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Author : Paul D. O'Malley
Publisher : Nova Publishers
ISBN 13 : 9781594547928
Total Pages : 266 pages
Book Rating : 4.5/5 (479 download)
Download or read book New Developments in Sickle Cell Disease Research written by Paul D. O'Malley and published by Nova Publishers. This book was released on 2006 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chaim Hershko
Publisher : Springer Science & Business Media
ISBN 13 : 1461505933
Total Pages : 275 pages
Book Rating : 4.4/5 (615 download)
Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the under standing of normal iron homeostasis. However, normal iron physiology offers little protec tion from the toxic effects of pathological iron accumulation, because nature did not equip us with effective mechanisms of iron excretion. Excess iron may be effectively removed by phlebotomy in hereditary hemochromatosis, but this method cannot be applied to chronic anemias associated with iron overload. In these diseases, iron chelating therapy is the only method available for preventing early death caused mainly by myocardial and hepatic iron toxicity. Iron chelating therapy has changed the quality of life and life expectancy of thalassemic patients. However, the high cost and rigorous requirements of deferoxamine therapy, and the significant toxicity of deferiprone underline the need for the continued development of new and improved orally effective iron chelators. Such development, and the evolution of improved strategies of iron chelating therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant develop ments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload (Chapters 1-5).
Author : Betty Pace
Publisher : World Scientific
ISBN 13 : 1908979917
Total Pages : 394 pages
Book Rating : 4.9/5 (89 download)
Download or read book Renaissance Of Sickle Cell Disease Research In The Genome Era written by Betty Pace and published by World Scientific. This book was released on 2007-01-24 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook./a
Author : Samir K. Ballas
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496331834
Total Pages : 1004 pages
Book Rating : 4.4/5 (963 download)
Download or read book Sickle Cell Pain written by Samir K. Ballas and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 1004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.
Author : Intsar S. Waked
Publisher : Nova Science Publishers
ISBN 13 : 9781634847049
Total Pages : 0 pages
Book Rating : 4.8/5 (47 download)
Download or read book Sickle Cell Anemia written by Intsar S. Waked and published by Nova Science Publishers. This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease (SCD), an inherited hemolytic anemia, is associated with multiple acute and chronic complications such as painful vasoocclusive events, cerebral vasculopathy, priapism, and renal or lung disease. These complications are variable and unpredictable, and can be associated with significant morbidity and poor quality of life. This book covers several areas regarding pathology, diagnosis, complications, signs, symptoms and medical treatments. There are few studies in literature on the role of physiotherapy as a resource to prevent and treat locomotor system disorders, respiratory problems and painful crises in SCD individuals. This book highlights the role of physiotherapy in sickle cell anemia. A comprehensive and authoritative monograph, this book will be equally interesting to both established researchers and to graduate students interested in both genetics and the physical therapy field.
Author : United States. Congress. Senate. Committee on Labor and Human Resources
Publisher :
ISBN 13 :
Total Pages : 68 pages
Book Rating : 4.3/5 (91 download)
Download or read book Sickle Disease Research written by United States. Congress. Senate. Committee on Labor and Human Resources and published by . This book was released on 1994 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 98 pages
Book Rating : 4.:/5 (18 download)
Download or read book Developments in Sickle Cell Anemia Research written by and published by . This book was released on with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309672988
Total Pages : 127 pages
Book Rating : 4.3/5 (96 download)
Download or read book Exploring Novel Clinical Trial Designs for Gene-Based Therapies written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-08-27 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical trials, explored how the safety of new therapies is assessed, reviewed the challenges involving dose escalation, and spoke about ethical issues such as informed consent and the role of clinicians in recommending trials as options to their patients. The workshop also included discussions of topics related to gene therapies in the context of other available and potentially curative treatments, such as bone marrow transplantation for hemoglobinopathies. This publication summarizes the presentation and discussion of the workshop.
Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309669634
Total Pages : 523 pages
Book Rating : 4.3/5 (96 download)
Download or read book Addressing Sickle Cell Disease written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-12-22 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease (SCD) is a genetic condition that affects approximately 100,000 people in the United States and millions more globally. Individuals with SCD endure the psychological and physiological toll of repetitive pain as well as side effects from the pain treatments they undergo. Some adults with SCD report reluctance to use health care services, unless as a last resort, due to the racism and discrimination they face in the health care system. Additionally, many aspects of SCD are inadequately studied, understood, and addressed. Addressing Sickle Cell Disease examines the epidemiology, health outcomes, genetic implications, and societal factors associated with SCD and sickle cell trait (SCT). This report explores the current guidelines and best practices for the care of patients with SCD and recommends priorities for programs, policies, and research. It also discusses limitations and opportunities for developing national SCD patient registries and surveillance systems, barriers in the healthcare sector associated with SCD and SCT, and the role of patient advocacy and community engagement groups.
Author : Fernando Ferreira Costa
Publisher : Springer
ISBN 13 : 3319067133
Total Pages : 439 pages
Book Rating : 4.3/5 (19 download)
Download or read book Sickle Cell Anemia written by Fernando Ferreira Costa and published by Springer. This book was released on 2016-03-29 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease’s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.
Author : Anjana Munshi
Publisher : BoD – Books on Demand
ISBN 13 : 9535121987
Total Pages : 198 pages
Book Rating : 4.5/5 (351 download)
Download or read book Inherited Hemoglobin Disorders written by Anjana Munshi and published by BoD – Books on Demand. This book was released on 2015-11-11 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book, Inherited Hemoglobin Disorders, describes the genetic defects of hemoglobins, disease complications, and therapeutic strategies. This book has two distinct sections. The first theme includes seven chapters devoted to the types of hemoglobinopathies, mutation spectrum, diagnostic methods, and disease complications, and the second theme includes three chapters focusing on various treatment strategies. The content of the chapters presented in the book is guided by the knowledge and experience of the contributing authors. This book serves as an important resource and review to the researchers in the field of hemoglobinopathies.
