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New Insights In The Landscape Of Rare Tumors Translational And Clinical Research Perspective
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Book Synopsis New Insights in the Landscape of Rare Tumors: Translational and Clinical Research Perspective by : Toni Ibrahim
Download or read book New Insights in the Landscape of Rare Tumors: Translational and Clinical Research Perspective written by Toni Ibrahim and published by Frontiers Media SA. This book was released on 2020-12-22 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: TI has received honoraria from Eisai as a consultant and grants or funding to his institution from Novartis. TI participated in congress for which travel and accommodations were paid by Ipsen, Pharmamar, and Novartis.
Book Synopsis Neuro-Oncology E-Book by : Jeremy Rees
Download or read book Neuro-Oncology E-Book written by Jeremy Rees and published by Elsevier Health Sciences. This book was released on 2010-05-12 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuro-Oncology—a new title in the Blue Books of Practical Neurology series—is a concise and clinically applicable guide to this dynamic subspecialty. Jeremy Rees, PhD, MRCP and Patrick Y. Wen, MD present the most current information on the treatment and management of primary CNS tumors, secondary brain tumors, and the neurological complications of other cancers and their therapies in a format and scope appealing to both the general neurologist and the subspecialist. Access comprehensive coverage of treatment for adult and pediatric conditions—including tumors of the spinal cord as well as the brain. Find coverage of recent advances easily thanks to the emphasis on the latest clinical and laboratory findings and their implications for clinical management and treatment. Apply the possibilities and outcomes of neuro-oncologic surgery within the context of neurologic practice. Address the neurologic complications of cancer and its treatment as well as of primary and secondary tumors. Tap into the global perspectives of experts from all around the world for a multi-disciplinary approach to practice.
Book Synopsis A National Cancer Clinical Trials System for the 21st Century by : Institute of Medicine
Download or read book A National Cancer Clinical Trials System for the 21st Century written by Institute of Medicine and published by National Academies Press. This book was released on 2010-07-08 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: The National Cancer Institute's (NCI) Clinical Trials Cooperative Group Program has played a key role in developing new and improved cancer therapies. However, the program is falling short of its potential, and the IOM recommends changes that aim to transform the Cooperative Group Program into a dynamic system that efficiently responds to emerging scientific knowledge; involves broad cooperation of stakeholders; and leverages evolving technologies to provide high-quality, practice-changing research.
Download or read book Thymic Tumors written by Roger Sarrazin and published by . This book was released on 1989 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The CTSA Program at NIH by : Institute of Medicine
Download or read book The CTSA Program at NIH written by Institute of Medicine and published by National Academies Press. This book was released on 2013-10-09 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2006 the National Institutes of Health (NIH) established the Clinical and Translational Science Awards (CTSA) Program, recognizing the need for a new impetus to encourage clinical and translational research. At the time it was very difficult to translate basic and clinical research into clinical and community practice; making it difficult for individual patients and communities to receive its benefits. Since its creation the CTSA Program has expanded, with 61 sites spread across the nation's academic health centers and other institutions, hoping to provide catalysts and test beds for policies and practices that can benefit clinical and translation research organizations throughout the country. The NIH contracted with the Institute of Medicine (IOM) in 2012 to conduct a study to assess and provide recommendations on appropriateness of the CTSA Program's mission and strategic goals and whether changes were needed. The study was also address the implementation of the program by the National Center for Advancing Translational Sciences (NCATS) while exploring the CTSA's contributions in the acceleration of the development of new therapeutics. A 13-member committee was established to head this task; the committee had collective expertise in community outreach and engagement, public health and health policy, bioethics, education and training, pharmaceutical research and development, program evaluation, clinical and biomedical research, and child health research. The CTSA Program at NIH: Opportunities for Advancing Clinical and Translational Research is the result of investigations into previous program evaluations and assessments, open-session meetings and conference class, and the review of scientific literature. Overall, the committee believes that the CTSA Program is significant to the advancement of clinical and translational research through its contributions. The Program would benefit from a variety of revisions, however, to make it more efficient and effective.
Book Synopsis Rare Diseases and Orphan Products by : Institute of Medicine
Download or read book Rare Diseases and Orphan Products written by Institute of Medicine and published by National Academies Press. This book was released on 2011-04-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rare diseases collectively affect millions of Americans of all ages, but developing drugs and medical devices to prevent, diagnose, and treat these conditions is challenging. The Institute of Medicine (IOM) recommends implementing an integrated national strategy to promote rare diseases research and product development.
Book Synopsis A New Deal for Cancer by : Abbe R. Gluck
Download or read book A New Deal for Cancer written by Abbe R. Gluck and published by PublicAffairs. This book was released on 2021-11-16 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: An unprecedented constellation of experts—leading cancer doctors, policymakers, cutting-edge researchers, national advocates, and more—explore the legacy and the shortcomings from the fifty-year war on cancer and look ahead to the future. The longest war in the modern era, longer than the Cold War, has been the war on cancer. Cancer is a complex, evasive enemy, and there was no quick victory in the fight against it. But the battle has been a monumental test of medical and scientific research and fundraising acumen, as well as a moral and ethical challenge to the entire system of medicine. In A New Deal for Cancer, some of today’s leading thinkers, activists, and medical visionaries describe the many successes in the long war and the ways in which our deeper failings as a society have held us back from a more complete success. Together they present an unrivaled and nearly complete map of the battlefield across dimensions of science, government, equity, business, the patient provider experience, and more, documenting our emerging understanding of cancer’s many unique dimensions and offering bold new plans to enable the American health care system to deliver progress and hope to all patients.
Book Synopsis Pediatric Cancer Therapy by : Carl Pochedly
Download or read book Pediatric Cancer Therapy written by Carl Pochedly and published by . This book was released on 1979 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Rare Genetic Disorders by : Muhammad Umair
Download or read book Rare Genetic Disorders written by Muhammad Umair and published by Springer Nature. This book was released on with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oxford Textbook of Cancer Biology by : Francesco Pezzella
Download or read book Oxford Textbook of Cancer Biology written by Francesco Pezzella and published by Oxford University Press. This book was released on 2019-05-06 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.
Book Synopsis Oncology Clinical Trials by : William Kevin Kelly, DO
Download or read book Oncology Clinical Trials written by William Kevin Kelly, DO and published by Springer Publishing Company. This book was released on 2018-03-28 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Oncology Clinical Trials has been thoroughly revised and updated and now contains the latest designs and methods of conducting and analyzing cancer clinical trials in the era of precision medicine with biologic agents—including trials investigating the safety and efficacy of targeted therapies, immunotherapies, and combination therapies as well as novel radiation therapy modalities. Now divided into six sections this revamped book provides the necessary background and expert guidance from the principles governing oncology clinical trials to the innovative statistical design methods permeating the field; from conducting trials in a safe and effective manner, analyzing and interpreting the data, to a forward-looking assessment and discussion of regulatory issues impacting domestic, international, and global clinical trials. Considered by many as the gold standard reference on oncology clinical trials in the field, the second edition continues to provide examples of real-life flaws and real-world examples for how to successfully design, conduct and analyze quality clinical trials and interpret them. With chapters written by oncologists, researchers, biostatisticians, clinical research administrators, and industry and FDA representatives, this volume provides a comprehensive guide in the design, conduct, monitoring, analysis, and reporting of clinical trials in oncology. NEW TO THIS EDITION: Outlines how to design clinical trials with and without biomarker testing—including genomics-based “basket” trials, and adaptive trials for all phases during treatment and quality-of-life trials Includes new chapters on immunotherapy trials, radiation therapy trials, multi-arm trials, meta-analysis and adaptive design, use of genomics, dose modifications and use of ancillary treatments in investigational studies, establishing surrogate endpoints, practical issues with correlative studies, cost-effectiveness analysis, and more Comprehensively covers all regulatory aspects in the pursuit of global oncology trials Digital access to the ebook included
Book Synopsis Perspectives in Primary Prevention Research for Breast Cancer: A Focus on Gene—Environment Interactions by : Sophie A. Lelièvre
Download or read book Perspectives in Primary Prevention Research for Breast Cancer: A Focus on Gene—Environment Interactions written by Sophie A. Lelièvre and published by Frontiers Media SA. This book was released on 2021-04-16 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genomics of Rare Diseases by : Claudia Gonzaga-Jauregui
Download or read book Genomics of Rare Diseases written by Claudia Gonzaga-Jauregui and published by Academic Press. This book was released on 2021-06-12 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics of Rare Diseases: Understanding Disease Genetics Using Genomic Approaches, a new volume in the Translational and Applied Genomics series, offers readers a broad understanding of current knowledge on rare diseases through a genomics lens. This clear understanding of the latest molecular and genomic technologies used to elucidate the molecular causes of more than 5,000 genetic disorders brings readers closer to unraveling many more that remain undefined and undiscovered. The challenges associated with performing rare disease research are also discussed, as well as the opportunities that the study of these disorders provides for improving our understanding of disease architecture and pathophysiology. Leading chapter authors in the field discuss approaches such as karyotyping and genomic sequencing for the better diagnosis and treatment of conditions including recessive diseases, dominant and X-linked disorders, de novo mutations, sporadic disorders and mosaicism. Compiles applied case studies and methodologies, enabling researchers, clinicians and healthcare providers to effectively classify DNA variants associated with disease and patient phenotypes Discusses the main challenges in studying the genetics of rare diseases through genomic approaches and possible or ongoing solutions Explores opportunities for novel therapeutics Features chapter contributions from leading researchers and clinicians
Book Synopsis Advances in Breast Cancer Research by :
Download or read book Advances in Breast Cancer Research written by and published by . This book was released on 1999 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309498511 Total Pages :103 pages Book Rating :4.3/5 (94 download)
Book Synopsis The Role of NIH in Drug Development Innovation and Its Impact on Patient Access by : National Academies of Sciences, Engineering, and Medicine
Download or read book The Role of NIH in Drug Development Innovation and Its Impact on Patient Access written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-27 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.
