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Non Coding Rnas In Colorectal Cancer
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Book Synopsis Non-coding RNAs in Colorectal Cancer by : Ondrej Slaby
Download or read book Non-coding RNAs in Colorectal Cancer written by Ondrej Slaby and published by Springer. This book was released on 2016-08-29 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to provide a broad framework for obtaining an in depth understanding of the state-of-the-art knowledge on abnormalities of non-coding RNAs found to be associated with colorectal cancer pathogenesis. Readers will discover possible mechanisms underlying the substantial roles played by non-coding RNAs in molecular hallmarks of colorectal cancer. This work further provides the comprehensive overview and novel insights into using of non-coding RNAs as colorectal cancer biomarkers enabling early detection of the disease, prognostic stratification of the patients and prediction of therapeutic response. The reader is introduced to the overview of modern non-coding RNAs-based therapeutic strategies, and summary of their preclinical testing performed in colorectal cancer. The work is written for researchers who want to explore current state of the knowledge in this interesting field of molecular oncology.
Download or read book Cancer Genomics written by Hui Ling and published by Elsevier Inc. Chapters. This book was released on 2013-11-21 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of microRNA (miRNA) involvement in cancer a decade ago, and the more recent findings of long non-coding RNAs in human diseases, challenged the long-standing view that RNAs without protein-coding potential are simply “junk” transcription within the human genome. These findings evidently changed the dogma that “DNA makes RNA makes protein” by showing that RNAs themselves can be essential regulators of cellular function and play key roles in cancer development. MiRNAs are evolutionarily conserved short single-stranded transcripts of 19–24 nucleotides in length. They do not code for proteins, but change the final output of protein-coding genes by regulating their transcriptional and/or translation process. Ultraconserved genes (UCGs) are non-coding RNAs with longer length (>200bp) that are transcribed from the ultraconserved genomic region. Both miRNAs and UCGs are located within cancer-associated genomic regions (CAGRs) and can act as tumor suppressors or oncogenes. In this chapter, we present principles and concepts that have been identified over the last decade with respect to our understanding of the function of non-coding RNAs, and summarize recent findings on the role of miRNAs and UCGs in cancer development. Finally, we will conclude by discussing the translational potential of this knowledge into clinical settings such as cancer diagnosis, prognosis and treatment.
Book Synopsis The Role of non-coding RNAs in Gastrointestinal Cancers by : Kanjoormana Aryan Manu
Download or read book The Role of non-coding RNAs in Gastrointestinal Cancers written by Kanjoormana Aryan Manu and published by Frontiers Media SA. This book was released on 2024-03-08 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gastrointestinal malignancies encompass a large number of tumor types, and collectively are responsible for a significant portion of new cancer cases annually. According to the IARC database, colorectal cancer alone is responsible for approximately 10% of new cases of cancer worldwide annually. There is significant heterogeneity across the various tumor types, with different pathways and factors involved in oncogenesis, as well as varying degrees of prognosis depending on the tumor type. Non-coding RNAs (ncRNAs) contribute to a significant portion of the human transcriptome, and of particular interest are the micro-RNAs (miRNAs), long ncRNAs (lncRNAs), and circular ncRNAs (circRNAs). With the advent of next-generation sequencing and new technologies such a minimally invasive biopsy techniques, there is a growing body of evidence elucidating the role of ncRNAs in the progression of various form of gastrointestinal cancers. Furthermore, in addition to their relevance to cancer progression, these ncRNAs have important potential as biomarkers and prognostic markers for various GI cancers.
Book Synopsis Non-coding RNAs in Gastrointestinal and Gynecological Cancers: New Insights Into the Mechanisms of Cancer Therapeutic Resistance by : Peixin Dong
Download or read book Non-coding RNAs in Gastrointestinal and Gynecological Cancers: New Insights Into the Mechanisms of Cancer Therapeutic Resistance written by Peixin Dong and published by Frontiers Media SA. This book was released on 2022-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Non-coding RNAs and Cancer by : Muller Fabbri
Download or read book Non-coding RNAs and Cancer written by Muller Fabbri and published by Springer Science & Business Media. This book was released on 2013-10-28 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of microRNAs and its role as gene expression regulators in human carcinogenesis represents one of the most important scientific achievements of the last decade. More recently, other non-coding RNAs have been discovered and its implications in cancer are emerging as well, suggesting a broader than anticipated involvement of the non-coding genome in cancer. Moreover, completely new and unexpected functions for microRNAs are being revealed, leading to the identification of new anticancer molecular targets. This book represents a comprehensive guide on non-coding RNAs and cancer, spanning from its role as cancer biomarkers, to providing the most useful bioinformatic tools, to presenting some of the most relevant discoveries, which indicates how these fascinating molecules act as fine orchestrators of cancer biology.
Book Synopsis Long Non-Coding RNAs in Cancer by : Alfons Navarro
Download or read book Long Non-Coding RNAs in Cancer written by Alfons Navarro and published by Humana. This book was released on 2022-06-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.
Book Synopsis The Long and Short Non-coding RNAs in Cancer Biology by : Erwei Song
Download or read book The Long and Short Non-coding RNAs in Cancer Biology written by Erwei Song and published by Springer. This book was released on 2016-07-04 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance), the role of ncRNAs in regulating cancer signaling circuitry programs (highlighting their involvement in c-myc, p53 and NFkB signaling), a systemic summary of clinical and preclinical studies that evaluate the potential of ncRNA signatures for cancer diagnosis and prognosis and strategies to delivery short ncRNAs as therapeutic molecules for cancer treatment. This book may serve as a comprehensive resource for researchers, graduate students and oncologists in ncRNA and cancer research and help drug development by identifying ncRNA targets.
Book Synopsis Clinical Applications of Noncoding RNAs in Cancer by : Subash Gupta
Download or read book Clinical Applications of Noncoding RNAs in Cancer written by Subash Gupta and published by Academic Press. This book was released on 2022-01-19 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Applications of Noncoding RNAs in Cancer summarizes the existing strategies, advances, and future opportunities on the role of noncoding RNAs in cancer patients. Established clinicians and researchers from all around the world share their views and expertise and provide readers with invaluable knowledge on the subject. This book provides a comprehensive collection of information on the utility of noncoding RNAs in the diagnosis, prognosis, and therapy of cancer. It also discusses the evolutionary significance of noncoding RNAs and how the molecular tools such as RNA-seq, RNA-FISH, ic-SHAPE, and quantitative real-time PCR help in the detection and elucidation of the functions of noncoding RNAs. Additionally, the challenges associated with noncoding RNA approaches and future developments are discussed. It is a valuable resource for cancer researchers, oncologists, clinicians, and other biomedical field members who want to learn more about noninvasive ways to diagnose and efficiently treat diverse cancer types. Presents a beginning chapter summary to help readers understand the content thoroughly Encompasses detailed description of information from clinical studies on noncoding RNAs in cancer therapy Discusses one cancer type per chapter making the content easy to reference
Book Synopsis Cellular Quiescence by : H. Daniel Lacorazza
Download or read book Cellular Quiescence written by H. Daniel Lacorazza and published by Humana Press. This book was released on 2017-10-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.
Book Synopsis The Interplay of Genetic Variation and Regulation of Long Noncoding RNAs in Colorectal Cancer by : Amany Abdel-Motaleb
Download or read book The Interplay of Genetic Variation and Regulation of Long Noncoding RNAs in Colorectal Cancer written by Amany Abdel-Motaleb and published by . This book was released on 2018 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Background: Colorectal cancer (CRC) is the third leading cause of death worldwide comprising ~8% of cancer deaths per year. The survival rates of metastatic CRC is 13% because of the lack of successful treatment due to a lack of understanding of the scope and environment of stage IV CRC. Materials and Methods: The transcripts of five normal colon mucosa tissue samples and their matched five stage IV CRC samples were chosen and analyzed from the dataset with the GEO Accession GSE50760. The Tuxedo Suite pipeline was used to determine the differentially expressed genes (DEGs) with a fold change cut off of ≥ 0.5 and ≤ -0.5 and a p value cut off of ≤ 0.05. Using the the DEG list, PANTHER database was used for pathway enrichment. LncRNA2Target database was used to find associated long non coding RNAs (lncRNAs) of the genes of interest. The Integrated Genome Viewer (IGV) was used to visualize any mutations or variations among the genes of interest. DeepSEA was used to functionally predict any potential novel SNPs. Using literature along with the results from PANTHER, lncRNA2Target, and IGV a novel connection was deduced. Results: There were 5,303 DEGs. The Wnt pathway had the greatest portion of DEGs indicating pathway activity. Interestingly, a number of inhibitors of the Wnt pathway were also upregulated including WIF1 and SFRP4. LncRNA2Target analysis showed that HOTAIR, a lncRNA, has a number of target genes and effectively silenced all of its targets except for WIF1 and CD82 in this dataset. WIF1, CD82, and SFRP4 has increased fold change values of 5.165, 1.05, 2.121, respectively. Additionally, lncRNAs, UCA1 and CRNDE, were found to positively regulate WNT5A, WNT2 and WNT3 and were upregulated. Using the integrative genome viewer, 10 SNPs were found in WIF1, SFRP4, CD82, WNT5A, and UCA1 of which one was novel. The potentially novel SNP in CD82 was functionally predicted to create a binding site with ZBTB7A. Additionally, CDKN2A and CDKN2B were found to have decreased expression with a fold change value of -2.266. Discussion: One synonymous SNP was in WIF1 and CD82. The missense SNPs in SFRP4 and CD82 are likely causing protein dysfunction resulting in ill-inhibition of the WNT pathway and metastasis, respectively. The novel SNP was found in CD82 at the location chr11:44,619,242 in the 3' untranslated region. Functional prediction showed that this SNP may create a binding site with ZBTB7A which may be repressing CD82 function. Although most of the SNPs found were recorded to result in synonymous codons, the prevalence and frequency of these SNPs in these vital genes requires further investigation to confirm whether if these SNPs are coincidental or if they are damaging. Moreover, it is also probable that WIF1 and SFRP4 may be competing with UCA1 to exert their effects on WNT5A. CRNDE may also be competing to ultimately positively regulate WNT2 and WNT3. Together with the SNPs, HOTAIR may not be able to silence WIF1 and CD82, WIF1 and SFRP4 are ineffective in inhibiting the WNT ligands, the missense and the potentially novel SNPs in CD82 may be the cause for the lack of metastasis suppression. Finally, the downreglulation of CDKN2A and CDKN2B may be due to environmental and/or ethnic causes as shown in previous studies with Egyptian and Chinese CRC patients.
Book Synopsis Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer by : Paul Holvoet
Download or read book Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer written by Paul Holvoet and published by Springer Nature. This book was released on 2021-03-26 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives insight into the functional role of non-coding RNAs in central pathways contributing to the development of obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, myocardial infarction, cardiomyopathy, and heart failure. It also sheds light on the relationship of this cluster with cancer. Tumor cells, in contrast to cells in cardiometabolic tissues, can regulate this cluster of non-coding RNAs to escape from oxidative stress and anti-tumor immunity and maintain insulin sensitivity, facilitating cancer progression. The book presents a cluster of non-coding RNAs that may be prospectively analyzed in extensive cohort studies to determine their value in risk-predicting machine learning algorithms. In addition, it emphasizes the role of microvesicles in communication between tumor-adjacent tissue, inflammatory cells, and tumor cells, with a special focus on the role of miR-155. The book intends to promote interdisciplinary research. Due to the comprehensive background information provided in each chapter, it is suitable for researchers in academia and industry and for graduate students in biology, bioengineering, and medicine.
Download or read book Cancer Genetics written by Boris Pasche and published by Springer Science & Business Media. This book was released on 2010-06-02 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genetics is a collection of chapters covering the key recent developments in cancer genetics which have an impact on clinical care. The target audience will be physicians and scientists who need to be apprised on the most recent developments in the field.
Book Synopsis Cancer and Noncoding RNAs by : Jayprokas Chakrabarti
Download or read book Cancer and Noncoding RNAs written by Jayprokas Chakrabarti and published by Academic Press. This book was released on 2017-10-13 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer and Noncoding RNAs offers an in-depth exploration of noncoding RNAs and their role in epigenetic regulation of complex human disease, most notably cancer. In addition to examining microRNAs, this volume provides a unique evaluation of more recently profiled noncoding RNAs now implicated in carcinogenesis, including lncRNAs, piRNAs, circRNAs, and tRNAs, identifying differences in function between these noncoding RNAs and how they interact with the rest of the epigenome. A broad range of chapters from experts in the field detail epigenetic regulation of various cancer types, along with recent next generation sequencing technologies, genome-wide association studies (GWAS) and bioinformatics approaches. This book will help researchers in genomic medicine and cancer biology better understand the role of noncoding RNAs in epigenetics, aiding in the development of useful biomarkers for diagnosis, prognosis and new RNA-based disease therapies. Provides a comprehensive analysis of noncoding RNAs implicated in epigenetic regulation of gene expression and chromatin dynamics Educates researchers and graduate students by highlighting, in addition to miRNAs, a range of noncoding RNAs newly associated with carcinogenesis Applies current knowledge of noncoding RNAs and epigenomics towards developing cancer and RNA-based disease therapies Features contributions by leading experts in the field
Book Synopsis Combating cancer with natural products: Non-coding RNA and RNA modification by : Yongye Huang
Download or read book Combating cancer with natural products: Non-coding RNA and RNA modification written by Yongye Huang and published by Frontiers Media SA. This book was released on 2023-03-15 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis AGO-Driven Non-Coding RNAs by : Bibekanand Mallick
Download or read book AGO-Driven Non-Coding RNAs written by Bibekanand Mallick and published by Academic Press. This book was released on 2019-01-20 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy
Book Synopsis Long Non Coding RNA Biology by : M.R.S. Rao
Download or read book Long Non Coding RNA Biology written by M.R.S. Rao and published by Springer. This book was released on 2017-08-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.
Book Synopsis From “Junk DNA” to Clinically Relevant Tools for Cancer Diagnosis, Staging, and Tailored Therapies: The Incredible Case of Non-Coding RNAs by : Marilena V. Iorio
Download or read book From “Junk DNA” to Clinically Relevant Tools for Cancer Diagnosis, Staging, and Tailored Therapies: The Incredible Case of Non-Coding RNAs written by Marilena V. Iorio and published by Frontiers Media SA. This book was released on 2019-08-22 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:
