Current Trends in Bayesian Methodology with Applications

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Publisher : CRC Press
ISBN 13 : 1482235129
Total Pages : 674 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Current Trends in Bayesian Methodology with Applications by : Satyanshu K. Upadhyay

Download or read book Current Trends in Bayesian Methodology with Applications written by Satyanshu K. Upadhyay and published by CRC Press. This book was released on 2015-05-21 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collecting Bayesian material scattered throughout the literature, Current Trends in Bayesian Methodology with Applications examines the latest methodological and applied aspects of Bayesian statistics. The book covers biostatistics, econometrics, reliability and risk analysis, spatial statistics, image analysis, shape analysis, Bayesian computation, clustering, uncertainty assessment, high-energy astrophysics, neural networking, fuzzy information, objective Bayesian methodologies, empirical Bayes methods, small area estimation, and many more topics. Each chapter is self-contained and focuses on a Bayesian methodology. It gives an overview of the area, presents theoretical insights, and emphasizes applications through motivating examples. This book reflects the diversity of Bayesian analysis, from novel Bayesian methodology, such as nonignorable response and factor analysis, to state-of-the-art applications in economics, astrophysics, biomedicine, oceanography, and other areas. It guides readers in using Bayesian techniques for a range of statistical analyses.

Bayesian Applications in Pharmaceutical Development

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Publisher : CRC Press
ISBN 13 : 1351584170
Total Pages : 533 pages
Book Rating : 4.3/5 (515 download)

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Book Synopsis Bayesian Applications in Pharmaceutical Development by : Mani Lakshminarayanan

Download or read book Bayesian Applications in Pharmaceutical Development written by Mani Lakshminarayanan and published by CRC Press. This book was released on 2019-11-07 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cost for bringing new medicine from discovery to market has nearly doubled in the last decade and has now reached $2.6 billion. There is an urgent need to make drug development less time-consuming and less costly. Innovative trial designs/ analyses such as the Bayesian approach are essential to meet this need. This book will be the first to provide comprehensive coverage of Bayesian applications across the span of drug development, from discovery, to clinical trial, to manufacturing with practical examples. This book will have a wide appeal to statisticians, scientists, and physicians working in drug development who are motivated to accelerate and streamline the drug development process, as well as students who aspire to work in this field. The advantages of this book are: Provides motivating, worked, practical case examples with easy to grasp models, technical details, and computational codes to run the analyses Balances practical examples with best practices on trial simulation and reporting, as well as regulatory perspectives Chapters written by authors who are individual contributors in their respective topics Dr. Mani Lakshminarayanan is a researcher and statistical consultant with more than 30 years of experience in the pharmaceutical industry. He has published over 50 articles, technical reports, and book chapters besides serving as a referee for several journals. He has a PhD in Statistics from Southern Methodist University, Dallas, Texas and is a Fellow of the American Statistical Association. Dr. Fanni Natanegara has over 15 years of pharmaceutical experience and is currently Principal Research Scientist and Group Leader for the Early Phase Neuroscience Statistics team at Eli Lilly and Company. She played a key role in the Advanced Analytics team to provide Bayesian education and statistical consultation at Eli Lilly. Dr. Natanegara is the chair of the cross industry-regulatory-academic DIA BSWG to ensure that Bayesian methods are appropriately utilized for design and analysis throughout the drug-development process.

Bayesian Statistics from Methods to Models and Applications

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Publisher : Springer
ISBN 13 : 3319162381
Total Pages : 175 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Bayesian Statistics from Methods to Models and Applications by : Sylvia Frühwirth-Schnatter

Download or read book Bayesian Statistics from Methods to Models and Applications written by Sylvia Frühwirth-Schnatter and published by Springer. This book was released on 2015-05-19 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Bayesian Young Statisticians Meeting (BAYSM 2014) and the research presented here facilitate connections among researchers using Bayesian Statistics by providing a forum for the development and exchange of ideas. WU Vienna University of Business and Economics hosted BAYSM 2014 from September 18th to the 19th. The guidance of renowned plenary lecturers and senior discussants is a critical part of the meeting and this volume, which follows publication of contributions from BAYSM 2013. The meeting's scientific program reflected the variety of fields in which Bayesian methods are currently employed or could be introduced in the future. Three brilliant keynote lectures by Chris Holmes (University of Oxford), Christian Robert (Université Paris-Dauphine), and Mike West (Duke University), were complemented by 24 plenary talks covering the major topics Dynamic Models, Applications, Bayesian Nonparametrics, Biostatistics, Bayesian Methods in Economics, and Models and Methods, as well as a lively poster session with 30 contributions. Selected contributions have been drawn from the conference for this book. All contributions in this volume are peer-reviewed and share original research in Bayesian computation, application, and theory.

