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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 441 Hershberger Bioassay In Rats A Short Term Screening Assay For Antiandrogenic Properties
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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 441: Hershberger Bioassay in Rats A Short-term Screening Assay for (Anti)Androgenic Properties by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 441: Hershberger Bioassay in Rats A Short-term Screening Assay for (Anti)Androgenic Properties written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 456: H295R Steroidogenesis Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 456: H295R Steroidogenesis Assay written by OECD and published by OECD Publishing. This book was released on 2011-07-28 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 443: Extended One-Generation Reproductive Toxicity Study by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 443: Extended One-Generation Reproductive Toxicity Study written by OECD and published by OECD Publishing. This book was released on 2018-06-27 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Book Synopsis Reproductive and Developmental Toxicology by : Ramesh C Gupta
Download or read book Reproductive and Developmental Toxicology written by Ramesh C Gupta and published by Academic Press. This book was released on 2022-02-11 with total page 1558 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Toxicology** Reproductive and Developmental Toxicology, Third Edition is a comprehensive and authoritative resource, providing the latest literature on this complex subject by focusing on three core components - parent, placenta and fetus - and the continuous changes that occur in each. Enriched with relevant references describing every aspect of reproductive toxicology, this revised and updated resource addresses the totality of the subject, discussing a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, and metals, among others. In addition, it is the only resource to include reproductive and developmental toxicity in domestic animals, fish and wildlife With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages. Completely revised and updated to include the most recent developments in the field, this book is an essential resource for advanced students and researchers in toxicology, as well as biologists, pharmacologists and teratologists from academia, industry and regulatory agencies. - Provides a complete, up-to-date, integrated source of information on the key risk stages during reproduction and development - Offers diverse and unique in vitro and in vivo toxicity models for reproductive and developmental toxicity testing in a user-friendly format that assists in comparative analysis - Includes new chapters on developments in systems toxicology and predictive modeling of male developmental toxicity, adverse outcome pathways in reproductive and developmental toxicology, ovarian and endometrial toxicity, developmental neurotoxicity of air pollution, and more
Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2021-09-19 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody's Core Titles® 2024 in Endocrinology/Metabolic Disease** Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations - Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology
Book Synopsis Ovarian Toxicology by : Patricia B. Hoyer
Download or read book Ovarian Toxicology written by Patricia B. Hoyer and published by CRC Press. This book was released on 2013-09-25 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today, we are exposed to an increasing number of chemicals in the environment and there is a growing awareness of the effects of these chemicals on the ovaries. Infertility resulting from environmental exposures may not be obvious until the reproductive life span is waning. As such, the potential for xenobiotic-induced infertility needs to be bette
Book Synopsis Developmental and Reproductive Toxicology by : Ronald D Hood
Download or read book Developmental and Reproductive Toxicology written by Ronald D Hood and published by CRC Press. This book was released on 2016-04-19 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e
Book Synopsis Toxicology and Risk Assessment by : Helmut Greim
Download or read book Toxicology and Risk Assessment written by Helmut Greim and published by John Wiley & Sons. This book was released on 2018-08-10 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.
Book Synopsis Handbook of Toxicology, Third Edition by : Michael J. Derelanko
Download or read book Handbook of Toxicology, Third Edition written by Michael J. Derelanko and published by CRC Press. This book was released on 2014-03-07 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more. New to this edition: Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.
Book Synopsis Test No. 421: Reproduction/Developmental Toxicity Screening Test by : OECD
Download or read book Test No. 421: Reproduction/Developmental Toxicity Screening Test written by OECD and published by OECD Publishing. This book was released on 1995-07-27 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...
Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre
Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations
Book Synopsis Male Fertility and Its Regulation by : E.S. Hafez
Download or read book Male Fertility and Its Regulation written by E.S. Hafez and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the 'Symposium on Male Fertility and its Regulation' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No.1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man uscripts from leaders in specific areas were solicited to provide additional range to the topics covered.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 456: H295R Steroidogenesis Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 456: H295R Steroidogenesis Assay written by OECD and published by OECD Publishing. This book was released on 2011-07-28 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 231: Amphibian Metamorphosis Assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 231: Amphibian Metamorphosis Assay written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Book Synopsis Endocrine Pharmacology by : P. J. Bentley
Download or read book Endocrine Pharmacology written by P. J. Bentley and published by CUP Archive. This book was released on 1980 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 1981 treatment of the action and uses of the hormones and drugs that influence endocrine functions in the body as seen by a pharmacologist. The book includes a description of available drug preparations and expected therapeutic responses, and an examination of their side effects and interactions with other drugs. Special emphasis is placed on how such drugs and hormones work and on how their biological effects are related to their chemical structures. The physiological background to the practical significance of such substances is given for both a healthy and a diseased state. The book assumes little prior knowledge of endocrinology or pharmacology.
Book Synopsis Toxicological Risk Assessment and Multi-System Health Impacts from Exposure by : Aristidis M. Tsatsakis
Download or read book Toxicological Risk Assessment and Multi-System Health Impacts from Exposure written by Aristidis M. Tsatsakis and published by Elsevier. This book was released on 2021-08-01 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Book Synopsis Environmental Risk Assessment by : Ted Simon
Download or read book Environmental Risk Assessment written by Ted Simon and published by CRC Press. This book was released on 2019-12-06 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of risk assessment is to support science-based decisions about how to solve complex societal problems. Indeed, the problems humankind faces in the 21st century have many social, political, and technical complexities. Environmental risk assessment in particular is of increasing importance as health and safety regulations grow and become more complicated. Environmental Risk Assessment: A Toxicological Approach, 2nd Edition looks at various factors relating to exposure and toxicity, human health, and risk. In addition to the original chapters being updated and expanded upon, four new chapters discuss current software and platforms that have recently been developed and provide examples of risk characterizations and scenarios. Features: Introduces the science of risk assessment—past, present, and future Provides environmental sampling data for conducting practice risk assessments Considers how bias and conflict of interest affect science-based decisions in the 21st century Includes fully worked examples, case studies, discussion questions, and suggestions for additional reading Discusses new software and computational platforms that have developed since the first edition Aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments, the book delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk.