Book Synopsis Canine lymphoma pathogenesis, diagnosis, prognosis and treatment: current and future perspectives by : Vittoria Castiglioni
Download or read book Canine lymphoma pathogenesis, diagnosis, prognosis and treatment: current and future perspectives written by Vittoria Castiglioni and published by Frontiers Media SA. This book was released on 2024-08-28 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canine lymphoma is the most common hematopoietic neoplasm in dogs, arising from monoclonal expansion of B lymphocytes, T lymphocytes, or null cells (non-B and non-T, natural killer cells - NK). It might originate in any area of the body and its most striking feature is its heterogeneity, accounting for more than 30 different subtypes. Novel entities have recently been described and characterized in canine medicine, such as diffuse small B-cell lymphoma and small cell T cell intestinal lymphoma, to list a few. Despite extensive studies, recent progression in therapeutical approaches and improved outcomes, relapse or recurrence remain a common problem with conventional therapy for intermediate/high grade lymphomas, in contrast with indolent ones that are generally characterized by a fairer outcome. In light of the aforementioned considerations, differentiation among different subtypes is essential for predicting behavior and determining adequate treatment and this still largely relies on immunophenotyping through immunohistochemistry (IHC), flow cytometry, and polymerase chain reaction (PCR) for antigen receptor rearrangements (PARR). Paralleling these techniques, molecular biomarkers MicroRNAs (miRNAs) for accurate and rapid diagnosis are developing, together with blood-based liquid biopsies detecting circulating tumor DNA. We aim to showcase new insights into canine lymphoma pathogenesis, biology, early diagnosis, prognosis, clinical-pathological features and therapeutic approaches. To do this we strongly encourage contributions from veterinary oncologists, radiologists, pathologists, immunologists and geneticists to get a comprehensive approach to this entity. The aim of this Research Topic is to provide an overview on tools currently available in pathogenesis, diagnosis, prognosis and treatment and give insights of new advances in canine lymphoma with a comparative oncology perspective. Submissions that focus on the following are highly encouraged: - Novel canine lymphoma diagnostic tools (e.g. enabling early tumor detection); - The treatment of canine lymphoma with novel therapeutic approaches exploiting immune- or targeted therapy; - The molecular and biological pathways driving tumor development and multicentric dissemination of canine lymphoma; - Novel insights on the epidemiology and risk factors of canine lymphoma; - Comparative studies on the similarities and differences between canine and lymphoma in humans or other species; - Advances in canine lymphoma staging (including evaluation of prognostic factors); - Study of paraneoplastic syndromes associated with canine lymphoma. With regards to methodological approaches, we will welcome articles that include: - Cytology and immunocytochemistry; - Histopathology and immunohistochemistry; - Clonality testing (PARR); - Flow cytometry; - Molecular landscape and gene analysis; - Animal model characterization; - Biomarker discovery and validation; - Diagnostic imaging; - Surgical approaches. Vittoria Castiglioni is an employee for IDEXX Laboratories (Germany) and Sabina Soldati is an Associate in Pathology Experts GmbH.
Book Synopsis WHO List of Priority Medical Devices for Cancer Management by : World Health Organization
Download or read book WHO List of Priority Medical Devices for Cancer Management written by World Health Organization and published by . This book was released on 2017-05-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the model list and clearing house of appropriate, basic, and priority medical devices based on the list of clinical interventions selected from clinical guidelines on prevention, screening, diagnosis, treatment, palliative care, monitoring, and end of life care. This publication addresses medical devices that can be used for the management of cancer and specifically describes medical devices for six types of cancer: breast, cervical, colorectal, leukemia, lung, and prostate. This book is intended for ministries of health, public health planners, health technology managers, disease management, researchers, policy makers, funding, and procurement agencies and support and advocacy groups for cancer patients.
