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Noncoordinate Regulation Of The Human And Murine Major Histocompatibility Complex Class Ii Genes
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Book Synopsis Noncoordinate Regulation of the Human and Murine Major Histocompatibility Complex Class II Genes by : John Douhan
Download or read book Noncoordinate Regulation of the Human and Murine Major Histocompatibility Complex Class II Genes written by John Douhan and published by . This book was released on 1996 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Negative Regulation in the Murine Major Histocompatibility Complex Class II Genes by : Jeffrey A. Brockman
Download or read book The Role of Negative Regulation in the Murine Major Histocompatibility Complex Class II Genes written by Jeffrey A. Brockman and published by . This book was released on 1994 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transgenic Mice and Mutants in MHC Research by : Igor K. Egorov
Download or read book Transgenic Mice and Mutants in MHC Research written by Igor K. Egorov and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains papers presented at the international conference on "Transgenic Mice and Mutants in MHC Research", held in Bar Harbor, Maine, in June, 1989. The meeting brought together eighty researchers working in the field. While mouse H-2 mutants have been known for many years their studies continue to contribute a great deal to our understanding of structure/function relationships and evolution of MHC molecules. Recently a new direction of research has emerged on regulation, expression and function of MHC genes using transgenic animals carrying exogenous MHC genes from the same or other species or engineered MHC genes. With the introduction of transgenic mice more specific questions about the various functions of MHC genes can be answered as, for example, the role of soluble and membrane-bound MHC molecules in self tolerance and elimination of specific T cell clones, recognition of human MHC antigens by the mouse immune system, the role of individual human MHC genes in disease susceptibility. New approaches for evaluation of the role of MHC linked and unlinked genes in susceptibility of mice to malignant tumors and their metastases have been also reported. Our purpose has been to provide a forum for discussion of these new developments. Many questions remain to be answered but the necessary tools have become available. We thank the contributors and hope that the readers will benefit from this Pro ceedings. We wish to acknowledge the financial sponsorship for the meeting by The Pew Charitable Trust and Howard Hughes Medical Institute.
Book Synopsis Murine Major Histocompatibility Complex Class II Genes by : Michael J. Kern
Download or read book Murine Major Histocompatibility Complex Class II Genes written by Michael J. Kern and published by . This book was released on 1990 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Major Histocompatibility Complex Class II Genes and the Molecular Basis of MHC Class II Deficiency by : Walter Reith
Download or read book Regulation of Major Histocompatibility Complex Class II Genes and the Molecular Basis of MHC Class II Deficiency written by Walter Reith and published by . This book was released on 1997 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Major Histocompatibility Complex (MHC) in Health and Disease by : Jerzy K. Kulski
Download or read book Major Histocompatibility Complex (MHC) in Health and Disease written by Jerzy K. Kulski and published by MDPI. This book was released on 2020-01-15 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.
Book Synopsis Major Histocompatibility Complex by : M. Kasahara
Download or read book Major Histocompatibility Complex written by M. Kasahara and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi zation of the MHC in humans and other model vertebrates, MHC-parasite co evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen eral.
Book Synopsis Molecular Evolution of the Major Histocompatibility Complex by : Jan Klein
Download or read book Molecular Evolution of the Major Histocompatibility Complex written by Jan Klein and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: From molecules to populations and back In biology, the most vigorous organisms often ensue from a union of two disparate, pure lines. In science, too, laws of hybrid vigor seem to operate at the interface between two disciplines, an interface that often proves to be fertile ground for germinating concepts and new outlooks. The fringes of research into the major histocompatibility complex (Mhc) have provided such an interface several times in the past and the encounters have invigorated fields such as transplantation biology, cellular immunology, and immunogenetics. In the last few years, a new interface has been emerging between Mhc and evolutionary genetics, and particularly the branch of evolutionary genetics dealing with molecular evolution. Mhc research relies upon molecular evolutionary genetics, with its grand superstructure of mathematical formulations, to come to grips with the events leading to and maintaining the Mhc polymorphism. Without the armament of rigorous statistical procedures developed by evolutionary geneticists, the intricate relationships among Mhc genes cannot be resolved. It will undoubtedly be a molecular geneticist who is the final arbiter in the dispute concerning the nature of the selection pressure molding the Mhc genes. And it is doubtful whether the true function of Mhc can ever be comprehended without the vantage point afforded by the elucidation of its evolutionary history.
Book Synopsis Natural History of the Major Histocompatibility Complex by : Jan Klein
Download or read book Natural History of the Major Histocompatibility Complex written by Jan Klein and published by Wiley-Interscience. This book was released on 1986 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work is a natural history of the major histocompatibility complex written for anyone who is working on the MHC but wants to step back and review the complex in its entirety; for anyone who wants to be introduced to the MHC; or for anyone who is just curious about this much talked-about chromosomal region. By natural history is meant an all encompassing treatment of the MHC, both human and mouse, in its entire range and its details - but presented in a way that anybody can understand without consulting a variety of other sources. Most of the details are summarized in the form of tables whereas the text concentrates on generalizations and discussions. Thus, the book will be of interest to immunologists and geneticists seeking an overview of the subject and to graduate students in these disciplines. It will also be of value to technicians working in HLA-typing laboratories.
Book Synopsis Analysis of the Murine Major Histocompatibility Complex Class III Genes C4 and Factor B by : Robert Sackstein
Download or read book Analysis of the Murine Major Histocompatibility Complex Class III Genes C4 and Factor B written by Robert Sackstein and published by . This book was released on 1984 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Organization and Evolution of the Class I Genes in the Murine Major Histocompatibility Complex by : Yi Henry Sun
Download or read book Organization and Evolution of the Class I Genes in the Murine Major Histocompatibility Complex written by Yi Henry Sun and published by . This book was released on 1986 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Evidence of Genotypic Variation, MHC Class I Copy Number Variation and Recombination Within the Chicken Major Histocompatibility Complex-y System by : Renee T. Kopulos
Download or read book Evidence of Genotypic Variation, MHC Class I Copy Number Variation and Recombination Within the Chicken Major Histocompatibility Complex-y System written by Renee T. Kopulos and published by . This book was released on 2016 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The major histocompatibility complex (MHC) is a gene region found in all jawed vertebrates. These highly polymorphic, tightly linked genes are responsible for immune regulation by presenting self and non-self antigens to the immune system. The MHC is the most polymorphic vertebrate genome region because its genes face considerable selective pressure since survival depends on the capacity to respond to bacterial, viral and parasitic diseases. The MHC organization in different species has clearly evolved in separate and unique ways since the time that birds and mammals diverged from a common ancestor 310 million years ago. The size and organization of chicken MHC genes is somewhat different from the MHC regions found in mice and humans. Given the wide variability in gene numbers revealed in this study, I wanted to determine whether genetic recombination, crossing over, in the MHC-Y region might be contributing to haplotypic variation. YF molecules seem to have a high recombination frequency between its multiple copies, perhaps on the order of 1% (1 map unit) or higher. This may be due to many similar genes present within the MHC-Y region. Proximity of a 41 base pair repeat known as PO41 might also contribute to instability of the region.
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1860 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology and Pathogenicity of Mycoplasmas by : Shmuel Razin
Download or read book Molecular Biology and Pathogenicity of Mycoplasmas written by Shmuel Razin and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: was the result of the efforts of Robert Cleverdon. The rapidly developing discipline of molecular biology and the rapidly expanding knowledge of the PPLO were brought together at this meeting. In addition to the PPLO specialists, the conference invited Julius Marmur to compare PPLO DNA to DNA of other organisms; David Garfinkel, who was one of the first to develop computer models of metabolism; Cyrus Levinthal to talk about coding; and Henry Quastler to discuss information theory constraints on very small cells. The conference was an announcement of the role of PPLO in the fundamental understanding of molecular biology. Looking back 40-some years to the Connecticut meeting, it was a rather bold enterprise. The meeting was international and inter-disciplinary and began a series of important collaborations with influences resonating down to the present. If I may be allowed a personal remark, it was where I first met Shmuel Razin, who has been a leading figure in the emerging mycoplasma research and a good friend. This present volume is in some ways the fulfillment of the promise of that early meeting. It is an example of the collaborative work of scientists in building an understanding of fundamental aspects of biology.
Book Synopsis HLA and MHC by : Michael J. Browning
Download or read book HLA and MHC written by Michael J. Browning and published by Taylor & Francis. This book was released on 1996 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.
Download or read book ICRDB Cancergram written by and published by . This book was released on 1986 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:
