Nuclear Chromosomal And Genomic Architecture In Biology And Medicine

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Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

Author : Malgorzata Kloc
Publisher : Springer Nature
ISBN 13 : 3031065735
Total Pages : 657 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine by : Malgorzata Kloc

Download or read book Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine written by Malgorzata Kloc and published by Springer Nature. This book was released on 2022-11-08 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Mouse Embryogenesis

Author : Paul Delgado-Olguin
Publisher : Humana Press
ISBN 13 : 9781493977130
Total Pages : 193 pages
Book Rating : 4.9/5 (771 download)

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Book Synopsis Mouse Embryogenesis by : Paul Delgado-Olguin

Download or read book Mouse Embryogenesis written by Paul Delgado-Olguin and published by Humana Press. This book was released on 2018-03-22 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores protocols for identifying mutant mice and characterizing parts of their anatomical, functional, cellular, and molecular phenotypes. The chapters in this book look at anatomical and functional phenotyping using quantitative imaging, isolation of specific embryonic cell types for cell culture, analysis of gene expression, and how to define chromatin structure. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Mouse Embryogenesis: Methods and Protocols is a valuable resource for experimentalists interested in discovering new aspects of embryogenesis control, organ function, and the origin of disease.

Mitonuclear Ecology

Author : Geoffrey E. Hill
Publisher :
ISBN 13 : 0198818254
Total Pages : 315 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Mitonuclear Ecology by : Geoffrey E. Hill

Download or read book Mitonuclear Ecology written by Geoffrey E. Hill and published by . This book was released on 2019 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This novel text provides a concise synthesis of how the interactions between mitochondrial and nuclear genes have played a major role in shaping the ecology and evolution of eukaryotes. The foundation for this new focus on mitonuclear interactions originated from research in biochemistry and cell biology laboratories, although the broader ecological and evolutionary implications have yet to be fully explored. The imperative for mitonuclear coadaptation is proposed to be a major selective force in the evolution of sexual reproduction and two mating types in eukaryotes, in the formation of species, in the evolution of ornaments and sexual selection, in the process of adaptation, and in the evolution of senescence. The book highlights the importance of mitonuclear coadaptation to the evolution of complex life and champions mitonuclear ecology as an important subdiscipline in ecology and evolution.

Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution

Author : Anja Weise
Publisher : Frontiers Media SA
ISBN 13 : 2889666816
Total Pages : 94 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution by : Anja Weise

Download or read book Chromosome Biology as a Key to Understand Disease Mechanisms, Genome Architecture and Evolution written by Anja Weise and published by Frontiers Media SA. This book was released on 2021-04-16 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena.

Genome Chaos

Author : Henry H. Heng
Publisher : Academic Press
ISBN 13 : 0128136367
Total Pages : 564 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genome Chaos by : Henry H. Heng

Download or read book Genome Chaos written by Henry H. Heng and published by Academic Press. This book was released on 2019-05-25 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. - Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine - Gathers the most pressing questions in genomic and cytogenomic research - Offers alternative explanations to timely puzzles in the field - Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Genomic and Personalized Medicine

Author :
Publisher : Academic Press
ISBN 13 : 0123822289
Total Pages : 1342 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Genomic and Personalized Medicine by :

Download or read book Genomic and Personalized Medicine written by and published by Academic Press. This book was released on 2012-10-30 with total page 1342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. - Highly Commended 2013 BMA Medical Book Award for Medicine - More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition - Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics - Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine - Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Mapping and Sequencing the Human Genome

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309038405
Total Pages : 128 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Mapping and Sequencing the Human Genome by : National Research Council

Download or read book Mapping and Sequencing the Human Genome written by National Research Council and published by National Academies Press. This book was released on 1988-01-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is growing enthusiasm in the scientific community about the prospect of mapping and sequencing the human genome, a monumental project that will have far-reaching consequences for medicine, biology, technology, and other fields. But how will such an effort be organized and funded? How will we develop the new technologies that are needed? What new legal, social, and ethical questions will be raised? Mapping and Sequencing the Human Genome is a blueprint for this proposed project. The authors offer a highly readable explanation of the technical aspects of genetic mapping and sequencing, and they recommend specific interim and long-range research goals, organizational strategies, and funding levels. They also outline some of the legal and social questions that might arise and urge their early consideration by policymakers.

