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Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tgcyp19a1bgfp Zebrafish Embryos
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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 250: EASZY assay - Detection of Endocrine Active Substances, acting through estrogen receptors, using transgenic tg(cyp19a1b:GFP) Zebrafish embrYos written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt: The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Book Synopsis OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 251: Rapid Androgen Disruption Activity Reporter (RADAR) assay by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 251: Rapid Androgen Disruption Activity Reporter (RADAR) assay written by OECD and published by OECD Publishing. This book was released on 2022-06-30 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 248: Xenopus Eleutheroembryonic Thyroid Assay (XETA) by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 248: Xenopus Eleutheroembryonic Thyroid Assay (XETA) written by OECD and published by OECD Publishing. This book was released on 2019-06-18 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2021-06-17 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems Test No. 230: 21-day Fish Assay A Short-Term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 2: Effects on Biotic Systems Test No. 230: 21-day Fish Assay A Short-Term Screening for Oestrogenic and Androgenic Activity, and Aromatase Inhibition written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vivo screening assay for certain endocrine active substances where sexually mature male and spawning female fish are held together and exposed to a chemical during a limited part of their life-cycle (21 days ...
Book Synopsis Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists by : OECD
Download or read book Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists written by OECD and published by OECD Publishing. This book was released on 2015-07-28 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Book Synopsis OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances written by OECD and published by OECD Publishing. This book was released on 2004-11-01 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 493: Performance-Based Test Guideline for Human Recombinant Estrogen Receptor (hrER) In Vitro Assays to Detect Chemicals with ER Binding Affinity written by OECD and published by OECD Publishing. This book was released on 2024-06-25 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology for human recombinant in vitro assays to detect substances with estrogen receptor binding affinity (hrER binding assays).
Book Synopsis OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption by : OECD
Download or read book OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption written by OECD and published by OECD Publishing. This book was released on 2018-09-03 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Book Synopsis Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists by : OECD
Download or read book Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists written by OECD and published by OECD Publishing. This book was released on 2012-10-02 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provides the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists (ER TAs). It comprises mechanistically and functionally similar test ...
Book Synopsis Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals by : OECD
Download or read book Test No. 455: The Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals written by OECD and published by OECD Publishing. This book was released on 2009-09-08 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vitro assay, which provides mechanistical information, and can be used for screening and prioritization purposes. The test system utilises the hERalpha-HeLa-9903 cell line derived from a human cervical tumor and ...
