The Renin-Angiotensin System and the Kidney

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Publisher : Biota Publishing
ISBN 13 : 1615046755
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Renin-Angiotensin System and the Kidney by : Xiao C. Li

Download or read book The Renin-Angiotensin System and the Kidney written by Xiao C. Li and published by Biota Publishing. This book was released on 2015-03-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) is one of the most important endocrine (tissue-to-tissue), paracrine (cell-to-cell) and intracrine (intracellular/nuclear) humoral systems in the regulation of blood pressure, cardiovascular, and kidney function in health and disease. The RAS has remarkably evolved from the initial discovery of the rate-limiting enzyme renin to a complex biochemical and physiological cascade involving more than a dozen members. Currently, there are up to five axes or pathways identified in the RAS; each has its substrate, enzyme, effector peptide, receptor, and downstream signaling pathways. These include the renin/ACE/ANG II/AT1 receptor, the APA/ANG III/AT2 receptor, the ACE2/ANG (1-7)/Mas receptor, the prorenin/prorenin receptor (PRR), and the ANG IV/AT4 receptor (IRAP) pathways. Accordingly, the roles of the RAS have expanded well beyond the classic endocrine paradigm as a powerful vasoconstrictor, a potent aldosterone stimulator, or a sodium-retaining hormonal system. The goals of this article are to review and discuss the current insights into and new perspectives on the expression, localization, and novel actions of the RAS with a focus in the kidney. Special emphasis will be placed on recently discovered new members of the RAS derived from studies using innovative mutant rats or mice that either overexpress (knockin) or are deficient (knockout) of a particular substrate, enzyme, ANG peptide, or receptor. This new knowledge will help improve our understanding how each of these pathways act directly or indirectly to regulate blood pressure, cardiovascular and kidney function in physiology, and can be targeted to treat hypertension, cardiovascular and renal diseases.

New Insights on Renin-Angiotensin System in the Kidney

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Publisher : S. Karger AG (Switzerland)
ISBN 13 : 9783805553780
Total Pages : 76 pages
Book Rating : 4.5/5 (537 download)

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Book Synopsis New Insights on Renin-Angiotensin System in the Kidney by : Norimoto Yanagawa

Download or read book New Insights on Renin-Angiotensin System in the Kidney written by Norimoto Yanagawa and published by S. Karger AG (Switzerland). This book was released on 1991-01-01 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Insights on the Renin-angiotensin System in the Kidney

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Author :
Publisher :
ISBN 13 : 9783318056815
Total Pages : 216 pages
Book Rating : 4.0/5 (568 download)

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Book Synopsis New Insights on the Renin-angiotensin System in the Kidney by :

Download or read book New Insights on the Renin-angiotensin System in the Kidney written by and published by . This book was released on 1991 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Local Cardiac Renin-Angiotensin Aldosterone System

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Publisher : Springer Science & Business Media
ISBN 13 : 1441905286
Total Pages : 187 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis The Local Cardiac Renin-Angiotensin Aldosterone System by : Edward D. Frohlich

Download or read book The Local Cardiac Renin-Angiotensin Aldosterone System written by Edward D. Frohlich and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until recently, the renin-angiotensin-aldosterone system has been considered a systemic endocrine hormonal system exclusively. It is now known that each component of the renin-angiotensin system is produced, synthesized and indeed, present in many organisms including the heart and vessels. This volume presents the most recent clinical and laboratory experiences of the leading physicians and investigators in the field of the local cardiac renin-angiotensin aldosterone system. Cardiovascular, renal and hypertension oriented physicians, investigators and scientists would find this book of interest. Edward D. Frohlich, M.D., M.A.C.P, F.A.C.C., is the Alton Ochsner Distinguished Scientist at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Professor of Medicine and of Physiology at Louisiana State University School of Medicine, New Orleans, and Clinical Professor of Medicine and Adjunct Professor of Pharmacology at Tulane University School of Medicine, New Orleans. He is past Editor-in-Chief of the American Heart Association journal HYPERTENSION. Richard N. Re, M.D., is the Section Head, Hypertension at the Ochsner Clinic Foundation in New Orleans, Louisiana. He is also Ochsner's Scientific Director of Research.

New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases

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Author :
Publisher : Bentham Science Publishers
ISBN 13 : 1681083132
Total Pages : 387 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases by : Dulce Elena Casarini

Download or read book New Aspects of the Renin Angiotensin System in Cardiovascular and Renal Diseases written by Dulce Elena Casarini and published by Bentham Science Publishers. This book was released on 2016-11-03 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic drugs. This monograph is a compilation of updated reviews on the RAS. The monograph covers describes the components of the system to explaining its physiological and clinical features in the cardiovascular system and the kidneys. This is followed by sections explaining the biochemistry of the RAS system in cardiovascular and renal disease and the pharmacology of relevant therapeutic drugs. Additional information on the effect of exercise states and methods to quantify angiotensins for molecular diagnosis is also presented in the concluding sections. Information in the monograph will be of interest to physiologists and endocrinologists involved in medical studies or clinical practice. Readers will be able to understand the RAS with a holistic frame of reference.

Renin Angiotensin System and the Heart

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Publisher : John Wiley & Sons
ISBN 13 : 0470862947
Total Pages : 256 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Renin Angiotensin System and the Heart by : Walmor C. De Mello

Download or read book Renin Angiotensin System and the Heart written by Walmor C. De Mello and published by John Wiley & Sons. This book was released on 2005-10-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function. It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone. Contains the most recent findings on the renin angiotensin system and the heart Written by an international team of distinguished scientists Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research

Selected Chapters from the Renin-Angiotensin System

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789854210
Total Pages : 179 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Selected Chapters from the Renin-Angiotensin System by : Aleksandar Kibel

Download or read book Selected Chapters from the Renin-Angiotensin System written by Aleksandar Kibel and published by BoD – Books on Demand. This book was released on 2020-08-19 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Selected Chapters from the Renin-Angiotensin System aims to provide a comprehensive overview of the most important physiological and pathophysiological roles of the renin-angiotensin system (RAS). The complex and convoluted RAS has been investigated for many years and, through rigorous scientific research, many important and previously unknown components and functions of the RAS have come to light. These discoveries have been crucial in the understanding of this system and provide a basis for effective modulation of the system as part of therapeutic strategies for a number of widespread disorders. New studies are continuing to elucidate the RAS and the mechanisms associated with its functions. This book discusses relevant scientific knowledge about the RAS and intends to introduce the reader to cutting-edge research with an accentuation on the mechanisms at the functional/physiological and molecular/cellular levels.

The Protective Arm of the Renin Angiotensin System (RAS)

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Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 312 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Protective Arm of the Renin Angiotensin System (RAS) by : Thomas Unger

Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

The More Complex Renin Angiotensin System

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Publisher :
ISBN 13 : 9783835956407
Total Pages : 139 pages
Book Rating : 4.9/5 (564 download)

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Book Synopsis The More Complex Renin Angiotensin System by : Florian Gembardt

Download or read book The More Complex Renin Angiotensin System written by Florian Gembardt and published by . This book was released on 2011 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Renin-Angiotensin System

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Publisher : Springer Science & Business Media
ISBN 13 : 3642611648
Total Pages : 251 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis The Renin-Angiotensin System by : Hideshi Kobayashi

Download or read book The Renin-Angiotensin System written by Hideshi Kobayashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system and the mechanisms regulating this system developed during the adaptive evolution of verte brates, along with many other systems involved in the in tegrated survival of the organism. Because animal species have evolved from common ancestral populations, a basis for the comparison of body structures and physiological processes ex ists among animal groups belonging to different classifications. The comparative approach provides a better understanding of the structure and function of adaptive systems and facilitates the development of general principles governing these systems among animal groups; further, this approach reveals significant characteristics specific to certain animal groups. As the evolu tion of adaptation of animals to environmental conditions is explored, directions for future research are suggested. In this book, advances in research on the renin-angiotensin system are described with emphasis on the comparative aspects. However, since studies on the renin-angiotensin system of birds, reptiles, amphibians and fishes are limited compared with those con ducted in mammals, in some chapters descriptions are con cerned primarily with mammals. It has taken a long time to write this volume, and the topic is a broad one, with new data always emerging; therefore, certain aspects, and sometimes the most recent information, may not be included. Chapters 1-3 and sections 8. 1-8. 4,8. 6, 8. 7 were written by H. K. ; Chapters 4-7 and Section 8. 5 by Y. T. ; Chapter 9 was written by both authors. H. Uemura, M. Nozaki, Y. Okawara, We are indebted to Drs.

Textbook of Nephro-Endocrinology

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Publisher : Academic Press
ISBN 13 : 0080920462
Total Pages : 534 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Textbook of Nephro-Endocrinology by : Ajay K. Singh

Download or read book Textbook of Nephro-Endocrinology written by Ajay K. Singh and published by Academic Press. This book was released on 2009-01-12 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Textbook of Nephro-Endocrinology is the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert, gold-standard analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and, hypoparathyroidism. Investigates both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems Presents a uniquely comprehensive and cross-disciplinary look at all aspects of nephro-endocrine disorders in one reference work Clear translational presentations by the top endocrinologists and nephrologists in each specific hormone or functional/systems field

The Renin-angiotensin System and Progression of Renal Diseases

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805572751
Total Pages : 278 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis The Renin-angiotensin System and Progression of Renal Diseases by : Gunter Wolf

Download or read book The Renin-angiotensin System and Progression of Renal Diseases written by Gunter Wolf and published by Karger Medical and Scientific Publishers. This book was released on 2001-01-01 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin-angiotensin system (RAS) has long been seen as a systemic endocrine system in which angiotensin II (ANG II) is solely involved in blood pressure regulation and the mediation of aldosterone release. However, it is now known that specific organ systems exhibit their own local RAS, functioning for the most part independently from their systemic counterpart. A deluge of data from the last decade has shown that ANG II displays many more functions than just regulating blood pressure: ANG II is a growth factor, exhibits profibrogenic actions, and even serves as a proinflammatory cytokine. It is now clear that this peptide plays a pivotal role in the progression of chronic kidney disease towards endstage renal failure. Clinical studies have provided compelling evidence that interference with ANG II slows this deterioration of renal function.This publication presents the first comprehensive summary of this important topic: Basic concepts as well as clinical aspects of the RAS are reviewed by international experts who made many of the key discoveries that constitute our contemporary understanding of ANG II as a central factor in the progression of renal disease. This publication should be read by physicians treating patients with chronic renal diseases (internists, nephrologists and urologists). Moreover, basic scientists such as renal physiologists, renal pathologists and biochemists who want a comprehensive overview of the subject will profit from reading this book.

The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases

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Publisher : Springer Nature
ISBN 13 : 3031236211
Total Pages : 499 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases by : Sukhwinder K. Bhullar

Download or read book The Renin Angiotensin System in Cancer, Lung, Liver and Infectious Diseases written by Sukhwinder K. Bhullar and published by Springer Nature. This book was released on 2023-03-14 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book of the series on “Advances in Biochemistry in Health and Disease” includes state-of-the-art information on the status of renin-angiotensin system (RAS) in the form of 24 chapters. This book has been organized into three sections: (i) General Implications of RAS in human health and Infectious Diseases, (ii) Lung, Liver and Kidney Diseases, and (iii) Development of Cancer. Each chapter has discussed comprehensive knowledge regarding the molecular and cellular aspects of the role of RAS in the pathophysiology and pharmacotherapy of different disease processes. Biochemical mechanisms associated with angiotensin II type 1 and type II receptors, and angiotensin (1-7) MAS receptors for the occurrence of both harmful and beneficial effects of prolonged activation of RAS in different diseases have been outlined. It is noteworthy to point out that different chapter in this book were prepared by recognized global expertise in the area of inflammation, oxidative stress and signal transduction pathways to highlight the role of RAS in different diseases. It is our sincere hope that this book will be of great interest to both biomedical investigators and health professionals as well as graduate students and postdoctoral fellows all over the world.

Special Issue "Renin Angiotensin Aldosterone System and Hypertension - New Insights"

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Publisher :
ISBN 13 :
Total Pages : 125 pages
Book Rating : 4.:/5 (314 download)

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Book Synopsis Special Issue "Renin Angiotensin Aldosterone System and Hypertension - New Insights" by : Detlev Ganten

Download or read book Special Issue "Renin Angiotensin Aldosterone System and Hypertension - New Insights" written by Detlev Ganten and published by . This book was released on 2008 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hypertension: New Insights for the Healthcare Professional: 2012 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464969922
Total Pages : 440 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Hypertension: New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Hypertension: New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hypertension. The editors have built Hypertension: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hypertension in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hypertension: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Angiotensin

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Publisher :
ISBN 13 : 9781621007739
Total Pages : 0 pages
Book Rating : 4.0/5 (77 download)

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Book Synopsis Angiotensin by : Sota Harada

Download or read book Angiotensin written by Sota Harada and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The renin angiotensin system (RAS) maintains the cardiovascular homeostasis and is involved in the pathogenesis of several disorders related to heart and kidney. There are several peptides under RAS in which angiotensin (Ang) II is the major contributor. In this book, the authors present topical research on angiotensin. Some of the topics discussed include the influence of renin-angiotensin-aldosteron system genes on hypertrophy development in hypertrophic caradiomyopathy; cardiac renin angiotensin system and exercise training; the role of the counter-regulatory renin angiotensin system in the heart and new roles for the neuropeptide angiotensin II.

The Renin Angiotensin System and Kidney Function

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Publisher :
ISBN 13 :
Total Pages : 64 pages
Book Rating : 4.U/5 (183 download)

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Book Synopsis The Renin Angiotensin System and Kidney Function by : Paul P. Leyssac

Download or read book The Renin Angiotensin System and Kidney Function written by Paul P. Leyssac and published by . This book was released on 1976 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: