Antibiotic Discovery and Development

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Publisher : Springer Science & Business Media
ISBN 13 : 1461414008
Total Pages : 1119 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Antibiotic Discovery and Development by : Thomas J. Dougherty

Download or read book Antibiotic Discovery and Development written by Thomas J. Dougherty and published by Springer Science & Business Media. This book was released on 2011-12-18 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of the antibiotic discovery and development process through Phase II/III. The contributors, a group of highly experienced individuals in both academics and industry, include chapters on the need for new antibiotic compounds, strategies for screening for new antibiotics, sources of novel synthetic and natural antibiotics, discovery phases of lead development and optimization, and candidate compound nominations into development. Beyond discovery , the handbook will cover all of the studies to prepare for IND submission: Phase I (safety and dose ranging), progression to Phase II (efficacy), and Phase III (capturing desired initial indications). This book walks the reader through all aspects of the process, which has never been done before in a single reference. With the rise of antibiotic resistance and the increasing view that a crisis may be looming in infectious diseases, there are strong signs of renewed emphasis in antibiotic research. The purpose of the handbook is to offer a detailed overview of all aspects of the problem posed by antibiotic discovery and development.

Mechanisms of antibiotic resistance

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889195260
Total Pages : 226 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Mechanisms of antibiotic resistance by : Jun Lin

Download or read book Mechanisms of antibiotic resistance written by Jun Lin and published by Frontiers Media SA. This book was released on 2015-06-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.

Nisin and Novel Lantibiotics

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Publisher : Springer Science & Business Media
ISBN 13 : 9789072199119
Total Pages : 518 pages
Book Rating : 4.1/5 (991 download)

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Book Synopsis Nisin and Novel Lantibiotics by : G. Jung

Download or read book Nisin and Novel Lantibiotics written by G. Jung and published by Springer Science & Business Media. This book was released on 1991-12-31 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the First International Workshop on Lantibiotics, April 15-18, 1991, Physikzentrum Bad Honnef, F.R.G.

New Insights Into the Transmission Dynamics and Control of Antimicrobial Resistance to Last-resort Antibiotics

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Publisher : Frontiers Media SA
ISBN 13 : 2889748839
Total Pages : 200 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis New Insights Into the Transmission Dynamics and Control of Antimicrobial Resistance to Last-resort Antibiotics by : Zhi Ruan

Download or read book New Insights Into the Transmission Dynamics and Control of Antimicrobial Resistance to Last-resort Antibiotics written by Zhi Ruan and published by Frontiers Media SA. This book was released on 2022-08-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2012 Edition

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Publisher : ScholarlyEditions
ISBN 13 : 1464972265
Total Pages : 109 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2012 Edition by :

Download or read book Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-10 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Methicillin-Resistant Staphylococcus aureus (MRSA). The editors have built Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Methicillin-Resistant Staphylococcus aureus (MRSA) in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Treating Infectious Diseases in a Microbial World

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Publisher : National Academies Press
ISBN 13 : 0309180686
Total Pages : 102 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Bacterial Pathogenesis

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Author :
Publisher : Academic Press
ISBN 13 : 0080860567
Total Pages : 643 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Bacterial Pathogenesis by :

Download or read book Bacterial Pathogenesis written by and published by Academic Press. This book was released on 1998-07-01 with total page 643 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established almost 30 years ago, Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Now totally revamped, revitalized, with a new format and expanded scope, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research. - Focuses on the methods most useful for the microbiologist interested in the way in which bacteria cause disease - Includes section devoted to 'Approaches to characterising pathogenic mechanisms' by Stanley Falkow - Covers safety aspects, detection, identification and speciation - Includes techniques for the study of host interactions and reactions in animals and plants - Describes biochemical and molecular genetic approaches - Essential methods for gene expression and analysis - Covers strategies and problems for disease control

Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2013 Edition

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Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481654195
Total Pages : 163 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2013 Edition by :

Download or read book Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-07-22 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Methicillin-Resistant Staphylococcus aureus (MRSA): New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

New Antibiotic Targets

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Publisher : Springer Science & Business Media
ISBN 13 : 1588299155
Total Pages : 274 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis New Antibiotic Targets by : W. Scott Champney

Download or read book New Antibiotic Targets written by W. Scott Champney and published by Springer Science & Business Media. This book was released on 2008-01-15 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.

Frontiers in Staphylococcus aureus

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Publisher : BoD – Books on Demand
ISBN 13 : 9535129813
Total Pages : 236 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Frontiers in Staphylococcus aureus by : Shymaa Enany

Download or read book Frontiers in Staphylococcus aureus written by Shymaa Enany and published by BoD – Books on Demand. This book was released on 2017-03-08 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Staphylococcus was first recognized as a human pathogen in 1880 and was named for its grape cluster-like appearance. In 1884, Staphylococcus aureus was identified and named for its vibrant golden color, which was later found to be the result of golden toxin production. Here, experts examine in-depth patterns of S. aureus colonization and exposures in humans, mammals, and birds that have led to the development of various clinical diseases. The mode of transmission of S. aureus and different methods for its detection in different samples are defined. Conventional antibiotic options to treat this aggressive, multifaceted, and readily adaptable pathogen are becoming limited. Alternative, novel chemotherapeutics to target S. aureus are discussed in the pages within, including herbal medicines, bee products, and modes of delivery.

Endotoxin in Health and Disease

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Publisher : CRC Press
ISBN 13 : 1000110389
Total Pages : 968 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Endotoxin in Health and Disease by : Helmut Brade

Download or read book Endotoxin in Health and Disease written by Helmut Brade and published by CRC Press. This book was released on 2020-10-28 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a basis for further research into the interactions of hosts and pathogens, this work gathers up-to-date findings, and details basic structures, functions and immunology. It provides descriptions of a variety of experimental endotoxin neutralizing agents, as well as a guide to clinical research initiatives and the latest treatments.

New Insights on Biofilm Antimicrobial Strategies

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Publisher : MDPI
ISBN 13 : 3036512217
Total Pages : 264 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis New Insights on Biofilm Antimicrobial Strategies by : Luís Melo

Download or read book New Insights on Biofilm Antimicrobial Strategies written by Luís Melo and published by MDPI. This book was released on 2021-08-17 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few decades, the study of microbial biofilms has been gaining interest among the scientific community. These microbial communities comprise cells adhered to surfaces that are surrounded by a self-produced exopolymeric matrix that protects biofilm cells against different external stresses. Biofilms can have a negative impact on different sectors within society, namely in agriculture, food industries, and veterinary and human health. As a consequence of their metabolic state and matrix protection, biofilm cells are very difficult to tackle with antibiotics or chemical disinfectants. Due to this problem, recent advances in the development of antibiotic alternatives or complementary strategies to prevent or control biofilms have been reported. This book includes different strategies to prevent biofilm formation or to control biofilm development and includes full research articles, reviews, a communication, and a perspective.

Racing for the Surface

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Publisher : Springer Nature
ISBN 13 : 3030344754
Total Pages : 648 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Racing for the Surface by : Bingyun Li

Download or read book Racing for the Surface written by Bingyun Li and published by Springer Nature. This book was released on 2020-03-02 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest research in biofilm, infection, and antimicrobial strategies in reducing and treating musculoskeletal, skin, transfusion, implant-related infections, etc. Topics covered include biofilms, small colony variants, antimicrobial biomaterials (antibiotics, antimicrobial peptides, hydrogels, bioinspired interfaces, immunotherapeutic approaches, and more), antimicrobial coatings, engineering and 3D printing, antimicrobial delivery vehicles, and perspectives on clinical impacts. Antibiotic resistance, which shifts the race toward bacteria, and strategies to reduce antibiotic resistance, are also briefly touched on. Combined with its companion volume, Racing for the Surface: Pathogenesis of Implant Infection and Advanced Antimicrobial Strategies, this book bridges the gaps between infection and tissue engineering, and is an ideal book for academic researchers, clinicians, industrial engineers and scientists, governmental representatives in national laboratories, and advanced undergraduate students and post-doctoral fellows who are interested in infection, microbiology, and biomaterials and devices.

Vascular Graft Infections

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Publisher : Wiley-Blackwell
ISBN 13 : 9780879935764
Total Pages : 420 pages
Book Rating : 4.9/5 (357 download)

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Book Synopsis Vascular Graft Infections by : TJ Bunt

Download or read book Vascular Graft Infections written by TJ Bunt and published by Wiley-Blackwell. This book was released on 1994-09-27 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular graft infection is a complex and challenging problem for the vascular surgeon. Despite significant advances that have been made in managing patient problems associated with graft infection during the last 25 years, the topic of vascular graft infection has been only loosely covered in various textbooks. Fortunately, this monograph fills this void of information by offering a wealth of useful, clearly organized clinical knowledge

Membrane Physiology

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Publisher : Springer Science & Business Media
ISBN 13 : 1461319439
Total Pages : 397 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Membrane Physiology by : Thomas E. Andreoli

Download or read book Membrane Physiology written by Thomas E. Andreoli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Physiology (Second Edition) is a soft-cover book containing portions of Physiology of Membrane Disorders (Second Edition). The parent volume contains six major sections. This text encompasses the first three sections: The Nature of Biological Membranes, Methods for Studying Membranes, and General Problems in Membrane Biology. We hope that this smaller volume will be helpful to individuals interested in general physiology and the methods for studying general physiology. THOMAS E. ANDREOLI JOSEPH F. HOFFMAN DARRELL D. FANESTIL STANLEY G. SCHULTZ vii Preface to the Second Edition The second edition of Physiology of Membrane Disorders represents an extensive revision and a considerable expansion of the first edition. Yet the purpose of the second edition is identical to that of its predecessor, namely, to provide a rational analysis of membrane transport processes in individual membranes, cells, tissues, and organs, which in tum serves as a frame of reference for rationalizing disorders in which derangements of membrane transport processes playa cardinal role in the clinical expression of disease. As in the first edition, this book is divided into a number of individual, but closely related, sections. Part V represents a new section where the problem of transport across epithelia is treated in some detail. Finally, Part VI, which analyzes clinical derangements, has been enlarged appreciably.

New edge of antibiotic development: antimicrobial peptides and corresponding resistance

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Author :
Publisher : Frontiers E-books
ISBN 13 : 2889193012
Total Pages : 145 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis New edge of antibiotic development: antimicrobial peptides and corresponding resistance by : Octavio L. Franco

Download or read book New edge of antibiotic development: antimicrobial peptides and corresponding resistance written by Octavio L. Franco and published by Frontiers E-books. This book was released on 2014-09-26 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antimicrobial peptides, commonly isolated from several organisms, have been considered part of innate immune system and also as potential antimicrobial drugs. Besides its antimicrobial activity, some AMPs also have antifungal activity, inmmunomodulatory and antitumural activities. Lately not only nature has become a source of AMPs. Besides isolation of natural organisms, antimicrobial peptides might be improved or created using computational tools. This opens even more this so amazing field by creating infinite novel and remarkable possibilities. Overall the current issue highlights the relevance of such Research Topic with perspectives to develop entirely new molecules with vast application within health and agricultural field with higher affinity for its target with concomitant reduction of side effects.

Insights Into New Strategies to Combat Biofilms

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889716171
Total Pages : 369 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Insights Into New Strategies to Combat Biofilms by : Sujogya Kumar Panda

Download or read book Insights Into New Strategies to Combat Biofilms written by Sujogya Kumar Panda and published by Frontiers Media SA. This book was released on 2021-11-09 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: