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Author : Jeffrey N. Weiss
Publisher : Springer Nature
ISBN 13 : 3031585577
Total Pages : 364 pages
Book Rating : 4.0/5 (315 download)
Download or read book Ocular Stem Cell Studies written by Jeffrey N. Weiss and published by Springer Nature. This book was released on with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen Tsang
Publisher : Springer Science & Business Media
ISBN 13 : 146145493X
Total Pages : 196 pages
Book Rating : 4.4/5 (614 download)
Download or read book Stem Cell Biology and Regenerative Medicine in Ophthalmology written by Stephen Tsang and published by Springer Science & Business Media. This book was released on 2012-12-09 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patient specific and disease specific stem cell lines have already introduced groundbreaking advances into the research and practice of ophthalmology. This volume provides a comprehensive and engaging overview of the latest innovations in the field. Twelve chapters discuss the fastest growing areas in ophthalmological stem cell research, from disease modelling, drug screening and gene targeting to clinical genetics and regenerative treatments. Innovative results from stem cell research of the past decade are pointing the way toward practicable treatments for retinitis pigmentosa, age related macular degeneration, and Stargardt disease. What future directions will stem cell research take? Researchers, graduate students, and fellows alike will find food for thought in this insightful guide tapping into the collective knowledge of leaders in the field. Stem Cells in Ophthalmology is part of the Stem Cells in Regenerative Medicine series dedicated to discussing current challenges and future directions in stem cell research.
Author : Brian G. Ballios
Publisher : Springer
ISBN 13 : 3319980807
Total Pages : 212 pages
Book Rating : 4.3/5 (199 download)
Download or read book Regenerative Medicine and Stem Cell Therapy for the Eye written by Brian G. Ballios and published by Springer. This book was released on 2019-02-18 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering. This book also Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers Examines the connection between cell therapy and gene editing, in particular relation to ocular disease
Author : Kapil Bharti
Publisher : Springer Nature
ISBN 13 : 3030284719
Total Pages : 201 pages
Book Rating : 4.0/5 (32 download)
Download or read book Pluripotent Stem Cells in Eye Disease Therapy written by Kapil Bharti and published by Springer Nature. This book was released on 2019-10-25 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses applications of pluripotent stem cells to study eye disease in vitro and to create novel therapies for degenerative eye diseases. Chapters are contributed by experts in the field and cover such topics as the use of pluripotent stem cells in 2D and 3D engineering of ocular tissues for disease modelling and drug testing as well as approaches to replace degenerated RPE and photoreceptors in macular degeneration and retinitis pigmentosa. Pluripotent Stem Cells in Eye Disease Therapy presents a comprehensive discussion of basic science and clinical applications and is an indispensable resource for everyone from advanced graduate students to advanced professionals who want to learn about the potential of stem cell biology and its role in the field of retinal diseases.
Author : Eman E. Taher
Publisher : Elsevier
ISBN 13 : 0323983162
Total Pages : 309 pages
Book Rating : 4.3/5 (239 download)
Download or read book The Eye written by Eman E. Taher and published by Elsevier. This book was released on 2023-03-31 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Eye, Volume Four, the latest release in the Stem Cell Innovation in Health and Disease series, addresses the recent data accumulated on the potential applications of stem cells to treat eye diseases. This volume highlights the recent development of cutting-edge in vitro and in vivo research tools and approaches, including human and murine organoid cultures, genetic editing in vitro and in vivo, human iPSC models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure eye diseases. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation, and is contributed by world-renowned authors in the field. This is a timely and fascinating collection of information and new discoveries that provides a contemporary snapshot album on the fast-moving field of regenerative medicine and stem cell therapeutics. - Provides cutting-edge research to understand stem cell functions used in disease treatments of the eye - Develops processes to bring stem cells from bench to bedside - Includes up-to-date references on stem cell biology and function in common eye diseases and disorders
Author : Jeffrey N. Weiss
Publisher : Springer Nature
ISBN 13 : 3030608506
Total Pages : 91 pages
Book Rating : 4.0/5 (36 download)
Download or read book Retinal and Optic Nerve Stem Cell Surgery written by Jeffrey N. Weiss and published by Springer Nature. This book was released on 2020-11-19 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a concise how-to of successfully treating previously deemed "untreatable" retinal and optic nerve conditions with stem cell therapies. Based on the results of 11 years of experience treating approximately 600 patients, this text will serve as a template for others to develop similar stem cell based treatments in their specialty. Author, Jeffrey N. Weiss, MD is specifically poised to offer dependable insight on stem cell surgery for both the retina and the optic nerve, having performed the first retinal stem cell surgery in 2010, with Institutional Review Board (IRB) approved studies that are registered with the National Institute of Health (NIH), and listed on ClinicalTrials.gov. Featuring all original work from Dr. Jeffrey Weiss's specialization in stem cell ophthalmology, this book is primarily written for ophthalmologists, but structured so that specialists across disciplines can take the model presented and create their own studies and clinical trials using stem cell therapies.