Genomic Medicine

Author : Dhavendra Kumar
Publisher : Oxford Monographs on Medical G
ISBN 13 : 019989602X
Total Pages : 853 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis Genomic Medicine by : Dhavendra Kumar

Download or read book Genomic Medicine written by Dhavendra Kumar and published by Oxford Monographs on Medical G. This book was released on 2014-10-15 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.

Chromosome Architecture

Author : Mark C. Leake
Publisher : Humana
ISBN 13 : 9781493936298
Total Pages : 0 pages
Book Rating : 4.9/5 (362 download)

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Book Synopsis Chromosome Architecture by : Mark C. Leake

Download or read book Chromosome Architecture written by Mark C. Leake and published by Humana. This book was released on 2016-06-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details a valuable collection of protocols and reviews, such as emerging experimental and theoretical approaches. These approaches have resulted in a substantial improvement in the understanding of chromosome architecture. Chromosome Architecture: Methods and Protocols guides readers through cutting-edge interdisciplinary methods which allow for an understanding of architecture of chromosomes with exceptionally enhanced resolution, both in terms of space and time. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Chromosome Architecture: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Cytogenomics

Author : Thomas Liehr
Publisher : Academic Press
ISBN 13 : 0128235802
Total Pages : 430 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Cytogenomics by : Thomas Liehr

Download or read book Cytogenomics written by Thomas Liehr and published by Academic Press. This book was released on 2021-05-25 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytogenomics demonstrates that chromosomes are crucial in understanding the human genome and that new high-throughput approaches are central to advancing cytogenetics in the 21st century. After an introduction to (molecular) cytogenetics, being the basic of all cytogenomic research, this book highlights the strengths and newfound advantages of cytogenomic research methods and technologies, enabling researchers to jump-start their own projects and more effectively gather and interpret chromosomal data. Methods discussed include banding and molecular cytogenetics, molecular combing, molecular karyotyping, next-generation sequencing, epigenetic study approaches, optical mapping/karyomapping, and CRISPR-cas9 applications for cytogenomics. The book's second half demonstrates recent applications of cytogenomic techniques, such as characterizing 3D chromosome structure across different tissue types and insights into multilayer organization of chromosomes, role of repetitive elements and noncoding RNAs in human genome, studies in topologically associated domains, interchromosomal interactions, and chromoanagenesis. This book is an important reference source for researchers, students, basic and translational scientists, and clinicians in the areas of human genetics, genomics, reproductive medicine, gynecology, obstetrics, internal medicine, oncology, bioinformatics, medical genetics, and prenatal testing, as well as genetic counselors, clinical laboratory geneticists, bioethicists, and fertility specialists. - Offers applied approaches empowering a new generation of cytogenomic research using a balanced combination of classical and advanced technologies - Provides a framework for interpreting chromosome structure and how this affects the functioning of the genome in health and disease - Features chapter contributions from international leaders in the field

Nuclear Structure and Gene Expression

Author : R. Curtis Bird
Publisher : Elsevier
ISBN 13 : 0080537812
Total Pages : 317 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Nuclear Structure and Gene Expression by : R. Curtis Bird

Download or read book Nuclear Structure and Gene Expression written by R. Curtis Bird and published by Elsevier. This book was released on 1996-11-28 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Exstrophy—Epispadias Complex

Author : John P. Gearhart
Publisher : Springer Science & Business Media
ISBN 13 : 9780306461286
Total Pages : 276 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis The Exstrophy—Epispadias Complex by : John P. Gearhart

Download or read book The Exstrophy—Epispadias Complex written by John P. Gearhart and published by Springer Science & Business Media. This book was released on 1999-07-31 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the most up-to-date scientific information on the anatomy, physiology, and pathophysiology of the bladder muscle, nerves, and collagen in the patient with bladder exstrophy. In addition, this book covers the most modern surgical treatment of the infant born with bladder exstrophy and those who fail initial reconstruction. Chapters are contributed by major children's centers throughout the world. The aims of this book are to familiarize both the resident and the experienced practitioner with the most modern methods for the treatment for bladder exstrophy and epispadias. This book deals with the function, innervation, and pathophysiology of the bladder muscle in the patient born with bladder exstrophy. New concepts from leading laboratories around the world regarding the function of the bladder are discussed. In addition, experts offer their advice, expertise, and thoughts concerning the management of the patient born with bladder exstrophy. This book is intended for researchers who are interested in both the innervation, structure and function of bladder muscle and for pediatricians, pediatric surgeons, pediatric orthopedic surgeons, and both adult and pediatric urologists who deal with patients from birth until adult life who are born with bladder exstrophy. This is the first book to deal specifically with the basic science of bladder exstrophy and the clinical management of the bladder exstrophy-epispadias complex.

The Nucleus, Second Edition

Author : Ana Pombo
Publisher :
ISBN 13 : 9781621823896
Total Pages : 300 pages
Book Rating : 4.8/5 (238 download)

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Book Synopsis The Nucleus, Second Edition by : Ana Pombo

Download or read book The Nucleus, Second Edition written by Ana Pombo and published by . This book was released on 2021-09 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nucleus is the most prominent structure in eukaryotic cells. It houses the cell's DNA and is the hub for DNA replication, transcription, and RNA processing. Despite its prominence and importance, our understanding of how the nucleus and its DNA are organized in space and time--and the implications of that organization for proper function--has lagged behind that of other cellular structures. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent advances in our understanding of nuclear organization and function. The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. Insights into DNA replication timing and RNA processing dynamics based on new technologies aimed at examining chromatin and other intranuclear structures at high resolution are also included. Multiple chapters are devoted to physiological and disease processes involving disruption of nuclear structure and function (e.g., viral infection). This volume is therefore essential reading for all cell and molecular biologists, as well as pathologists interested in the role of nuclear architecture in disease.

Biophysics for Beginners

Author : Helmut Schiessel
Publisher : CRC Press
ISBN 13 : 9814241652
Total Pages : 420 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Biophysics for Beginners by : Helmut Schiessel

Download or read book Biophysics for Beginners written by Helmut Schiessel and published by CRC Press. This book was released on 2013-12-20 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a new way of looking at living matter. It uses quantitative experimental and theoretical methods to open a new window for studying and understanding life processes. This textbook gives compact introductions to the basics of the field, including molecular cell biology and statistical physics. It then presents in-depth discussions of more advanced biophysics subjects, progressing to state-of-the-art experiments and their theoretical interpretations. The book is unique by offering a general introduction to biophysics, yet at the same time restricting itself to processes that occur inside the cell nucleus and that involve biopolymers (DNA, RNA, and proteins). This allows for an accessible read for beginners and a springboard for specialists who wish to continue their study in more detail.

The Cell Biology of Stem Cells

Author : Eran Meshorer
Publisher : Springer Science & Business Media
ISBN 13 : 1441970371
Total Pages : 246 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Cell Biology of Stem Cells by : Eran Meshorer

Download or read book The Cell Biology of Stem Cells written by Eran Meshorer and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells have been gaining a lot of attention in recent years. Their unique potential to self-renew and differentiate has turned them into an attractive model for the study of basic biological questions such as cell division, replication, transcription, cell fate decisions, and more. With embryonic stem (ES) cells that can generate each cell type in the mammalian body and adult stem cells that are able to give rise to the cells within a given lineage, basic questions at different developmental stages can be addressed. Importantly, both adult and embryonic stem cells provide an excellent tool for cell therapy, making stem cell research ever more pertinent to regenerative medicine. As the title The Cell Biology of Stem Cells suggests, our book deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming. In the first chapter, “Early embryonic cell fate decisions in the mouse”, Amy Ralson and Yojiro Yamanaka describe the mechanisms that support early developmental decisions in the mouse pre-implantation embryo and the current understanding of the source of the most immature stem cell types, which includes ES cells, trophoblast stem (TS) cells and extraembryonic endoderm stem (XEN) cells.

The Mouse Nervous System

Author : Charles Watson
Publisher : Academic Press
ISBN 13 : 0123694973
Total Pages : 815 pages
Book Rating : 4.1/5 (236 download)

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Book Synopsis The Mouse Nervous System by : Charles Watson

Download or read book The Mouse Nervous System written by Charles Watson and published by Academic Press. This book was released on 2011-11-28 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness