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Non Alcoholic Steatohepatitis Nash Metabolic Contributors And Therapeutic Targets
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Book Synopsis Non-Alcoholic Steatohepatitis (NASH) – Metabolic Contributors and Therapeutic Targets by : Magdalene K. Montgomery
Download or read book Non-Alcoholic Steatohepatitis (NASH) – Metabolic Contributors and Therapeutic Targets written by Magdalene K. Montgomery and published by Frontiers Media SA. This book was released on 2022-09-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Non-Alcoholic Fatty Liver Disease Research 2016 by : Amedeo Lonardo
Download or read book Non-Alcoholic Fatty Liver Disease Research 2016 written by Amedeo Lonardo and published by MDPI. This book was released on 2018-09-19 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Non-Alcoholic Fatty Liver Disease Research 2016" that was published in IJMS
Book Synopsis Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease by : Andrew J. Krentz
Download or read book Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease written by Andrew J. Krentz and published by Springer. This book was released on 2019-04-02 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders. Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs. This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Book Synopsis Portal Hypertension by : Gerond V. Lake-Bakaar
Download or read book Portal Hypertension written by Gerond V. Lake-Bakaar and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cirrhotic liver is significantly more vulnerable to injury. This vulnerability is particularly evident after the advent of portal hypertension. In the normal liver, up to 75 percent can be resected without decompensation. By contrast, in the cirrhotic liver with portal hypertension, liver decompensation can occur even after less than 50 percent of the liver is resected. This book begins with an attempt to provide insights into this unanswered puzzle. The normal liver is soft and elastic. By contrast, the cirrhotic liver is inelastic and rigid. Flow in rigid tubes is governed by the Hagen-Poiseuille law. The law dictates that pressure gradient increases exponentially by the fourth power of the radius of the rigid sinusoid. This makes the cirrhotic liver virtually incapable of accommodating any increase in flow. The increase in pressure gradient is equivalent to the fourth power of the vessel radius. The first chapter explores the major new insight that decompensation in the cirrhotic liver is related to the loss of elasticity and the development of vessel wall rigidity, which thereafter subjects flow in the hepatic sinusoids to the Hagen-Poiseuille law. The rest of the book addresses portal hypertension in its clinical context. It invites the reader to survey multiple avenues associated with portal hypertension, including idiopathic non-cirrhotic portal hypertension, INCPH and non-alcoholic fatty liver disease, NAFLD. It also includes chapters on relationships between portal hypertension, the gastrointestinal system and the renal system. In general, the book provides several new insights into portal hypertension.
Book Synopsis GI Epidemiology by : Nicholas J. Talley
Download or read book GI Epidemiology written by Nicholas J. Talley and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative new text from the experts in GI populationstudies This book covers both key methodological issues and the mostimportant information in the field, disease by disease. It focuseson population-based information and studies looking at principlesand approaches to diagnosis and treatment of diseases. GI Epidemiology brings together world authorities inmultiple disciplines for the very first time, to create one clearand comprehensive source. The bulk of the chapters are divided intotwo parts, covering methodological issues and the epidemiology ofspecific GI diseases. Each chapter begins with a list of keypoints, followed by a review written in a clear and simplestyle. The methodologic chapters cover evidence-based medicine,meta-analysis, systematic reviews, genetic and molecularepidemiology, clinical trials, questionnaire design, and healtheconomics. The disease-specific chapters note the current gaps inknowledge and suggest areas for further study. GI Epidemiology serves as both a useful refresher and areliable reference on the methods and techniques used inepidemiological studies for consultants and researchers ingastroenterology. It is also an invaluable tool for fellows/trainees ingastroenterology, candidates for recertification in the combineddisciplines of gastroenterology, pediatric gastroenterology andcolorectal surgery, and anyone completing MPH training.
Book Synopsis Global Status Report on Alcohol and Health 2018 by : World Health Organization
Download or read book Global Status Report on Alcohol and Health 2018 written by World Health Organization and published by World Health Organization. This book was released on 2019-02-14 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The report provides an overview of alcohol consumption and harms in relation to the UN Sustainable Development Goals (Chapter 1) presents global strategies action plans and monitoring frameworks (Chapter 2) gives detailed information on: the consumption of alcohol in populations (Chapter 3); the health consequences of alcohol consumption (Chapter 4); and policy responses at national level (Chapter 5). In its final chapter 6 the imperative for reducing harmful use of alcohol in a public health perspective is presented. In addition the report contains country profiles for WHO Member States and appendices with statistical annexes a description of the data sources and methods used to produce the estimates and references.
Book Synopsis Colorectal Cancer by : Valeria Barresi
Download or read book Colorectal Cancer written by Valeria Barresi and published by . This book was released on 2022 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer is one of the most common malignancies worldwide, and the pathogenesis of this neoplasm is probably one of the most studied. The knowledge obtained over time has led to the development of screening and early diagnosis systems, allowing a significant reduction in the incidence of this neoplasm. However, what is currently known probably represents only the tip of the iceberg of the biology of this tumor. It was recently shown that the gut microbiota may contribute to colorectal cancerogenesis. In addition, several novel targeted therapies are now applied to patients with colorectal carcinoma. Nonetheless, several questions are still unanswered. Could the modulation of the gut microbiota modify the risk of tumor progression or the efficacy of therapies? Are there any predictive biomarkers of the risk of tumor progression or the efficacy of target therapies? Is metastatic colorectal cancer one or more diseases? This book collects a series of scientific articles reflecting part of the state of the art regarding colorectal cancer, seeking to answer these questions.
