New Frontiers In Cancer Therapies Focus On Transcription Factors Gtpases Phosphatases And Gpcrs 2018 2030

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New Frontiers in Cancer Therapies: Focus on Transcription Factors, GTPases, Phosphatases and GPCRs, 2018-2030

Author : Roots Analysis
Publisher : Roots Analysis
ISBN 13 :
Total Pages : 306 pages
Book Rating : 4./5 ( download)

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Book Synopsis New Frontiers in Cancer Therapies: Focus on Transcription Factors, GTPases, Phosphatases and GPCRs, 2018-2030 by : Roots Analysis

Download or read book New Frontiers in Cancer Therapies: Focus on Transcription Factors, GTPases, Phosphatases and GPCRs, 2018-2030 written by Roots Analysis and published by Roots Analysis. This book was released on 2018-05-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ‘New Frontiers in Cancer Therapies: Focus on Transcription Factors, GTPases, Phosphatases and GPCRs, 2018-2030’ report provides a comprehensive study on the current market and therapeutic potential of the various pharmacological interventions designed against difficult-to-modulate cancer targets. It features an elaborate discussion on the future potential of this evolving domain, focusing on phosphatases, transcription factors, small GTPases (specifically Ras family) and undruggable G-protein coupled receptors (GPCRs). One of the key objectives of the study was to review and quantify the future opportunity for the ongoing product development programs of both small and big pharmaceutical firms. Amongst other elements, the report features: 1) A detailed assessment of the current market landscape of drugs being developed against various undruggable cancer targets, featuring information on the developer, phase of development (clinical, preclinical or discovery stage) of product candidate(s), information on type of molecule(s), biological target(s), mechanism of action, route of administration, and key therapeutic indication(s). 2) Elaborate profiles of key companies (selected based on pipeline strength); each profile features an overview of the company, details on it product portfolio, technology overview (wherever applicable), detailed information on advanced stage pipeline candidates (featuring a drug overview, clinical trial information and recent developments) and a comprehensive future outlook. 3) A section on emerging technologies and platforms that are aiding the development of therapies capable of targeting biological molecules which were previously considered as undruggable. 4) A detailed publication analysis on more than 70 research articles that have been published between January 2014 and March 2018, highlighting the key focus areas (biological targets and indications) of the ongoing research activity in this field. 5) An analysis of the partnerships that have been established in this domain in the recent past, covering R&D agreements, license agreements, clinical trial collaborations, mergers and acquisitions, and other relevant agreements. 6) An analysis of the investments made at various stages of development in companies that are focused in this area, including seed financing, venture capital financing, debt financing, grants, capital raised from IPOs and subsequent offerings. 7) A compilation of key insights derived based on various parameters; these include [A] a bull’s eye analysis highlighting the distribution of pipeline candidates in terms of phase of development, type of target family and type of molecule [B] a three-dimensional and five-dimensional spider web analyses of candidate therapeutics based on different parameters, namely number of publications, grants awarded to promote development, active clinical trials, current phase of development and the number of companies developing drugs against various undruggable targets, and [C] a world map representation, depicting the most active geographies in terms of the presence of companies developing drug candidates against difficult-to-modulate cancer targets.

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

Author : Nosheen Masood
Publisher : Springer Nature
ISBN 13 : 9811510679
Total Pages : 499 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by : Nosheen Masood

Download or read book 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine written by Nosheen Masood and published by Springer Nature. This book was released on 2020-03-20 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Colon Cancer Diagnosis and Therapy

Author : Ganji Purnachandra Nagaraju
Publisher : Springer Nature
ISBN 13 : 3030633691
Total Pages : 374 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Colon Cancer Diagnosis and Therapy by : Ganji Purnachandra Nagaraju

Download or read book Colon Cancer Diagnosis and Therapy written by Ganji Purnachandra Nagaraju and published by Springer Nature. This book was released on 2021-06-10 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colorectal cancer (CRC) is a major global health challenge as the third leading cause for cancer related mortalities worldwide. Despite advances in therapeutic strategies, the five-year survival rate for CRC patients has remained the same over time due to the fact that patients are often diagnosed in advanced metastatic stages. Drug resistance is another common reason for poor prognosis. Researchers are now developing advanced therapeutic strategies such as immunotherapy, targeted therapy, and combination nanotechnology for drug delivery. In addition, the identification of new biomarkers will potentiate early stage diagnosis. This book is the first of three volumes on recent developments in colorectal diagnosis and therapy. Each volume can be read on its own, or together. Each volume focuses on different novel therapeutic advances, biomarkers, and identifies therapeutic targets for treatment. Written by leading international experts in the field, coverage also addresses the role of diet habits and lifestyle in reducing gastrointestinal disorders and incidence of CRC. Chapters discuss current and future diagnostic and therapeutic options for colorectal cancer patients, focusing on immunotherapeutic, nanomedicine, biomarkers, and dietary factors for the effective management of colon cancer.

