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Novel Approaches In Metronomic Chemotherapy For Breast Cancer Treatment
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Book Synopsis Novel Approaches in Metronomic Chemotherapy for Breast Cancer Treatment by : Manzoor Ahmad Mir
Download or read book Novel Approaches in Metronomic Chemotherapy for Breast Cancer Treatment written by Manzoor Ahmad Mir and published by CRC Press. This book was released on 2024-05-28 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug delivery systems and nanoformulations. The clinical pharmacology of metronomic chemotherapy, including pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions, are also examined. Key Features: Introduces metronomics therapy in the neoadjuvant and adjuvant treatment of breast cancer Explores the potential of metronomics in terms of personalized chemotherapy Present pharmacological bases of metronomic chemotherapy Covers the latest developments in drug delivery systems, nanotechnology, and nanoformulations Discusses antiangiogenic effects and the impact of metronomics on immunity This book is useful for students, researchers, oncologists, pharmacologists, and healthcare experts interested in understanding the clinical potential of metronomic chemotherapy in breast cancer.
Book Synopsis Metronomic Chemotherapy by : Guido Bocci
Download or read book Metronomic Chemotherapy written by Guido Bocci and published by Springer. This book was released on 2014-09-04 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
Book Synopsis A Review of Novel Approaches to Enhance Efficacy of Medical Treatment of by : Christopher Lee
Download or read book A Review of Novel Approaches to Enhance Efficacy of Medical Treatment of written by Christopher Lee and published by . This book was released on 2017 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this project is to review approaches to improve the medical treatment of breast cancer. This review will focus on the current literature that addresses (1) the current strategy for the sequence of adjuvant chemohormonal therapy in non-metastatic hormone receptor positive (HR+), human epidermal growth factor 2 (HER2) negative breast cancer, (2) progesterone therapy in the neoadjuvant setting, (3) high dose estrogens as salvage therapy in hormone therapy-refractory patients, (4) the concurrent use of mTOR or CDK4/6 inhibitors with hormone therapy, and (5) the use of efflux pump reversal agents in chemotherapy-refractory patients. Based on the presented evidence, discussions will focus on limitations of the current data and the role of novel therapies within the framework of current standard of care.
Book Synopsis New Approaches in the Therapy of Breast Cancer by : Robert Brent Dickson
Download or read book New Approaches in the Therapy of Breast Cancer written by Robert Brent Dickson and published by . This book was released on 1996 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Rx for Hope written by Nick Chen and published by Rowman & Littlefield. This book was released on 2018-10-16 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: In our current era of rapidly developing cancer drugs and therapies, we also see improvement of cancer treatment outcomes stagnating when it comes to determining quality of life or long-term survival. This is because while new treatments are making small incremental progress in outcomes, most cancer patients still depend on conventional methods that are both toxic and ineffective. While new cancer drugs are becoming more precise or targeted, less attention is being paid to the overall health and wellbeing of the patient, which we propose is essential for long-term cancer control and improving a patient’s quality of life. Rx for Hope, backed by rigorous science and real-life patient cases, calls for an urgent reevaluation of the current conventional approach to cancer treatments and encourages a progressive treatment model combining metronomic low-dose chemotherapy with complementary integrative medicine. Along with new, breakthrough immunotherapy drugs, these treatments can potentially create a response powerful enough to not only eradicate the presence of cancer but also to prevent it from returning. Because every 23 seconds someone in America is diagnosed with cancer, the number of people affected is growing rapidly. The American Cancer Society estimates that nearly two million new patients will need treatment in the coming year. Judging by current trends and methods of treatment, far too many of these people will be treated without the benefits of low-dose chemotherapy, and even less will enjoy the positive impact of immune-supportive complementary integrative medicine. Rx for Hope offers insight into a powerful way of treating cancer that patients and doctors can implement immediately for optimal results.
Book Synopsis Treatment of Breast Cancer: New Approaches by : Nadeem Sheikh
Download or read book Treatment of Breast Cancer: New Approaches written by Nadeem Sheikh and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of Breast Cancer: New Approaches.