Author : R. L. Nagel
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (63 download)
Download or read book Developments in Sickle Cell Anemia Research written by R. L. Nagel and published by . This book was released on 1993 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gabriel Gachelin
Publisher : John Libbey Eurotext
ISBN 13 : 9782742000630
Total Pages : 672 pages
Book Rating : 4.0/5 (6 download)
Download or read book Genes for Development, Cell Growth and Infectious Diseases written by Gabriel Gachelin and published by John Libbey Eurotext. This book was released on 1995 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work which was published to mark the tenth anniversary of the collaboration between the Institut Pasteur and the Riken Institute in Japan, covers a number of research fields in which both laboratories are active: precocious development in mice and the effect on them of disactivating genes, nuclear oncogenes and their role in controlling cell division, and the molecular bases of bacterial and viral infections. There are also chapters dealing with specific aspects of immune recognition, the genetics of sexual determination in humans and a new technique for studying the human genome. This book is intended for researchers and physicians in the fields of immunology, genetics, bacteriology/virology, cancerology, developmental biology, cellular biology and neurobiology.
Author : Martin H. Steinberg
Publisher : Cambridge University Press
ISBN 13 : 0521875196
Total Pages : 883 pages
Book Rating : 4.5/5 (218 download)
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2009-08-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the definitive reference on disorders of hemoglobin.
Author : M D George R Buchanan
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781502452788
Total Pages : 0 pages
Book Rating : 4.4/5 (527 download)
Download or read book Evidence-Based Management of Sickle Cell Disease written by M D George R Buchanan and published by Createspace Independent Publishing Platform. This book was released on 2014-09-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell disease can be severe and disabling. When properly treated, patients live longer and with better quality life. This is a US government publication intended to provide evidence-based guidelines for the care of these patients for the use of all concerned providers as well as patients and family members. This book is available in print here for convenience.
Author : Marwa Zakaria
Publisher : BoD – Books on Demand
ISBN 13 : 0854669205
Total Pages : 138 pages
Book Rating : 4.8/5 (546 download)
Download or read book Current Practices in Sickle Cell Disease written by Marwa Zakaria and published by BoD – Books on Demand. This book was released on 2024-09-11 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sickle cell anemia is an inherited disorder of the globin chains that causes hemolysis and chronic organ damage. Sickle cell anemia is the most common form of sickle cell disease (SCD), with a lifelong affliction of hemolytic anemia requiring blood transfusions, pain crises, and organ damage. Since the first description of the irregular sickle-shaped red blood cells (RBCs) more than 100 years ago, our understanding of the disease has evolved tremendously. Recent advances in the field, more so within the last three decades, have alleviated symptoms for countless patients, especially in high-income countries. Although there is evidence of several important therapies in the pipeline, greater investment in research is needed into both of these therapies and the dissemination of effective care to the affected population, especially because of historical mistrust. In this book, we present an overview of sickle cell disease, pathogenesis, clinical presentation, complications, and recent treatment modalities and prospective research that will enable the reader to get a better understanding of this hot topic.
Author : U. S. Department of Health
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781495279157
Total Pages : 0 pages
Book Rating : 4.2/5 (791 download)
Download or read book The Management of Sickle Cell Disease written by U. S. Department of Health and published by Createspace Independent Publishing Platform. This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: #1 Best Seller on Sickle Cell Disease (SCD). Sickle cell disease is a group of blood disorders passed down from parents to children. Sickle cell anemia shortens life expectancy by 30 years via bacterial infections, painful swellings, fever, arthritis, leg ulcers, eye, lung & heart damage. Over 100,000 people, mostly African-Americans, in the United States have sickle cell disease. Over 2 million people have sickle cell trait in America. It is estimated that more than 300,000 children are born each year with SCD around the world. This edition of The Management of Sickle Cell Disease (SCD) is organized into four parts: 1. Diagnosis and Counseling 2. Health Maintenance 3. Treatment of Acute and Chronic Complications 4. Special Topics. The original intent was to incorporate evidence-based medicine into each chapter, but there was variation among evidence-level scales, and some authors felt recommendations could be made, based on accepted practice, without formal trials in this rare disorder. The best evidence still is represented by randomized, controlled trials (RCTs), but variations exist in their design, conduct, endpoints, and analyses. It should be emphasized that selected people enter a trial, and results should apply in practice specifically to populations with the same characteristics as those in the trial. Randomization is used to reduce imbalances between groups, but unexpected factors sometimes may confound analysis or interpretation. In addition, a trial may last only a short period of time, but long-term clinical implications may exist. Another issue is treatment variation, for example, a new pneumococcal vaccine developed after the trial, which has not been tested formally in a sickle cell population. Earlier trial results may be accepted, based on the assumption that the change is small. In some cases, RCTs cannot be done satisfactorily (e.g., for ethical reasons, an insufficient number of patients, or a lack of objective measures for sickle cell "crises"). Thus the bulk of clinical experience in SCD still remains in the moderately strong and weaker categories of evidence. Not everyone has an efficacious outcome in a clinical trial, and the frequency of adverse events, such as with long-term transfusion programs or hematopoietic transplants, might not be considered. Thus, an assessment of benefit-to-risk ratio should enter into translation of evidence levels into practice recommendations. A final issue is that there may be two alternative approaches that are competitive (e.g., transfusions and hydroxyurea). In this case the pros and cons of each course of treatment should be discussed with the patient. This book is B&W copy of the government agency publication.
