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Ocular Transporters And Receptors
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Book Synopsis Ocular Transporters and Receptors by : Ashim K Mitra
Download or read book Ocular Transporters and Receptors written by Ashim K Mitra and published by Elsevier. This book was released on 2013-10-31 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery
Book Synopsis Ocular Transporters in Ophthalmic Diseases and Drug Delivery by : Joyce Tombran-Tink
Download or read book Ocular Transporters in Ophthalmic Diseases and Drug Delivery written by Joyce Tombran-Tink and published by Springer Science & Business Media. This book was released on 2008-04-09 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, the movements of fluids across the ciliary epithelium and nutrients across the retinal pigment epithelium.
Download or read book Webvision written by Helga Kolb and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Anatomy ;Ocular physiology ;Biochemistry and genetics ;Pathology ;Microbiology ;Immunology ;Growth and senescence ;Optics ;Therapeutics ;Lasers and instrument technology ;Basic biostatistical and epidemiological terms by : Louise Bye
Download or read book Anatomy ;Ocular physiology ;Biochemistry and genetics ;Pathology ;Microbiology ;Immunology ;Growth and senescence ;Optics ;Therapeutics ;Lasers and instrument technology ;Basic biostatistical and epidemiological terms written by Louise Bye and published by OUP Oxford. This book was released on 2013-05-23 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable and fully comprehensive textbook, this covers the basic sciences in ophthalmology and is the only book you need to pass the FRCOphth Part 1 exam.
Book Synopsis Pharmacology of Ocular Therapeutics by : Thirumurthy Velpandian
Download or read book Pharmacology of Ocular Therapeutics written by Thirumurthy Velpandian and published by Springer. This book was released on 2016-02-29 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.
Book Synopsis Ophthalmic Drug Delivery Systems by : Ashim K. Mitra
Download or read book Ophthalmic Drug Delivery Systems written by Ashim K. Mitra and published by CRC Press. This book was released on 2019-12-02 with total page 847 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this text assembles significant ophthalmic advances and encompasses breakthroughs in gene therapy, ocular microdialysis, vitreous drug disposition modelling, and receptor/transporter targeted drug delivery.
Book Synopsis Drug Delivery (book) by : Ashim K. Mitra
Download or read book Drug Delivery (book) written by Ashim K. Mitra and published by Jones & Bartlett Publishers. This book was released on 2014-08-08 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Delivery is the latest and most up-to-date text on drug delivery and offers an excellent working foundation for students and clinicians in health professions and graduate students including nursing, pharmacy, medicine, dentistry, as well as researchers and scientists. Presenting this complex content in an organized and concise format, Drug Delivery allows students to gain a strong understanding of the key concepts of drug delivery. This text focuses on the basic concepts of drug delivery while thoroughly examining various topics such as: CNS delivery Gene delivery Ocular delivery World-wide research on drug delivery Recent advances in drug delivery A significant advancement has been made in the field of drug delivery. This text provides a detailed overview of drug delivery systems, routes of drug administration and development of various formulations. The cutting edge research being carried out in this field will be compiled and a focus on worldwide research on drug delivery and targeting at the molecular, cellular, and organ levels will also be summarized. Each new print copy includes access to the Navigate Companion Website including: Chapter Quizzes, Interactive Glossary, Crossword Puzzles , Interactive Flashcards, and Matching Exercises
Book Synopsis Cell Biology of the Eye by : David Mcdevitt
Download or read book Cell Biology of the Eye written by David Mcdevitt and published by Elsevier. This book was released on 2012-12-02 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Biology of the Eye discusses the eye tissues and its role in the investigations on active transport, growth factors, receptors, and differentiation. The book is comprised of articles which discuss corneal proteoglycans; transport of ions and metabolites across the corneal endothelium; the ontogeny and localization of the crystallins in eye lens development and regeneration; the biological-physical basis of lens transparency; the chromatic organization of the retina; and the dopamine neurons in the retina. This treatise will serve as a valuable reference text for graduate and professional students, teachers, researchers, clinicians, and to all in the vision field.
Book Synopsis Drug Discovery and Evaluation: Methods in Clinical Pharmacology by : H.Gerhard Vogel
Download or read book Drug Discovery and Evaluation: Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Book Synopsis The Biology of the Eye by : Jorge Fischbarg
Download or read book The Biology of the Eye written by Jorge Fischbarg and published by Elsevier. This book was released on 2005-12-09 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I would therefore like to acknowledge and thank the following for their outstanding contributions to editing the work: Dr. Morten Dornonville la Cour (MD, Dr. Med. Sci.) solicited and edited the chapters on retina, RPE, choroid, vitreous, immunology, and sclera. Dr. la Cour is a Lecturer, Eye Department, Copenhagen University Hospital, specializes in vitreoretinal surgery, and frequently lectures in the international scene. A trained mathematician, he has done research in retinal pigment epithelial physiology in the laboratories of Drs. Thomas Zeuthen and Sheldon Miller. Dr. Friedrich P.J. Diecke and Dr. Elliott M. Kanner also provided invaluable editorial assistance. Dr Diecke, who was formerly Professor and Chairman of the Department of Physiology, UMDNJ-New Jersey Medical School, is a Professor Emeritus at that institution. His research has concentrated on membrane transport mechanisms in lens epithelial cells, corneal endothelial cells and peripheral nerve and on the regulation of vascular smooth muscle contraction. Dr. Elliott M. Kanner was born in Canada in 1970. He graduated from Yale University in 1992 with a BS/MS degree in Molecular Biophysics and Biochemistry. He received his PhD degree from the Rockefeller University in 1999 and his MD degree from Weill/Cornell in 2001. He is currently an Ophthalmology resident at Columbia University. Jorge Fischbarg, December 2005 This book explores the many recent novel ideas about the eye in a systematic and synthetic way. It includes both basic sciences and applications towards clinical research. Chapters include both anatomical and functional descriptions of the different ocular tissues and treatments of a few subjects of practical importance for ophthalmologists. This book is intended for students in basic biomedical science interested in the eye, as well as ophthalmologists a comprehensive source on recent developments in ocular research. * Combines basic science and practical opthalmological subjects * Written with the simplicity of a textbook, while maintaining the comprehensive and rigorous approach of science papers * Includes contributions by well-known experts
Book Synopsis Innovative Dosage Forms by : Yogeshwar Bachhav
Download or read book Innovative Dosage Forms written by Yogeshwar Bachhav and published by John Wiley & Sons. This book was released on 2019-12-04 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.
Book Synopsis Drug Delivery for the Retina and Posterior Segment Disease by : Jayvadan K. Patel
Download or read book Drug Delivery for the Retina and Posterior Segment Disease written by Jayvadan K. Patel and published by Springer. This book was released on 2018-10-08 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the aging population. A rapid expansion of new technologies in ocular drug delivery and new drug candidates, including biologics, to treat these challenging diseases in the retina and posterior segments of the eye have recently emerged. These approaches are necessary because the eye has many unique barriers to drug delivery. Thus, this timely reference Drug Delivery for the Retina and Posterior Segment Disease compiles and analyzes recent advances in the research and development of drug delivery systems for retina and posterior segment diseases of the eye, with an emphasis on the use of implantable devices, iontophoresis as well as micro- and nanoparticles.
Book Synopsis Prodrugs and Targeted Delivery by : Jarkko Rautio
Download or read book Prodrugs and Targeted Delivery written by Jarkko Rautio and published by John Wiley & Sons. This book was released on 2011-01-11 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing organ- and site-selective prodrugs. Every company employing medicinal chemists will be interested in this practice-oriented overview of a key strategy in modern drug discovery and development.
Book Synopsis Intraocular Inflammation by : Manfred Zierhut
Download or read book Intraocular Inflammation written by Manfred Zierhut and published by Springer. This book was released on 2016-01-12 with total page 1530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-structured and lavishly illustrated book is a comprehensive reference on intraocular inflammation that encompasses all anatomic forms, settings and etiologies. Individual sections are devoted to uveitis associated with systemic disorders, uveitis syndromes restricted to the eye, bacterial uveitis, viral uveitis, fungal uveitis, parasitic uveitis, uveitis caused by other microbes, traumatic uveitis, and masquerade syndromes. Chapters on the different forms of uveitis are in a homogeneous reader-friendly format, with identification of core messages, explanation of etiology and pathogenesis, up-to-date information on diagnostics and differential diagnosis and guidance on the most appropriate forms of treatment and prognosis. Helpful flow charts are included to assist in identification of potential underlying disorders and the reader will also have online access to one hundred informative case reports demonstrating the different courses of intraocular inflammation. The authors are world experts keen to share their vast experience with the reader. Intraocular Inflammation will be a valuable resource for all physicians who deal with patients with inflammatory eye disease.
Book Synopsis Nanotechnology in Ophthalmology by : Mahendra Rai
Download or read book Nanotechnology in Ophthalmology written by Mahendra Rai and published by Elsevier. This book was released on 2023-07-18 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology in Ophthalmology is a comprehensive and up-to-date reference on the role and applications of nanotechnology in ophthalmology, from drug delivery and treatment of ocular diseases to toxicity issues. Written by experts from the nanotechnology, ophthalmology, and pharmacology fields, this book has a unique, broad and diverse scope, including chapters on nanosensor-based diagnostic tools, delivery of nanobiomaterials, implantable materials and devices, delivery of nanobiomaterials, nanotechnology for medical and surgical treatment, regenerative medicine, and more. This book provides a valuable reference to researchers working in the areas of ophthalmology, nanoscience and pharmacology, and clinical fellows who are interested in nanoophthalmology as a reference for their practice and research. Provides a comprehensive review of the literature in the area of nanoophthalmology Discusses regenerative medicine, drug delivery, imaging, and medical device applications Analyzes treatment strategies for emerging and multidrug-resistant ocular pathogens
Book Synopsis Targeted Delivery of Small and Macromolecular Drugs by : Ajit S. Narang
Download or read book Targeted Delivery of Small and Macromolecular Drugs written by Ajit S. Narang and published by CRC Press. This book was released on 2017-07-26 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local routes of administration, Targeted Delivery of Small and Macromolecular Drugs brings together field experts who summarize current progress and discuss novel ideas currently being explored to overcome these challenges. The contributors discuss the most promising strategies for drug targeting and also examine targeted drug delivery platforms and technologies at various stages of clinical and preclinical development, including: Active targeting Nucleic acid delivery and targeting Intracellular/organelle-specific strategies Prodrug strategies Organ or tissue-specific drug delivery Drug-polymer conjugates and micelles Stimuli-responsive systems The book demonstrates why targeted delivery is one of the most exciting contributions pharmaceutical sciences can make to drug therapy.
Book Synopsis Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease by : Xian-Cheng Jiang
Download or read book Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease written by Xian-Cheng Jiang and published by Springer Nature. This book was released on 2020-07-23 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an up-to-date review of the fundamentals of lipid metabolism and its role in cardiovascular diseases. Focusing on lipid transfer proteins in the circulation and cells, the role of important lipid transporters, the effect of recently discovered lipid binding proteins, and the link between lipid metabolism disorders and cardiovascular diseases, it covers phospholipid transfer protein, cholesteryl ester transfer protein, lipopolysaccharide binding protein, microsomal triglyceride transfer protein, ABC binding cassette members, and more. The book offers graduate students and researchers a coherent overview of lipid transfer and transport, as well as the limitations of current research in the field, and promotes further studies on cardiovascular diseases, as well as pharmaceutical research on drug discovery based on lipid transfer, transport, and binding.