Intercellular Communication in Cancer

Author : Mustapha Kandouz
Publisher : Springer
ISBN 13 : 9401773807
Total Pages : 370 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Intercellular Communication in Cancer by : Mustapha Kandouz

Download or read book Intercellular Communication in Cancer written by Mustapha Kandouz and published by Springer. This book was released on 2015-11-20 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells are by nature compelled to live in groups. They develop dependence over signaling cues received from their microenvironment, in particular from other cells, whether of their own “kind” or of a different type. Therefore, communicating with these cells is a critical aspect of their behavior and fate, as they live and die normally or as they undergo disease-related pathological changes, with dramatic repercussions. In this book, we have asked expert researchers in the field of Intercellular Communication in Cancer to provide chapters on different aspects of interaction between neighboring cells, in the context of cancer diseases. We have specifically focused our efforts on membrane-to-membrane contact-based rather than growth factors-mediated modes of intercellular communications. The contributing authors provide an extensive overview of their respective area of specialization, with an in-depth discussion of the molecular mechanisms of cell-cell interactions, the impact on tumor progression and response to therapies, as well as the cancer diagnostic value of this scientific information. This book aims to introduce essential aspects of the normal and pathological cellular fate and homeostasis to both scientists and clinicians, and also to provide established researchers with an update on the novelties and future directions this expanding field is witnessing.

Cerebral Ischemic Reperfusion Injuries (CIRI)

Author : Weijian Jiang
Publisher : Springer
ISBN 13 : 331990194X
Total Pages : 259 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Cerebral Ischemic Reperfusion Injuries (CIRI) by : Weijian Jiang

Download or read book Cerebral Ischemic Reperfusion Injuries (CIRI) written by Weijian Jiang and published by Springer. This book was released on 2018-06-29 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.

Abiotic Stress-Mediated Sensing and Signaling in Plants: An Omics Perspective

Author : Sajad Majeed Zargar
Publisher : Springer
ISBN 13 : 9811074798
Total Pages : 358 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Abiotic Stress-Mediated Sensing and Signaling in Plants: An Omics Perspective by : Sajad Majeed Zargar

Download or read book Abiotic Stress-Mediated Sensing and Signaling in Plants: An Omics Perspective written by Sajad Majeed Zargar and published by Springer. This book was released on 2018-02-20 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The natural environment for plants is composed of a complex set of abiotic and biotic stresses; plant responses to these stresses are equally complex. Systems biology allows us to identify regulatory hubs in complex networks. It also examines the molecular “parts” (transcripts, proteins and metabolites) of an organism and attempts to combine them into functional networks or models that effectively describe and predict the dynamic activities of that organism in different environments. This book focuses on research advances regarding plant responses to abiotic stresses, from the physiological level to the molecular level. It highlights new insights gained from the integration of omics datasets and identifies remaining gaps in our knowledge, outlining additional focus areas for future crop improvement research. Plants have evolved a wide range of mechanisms for coping with various abiotic stresses. In many crop plants, the molecular mechanisms involved in a single type of stress tolerance have since been identified; however, in order to arrive at a holistic understanding of major and common events concerning abiotic stresses, the signaling pathways involved must also be elucidated. To date several molecules, like transcription factors and kinases, have been identified as promising candidates that are involved in crosstalk between stress signalling pathways. However, there is a need to better understand the tolerance mechanisms for different abiotic stresses by thoroughly grasping the signalling and sensing mechanisms involved. Accordingly, this book covers a range of topics, including the impacts of different abiotic stresses on plants, the molecular mechanisms leading to tolerance for different abiotic stresses, signaling cascades revealing cross-talk among various abiotic stresses, and elucidation of major candidate molecules that may provide abiotic stress tolerance in plants.

Microbial Metatranscriptomics Belowground

Author : Manoj Nath
Publisher : Springer Nature
ISBN 13 : 9811597588
Total Pages : 677 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Microbial Metatranscriptomics Belowground by : Manoj Nath

Download or read book Microbial Metatranscriptomics Belowground written by Manoj Nath and published by Springer Nature. This book was released on 2021-06-02 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book emphasizes role of functional microbes in soil to improve fertility and plant health in agro-ecosystem. In this compendium main emphasis is on occurrence and distribution of microbial communities, In situ active microbial quorum in rhizosphere, metratranscriptomics for microflora- and fauna, and fnctional diversity in rhizosphere. The book also highlights the importance of PGPRs in rhizosphere, root endotrophic microbes, functional niche under biotic stress, functional niche under abiotic stress, functional root derived signals, as well as functional microbe derived signals. Approaches deployed in metatranscriptomics, and molecular Tools used in rhizosphere are also discussed in detail. The book presents content is useful for students, academicians, researchers working on soil rhizosphere and as a policy document on sustenance of agriculture.

Lysosomes

Author : Frederick R. Maxfield
Publisher : John Wiley & Sons
ISBN 13 : 1118978315
Total Pages : 586 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Lysosomes by : Frederick R. Maxfield

Download or read book Lysosomes written by Frederick R. Maxfield and published by John Wiley & Sons. This book was released on 2016-06-22 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discussing recent findings, up-to-date research, and novel strategies, the book integrates perspectives from pharmacology, toxicology, and biochemistry to illustrate the potential of lysosomes in drug discovery and development. • Explores basic principles and properties of lysosomes that allow them to act as regulators of cell metabolism, therapeutic targets, and sites for activation of drug conjugates • Discusses the role of lysosomes in metabolism, drug targeting, apoptosis, cancer, aging, inflammation, autophagy, metabolism, toxicity, and membrane repair • Introduces new pathways in therapeutic development and new mechanisms in drug development

Molecular Basis of Resilience

Author : Patrick L. Iversen
Publisher : Springer
ISBN 13 : 9783030074609
Total Pages : 0 pages
Book Rating : 4.0/5 (746 download)

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Book Synopsis Molecular Basis of Resilience by : Patrick L. Iversen

Download or read book Molecular Basis of Resilience written by Patrick L. Iversen and published by Springer. This book was released on 2019-01-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illuminates mechanisms of resilience. Threats and defense systems lead to adaptive changes in gene expression. Environmental conditions may dampen adaptive responses at the level of RNA expression. The first seven chapters elaborate threats to human health. Human populations spontaneously invade niche boundaries exposing us to threats that drive the resilience process. Emerging RNA viruses are a significant threat to human health. Antiviral drugs are reviewed and how viral genomes respond to the environment driving genome sequence plasticity. Limitations in predicting the human outcome are described in “nonlinear anomalies.” An example includes medical countermeasures for Ebola and Marburg viruses under the “Animal Rule.” Bacterial infections and a review of antibacterial drugs and bacterial resilience mediated by horizontal gene transfer follow. Chapter 6 shifts focus to cancer and discovery of novel therapeutics for leukemia. The spontaneous resolution of AML in children with Down syndrome highlights human resilience. Chapter 7 explores chemicals in the environment. Examples of chemical carcinogenesis illustrate how chemicals disrupt genomes. Historic research ignored RNA damage from chemically induced nucleic acid damage. The emergence of important forms of RNA and their possible role in resilience is proposed. Chapters 8-10 discuss threat recognition and defense systems responding to improve resilience. Chapter 8 describes the immune response as a threat recognition system and response via diverse RNA expression. Oligonucleotides designed to suppress specific RNA to manipulate the immune response including exon-skipping strategies are described. Threat recognition and response by the cytochrome P450 enzymes parallels immune responses. The author proposes metabolic clearance of small molecules is a companion to the immune system. Chapter 10 highlights RNA diversity expressed from a single gene. Molecular Resilience lists paths to RNA transcriptome plasticity forms the molecular basis for resilience. Chapter 11 is an account of ExonDys 51, an approved drug for the treatment of Duchenne muscular dystrophy. Chapter 12 addresses the question “what informs molecular mechanisms of resilience?” that drives the limits to adaptation and boundaries for molecular resilience. He speculates that radical oxygen, epigenetic modifications, and ligands to nuclear hormone receptors play critical roles in regulating molecular resilience.

Computer-Aided Drug Design

Author : Dev Bukhsh Singh
Publisher : Springer Nature
ISBN 13 : 9811568154
Total Pages : 308 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Computer-Aided Drug Design by : Dev Bukhsh Singh

Download or read book Computer-Aided Drug Design written by Dev Bukhsh Singh and published by Springer Nature. This book was released on 2020-10-09 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides up-to-date information on bioinformatics tools for the discovery and development of new drug molecules. It discusses a range of computational applications, including three-dimensional modeling of protein structures, protein-ligand docking, and molecular dynamics simulation of protein-ligand complexes for identifying desirable drug candidates. It also explores computational approaches for identifying potential drug targets and for pharmacophore modeling. Moreover, it presents structure- and ligand-based drug design tools to optimize known drugs and guide the design of new molecules. The book also describes methods for identifying small-molecule binding pockets in proteins, and summarizes the databases used to explore the essential properties of drugs, drug-like small molecules and their targets. In addition, the book highlights various tools to predict the absorption, distribution, metabolism, excretion (ADME) and toxicity (T) of potential drug candidates. Lastly, it reviews in silico tools that can facilitate vaccine design and discusses their limitations.

The P2X7 Receptor

Author : Annette Nicke
Publisher : Springer Nature
ISBN 13 : 1071623842
Total Pages : 401 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis The P2X7 Receptor by : Annette Nicke

Download or read book The P2X7 Receptor written by Annette Nicke and published by Springer Nature. This book was released on 2022-07-01 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume covers diverse aspects of P2X7 receptor analysis, ranging from its molecular structure to related pharmacological and immunological tools, via its analysis in heterologous expression systems as well as assays using primary cells and whole animal models. After three introductory chapters that focus on its structure, ligands, and physiological functions, the book details the generation of antibody and nanobody tools for P2X7 receptors, provides protocols for the analysis of expressed P2X7 receptors with a focus on their electrophysiological analysis, as well as protocols for the investigation of P2X7 down-stream signaling in immune cells by flow cytometry. Mouse models and procedures suited to investigate P2X7-mediated effects in other primary cells and in vivo are also explained. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The P2X7 Receptor: Methods and Protocols is a valuable reference not only for the growing community fascinated by this unusual ion channel but also for a broad readership interested in ion channels or purinergic receptors.

The Biophysics of Cell Membranes

Author : Richard M. Epand
Publisher : Springer
ISBN 13 : 9811062447
Total Pages : 224 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis The Biophysics of Cell Membranes by : Richard M. Epand

Download or read book The Biophysics of Cell Membranes written by Richard M. Epand and published by Springer. This book was released on 2017-09-25 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the modulation of biological membranes by specific biophysical properties. The readers are introduced to emerging biophysical approaches that mimick specific states (like membrane lipid asymmetry, membrane curvature, lipid flip-flop, lipid phase separation) that are relevant to the functioning of biological membranes. The first chapter describes innovative methods to mimic the prevailing asymmetry in biological membranes by forming asymmetrical membranes made of monolayers with different compositions. One of the chapters illustrates how physical parameters, like curvature and elasticity, can affect and modulate the interactions between lipids and proteins. This volume also describes the sensitivity of certain ion channels to mechanical forces and it presents an analysis of how cell shape is determined by both the cytoskeleton and the lipid domains in the membrane. The last chapter provides evidence that liposomes can be used as a minimal cellular model to reconstitute processes related to the origin of life. Each topic covered in this volume is presented by leading experts in the field who are able to present clear, authoritative and up-to-date reviews. The novelty of the methods proposed and their potential for a deeper molecular description of membrane functioning are particularly relevant experts in the areas of biochemistry, biophysics and cell biology, while also presenting clear and thorough introductions, making the material suitable for students in these fields as well.

Fungal Biotechnology and Bioengineering

Author : Abd El-Latif Hesham
Publisher : Springer
ISBN 13 : 9783030418694
Total Pages : 482 pages
Book Rating : 4.4/5 (186 download)

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Book Synopsis Fungal Biotechnology and Bioengineering by : Abd El-Latif Hesham

Download or read book Fungal Biotechnology and Bioengineering written by Abd El-Latif Hesham and published by Springer. This book was released on 2020-08-08 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are eukaryotic microorganisms that include both unicellular and multicellular species. They have a worldwide distribution and a wide range of applications in diverse sectors, from environmental, food and medicine to biotechnological innovations. Fungal biochemical genetics involves the study of the relationships between genome, proteome and metabolome, and the underlying molecular processes in both native and bioengineered fungi. This book provides a valuable resource on the challenges and potential of fungal biotechnology and related bioengineering and functional diversity for various industrial applications in the food, environmental, bioenergy and biorefining, and the biopharma sectors. In comparison to previous and related publications in the area of applied myco-biotech-engineering, this book bridges a knowledge gap in the areas related to prospects and investment as well as intellectual and technical issues. This book also provides information on recent commercial and economic interests in the area by juxtaposing the developments achieved in recent worldwide research and its many challenges.