Book Synopsis Novel Approaches in the Early Treatment of Breast Cancer by :
Download or read book Novel Approaches in the Early Treatment of Breast Cancer written by and published by . This book was released on 2001 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Innovative Approaches to Breast Cancer Treatment by : Jos H. Beijnen
Download or read book Innovative Approaches to Breast Cancer Treatment written by Jos H. Beijnen and published by . This book was released on 1995 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Novel Approach for Local Treatment of Early Breast Cancer by : Jayant Sharad Vaidya
Download or read book A Novel Approach for Local Treatment of Early Breast Cancer written by Jayant Sharad Vaidya and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Approaches in the Therapy of Breast Cancer by :
Download or read book New Approaches in the Therapy of Breast Cancer written by and published by . This book was released on 1996 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Innovative Approaches to Breast Cancer Treatment by :
Download or read book Innovative Approaches to Breast Cancer Treatment written by and published by . This book was released on 1995 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Low Dose Metronomic Chemotherapy as an Efficient Treatment Option in Metastatic Breast Cancer - Results of an Exploratory Case-control Study by : Slavomir Krajnak
Download or read book Low Dose Metronomic Chemotherapy as an Efficient Treatment Option in Metastatic Breast Cancer - Results of an Exploratory Case-control Study written by Slavomir Krajnak and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background:There is a growing importance of low-dose metronomic chemotherapy (LDMC) in metastatic breast cancer (MBC). In this retrospective case-control-analysis we compared the efficacy of LDMC and conventional chemotherapy in MBC.Methods:Each LDMC patient receiving oral cyclophosphamide (CTX) (50 mg daily) and methotrexate (MTX) (2.5 mg every other day) was matched with two patients who received conventional chemotherapy. Age, number of chemotherapy lines and metastatic lesions as well as hormone receptor (HR) status were considered as matching criteria. Primary endpoint was disease control rate greater than 24 weeks (DCR). Secondary endpoints were DCR in subgroups (age at begin of therapy, number of chemotherapy lines, number of different metastatic lesions and HR status), progression-free survival (PFS) and duration of response (DoR).Results:A total of 40 cases and 80 controls entered the study. 30% patients with LDMC and 23% patients with conventional chemotherapy showed DCR (p=0.380). Among younger patients DCR was 40% in LDMC vs. 25% in the control group (p=0.249). In addition, DCR was achieved in 33% vs. 26% patients with u2264 2 chemotherapy lines (p=0.568) and in 36% vs. 18% patients with u2264 2 different metastatic lesions (p=0.096), respectively. In the triple negative group 30% LDMC vs. 5% control patients showed DCR (p=0.095). The median PFS was 12.5 weeks in both groups (p=0.218). The median DoR was 31 weeks in LDMC and 21 weeks in the control group (p=0.383).Conclusion:In this retrospective case-control study we demonstrated a similar efficacy of LDMC compared to conventional chemotherapy in the treatment of MBC. Moreover, no significant differences were found in the subgroups studied. Therefore, the concept of LDMC may also be a treatment option in both younger and non-heavily pre-treated MBC patients who do not need rapid remission.
Book Synopsis Breast Cancer by : Alphonse G. Taghian
Download or read book Breast Cancer written by Alphonse G. Taghian and published by . This book was released on 2010 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies by : Manmohan Singh
Download or read book Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies written by Manmohan Singh and published by Academic Press. This book was released on 2014-12-30 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies
Book Synopsis Breast Cancer in Young Women by : Oreste Gentilini
Download or read book Breast Cancer in Young Women written by Oreste Gentilini and published by Springer Nature. This book was released on 2020-02-07 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.
Book Synopsis An Innovative Approach to Understanding and Treating Cancer: Targeting pH by : Tomas Koltai
Download or read book An Innovative Approach to Understanding and Treating Cancer: Targeting pH written by Tomas Koltai and published by Academic Press. This book was released on 2020-01-16 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs
Book Synopsis The Prime Cause of Cancer by : Otto Warburg
Download or read book The Prime Cause of Cancer written by Otto Warburg and published by EnCognitive.com. This book was released on 2015-12-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is book 2 of 5 of the “Understand Cancer” series. It is based on the best-available science. The SECONDARY causes of cancer were discussed in book one. This book continues from book one and discusses the PRIME cause of cancer as discovered by Nobel Prize Laureate Dr. Otto Warburg—considered by many as the founder of modern biochemistry. “There are prime and secondary causes of diseases. For example, the prime cause of the plague is the plague bacillus, but secondary causes of the plague are filth, rats, and the fleas that transfer the plague bacillus from rats to man. By a prime cause of a disease I mean one that is found in every case of the disease...Cancer, above all other diseases, has countless secondary causes. But, even for cancer, there is only one prime cause. Summarized in a few words, the prime cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar. All normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs in great part by fermentation. All normal body cells are thus obligate aerobes, whereas all cancer cells are partial anaerobes. From the standpoint of the physics and chemistry of life this difference between normal and cancer cells is so great that one can scarcely picture a greater difference. Oxygen gas, the donor of energy in plants and animals is dethroned in the cancer cells and replaced by an energy yielding reaction of the lowest living forms, namely, a fermentation of glucose.” —Dr. Otto Warburg
