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Oecd Guidelines For The Testing Of Chemicals Section 4 Health Effects Test No 437 Bovine Corneal Opacity And Permeability Test Method For Identifying Ocular Corrosives And Severe Irritants
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Book Synopsis Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants by : OECD
Download or read book Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to classify substances as 'ocular corrosives and severe irritants'. The BCOP uses isolated corneas from the eyes of cattle slaughtered for ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline proposes defined approaches (DA) combining data generated in vitro methods, with information sources such as physicochemical properties.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the Classification and ...
Book Synopsis A Practical Guide to Toxicology and Human Health Risk Assessment by : Laura Robinson
Download or read book A Practical Guide to Toxicology and Human Health Risk Assessment written by Laura Robinson and published by John Wiley & Sons. This book was released on 2018-11-20 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro assay that may be used for identifying water soluble ocular corrosives and severe irritants as defined by the UN Globally Harmonized System of Classification and Labelling, Category 1. The assay is performed ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 494: Vitrigel-Eye Irritancy Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Vitrigel-Eye Irritancy Test (EIT) method is an in vitro test method that allows the identification of test chemicals not requiring classification and labelling for eye irritation or serious eye damage. This test measures the eye irritation potential of a test chemical based on its ability to induce damage to the barrier function of the human corneal epithelium (hCE) models used in the Vitrigel-EIT method. It is known that chemicals that are irritating to the eye first destroy tear film and epithelial barrier function of the eye, subsequently induce epithelial cell death, and finally produce stromal degeneration and endothelial cell death, resulting in corneal opacity. Therefore, the change of the epithelial barrier function is a relevant endpoint for detecting eye irritation. In the Vitrigel Eye Irritancy test method , time-dependent changes in the Transepithelial Electrical Resistance (TEER) values are indicative of damage to the barrier function of the corneal epithelium following exposure to a test chemical; this situation is similar to the observed damage of the rabbit cornea following exposure to a test chemical, which is an important mode of action leading to damage of the corneal epithelium and eye irritation. The Vitrigel-Eye Irritancy Test (EIT) method can be used within the limited applicability domain of test chemicals having pH > 5.0 (based on 2.5% weight/volume (w/v) preparation).
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 496: In vitro Macromolecular Test Method for Identifying Chemicals Inducing Serious Eye Damage and Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro macromolecular test method is a biochemical in vitro test method that can be used to identify chemicals (substances and mixtures) that have the potential to induce serious eye damage as well as chemicals not requiring classification for eye irritation or serious eye damage.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes a cytotoxicity-based in vitro assay that is performed on a confluent monolayer of Statens Seruminstitut Rabbit Cornea (SIRC) cells, cultured on a 96-well polycarbonate microplate.
Book Synopsis OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Document on Classification Systems for Eye Irritation/Corrosion in OECD Member Countries by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Document on Classification Systems for Eye Irritation/Corrosion in OECD Member Countries written by OECD and published by OECD Publishing. This book was released on 2002-05-10 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed review document examines member country classification systems for eye irritation/corrosion.
Book Synopsis OECD Series on Testing and Assessment Second Edition - Guidance Document on Integrated Approaches to Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation by : OECD
Download or read book OECD Series on Testing and Assessment Second Edition - Guidance Document on Integrated Approaches to Testing and Assessment (IATA) for Serious Eye Damage and Eye Irritation written by OECD and published by OECD Publishing. This book was released on 2019-07-25 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This document suggests an Integrated Approach on Testing and Assessment (IATA) for serious eye damage and eye irritation hazard identification. The document also provides key information characteristics of each of the individual information sources comprising the IATA. Furthermore it provides guidance on how and when to integrate existing and/or newly generated information for decision making, including decisions on the need for further testing or final decisions on classification and labelling regarding the potential eye hazard effects of test chemicals.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro procedure the identification on its own of chemicals (substances and mixtures) not requiring classification (No Cat), requiring classification for eye irritation (Cat 2) and requiring classification for serious eye damage (Cat 1) according to the UN GHS ocular hazard categories. It makes use of reconstructed human cornea-like epithelium (RhCE) which closely mimics the histological, morphological, biochemical and physiological properties of the human corneal epithelium.
Book Synopsis Test No. 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants by : OECD
Download or read book Test No. 438: Isolated Chicken Eye Test Method for Identifying Ocular Corrosives and Severe Irritants written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Isolated Chicken Eye (ICE) test method is an in vitro test method that can be used to classify substances as “ocular corrosives and severe irritants”. The ICE method uses eyes collected from chickens obtained from slaughterhouses where they are ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 405: Acute Eye Irritation/Corrosion by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 405: Acute Eye Irritation/Corrosion written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
Download or read book Federal Register written by and published by . This book was released on 2012-07 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Test No. 405: Acute Eye Irritation/Corrosion by : OECD
Download or read book Test No. 405: Acute Eye Irritation/Corrosion written by OECD and published by OECD Publishing. This book was released on 2002-04-24 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 404: Acute Dermal Irritation/Corrosion written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or ex vivo tests for corrosion/irritation.
Book Synopsis Ecotoxicology of Nanoparticles in Aquatic Systems by : Julian Blasco
Download or read book Ecotoxicology of Nanoparticles in Aquatic Systems written by Julian Blasco and published by CRC Press. This book was released on 2019-07-19 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of nanoparticles in medicine, industrial, and other applications has triggered an interest in their potential. This book explores the use of nanoparticles related to their occurrence in the environment, their impact on biota in aquatic systems, application of new methodologies, and changes associated with new global scenarios. The book also covers the bioaccumulation and internalization of nanoparticles as key aspects to assess their uptake and discusses the methodologies for testing ENPs ecotoxicity at different trophic levels.