Bayesian Methods for Hackers

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Publisher : Addison-Wesley Professional
ISBN 13 : 0133902927
Total Pages : 551 pages
Book Rating : 4.1/5 (339 download)

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Book Synopsis Bayesian Methods for Hackers by : Cameron Davidson-Pilon

Download or read book Bayesian Methods for Hackers written by Cameron Davidson-Pilon and published by Addison-Wesley Professional. This book was released on 2015-09-30 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master Bayesian Inference through Practical Examples and Computation–Without Advanced Mathematical Analysis Bayesian methods of inference are deeply natural and extremely powerful. However, most discussions of Bayesian inference rely on intensely complex mathematical analyses and artificial examples, making it inaccessible to anyone without a strong mathematical background. Now, though, Cameron Davidson-Pilon introduces Bayesian inference from a computational perspective, bridging theory to practice–freeing you to get results using computing power. Bayesian Methods for Hackers illuminates Bayesian inference through probabilistic programming with the powerful PyMC language and the closely related Python tools NumPy, SciPy, and Matplotlib. Using this approach, you can reach effective solutions in small increments, without extensive mathematical intervention. Davidson-Pilon begins by introducing the concepts underlying Bayesian inference, comparing it with other techniques and guiding you through building and training your first Bayesian model. Next, he introduces PyMC through a series of detailed examples and intuitive explanations that have been refined after extensive user feedback. You’ll learn how to use the Markov Chain Monte Carlo algorithm, choose appropriate sample sizes and priors, work with loss functions, and apply Bayesian inference in domains ranging from finance to marketing. Once you’ve mastered these techniques, you’ll constantly turn to this guide for the working PyMC code you need to jumpstart future projects. Coverage includes • Learning the Bayesian “state of mind” and its practical implications • Understanding how computers perform Bayesian inference • Using the PyMC Python library to program Bayesian analyses • Building and debugging models with PyMC • Testing your model’s “goodness of fit” • Opening the “black box” of the Markov Chain Monte Carlo algorithm to see how and why it works • Leveraging the power of the “Law of Large Numbers” • Mastering key concepts, such as clustering, convergence, autocorrelation, and thinning • Using loss functions to measure an estimate’s weaknesses based on your goals and desired outcomes • Selecting appropriate priors and understanding how their influence changes with dataset size • Overcoming the “exploration versus exploitation” dilemma: deciding when “pretty good” is good enough • Using Bayesian inference to improve A/B testing • Solving data science problems when only small amounts of data are available Cameron Davidson-Pilon has worked in many areas of applied mathematics, from the evolutionary dynamics of genes and diseases to stochastic modeling of financial prices. His contributions to the open source community include lifelines, an implementation of survival analysis in Python. Educated at the University of Waterloo and at the Independent University of Moscow, he currently works with the online commerce leader Shopify.

Bayesian Non- and Semi-parametric Methods and Applications

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Publisher : Princeton University Press
ISBN 13 : 0691145326
Total Pages : 218 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Bayesian Non- and Semi-parametric Methods and Applications by : Peter Rossi

Download or read book Bayesian Non- and Semi-parametric Methods and Applications written by Peter Rossi and published by Princeton University Press. This book was released on 2014-04-27 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews and develops Bayesian non-parametric and semi-parametric methods for applications in microeconometrics and quantitative marketing. Most econometric models used in microeconomics and marketing applications involve arbitrary distributional assumptions. As more data becomes available, a natural desire to provide methods that relax these assumptions arises. Peter Rossi advocates a Bayesian approach in which specific distributional assumptions are replaced with more flexible distributions based on mixtures of normals. The Bayesian approach can use either a large but fixed number of normal components in the mixture or an infinite number bounded only by the sample size. By using flexible distributional approximations instead of fixed parametric models, the Bayesian approach can reap the advantages of an efficient method that models all of the structure in the data while retaining desirable smoothing properties. Non-Bayesian non-parametric methods often require additional ad hoc rules to avoid "overfitting," in which resulting density approximates are nonsmooth. With proper priors, the Bayesian approach largely avoids overfitting, while retaining flexibility. This book provides methods for assessing informative priors that require only simple data normalizations. The book also applies the mixture of the normals approximation method to a number of important models in microeconometrics and marketing, including the non-parametric and semi-parametric regression models, instrumental variables problems, and models of heterogeneity. In addition, the author has written a free online software package in R, "bayesm," which implements all of the non-parametric models discussed in the book.

Bayesian Methods in Pharmaceutical Research

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Author :
Publisher : CRC Press
ISBN 13 : 1351718673
Total Pages : 547 pages
Book Rating : 4.3/5 (517 download)

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Book Synopsis Bayesian Methods in Pharmaceutical Research by : Emmanuel Lesaffre

Download or read book Bayesian Methods in Pharmaceutical Research written by Emmanuel Lesaffre and published by CRC Press. This book was released on 2020-04-15 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the early 2000s, there has been increasing interest within the pharmaceutical industry in the application of Bayesian methods at various stages of the research, development, manufacturing, and health economic evaluation of new health care interventions. In 2010, the first Applied Bayesian Biostatistics conference was held, with the primary objective to stimulate the practical implementation of Bayesian statistics, and to promote the added-value for accelerating the discovery and the delivery of new cures to patients. This book is a synthesis of the conferences and debates, providing an overview of Bayesian methods applied to nearly all stages of research and development, from early discovery to portfolio management. It highlights the value associated with sharing a vision with the regulatory authorities, academia, and pharmaceutical industry, with a view to setting up a common strategy for the appropriate use of Bayesian statistics for the benefit of patients. The book covers: Theory, methods, applications, and computing Bayesian biostatistics for clinical innovative designs Adding value with Real World Evidence Opportunities for rare, orphan diseases, and pediatric development Applied Bayesian biostatistics in manufacturing Decision making and Portfolio management Regulatory perspective and public health policies Statisticians and data scientists involved in the research, development, and approval of new cures will be inspired by the possible applications of Bayesian methods covered in the book. The methods, applications, and computational guidance will enable the reader to apply Bayesian methods in their own pharmaceutical research.

Maximum Entropy and Bayesian Methods

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Publisher : Springer Science & Business Media
ISBN 13 : 940113460X
Total Pages : 356 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Maximum Entropy and Bayesian Methods by : W.T. Grandy Jr.

Download or read book Maximum Entropy and Bayesian Methods written by W.T. Grandy Jr. and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 10th International Workshop on Maximum Entropy and Bayesian Methods, MaxEnt 90, was held in Laramie, Wyoming from 30 July to 3 August 1990. This volume contains the scientific presentations given at that meeting. This series of workshops originated in Laramie in 1981, where the first three of what were to become annual workshops were held. The fourth meeting was held in Calgary. the fifth in Laramie, the sixth and seventh in Seattle, the eighth in Cambridge, England, and the ninth at Hanover, New Hampshire. It is most appropriate that the tenth workshop, occurring in the centennial year of Wyoming's statehood, was once again held in Laramie. The original purpose of these workshops was twofold. The first was to bring together workers from diverse fields of scientific research who individually had been using either some form of the maximum entropy method for treating ill-posed problems or the more general Bayesian analysis, but who, because of the narrow focus that intra-disciplinary work tends to impose upon most of us, might be unaware of progress being made by others using these same techniques in other areas. The second was to introduce to those who were somewhat aware of maximum entropy and Bayesian analysis and wanted to learn more, the foundations, the gestalt, and the power of these analyses. To further the first of these ends, presenters at these workshops have included workers from area. s as varied as astronomy, economics, environmenta.

Statistical Guidelines: New Developments in Statistical Methods and Psychometric Tools

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Publisher : Frontiers Media SA
ISBN 13 : 2889747611
Total Pages : 480 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Statistical Guidelines: New Developments in Statistical Methods and Psychometric Tools by : Pietro Cipresso

Download or read book Statistical Guidelines: New Developments in Statistical Methods and Psychometric Tools written by Pietro Cipresso and published by Frontiers Media SA. This book was released on 2022-03-25 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Contributions to the Theory and Application of Statistics

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Publisher : Academic Press
ISBN 13 : 1483261271
Total Pages : 573 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Contributions to the Theory and Application of Statistics by : Alan E. Gelfand

Download or read book Contributions to the Theory and Application of Statistics written by Alan E. Gelfand and published by Academic Press. This book was released on 2014-05-10 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributions to the Theory and Application of Statistics: A Volume in Honor of Herbert Solomon is a collection of 20 papers that cover the significant contributions of Herbert Solomon in the field of statistics. This text is organized into four sections encompassing 20 chapters. Each section defines an area in which Herb has made a contribution and the papers are ordered alphabetically. The first section consists of four papers in the area of operations research and applied probability, while the second section gathers six papers looking into problems in distribution theory and geometric probability. The third section contains five applied articles in the areas of law and justice, medicine, and psychology. The fourth section covers five papers that explore several inference issues. This book will be of value to statisticians and advance students.

New Developments and Applications in Sensing Technology

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Publisher : Springer Science & Business Media
ISBN 13 : 3642179436
Total Pages : 333 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis New Developments and Applications in Sensing Technology by : Subhas Chandra Mukhopadhyay

Download or read book New Developments and Applications in Sensing Technology written by Subhas Chandra Mukhopadhyay and published by Springer Science & Business Media. This book was released on 2011-01-22 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has focussed on different aspects of smart sensors and sensing technology, i.e. intelligent measurement, information processing, adaptability, recalibration, data fusion, validation, high reliability and integration of novel and high performance sensors in the areas of magnetic, ultrasonic, vision and image sensing, wireless sensors and network, microfluidic, tactile, gyro, flow, surface acoustic wave, humidity and ultra-wide band. While future interest in this field is ensured by the constant supply of emerging modalities, techniques and engineering solutions, as well as an increasing need from aging structures, many of the basic concepts and strategies have already matured and now offer opportunities to build upon. The book has primarily been focussed for postgraduate and research students working on different aspects of design and developments of smart sensors and sensing technology.

Bayesian Analysis with R for Drug Development

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Publisher : CRC Press
ISBN 13 : 1351585932
Total Pages : 251 pages
Book Rating : 4.3/5 (515 download)

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Book Synopsis Bayesian Analysis with R for Drug Development by : Harry Yang

Download or read book Bayesian Analysis with R for Drug Development written by Harry Yang and published by CRC Press. This book was released on 2019-06-26 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is an iterative process. The recent publications of regulatory guidelines further entail a lifecycle approach. Blending data from disparate sources, the Bayesian approach provides a flexible framework for drug development. Despite its advantages, the uptake of Bayesian methodologies is lagging behind in the field of pharmaceutical development. Written specifically for pharmaceutical practitioners, Bayesian Analysis with R for Drug Development: Concepts, Algorithms, and Case Studies, describes a wide range of Bayesian applications to problems throughout pre-clinical, clinical, and Chemistry, Manufacturing, and Control (CMC) development. Authored by two seasoned statisticians in the pharmaceutical industry, the book provides detailed Bayesian solutions to a broad array of pharmaceutical problems. Features Provides a single source of information on Bayesian statistics for drug development Covers a wide spectrum of pre-clinical, clinical, and CMC topics Demonstrates proper Bayesian applications using real-life examples Includes easy-to-follow R code with Bayesian Markov Chain Monte Carlo performed in both JAGS and Stan Bayesian software platforms Offers sufficient background for each problem and detailed description of solutions suitable for practitioners with limited Bayesian knowledge Harry Yang, Ph.D., is Senior Director and Head of Statistical Sciences at AstraZeneca. He has 24 years of experience across all aspects of drug research and development and extensive global regulatory experiences. He has published 6 statistical books, 15 book chapters, and over 90 peer-reviewed papers on diverse scientific and statistical subjects, including 15 joint statistical works with Dr. Novick. He is a frequent invited speaker at national and international conferences. He also developed statistical courses and conducted training at the FDA and USP as well as Peking University. Steven Novick, Ph.D., is Director of Statistical Sciences at AstraZeneca. He has extensively contributed statistical methods to the biopharmaceutical literature. Novick is a skilled Bayesian computer programmer and is frequently invited to speak at conferences, having developed and taught courses in several areas, including drug-combination analysis and Bayesian methods in clinical areas. Novick served on IPAC-RS and has chaired several national statistical conferences.

Bayesian Data Analysis, Third Edition

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Publisher : CRC Press
ISBN 13 : 1439840954
Total Pages : 677 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Bayesian Data Analysis, Third Edition by : Andrew Gelman

Download or read book Bayesian Data Analysis, Third Edition written by Andrew Gelman and published by CRC Press. This book was released on 2013-11-01 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.

Bayesian Analysis of Linear Models

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Publisher : Routledge
ISBN 13 : 1351464477
Total Pages : 480 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Bayesian Analysis of Linear Models by : Broemeling

Download or read book Bayesian Analysis of Linear Models written by Broemeling and published by Routledge. This book was released on 2017-11-22 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: With Bayesian statistics rapidly becoming accepted as a way to solve applied statisticalproblems, the need for a comprehensive, up-to-date source on the latest advances in thisfield has arisen.Presenting the basic theory of a large variety of linear models from a Bayesian viewpoint,Bayesian Analysis of Linear Models fills this need. Plus, this definitive volume containssomething traditional-a review of Bayesian techniques and methods of estimation, hypothesis,testing, and forecasting as applied to the standard populations ... somethinginnovative-a new approach to mixed models and models not generally studied by statisticianssuch as linear dynamic systems and changing parameter models ... and somethingpractical-clear graphs, eary-to-understand examples, end-of-chapter problems, numerousreferences, and a distribution appendix.Comprehensible, unique, and in-depth, Bayesian Analysis of Linear Models is the definitivemonograph for statisticians, econometricians, and engineers. In addition, this text isideal for students in graduate-level courses such as linear models, econometrics, andBayesian inference.

New Developments in Statistical Modeling, Inference and Application

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Publisher : Springer
ISBN 13 : 3319425714
Total Pages : 218 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis New Developments in Statistical Modeling, Inference and Application by : Zhezhen Jin

Download or read book New Developments in Statistical Modeling, Inference and Application written by Zhezhen Jin and published by Springer. This book was released on 2016-10-28 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers in this volume represent the most timely and advanced contributions to the 2014 Joint Applied Statistics Symposium of the International Chinese Statistical Association (ICSA) and the Korean International Statistical Society (KISS), held in Portland, Oregon. The contributions cover new developments in statistical modeling and clinical research: including model development, model checking, and innovative clinical trial design and analysis. Each paper was peer-reviewed by at least two referees and also by an editor. The conference was attended by over 400 participants from academia, industry, and government agencies around the world, including from North America, Asia, and Europe. It offered 3 keynote speeches, 7 short courses, 76 parallel scientific sessions, student paper sessions, and social events.

Subjective and Objective Bayesian Statistics

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Publisher : John Wiley & Sons
ISBN 13 : 0470317949
Total Pages : 591 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Subjective and Objective Bayesian Statistics by : S. James Press

Download or read book Subjective and Objective Bayesian Statistics written by S. James Press and published by John Wiley & Sons. This book was released on 2009-09-25 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ein Wiley-Klassiker über Bayes-Statistik, jetzt in durchgesehener und erweiterter Neuauflage! - Werk spiegelt die stürmische Entwicklung dieses Gebietes innerhalb der letzten Jahre wider - vollständige Darstellung der theoretischen Grundlagen - jetzt ergänzt durch unzählige Anwendungsbeispiele - die wichtigsten modernen Methoden (u. a. hierarchische Modellierung, linear-dynamische Modellierung, Metaanalyse, MCMC-Simulationen) - einzigartige Diskussion der Finetti-Transformierten und anderer Themen, über die man ansonsten nur spärliche Informationen findet - Lösungen zu den Übungsaufgaben sind enthalten

New Developments for Embracing Genomic Selection in Breeding Applications

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Publisher : Frontiers Media SA
ISBN 13 : 2889744345
Total Pages : 197 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis New Developments for Embracing Genomic Selection in Breeding Applications by : Diego Jarquin

Download or read book New Developments for Embracing Genomic Selection in Breeding Applications written by Diego Jarquin and published by Frontiers Media SA. This book was released on 2022-02-18 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bayesian Thinking, Modeling and Computation

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Author :
Publisher : Elsevier
ISBN 13 : 0080461174
Total Pages : 1062 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Bayesian Thinking, Modeling and Computation by :

Download or read book Bayesian Thinking, Modeling and Computation written by and published by Elsevier. This book was released on 2005-11-29 with total page 1062 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes how to develop Bayesian thinking, modelling and computation both from philosophical, methodological and application point of view. It further describes parametric and nonparametric Bayesian methods for modelling and how to use modern computational methods to summarize inferences using simulation. The book covers wide range of topics including objective and subjective Bayesian inferences with a variety of applications in modelling categorical, survival, spatial, spatiotemporal, Epidemiological, software reliability, small area and micro array data. The book concludes with a chapter on how to teach Bayesian thoughts to nonstatisticians. Critical thinking on causal effects Objective Bayesian philosophy Nonparametric Bayesian methodology Simulation based computing techniques Bioinformatics and Biostatistics