Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Nucleocytoplasmic Transport full books in PDF, epub, and Kindle. Read online Nucleocytoplasmic Transport ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Reiner Peters
Publisher : Springer Science & Business Media
ISBN 13 : 3642715656
Total Pages : 296 pages
Book Rating : 4.6/5 (427 download)
Download or read book Nucleocytoplasmic Transport written by Reiner Peters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul S. Agutter
Publisher : Springer Science & Business Media
ISBN 13 : 3662225026
Total Pages : 205 pages
Book Rating : 4.6/5 (622 download)
Download or read book The Meaning of Nucleocytoplasmic Transport written by Paul S. Agutter and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.
Author : Weidong Yang
Publisher : Springer
ISBN 13 : 3319773097
Total Pages : 277 pages
Book Rating : 4.3/5 (197 download)
Download or read book Nuclear-Cytoplasmic Transport written by Weidong Yang and published by Springer. This book was released on 2018-07-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Author :
Publisher : Elsevier
ISBN 13 : 0124171788
Total Pages : 553 pages
Book Rating : 4.1/5 (241 download)
Download or read book Nuclear Pore Complexes and Nucleocytoplasmic Transport - Methods written by and published by Elsevier. This book was released on 2014-05-20 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines. - Describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (mammalian cells, Xenopus, C. elegans, yeast) - Chapters are written by experts in the field - Cutting-edge material
Author : Rita Sattler
Publisher : Springer
ISBN 13 : 331989689X
Total Pages : 321 pages
Book Rating : 4.3/5 (198 download)
Download or read book RNA Metabolism in Neurodegenerative Diseases written by Rita Sattler and published by Springer. This book was released on 2018-06-18 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464953449
Total Pages : 31 pages
Book Rating : 4.4/5 (649 download)
Download or read book Nucleocytoplasmic Transport Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleocytoplasmic Transport Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Nucleocytoplasmic Transport Proteins in a compact format. The editors have built Nucleocytoplasmic Transport Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nucleocytoplasmic Transport Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nucleocytoplasmic Transport Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Ross Dalbey
Publisher : Elsevier
ISBN 13 : 0080480500
Total Pages : 441 pages
Book Rating : 4.0/5 (84 download)
Download or read book Protein Targeting, Transport, and Translocation written by Ross Dalbey and published by Elsevier. This book was released on 2002-04-09 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. - Basic principles and techniques - Targeting adn sorting sequences - Protein export in bacteria - Membrane protein integration into ER and bacterial membranes - Protein translocation across the ER - Disulfide bond formation in prokaryotes and eukaryotes - Quality control in the export pathway - Import of proteins into organelles - The secretory pathway - Vesicular transport - Spectacular color throughout
Author : Karsten Weis
Publisher : Springer Science & Business Media
ISBN 13 : 9783540423683
Total Pages : 222 pages
Book Rating : 4.4/5 (236 download)
Download or read book Nuclear Transport written by Karsten Weis and published by Springer Science & Business Media. This book was released on 2002 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
Author : Van G. Wilson
Publisher : Springer
ISBN 13 : 3319500449
Total Pages : 413 pages
Book Rating : 4.3/5 (195 download)
Download or read book SUMO Regulation of Cellular Processes written by Van G. Wilson and published by Springer. This book was released on 2017-02-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins. The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria. Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research. This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.
Author : Ramón Cacabelos
Publisher : Academic Press
ISBN 13 : 0128139404
Total Pages : 986 pages
Book Rating : 4.1/5 (281 download)
Download or read book Pharmacoepigenetics written by Ramón Cacabelos and published by Academic Press. This book was released on 2019-06-04 with total page 986 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacoepigenetics provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. - Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development - Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry - Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety - Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine
Author : Tzvi Tzfira
Publisher : Springer Science & Business Media
ISBN 13 : 0387277471
Total Pages : 239 pages
Book Rating : 4.3/5 (872 download)
Download or read book Nuclear Import and Export in Plants and Animals written by Tzvi Tzfira and published by Springer Science & Business Media. This book was released on 2007-02-25 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Author : Grace Pavlath
Publisher : Academic Press
ISBN 13 : 0123859409
Total Pages : 376 pages
Book Rating : 4.1/5 (238 download)
Download or read book Myogenesis written by Grace Pavlath and published by Academic Press. This book was released on 2011-06-08 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myogenesis is the formation of muscular tissue, in particular during embryonic development. This new volume in the "Current topics in Developmental Biology" series covers chapters on such topics as Control of nuclear import during myogenesis, Pathways contributing to fibrosis in skeletal muscle, and Ferlin family members in myogenesis. With an international team of authors, this volume is a must-have addition for researchers and students alike. This new volume in the "Current topics in Developmental Biology" series covers chapters on such topics as Control of nuclear import during myogenesis, Pathways contributing to fibrosis in skeletal muscle, and Ferlin family members in myogenesis With an international team of authors, this volume is a must-have addition for researchers and students alike
Author : Heinz-Christoph Schröder
Publisher :
ISBN 13 :
Total Pages : 166 pages
Book Rating : 4.3/5 (91 download)
Download or read book Methods for Investigating Nucleo-cytoplasmic Transport of RNA written by Heinz-Christoph Schröder and published by . This book was released on 1989 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Udo Rüb
Publisher : Springer
ISBN 13 : 331919285X
Total Pages : 154 pages
Book Rating : 4.3/5 (191 download)
Download or read book The Neuropathology of Huntington’s Disease: Classical Findings, Recent Developments and Correlation to Functional Neuroanatomy written by Udo Rüb and published by Springer. This book was released on 2015-09-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph describes the progress in neuropathological HD research made during the last century, the neuropathological hallmarks of HD and their pathogenic relevance. Starting with the initial descriptions of the progressive degeneration of the striatum as one of the key events in HD, the worldwide practiced Vonsattel HD grading system of striatal neurodegeneration will be outlined. Correlating neuropathological data with results on the functional neuroanatomy of the human brain, subsequent chapters will highlight recent HD findings: the neuronal loss in the cerebral neo-and allocortex, the neurodegeneration of select thalamic nuclei, the affection of the cerebellar cortex and nuclei, the involvement of select brainstem nuclei, as well as the pathophysiological relevance of these pathologies for the clinical picture of HD. Finally, the potential pathophysiological role of neuronal huntingtin aggregations and the most important and enduring challenges of neuropathological HD research are discussed.
Author : Lionel A. Manson
Publisher : Springer
ISBN 13 : 9780306398025
Total Pages : 304 pages
Book Rating : 4.3/5 (98 download)
Download or read book Biomembranes written by Lionel A. Manson and published by Springer. This book was released on 1971-01-10 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the contributions to a symposium held at Gatlinburg, Tennessee, under the auspices of the Oak Ridge National Laboratory, in April, 1971. In the past, these proceedings had appeared as a supplement to the Journal of Cellular Physiology. Due to the nature of the subject ma terial and the relevance of the topic of the symposium to the readers of BIOMEMBRANES, it was agreed by the organizers of the symposium to publish the contributions of the partici pants as a separate volume in BIOMEMBRANES. It had been originally envisaged that, from time to time, the proceedings of a conference whose subject matter was directly related to the scope of this series would be included. The proceedings are being published exactly as they have been submitted to the Editor without the usual editorial re V1S10n. This is being done to increase the speed of publica tion. For the same rOeason, no indices have been provided since the time needed to prepare an adequate subject index would have unnecessarily delayed publication. Included in the proceedings are short reports of a number of workshops that were held during the conference. The editor has received excellent cooperation from both the organizers of the conference and the several contributors to this volume. If the experiment is a success, it is thanks to their promptness.
Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)
Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