Download or read book Network Pharmacology written by Shao Li and published by Springer Nature. This book was released on 2021-09-29 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
Book Synopsis Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets by : Gianfranco Danilo Alpini
Download or read book Mechanisms of Chronic Liver Diseases: Identifying New Therapeutic Targets written by Gianfranco Danilo Alpini and published by Frontiers Media SA. This book was released on 2022-01-25 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug-Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Book Synopsis Dietary Interventions in Liver Disease by : Ronald Ross Watson
Download or read book Dietary Interventions in Liver Disease written by Ronald Ross Watson and published by Academic Press. This book was released on 2019-01-10 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary Interventions in Liver Disease: Foods, Nutrients, and Dietary Supplements provides valuable insights into the agents that affect metabolism and other health-related conditions in the liver. It provides nutritional treatment options for those suffering from liver disease. Information is presented on a variety of foods, including herbs, fruits, soy and olive oil, thus illustrating that variations in intake can change antioxidant and disease preventing non-nutrients that affect liver health and/or disease promotion. This book is a valuable resource for biomedical researchers who focus on identifying the causes of liver diseases and food scientists targeting health-related product development. Provides information on agents that affect metabolism and other health-related conditions in the liver Explores the impact of composition, including differences based on country of origin and processing techniques Addresses the most positive results from dietary interventions using bioactive foods to impact liver disease, including reduction of inflammation and improved function
Book Synopsis Diagnosis of Liver Disease by : Etsuko Hashimoto
Download or read book Diagnosis of Liver Disease written by Etsuko Hashimoto and published by Springer. This book was released on 2019-07-18 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book guides practitioners in the assessment of patients with a liver problem. The emphasis is on the role of macro- and microscopic pathology in elucidating pathogenesis as well as identifying confounding features of image findings that may lead to a more elaborate differential diagnosis. If appropriate, the role of light and electron microscopic examination, along with the role of specific stains and molecular techniques, is illustrated. In addition, the concept of each liver disease is summarized briefly and its up-to-data is provided, and unresolved problems in diagnosis, treatment, and pathogenesis are clearly described.The approach in this book is a practical one with a focus on the evaluation of illustrative cases, simultaneously demonstrating cross-sectional images (ultrasonography, computed tomography, magnetic resonance imaging, and angiography), pathological findings, and peritoneoscopic images. The diagnosis and therapy are summed up in helpful tables, and association of clinical manifestations with image analysis and pathological findings is shown to be important in differential diagnosis and treatment. With the authors comprising internationally renowned experts, this book will serve as a useful source of information for medical students, physicians, internists, hepatologists, gastroenterologists, radiologists, and pathologists worldwide.
Book Synopsis Liver Research and Clinical Management by : Luis Rodrigo
Download or read book Liver Research and Clinical Management written by Luis Rodrigo and published by BoD – Books on Demand. This book was released on 2018-05-02 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatology is the medical specialty that studies the normal functioning of the liver and its diseases. It has experienced a steady progress in recent decades, as well as occurred in other medical specialties. It deals with the acute and chronic inflammatory processes of the liver, among which is the viral hepatitis. Recently, very effective drugs have been introduced in this field that achieves the elimination of the hepatitis C virus in the great majority of patients. Nonalcoholic steatohepatitis has increased markedly worldwide especially in Western countries in relation to overweight, diabetes, and other metabolic conditions. Cirrhosis and its complications are better managed, and patients live longer, thanks also to the earlier detection of hepatocarcinoma and the generalization of the use of liver transplants. This book deals with all of these interesting topics, thanks to the excellent collaboration of a great group of specialists that have collaborated with their knowledge and expertise in this edition.
Book Synopsis The Mediterranean Diet by : Dr Catherine Itsiopoulos
Download or read book The Mediterranean Diet written by Dr Catherine Itsiopoulos and published by Macmillan Publishers Aus.. This book was released on 2015-07-16 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This beautifully photographed book is your complete guide to the world's most famous, effective and sustainable diet by one of Australia's leading researchers. The Mediterranean Diet is the diet on which others are based. Its positive health effects have been rigorously tested for more than 60 years, and the results are clear. The diet has been proven to prevent heart disease and diabetes, help with weight management, slow the progress of Alzheimer's and promote longevity. Dr Catherine Itsiopoulos has spent her working life researching the diet. Drawing on the food traditions of her Greek heritage, Dr Itsiopoulos provides 80 delicious recipes, eating plans and nutritional advice, as well as sharing the evidence as to why this diet is the gold standard of healthy eating. Sustainable, satisfying and suitable for the whole family, this is a diet for life, one that celebrates the pleasures of food as much as it promotes long-term good health and wellbeing.
Book Synopsis Nutrition and Liver Disease by : Pietro Vajro
Download or read book Nutrition and Liver Disease written by Pietro Vajro and published by MDPI. This book was released on 2018-06-22 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Nutrition and Liver Disease" that was published in Nutrients
Book Synopsis Liver Cirrhosis by : Georgios Tsoulfas
Download or read book Liver Cirrhosis written by Georgios Tsoulfas and published by BoD – Books on Demand. This book was released on 2017-07-05 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver cirrhosis represents one of the major challenges for most physicians and surgeons on a global scale. This book provides practicing hepatologists, gastroenterologists and liver surgeons with a valuable tool in their efforts to understand the (molecular) mechanisms involved, be updated regarding the newest and less invasive diagnostic methods, and educate themselves about the challenges involved in the management of liver cirrhosis and its complications. The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of liver cirrhosis, giving us a well-rounded overview.
Book Synopsis Advances in Non-Alcoholic Fatty Liver Disease Therapeutics: Pathogenic Mechanisms and Targets by : Ana Blas-García
Download or read book Advances in Non-Alcoholic Fatty Liver Disease Therapeutics: Pathogenic Mechanisms and Targets written by Ana Blas-García and published by Frontiers Media SA. This book was released on 2022-12-05 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
