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Novel Insights Into The Immune Mechanisms Associated With The Pathogenesis Of Chagas Disease
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Book Synopsis Novel Insights Into the Immune Mechanisms Associated With the Pathogenesis of Chagas Disease by : Giovane R. Sousa
Download or read book Novel Insights Into the Immune Mechanisms Associated With the Pathogenesis of Chagas Disease written by Giovane R. Sousa and published by Frontiers Media SA. This book was released on 2022-06-16 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Insights Into the Pathophysiology of Chagas' Cardiomyopathy by : Philipp Stahl
Download or read book Novel Insights Into the Pathophysiology of Chagas' Cardiomyopathy written by Philipp Stahl and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The protozoan hemoflagellate Trypanosoma cruzi (T. cruzi) is the etiologic agent of the zoonotic Chagas' disease that affects approximately six to seven million people in Central and South America, causing dilated cardiomyopathy and megavisceral disease. Although Chagas' disease is the leading cause of heart failure in Latin America among people living in poverty and places an immense socioeconomic burden on society, it is still currently classified as a neglected tropical disease (NTD). The disease is typically transmitted by reduviid bugs or orally by contaminated food, while the transmission of parasitic organisms by other routes such as blood transfusion, organ transplantation, and transplacental infection is relatively rare. Given the wide cellular tropism infecting virtually all nucleated cells, the protozoan is able to persist asymptomatically for decades until ultimately causing organ-specific symptoms of chronic Chagas' disease such as chronic heart failure. The acute phase of the disease triggers an immune response that often does not restrict the dissemination of the parasite and may cause skin lesions, fever, enlarged lymph nodes, pallor, swelling, and abdominal and chest pain. Despite recent advances in our knowledge about the pathogenesis of this disease, the complex host-parasite interactions are not completely understood and, in particular, the persistence of parasites in host cells for such a long time remains largely undefined. In this book chapter, we focus on the pathophysiology of American trypanosomiasis and emphasize the role of host-specific transcription factors executing antiparasitic immune reactions.
Book Synopsis Molecular Mechanisms of Pathogenesis in Chagas' Disease by : John M. Kelly
Download or read book Molecular Mechanisms of Pathogenesis in Chagas' Disease written by John M. Kelly and published by Springer Science & Business Media. This book was released on 2003-08-31 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas' disease, which results from infection with the single cell parasite Trypanosoma cruzi, is a debilitating condition that is a major problem in many parts of Latin America. Rapid technical progress is now facilitating dissection of the molecular mechanisms of disease pathogenesis, a process that will ultimately provide new strategies to alleviate the enormous public health burden associated with the infection. In this book, international experts review the buoyant status of Chagas' disease research as we enter the "post-genome" era and speculate on how the new findings will impact on drug and vaccine development. The chapters outline how progress is being made on several fronts ranging from parasite population genetics to human immunology. Researchers, physicians and students with an interest in any aspect of molecular parasitology should find this book to be a valuable reference
Book Synopsis Chagas Disease by : María-Jesús Pinazo Delgado
Download or read book Chagas Disease written by María-Jesús Pinazo Delgado and published by Springer Nature. This book was released on 2020-07-20 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive resource on various aspects of the parasite Trypanosoma cruzi and the neglected tropical disease Chagas disease (American trypanosomiasis), the disorder resulting from infection with the parasite. Topics include the biological description and taxonomy of the parasite, epidemiology and transmission routes, laboratory techniques in use when working with the parasite, as well as diagnostic measures and treatment of Chagas disease. Furthermore, a chapter with life stories of people in contact with the disease in endemic as well as non-endemic countries is included. The book is therefore a valuable source for individuals engaged in basic research as well as patient care and health management related to American trypanosomiasis.
Book Synopsis Pathophysiology of the Heart by : Gordon Ross
Download or read book Pathophysiology of the Heart written by Gordon Ross and published by . This book was released on 1982 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Control of Innate and Adaptive Immune Responses during Infectious Diseases by : Julio Aliberti
Download or read book Control of Innate and Adaptive Immune Responses during Infectious Diseases written by Julio Aliberti and published by Springer Science & Business Media. This book was released on 2011-09-21 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatory pathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance.
Book Synopsis American Trypanosomiasis by : Jenny Telleria
Download or read book American Trypanosomiasis written by Jenny Telleria and published by Elsevier. This book was released on 2010-09-03 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: - The host: human and mammalian reservoirs - The insect vectors: domestic and sylvatic vectors - The causative parasite: Trypanosoma cruzi - Informs and updates on all the latest developments in the field - Contributions from leading authorities and industry experts
Book Synopsis Pathology of Infectious Diseases E-Book by : Gary W. Procop
Download or read book Pathology of Infectious Diseases E-Book written by Gary W. Procop and published by Elsevier Health Sciences. This book was released on 2014-07-21 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathology of Infectious Diseases, by Gary W. Procop, MD, A Volume in the Foundations in Diagnostic Pathology Series, packs all of today's most essential information on infectious disease pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify pathogenic organisms. Chapters on immunohistochemical and molecular techniques as well as artifacts and pitfalls guide you to accurate detection and identifications. Quickly find the information you need thanks to a well-organized, user-friendly format with templated headings, detailed illustrations, at-a-glance tables, and segmentation by type of infectious organism—viral, bacterial, fungal, and parasitic. Avoid common problems that can lead to an incorrect diagnosis. A special section on artifacts and pitfalls shows you what to look for. Get superb visual guidance from an abundance of full-color, high-quality photomicrographs and clinical photos. Employ the latest diagnostic advancements including immunohistochemical and molecular techniques. Learn from one of the very best. Dr. Gary W. Procop, one of the most outstanding young clinical pathologists in medical microbiology in American medicine, shares his vision about how new technologies may be used to rapidly identify pathogenic organisms and detect resistance to treatment regimens. Recognized for distinguished research contributions to the discipline of clinical microbiology, he was the recipient of the 2007 American Society for Microbiology (ASM) BD Award for Research in Clinical Microbiology and elected to the American Academy of Microbiology in recognition of his scientific achievements. Implement proven diagnostic approaches such as real-time PCR assays and pepticnucleic acid probes with guidance from the pioneer of these techniques!
Download or read book Cardiomyopathies written by Kaan Kırali and published by BoD – Books on Demand. This book was released on 2017-04-12 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiomyopathies are the most featured cardiac pathologies in the twenty-first century, that threaten public health and burden healthcare budgets. This book is composed of the main topics on pathophysiology, general forms and specific types of cardiomyopathies and it also introduces new research in the field. Specific forms with or without genetic inheritance are discussed separately to attract the readers' attention on these topics. Well-known medical follow-up strategies occur ineffective at the end-stage heart failure, however, new surgical approaches can be an alternative for these patients to get a chance at the last crossroad and to improve their life quality and survival and also to gain or prolong time until possible heart transplantation.
Book Synopsis Vectors and Vector-Borne Parasitic Diseases: Infection, Immunity, and Evolution by : Jun-Hu Chen
Download or read book Vectors and Vector-Borne Parasitic Diseases: Infection, Immunity, and Evolution written by Jun-Hu Chen and published by Frontiers Media SA. This book was released on 2021-09-28 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular and Molecular Pathobiology of Cardiovascular Disease by : Monte Willis
Download or read book Cellular and Molecular Pathobiology of Cardiovascular Disease written by Monte Willis and published by Academic Press. This book was released on 2013-12-23 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. - Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research - Gives concise explanations of key issues and background reading suggestions - Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Book Synopsis Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases by : Sanket Joshi
Download or read book Systems Biology Approaches: Prevention, Diagnosis, and Understanding Mechanisms of Complex Diseases written by Sanket Joshi and published by Springer Nature. This book was released on with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chagas disease novel drug targets and treatments by : Vilma G. Duschak
Download or read book Chagas disease novel drug targets and treatments written by Vilma G. Duschak and published by Frontiers Media SA. This book was released on 2023-06-22 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Control of Chagas Disease by : World Health Organization
Download or read book Control of Chagas Disease written by World Health Organization and published by World Health Organization. This book was released on 2002-05 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report of a WHO Expert Committee reviews current knowledge of Chagas disease and its pathogenesis discusses the causative parasite the triatomine vectors and the natural reservoirs of infection and considers the epidemiology and incidence trends of the disease. Prevention and control strategies are described as are the various formal initiatives for interruption of disease transmission. The report concludes by identifying priorities for research and offering guidance for the planning implementation and strengthening of national control programmes. ... this book makes an extremely valuable contribution toward understanding Chagas disease and promoting solid prevention and control efforts. It will no doubt be an important addition to the library of anyone student and expert alike with interests in Chagas disease. The authors are to be congratulated on the completion of a work of excellence - an extremely difficult endeavour at a time when our knowledge of vectors parasites and methodologies is expanding so rapidly. - Transactions of the Royal Society of Tropical Medicine and Hygiene
Book Synopsis Investing to Overcome the Global Impact of Neglected Tropical Diseases by : World Health Organization
Download or read book Investing to Overcome the Global Impact of Neglected Tropical Diseases written by World Health Organization and published by World Health Organization. This book was released on 2015-08-05 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The presence, or absence, of neglected tropical diseases (NTDs) can be seen as a proxy for poverty and for the success of interventions aimed at reducing poverty. Today, coverage of the public-health interventions recommended by the World Health Organization (WHO) against NTDs may be interpreted as a proxy for universal health coverage and shared prosperity - in short, a proxy for coverage against neglect. As the world's focus shifts from development to sustainable development, from poverty eradication to shared prosperity, and from disease-specific goals to universal health coverage, control of NTDs will assume an important role towards the target of achieving universal health coverage, including individual financial risk protection. Success in overcoming NTDs is a "litmus test" for universal health coverage against NTDs in endemic countries. The first WHO report on NTDs (2010) set the scene by presenting the evidence for how these interventions had produced results. The second report (2013) assessed the progress made in deploying them and detailed the obstacles to their implementation. This third report analyses for the first time the investments needed to achieve the scale up of implementation required to achieve the targets of the WHO Roadmap on NTDs and universal coverage against NTDs. INVESTING TO OVERCOME THE GLOBAL IMPACT OF NEGLECTED TROPICAL DISEASES presents an investment strategy for NTDs and analyses the specific investment case for prevention, control, elimination and eradication of 12 of the 17 NTDs. Such an analysis is justified following the adoption by the Sixty-sixth World Health Assembly in 2013 of resolution WHA6612 on neglected tropical diseases, which called for sufficient and predictable funding to achieve the Roadmap's targets and sustain control efforts. The report cautions, however, that it is wise investment and not investment alone that will yield success. The report registers progress and challenges and signals those that lie ahead. Climate change is expected to increase the spread of several vector-borne NTDs, notably dengue, transmission of which is directly influenced by temperature, rainfall, relative humidity and climate variability primarily through their effects on the vector. Investments in vector-borne diseases will avoid the potentially catastrophic expenditures associated with their control. The presence of NTDs will thereby signal an early warning system for climate-sensitive diseases. The ultimate goal is to deliver enhanced and equitable interventions to the most marginalized populations in the context of a changing public-health and investment landscape to ensure that all peoples affected by NTDs have an opportunity to lead healthier and wealthier lives."--Publisher's description.
Book Synopsis Integrated Omics Approaches to Infectious Diseases by : Saif Hameed
Download or read book Integrated Omics Approaches to Infectious Diseases written by Saif Hameed and published by Springer Nature. This book was released on 2021-07-18 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.
Book Synopsis Immunology and Evolution of Infectious Disease by : Steven A. Frank
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