Oxidative Stress in Lung Diseases

Author : Sajal Chakraborti
Publisher : Springer Nature
ISBN 13 : 9811384134
Total Pages : 491 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Oxidative Stress in Lung Diseases by : Sajal Chakraborti

Download or read book Oxidative Stress in Lung Diseases written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-08-31 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first volume of the comprehensive, two-volume work on oxidative stress in lung disease introduces the molecular mechanisms, and the role of oxidants in the progression of different lung diseases. The lungs of humans and animals are under constant threat from oxidants from either endogenous (e.g. in situ metabolic reactions) or exogenous sources (e.g. air pollutants). Further, oxidative stress causes the oxidation of proteins, DNA and lipids, which in turn generates secondary metabolic products. The book consists of sections, each focusing on different aspects of oxidant-mediated lung diseases. As such it is a unique reference resource for postgraduate students, biomedical researchers and also for the clinicians who are interested in studying and understanding oxidant-mediated lung diseases. The second volume will incorporate other aspects of oxidant-mediated lung diseases, including prevention and therapeutics.

Basic Concepts of Molecular Pathology

Author : Philip T. Cagle
Publisher : Springer Science & Business Media
ISBN 13 : 0387896260
Total Pages : 195 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Basic Concepts of Molecular Pathology by : Philip T. Cagle

Download or read book Basic Concepts of Molecular Pathology written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades there has been an explosion in knowledge about the molecular pathology of human diseases which accelerated with the sequencing of the human genome in 2003. Molecular diagnostics and molecular targeted therapy have contributed to the current concept of personalized patient care that is now routine in many medical centers. As a result, general and subspecialty pathologists, clinical practitioners of all types and radiologists must now have an understanding of the basic concepts of molecular pathology and their role in new diagnostic and therapeutic applications to patient care. The Molecular Pathology Library series was created to bridge the gap between traditional basic science textbooks in molecular biology and traditional medical textbooks for organ-specific diseases. Basic Concepts of Molecular Pathology is designed as a stand-alone book to provide the pathologist, clinician or radiologist with a concise review of the essential terminology, concepts and tools of molecular biology that are applied to the understanding, diagnosis and treatment of human diseases in the age of personalized medicine. Those medical practitioners, residents, fellows and students who need to refer to the terminology and concepts of molecular pathology in their patient care will find the Basic Concepts of Molecular Pathology to be a succinct, portable, user-friendly aid in their practice and studies. The service-based physician will find this handy reference to be valuable at the laboratory benchside, at the patient bedside, at multidisciplinary patient care conferences or as a review for examinations.

Oxford Textbook of Cancer Biology

Author : Francesco Pezzella
Publisher : Oxford University Press
ISBN 13 : 0198779453
Total Pages : 505 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Oxford Textbook of Cancer Biology by : Francesco Pezzella

Download or read book Oxford Textbook of Cancer Biology written by Francesco Pezzella and published by Oxford University Press. This book was released on 2019-05-02 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.

Ecdysone: Structures and Functions

Author : Guy Smagghe
Publisher : Springer Science & Business Media
ISBN 13 : 1402091125
Total Pages : 583 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Ecdysone: Structures and Functions by : Guy Smagghe

Download or read book Ecdysone: Structures and Functions written by Guy Smagghe and published by Springer Science & Business Media. This book was released on 2009-03-06 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecdysone is the steroidal prohormone of the major insect moulting hormone 20-hydroxyecdysone. It groups with its homologues the steroidal molting hormones in arthropods, but they also occur in other phyla where they can play different roles. Besides ecdysteroids appear in many plants mostly as protection agents (toxins or antifeedants) against herbivorous insects. The important developments and achievements in modern ecdysone science since the first edition in 1989 by J. Koolman have led to this new revised, expanded and retitled reference work. New chapters in this edition include RNA interference, the ecdysone receptor crystal structures and structure activity relationships, etc. Each article may also be read independently, as a review of that particular subject. Complete up-to-date coverage of many important topics - the book is divisible into five conceptual areas: (1) Distribution and diversity of ecdysteroids in the two kingdoms is still basis, (2) In the post-genomic era, ecdysteroid genetic hierarchies in insect growth and reproduction, (3) Role of cross talk of genes and growth factors in ecdysteroid titers and signaling, (4) Ecdysteroids function through nuclear and membrane receptors, and (5) Ecdysteroids in modern agriculture, medicine, doping and ecotoxicology. Each of the 23 chapters is written by scientists active in the reviewed research area and a truly distinguished international team of contributors has been chosen. Ecdysone, Structures and Functions will be of immense use and contains essential information for scientists, students, and professionals alike in entomology, endocrinology, physiology, chemistry, and agricultural, plant, biomedicine and environmental sciences.