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Ntp Workshop On Validation And Regulatory Acceptance Of Alternative Toxicological Test Methods
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Book Synopsis Validation and Regulatory Acceptance of Toxicological Test Methods by : DIANE Publishing Company
Download or read book Validation and Regulatory Acceptance of Toxicological Test Methods written by DIANE Publishing Company and published by DIANE Publishing. This book was released on 1998-02 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Validation and Regulatory Acceptance of Toxicological Test Methods by :
Download or read book Validation and Regulatory Acceptance of Toxicological Test Methods written by and published by . This book was released on 1997 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicity Assessment Alternatives by : Harry Salem
Download or read book Toxicity Assessment Alternatives written by Harry Salem and published by Springer Science & Business Media. This book was released on 1999-07-02 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicity Assessment Alternatives: Methods, Issues, Opportunities contains a broad array of critical surveys, contributed by active and respected investigators, describing their research and offering updates on toxicity assessment alternatives, directions determined by current and future grant programs, opportunities for mechanistically based test methods to detect endocrine disruptor activity, the use of alternatives in the Department of Defense hazard assessment initiatives, and the issues and opportunities for validation and regulatory acceptance. Several of these advances make use oftransgenic models that reduce the time and cost of carcinogenicity testing. Others use tissue cultures for the assessment of endocrine disrupting chemicals. Cultures of human epidermal keratinocytes are applicable as models for sulfur mustard lesions, and in vitro protein denaturation is used as a chemical test for assessing the ocular and dermal irritation potential of cosmetic prod ucts. Molecular modeling is applied to explaining chemical toxicity. Commercially developed assay systems have undergone extensive evaluation by their manufacturers. Some of these await external valida tion, and others await acceptance by North American and European regulatory agencies. Toxicity Assessment Alternatives: Methods, Issues, Opportunities provides information from members of the scientific and regulatory communities on what has been achieved and what has been accepted in alternatives to animal testing.
Book Synopsis NTP Workshop on Validation and Regulatory Acceptance of Alternative Toxicological Test Methods by : Kenneth Olden
Download or read book NTP Workshop on Validation and Regulatory Acceptance of Alternative Toxicological Test Methods written by Kenneth Olden and published by . This book was released on 1997-02 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the NTP Workshop on Validation & Regulatory Acceptance of Alternative Toxicological Test Methods was to receive comments & recommendations from the public & invited experts on their draft report. It provided recommended criteria & processes for the validation & regulatory acceptance of new & revised toxicological testing methods. This report is a summary of the recommend. developed by the workshop participants. One of the goals of the NTP is developing & validating improved alternative toxicological test methods. The NTP Revit. Act directed NIEHS to: establish criteria for the validation & regulatory acceptance of alternative testing methods: & to recommend a process through which scientifically validated alternative methods can be accepted for regulatory use.
Download or read book Federal Register written by and published by . This book was released on 2013-11 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis NTP, Current Directions and Evolving Strategies by : National Toxicology Program (U.S.)
Download or read book NTP, Current Directions and Evolving Strategies written by National Toxicology Program (U.S.) and published by . This book was released on 2000 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Molecular Toxicology by : Claude Reiss
Download or read book Advances in Molecular Toxicology written by Claude Reiss and published by VSP. This book was released on 1998-02 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.
Book Synopsis Neurotoxicology in Vitro by : V. Pentreath
Download or read book Neurotoxicology in Vitro written by V. Pentreath and published by CRC Press. This book was released on 1999-05-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a distinguished panel of experts, students and researchers will find that this comprehensive and accessible volume provides a framework for the study of nerve cells ^in vitro^n for use in experimental neurotoxicology.
Book Synopsis Alternative Toxicological Methods by : Harry Salem
Download or read book Alternative Toxicological Methods written by Harry Salem and published by CRC Press. This book was released on 2003-03-26 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Book Synopsis Annual Plan for Fiscal Year ... by : National Toxicology Program (U.S.)
Download or read book Annual Plan for Fiscal Year ... written by National Toxicology Program (U.S.) and published by . This book was released on 1990 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Animal Welfare Information Center Newsletter by :
Download or read book Animal Welfare Information Center Newsletter written by and published by . This book was released on 1997 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1998 by :
Download or read book Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1998 written by and published by . This book was released on 1997 with total page 1626 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The History of Alternative Test Methods in Toxicology by :
Download or read book The History of Alternative Test Methods in Toxicology written by and published by Academic Press. This book was released on 2018-10-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.
Author :United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies Publisher : ISBN 13 : Total Pages :1556 pages Book Rating :4.0/5 (18 download)
Book Synopsis Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1999 by : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Download or read book Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 1999 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 1998 with total page 1556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies Publisher : ISBN 13 : Total Pages :712 pages Book Rating :4.:/5 (51 download)
Book Synopsis Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations for Fiscal Year 1998 by : United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies
Download or read book Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations for Fiscal Year 1998 written by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 1998 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Reducing, Refining and Replacing the Use of Animals in Toxicity Testing by : Dave Allen
Download or read book Reducing, Refining and Replacing the Use of Animals in Toxicity Testing written by Dave Allen and published by Royal Society of Chemistry. This book was released on 2013-10-31 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
Book Synopsis Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) by :
Download or read book Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) written by and published by . This book was released on 1998 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
