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Download or read book New Trends in the Molecular and Biological Basis for Clinical Oncology (2009). written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tetsuhiko Tachikawa
Publisher : Springer Science & Business Media
ISBN 13 : 443188663X
Total Pages : 209 pages
Book Rating : 4.4/5 (318 download)
Download or read book New Trends in the Molecular and Biological Basis for Clinical Oncology written by Tetsuhiko Tachikawa and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Newly developed molecular target anticancer drugs have shown remarkable efficacy even in the treatment of intractable cancers such as hepatoma and renal cell carcinoma. As cancer research is becoming a multidisciplinary endeavor, close cooperation across the basic, translational, and clinical research fields holds the promise of further advances in cancer therapeutics. This book sets forth new strategies for development: cancer therapy targeting receptor tyrosine kinases with clinical utilization of new signaling regulations; interaction between cancer progression and extracellular environments such as inflammatory cytokines and the extracellular matrix; and investigation of biomarkers for personalized cancer therapy, with microarray analysis and pharmacogenomics technology. These and other findings from the latest investigations into cancer cell biology and therapeutics make this book an invaluable source for investigators in both the clinical and basic cancer research fields.
Author : Ian Tannock
Publisher :
ISBN 13 : 9780071767323
Total Pages : 575 pages
Book Rating : 4.7/5 (673 download)
Download or read book The Basic Science of Oncology written by Ian Tannock and published by . This book was released on 2013 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the science of cancer with this newly revised, essential introduction to cancer biology and genetics. Here in one well-organized, reader-friendly volume, you'll find everything you must know about the biology underlying cancer and its treatment, supported by the latest peer-reviewed research. Written by preeminent oncology researchers and clinicians, the book highlights the full range of important oncology topics and takes you through the biological basis of current and future biological therapy as well as more traditional approaches to cancer treatment. This text is thoroughly updated and refreshed to reflect the latest critical thinking in oncology. For graduate students, oncologists, residents, and fellows, there can be no more useful guide to the bedrock science and practice of oncology than this all-in-one reference.
Author : Yves Martinet
Publisher : Birkhäuser
ISBN 13 : 3034889240
Total Pages : 332 pages
Book Rating : 4.0/5 (348 download)
Download or read book Clinical and Biological Basis of Lung Cancer Prevention written by Yves Martinet and published by Birkhäuser. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book results from two recent International Association for the Study of Lung Cancer (IASLC) Workshops on lung cancer prevention. It strikes a balance between considering public health approaches to tobacco control and population-based screening, advances in clinical evaluation of chemoprevention approaches, and the biology of lung carcinogenesis. Indeed, while the science of smoking cessation is evolving as new pharmacological tools are moving into clinical evaluation, the current impact of molecular diagnostics is profound. The rapidly-evolving diagnostic technologies are revolutionizing basic scientific investigation of cancer, and this trend is expected to soon spill over into the clinical practice of medicine. The evolution of economical diagnostic platforms to allow for direct bronchial epithelial evaluation in high-risk populations promises to improve the diagnostic lead-time for this disease. The hope is that enough progress will occur to permit lung cancer detection in advance of clinical cancer so that the disease can be addressed early on, while it is still confined to the site of origin. Chemoprevention, which is designed to intervene in the early phase of carcinogenesis prior to any subjective clinical manifestation of a cancer, is also generating greater research interest. Moreover, the benefit of aerosolized administration of chemoprevention agents over conventional oral administration has strong appeal and may result in the reduction of the incidence of cancer when combined with new diagnostic technologies.
Author : Ian F. Tannock
Publisher : McGraw Hill Professional
ISBN 13 : 0071813497
Total Pages : 588 pages
Book Rating : 4.0/5 (718 download)
Download or read book Basic Science of Oncology, Fifth Edition written by Ian F. Tannock and published by McGraw Hill Professional. This book was released on 2013-09-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOW IN FULL COLOR! Discover the science of cancer--with this newly revised, essential introduction to cancer biology and genetics Here in one well-organized, reader-friendly volume, you'll find everything you must know about the biology underlying cancer and its treatment, supported by the latest peer-reviewed research. Written by preeminent oncology researchers and clinicians, the book highlights the full range of important oncology topics and takes you through the biological basis of current and future biological therapy as well as more traditional approaches to cancer treatment. Presented in full color, the Fifth Edition of The Basic Science of Oncology is thoroughly updated and refreshed to reflect the latest critical thinking in oncology. For graduate students, oncologists, residents, and fellows, there can be no more useful guide to the bedrock science and practice of oncology than this all-in-one reference. FEATURES: The most current, evidence-based oncology primer--one that encapsulates the science of cancer causation, cancer biology, and cancer therapy Key insights into molecular and genetic aspects of cancer familiarize you with cancer biology as applied to prognosis and personalized cancer medicine In-depth focus on the discovery, evaluation, and biology of anti-cancer drugs, immunotherapy, and molecularly-targeted agents Up-to-date coverage of the basic science of radiation therapy Specific chapters/sections on intratumor heterogeneity as it relates to potential new treatment strategies--including tumor microenvironment and metabolism, tumor stem cells, and genomic/proteomic heterogeneity NEW! Chapter Essentials synthesize chapter content in a convenient list NEW! Color diagrams and schematics summarize important data
Author : Miguel H. Bronchud
Publisher : Springer Science & Business Media
ISBN 13 : 1592592228
Total Pages : 477 pages
Book Rating : 4.5/5 (925 download)
Download or read book Principles of Molecular Oncology written by Miguel H. Bronchud and published by Springer Science & Business Media. This book was released on 2000-02-14 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
Author : G. M. Rubanyi
Publisher : Springer Science & Business Media
ISBN 13 : 9783540004134
Total Pages : 276 pages
Book Rating : 4.0/5 (41 download)
Download or read book Human Gene Therapy: Current Opportunities and Future Trends written by G. M. Rubanyi and published by Springer Science & Business Media. This book was released on 2003-07-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.
Author : Rolf Neth
Publisher : Springer
ISBN 13 : 9783540543602
Total Pages : 0 pages
Book Rating : 4.5/5 (436 download)
Download or read book Modern Trends in Human Leukemia IX written by Rolf Neth and published by Springer. This book was released on 1992-10-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Author : Trevor McMillan
Publisher : Springer
ISBN 13 : 9780412712708
Total Pages : 353 pages
Book Rating : 4.7/5 (127 download)
Download or read book Molecular Biology for Oncologists written by Trevor McMillan and published by Springer. This book was released on 1996-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pathophysiology, cell proliferation kinetics and metastasis of cancers and their responses to the currently employed therapies are increasingly being understood in terms of their genetic control mechanisms. Parallel genetic investigations are being aggressively pursued for normal tissue systems. The resultant greatly enhanced understanding is leading to clinically useful predictors of prognosis and the beginnings of new therapeutic strategies so as to augment the differential effect on tumour and normal tissues. This includes not only manoeuvres which deploy the currently available treatment methods with greater effect, but also the intro duction into the clinic of conceptually different treatment strategies, with the potential of great positive impact. Development in the field of basic genetics of cancer biology, cell cycle control, angiogenesis, immunology, etc. have been extraordinarily rapid with exceptional importance to medicine. This area has attracted some of the keenest intellects and greatest enthusiasm in biology and medicine. To illustrate the vigour and the growth rate of the research activity in this area, note that the numbers of journal articles published with the words gene and cancer (carcinoma, sarcoma, neoplasm, tumour) in the title or abstract for 1975 was 14 and for 1995 was 14 593. This number has increased dramatically over the past two decades. The entire field of oncology (clinical and laboratory) has, likewise, been growing at a remarkable pace.
Author : Rolf Neth
Publisher :
ISBN 13 : 9783642768309
Total Pages : 476 pages
Book Rating : 4.7/5 (683 download)
Download or read book Modern Trends in Human Leukemia IX written by Rolf Neth and published by . This book was released on 1992-10-29 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Author : G M Rubanyi
Publisher : Springer
ISBN 13 : 9783662053539
Total Pages : 276 pages
Book Rating : 4.0/5 (535 download)
Download or read book Human Gene Therapy written by G M Rubanyi and published by Springer. This book was released on 2014-01-15 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sundas Fayyaz
Publisher : Springer
ISBN 13 : 9783030100742
Total Pages : 308 pages
Book Rating : 4.1/5 (7 download)
Download or read book Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs written by Sundas Fayyaz and published by Springer. This book was released on 2019-01-26 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.
Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309224187
Total Pages : 354 pages
Book Rating : 4.3/5 (92 download)
Download or read book Evolution of Translational Omics written by Institute of Medicine and published by National Academies Press. This book was released on 2012-09-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Author : John Mendelsohn
Publisher : Elsevier Health Sciences
ISBN 13 : 1437710999
Total Pages : 1948 pages
Book Rating : 4.4/5 (377 download)
Download or read book The Molecular Basis of Cancer written by John Mendelsohn and published by Elsevier Health Sciences. This book was released on 2008-04-01 with total page 1948 pages. Available in PDF, EPUB and Kindle. Book excerpt: Successfully fighting cancer starts with understanding how it begins. This thoroughly revised 3rd Edition explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of cancer. A team of leading experts thoroughly explain the molecular biologic principles that underlie the diagnostic tests and therapeutic interventions now being used in clinical trials and practice. Incorporating cutting-edge advances and the newest research, the book provides thorough descriptions of everything from molecular abnormalities in common cancers to new approaches for cancer therapy. Features sweeping updates throughout, including molecular targets for the development of anti-cancer drugs, gene therapy, and vaccines...keeping you on the cutting edge of your specialty. Offers a new, more user-friendly full-color format so the information that you need is easier to find. Presents abundant figures-all redrawn in full color-illustrating major concepts for easier comprehension. Features numerous descriptions of the latest clinical strategies-helping you to understand and take advantage of today’s state-of-the-art biotechnology advances.
Author : Charles Swanton
Publisher : Perspectives Cshl
ISBN 13 : 9781621821434
Total Pages : 350 pages
Book Rating : 4.8/5 (214 download)
Download or read book Cancer Evolution written by Charles Swanton and published by Perspectives Cshl. This book was released on 2017 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
Author :
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.3/5 (243 download)
Download or read book Highlights of Progress in Research on Cancer written by and published by . This book was released on 1957 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : George Klein
Publisher :
ISBN 13 :
Total Pages : 874 pages
Book Rating : 4.3/5 (91 download)
Download or read book Viral Oncology written by George Klein and published by . This book was released on 1980 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