Author : Alice Pébay
Publisher : Springer
ISBN 13 : 1493907875
Total Pages : 310 pages
Book Rating : 4.4/5 (939 download)
Download or read book Regenerative Biology of the Eye written by Alice Pébay and published by Springer. This book was released on 2014-05-23 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a comprehensive look at the current knowledge on stem cell application for vision loss, showcasing different types of stem cells (adult, embryonic, iPSCs) for diseases of the front and the back of the eye. It also highlights data obtained in various models from fish to human, as well as from the bionic eye project for vision regeneration. This volume in the Stem Cell Biology and Regenerative Medicine series is essential reading for stem cell biologists, ophthalmologists, advanced and graduate students, in addition to academics and medical staff who work in these disciplines.
Author : Leonard A. Levin
Publisher : CRC Press
ISBN 13 : 0203911946
Total Pages : 343 pages
Book Rating : 4.2/5 (39 download)
Download or read book Ocular Neuroprotection written by Leonard A. Levin and published by CRC Press. This book was released on 2003-07-15 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many retinal and optic nerve disorders have no effective therapy, or are treated incompletely and with considerable side effects. Recent advances have suggested the significant benefits associated with neuroprotection - that is, when treatment strategies are directed to photoreceptors, retinal ganglion cells, or other neural targets. Enter Ocular N
Author : Daniel H. Scorsetti
Publisher : Jaypee Brothers Medical Publishers Pvt. Limited
ISBN 13 : 9789962678762
Total Pages : 0 pages
Book Rating : 4.6/5 (787 download)
Download or read book Stem Cells in Ophthalmology written by Daniel H. Scorsetti and published by Jaypee Brothers Medical Publishers Pvt. Limited. This book was released on 2015-01-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells in Ophthalmology describes a wide range of therapeutic applications of stem cells in ophthalmological treatments. This book is written and edited by distinguished international authors, who have drawn heavily on their in-depth academic knowledge, practical experience and research. Comprised of 17 chapters, the book initially covers basic stem cell biology and immunity, proceeding to detail the use of stem cell therapy to regenerate all the structures of the visual system and ocular adnexa. Immunologic factors, such as antigen identification and functional rejection pathways are discussed in detail. The book also details practice of translational medicine and facilities, and governmental requirements needed to establish an ocular stem cell program. Stem Cells in Ophthalmology gives extensive coverage to the regenerative use of stem cells in ophthalmology. Enhanced by 84 colour images and illustrations, this is an essential resource for ophthalmologists and stem cell therapists. Key Features 84 full colour images and illustrations Covers all structures of the visual system in detail Edited by pan-American team of ophthalmology experts from Argentina, USA and Brazil
Author : Matthew M. LaVail
Publisher : Springer Science & Business Media
ISBN 13 : 1461406315
Total Pages : 867 pages
Book Rating : 4.4/5 (614 download)
Download or read book Retinal Degenerative Diseases written by Matthew M. LaVail and published by Springer Science & Business Media. This book was released on 2011-12-21 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
Author : Surajit Pathak
Publisher : Academic Press
ISBN 13 : 0128204133
Total Pages : 322 pages
Book Rating : 4.1/5 (282 download)
Download or read book Stem Cells and Aging written by Surajit Pathak and published by Academic Press. This book was released on 2021-03-17 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. - Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population - Addresses the effect of time and age on human stem cells - Includes chapters from contributors exploring the biology of stem cell aging around the globe
Author : Marco A. Zarbin
Publisher : Springer
ISBN 13 : 3030052222
Total Pages : 280 pages
Book Rating : 4.0/5 (3 download)
Download or read book Cell-Based Therapy for Degenerative Retinal Disease written by Marco A. Zarbin and published by Springer. This book was released on 2019-03-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses why specific diseases are being targeted for cell-based retinal therapy, what evidence exists that justifies optimism for this approach, and what challenges must be managed in order to bring this technology from the laboratory into routine clinical practice. There are a number of unanswered questions (e.g., surgical approach to cell delivery, management of immune response, optimum cell type to transplant) that very likely are not going to be answered until human trials are undertaken, but there is a certain amount of “de-risking” that can be done with preclinical experimentation. This book is essential reading for scientists, clinicians, and advanced students in stem cell research, cell biology, and ophthalmology.
Author : Steven D. Schwartz
Publisher : Springer
ISBN 13 : 3319494791
Total Pages : 149 pages
Book Rating : 4.3/5 (194 download)
Download or read book Cellular Therapies for Retinal Disease written by Steven D. Schwartz and published by Springer. This book was released on 2017-06-20 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book familiarizes the reader with the current landscape of cell-based therapies for the treatment of retinal disease, including diseases that affect the choriocapillaris, retinal pigment epithelium, photoreceptors, and retinal ganglion cells. Instead of utilizing a disease-centric approach to the topic, this book—edited by two world-renowned stem cell scientists—focuses on strategies for developing and transplanting the cells. This includes the creation of replacement cells, cell-based neuroprotection, and in vitro disease modeling and testing. The final chapters briefly review parallel approaches that do not directly utilize cellular transplantation. The use of cellular transplantation to treat retinal disease has recently become a viable and exciting therapeutic approach. The visibility of the retina and its laminar cellular architecture render it an ideal organ for the development of surgically delivered cellular therapies. Having an in-depth understanding of the current state of cell therapy for the eye is an essential first step toward utilizing similar approaches in other organs. Ophthalmologists, translational clinician-scientists, stem cell scientists, and researchers interested in eye disease will find Cellular Therapies for Retinal Disease: A Strategic Approach essential reading and it is also suitable for workshops or courses at the undergraduate or Ph.D. level.
Author : R.P. Casaroli-Marano
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318025852
Total Pages : 220 pages
Book Rating : 4.3/5 (18 download)
Download or read book Cell-Based Therapy for Retinal Degenerative Disease written by R.P. Casaroli-Marano and published by Karger Medical and Scientific Publishers. This book was released on 2014-04-22 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this volume, some of the leading authorities present their exploration of applications of stem cell therapy to the treatment of major causes of blindness, including degenerative diseases and glaucoma. The diagnostic approach to patients, general concepts of cell-based therapy, immunological considerations, approaches to cell delivery (including engineered scaffolds), combined cell and gene therapy, nanomedicine applications to cell therapy and regulatory issues pertaining to manufacture and production are all considered in detail. The book serves as an excellent introduction to a field that is now entering early-stage clinical trials and promises to operate at the leading edge of regenerative medicine. Retina specialists, general ophthalmologists as well as researchers will find here a wealth of information on the translational aspects of cell-based therapies. Further, business executives and students interested in understanding the potential applications of stem cell therapy to retinal degenerative disease and glaucoma will also find this book informative reading.
Author : Yanhong Shi
Publisher : Springer Science & Business Media
ISBN 13 : 1402085028
Total Pages : 336 pages
Book Rating : 4.4/5 (2 download)
Download or read book Stem Cell Research and Therapeutics written by Yanhong Shi and published by Springer Science & Business Media. This book was released on 2008-07-15 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an updated reference for one of the most exciting field of biomedical researches- Stem Cell Research and its therapeutic applications. Stem cell research holds great promise for the treatment of many human diseases that currently lack effective therapies. The set of chapters in this book provide insights into both basic stem cell biology and clinical applications of stem cell-based cell replacement therapies for a variety of human diseases, including cardiovascular diseases, neurological disorders, and li ver degeneration. It also covers novel technologies for the culture and differentiation of both human embryonic stem cells and adult tissue stem cells. This book summarizes our current state of knowledge in stem cell research and integrates basic stem cell biology with regenerative medicine in an overall context. It is an essential reference for students, postdoctoral fellows, academic and industrial scientists, and clinicians. v Acknowledgements The editors would like to thank Ms. Jill Brantley, Rose Chavarin, Alina Haas, and Emily Sun for their administrative assistance and proof-reading of this book. We would also like to thank all the authors for their contributions. vii The editors wish to dedicate this book to our mentors Ron Evans, Fred Gage, and, in memory of Daniel E. Koshland, Jr. Contents Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Acknowledgements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . vii Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . xi 1 Retinal Pigment Epithelial Cells: Development In Vivo and Derivation from Human Embryonic Stem Cells In Vitro for Treatment of Age-Related Macular Degeneration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Dennis O. Clegg, David Buchholz, Sherry Hikita, Teisha Rowland, Qirui Hu, and Lincoln V.
Author : Jorge L. Alió
Publisher : Springer
ISBN 13 : 3030013049
Total Pages : 507 pages
Book Rating : 4.0/5 (3 download)
Download or read book Corneal Regeneration written by Jorge L. Alió and published by Springer. This book was released on 2019-02-20 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides expert instruction on the varying surgical techniques currently employed for the regeneration of the ocular surface. Corneal Regeneration: Therapy and Surgery begins with a thorough discussion of current research based on data obtained in clinical human studies, and discusses the potential clinical implications for this promising new stage of eye surgery. Sections devoted to the stem cell, regenerative surgery and therapy of the ocular surface epithelium, corneal stroma, and corneal endothelium follow, each section comprehensively covering applied anatomy, current therapy and regenerative techniques, with a look to future directions of the field including eventual cell therapy. Corneal Regeneration: Therapy and Surgery is the first book of its kind, systematically covering the developments the medical community has achieved in corneal regeneration from all angles. Written and edited by leading experts in the field, researchers and ophthalmologists alike will find this to be a unique source of information on corneal regeneration, as well as a thoughtful reflection on potential applications of regenerative surgery in ophthalmology as a whole.
Author : Atta- ur-Rahman
Publisher : Bentham Science Publishers
ISBN 13 : 1608059944
Total Pages : 151 pages
Book Rating : 4.6/5 (8 download)
Download or read book Frontiers in Stem Cell and Regenerative Medicine Research written by Atta- ur-Rahman and published by Bentham Science Publishers. This book was released on 2015-03-13 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be practiced in the years to come. Challenges in 21st century to combat cancer, Alzheimer and related diseases may well be addressed employing stem cell therapies and tissue regeneration. The first volume of ‘Frontiers in Stem Cell and Regenerative Medicine Research’ features reviews written by experts in key areas of stem cells and regenerative medicine. It summarizes the safety assessment of mesenchymal stem cells (MSC) in musculoskeletal implantation that can bridge the gap between translation from animals to humans. The most prevalent strategies to improve immune reconstitution after hematopoietic stem cell transplantation have also been focused upon. This is particularly important because chemotherapy and pre-transplant conditioning impairs thymic function. The application of regenerative medicine for repair of damaged cornea and ocular has also been discussed. The emerging techniques for tissue engineering of functional corneal equivalents represent a new and fascinating way to treat corneal diseases. The area of recently used nanofibrous substrates, as an alternative tool for the expansion and differentiation of embryonic stem cells, has been included in this e-book. In future, such technologies could promote the use of hESC-derived cells for clinical applications successfully.
