series on Testing and Assessment Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals by : OECD
Download or read book OECD Series on Testing and Assessment Considerations for Assessing the Risks of Combined Exposure to Multiple Chemicals written by OECD and published by OECD Publishing. This book was released on 2018-12-06 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The report outlines the technical aspects of the various approaches and methodologies available with respect to the assessment of risks from combined exposures to multiple chemicals. The document draws from approaches applied and experience gained in the regulatory context and will therefore be most relevant to the regulatory authorities addressing chemicals, the regulated community and other interested stakeholders.
