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Neurotrophic Factors
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Book Synopsis Neurotrophic Factors by : Sandra E. Loughlin
Download or read book Neurotrophic Factors written by Sandra E. Loughlin and published by Academic Press. This book was released on 1993 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume clearly synthesizes current information on defined neurotrophic factors, emphasizing their localization and molecular/cellular function in the central nervous system. Brain development and aging, neurodegenerative disorders, plasticity, and memory all are closely examined within the context of this rapidly expanding field. Researchers in neurobiology, cell biology, and molecular biology will find Neurotrophic Factors an invaluable reference for their research libraries. Offers the most up-do-date synthesis of concepts on neurotrophic factors in the nervous system Integrates molecular, cellular, and neuroanatomical concepts of neurotrophic factor function Includes special chapters on primary, secondary, and tertiary messenger systems Examines brain development, differentiation, neurodegenerative disorders, and adult plasticity
Book Synopsis Neurotrophic Factors by : Gary R. Lewin
Download or read book Neurotrophic Factors written by Gary R. Lewin and published by Springer Science & Business Media. This book was released on 2014-03-25 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.
Book Synopsis Translational Pain Research by : Lawrence Kruger
Download or read book Translational Pain Research written by Lawrence Kruger and published by CRC Press. This book was released on 2009-11-24 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.
Book Synopsis CNS Regeneration by : Jeffrey Kordower
Download or read book CNS Regeneration written by Jeffrey Kordower and published by Elsevier. This book was released on 2011-04-28 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS
Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi
Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Book Synopsis Basic Neurochemistry by : George J. Siegel
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Book Synopsis Life and Death in the Nervous System by : C. F. Ibanez
Download or read book Life and Death in the Nervous System written by C. F. Ibanez and published by Elsevier Health Sciences. This book was released on 1995-12-22 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life and Death in the Nervous System
Book Synopsis Neurotrophic Factors by : Patrick Aebischer
Download or read book Neurotrophic Factors written by Patrick Aebischer and published by Springer. This book was released on 1998-10 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions of numerous experts.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Ageing and Dementia by : Kurt Jellinger
Download or read book Ageing and Dementia written by Kurt Jellinger and published by Springer Science & Business Media. This book was released on 2002-08-20 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies, modern clinical, neuroimaging, neuropsychological, molecular biological, and genetic studies have considerably enhanced our knowledge about ageing processes of the human brain, its sequelae, diagnostic, and therapeutic possibilities and limits. In addition to Alzheimer's disease and other degenerative dementias, the impact of cerebrovascular lesions and their risk factors in the pathogenesis of cognitive disorders of the aged are increasingly acknowledged, and the recognition of mild cognitive impairment as a frequent initial stage of developing dementia is becoming an increasingly important diagnostic and therapeutic problem. The included papers were presented at the 7th International Symposium in Graz, Sept. 2001 and give a timely overview of the current and future concepts of pathogenesis, diagnosis, and treatment strategies of pathological brain ageing and dementias, early recognition of mild cognitive impairment and future possiblities of prevention of dementing processes.
Book Synopsis Neurotrophic Factors by : Stephen D Skaper
Download or read book Neurotrophic Factors written by Stephen D Skaper and published by Humana Press. This book was released on 2012-02-25 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system development evolves from the well-orchestrated processes of neural induction, cell proliferation, differentiation, cell migration, survival, and synapse formation. Among these environmental cues, neurotrophic factors are secreted proteins that promote neurite outgrowth, neuronal cell differentiation and survival both in vivo and in vitro. Nerve growth factor (NGF) is the founding and best characterized member of the neurotrophin family of neurotrophic polypeptides. Neurotrophic Factors: Methods and Protocols presents a selection of protocols and procedures which make use of cellular, tissue, and whole animal models which can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. Chapters cover a wide-range of topics such as dealing with the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia co-culture models, and cell-based assays for the evaluation of neuroprotective molecules, as well as assays which can be applied to the study of agents with neuroregenerative potential. Protocols describing viral- and nanoparticle-based delivery methods to neural cells are also presented, following by chapters dealing with organotypic slice culture protocols. Lastly, several chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Neurotrophic Factors: Methods and Protocols seeks to serve both professionals and novices alike with its well-honed methodologies in an effort to further our knowledge of what has been described as the last frontier of science.
Book Synopsis Molecular and Cellular Therapies for Motor Neuron Diseases by : Nicholas M Boulis
Download or read book Molecular and Cellular Therapies for Motor Neuron Diseases written by Nicholas M Boulis and published by Academic Press. This book was released on 2017-01-18 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular and Cellular Therapies for Motor Neuron Diseases discusses the basics of the diseases, also covering advances in research and clinical trials. The book provides a resource for students that will help them learn the basics in a detailed manner that is required for scientists and clinicians. Users will find a comprehensive overview of the background of Amyotrophic Lateral Sclerosis (ALS/Lou Gehrig’s Disease) and Spinal Muscular Atrophy (SMA), along with the current understanding of their genetics and mechanisms. In addition, the book details gene and cell therapies that have been developed and their translation to clinical trials. Provides an overview of gene and cell therapies for amyotrophic lateral sclerosis (ALS) and other motor neuron diseases Edited by a leading Neurosurgeon and two research scientists to promote synthesis between basic neuroscience and clinical relevance Presents a great resource for researchers and practitioners in neuroscience, neurology, and gene and cell therapy
Book Synopsis Clinical Applications of Neurotrophic Factors by : Stuart C. Apfel
Download or read book Clinical Applications of Neurotrophic Factors written by Stuart C. Apfel and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurotrophic Factors by : Franz Hefti
Download or read book Neurotrophic Factors written by Franz Hefti and published by . This book was released on 1998-10-01 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the first comprehensive overview of a novel field of neuropharmacology. Neurotrophic factors are currently in clinical trials and there is a broad research effort which aims at alternative administration strategies and at replacing them with small molecule mimetics. The field represents a unique and novel approach to the treatment of neurodegenerative diseases.
Book Synopsis Neurotrophin Protocols by : Robert A. Rush
Download or read book Neurotrophin Protocols written by Robert A. Rush and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past decade has seen an extraordinary growth in research interest in neurotrophic factors, and the study of the neurotrophin family has led this activity. Nevertheless, this area of research has often struggled as a result of techniques that were either inadequate or just emerging from other research fields and disciplines. Neurotrophin Protocols has brought together many leaders in the neurotrophin field who detail their special expertise in a wide variety of techniques. Though most procedures are valid across many diff- ent fields of research, some of those described here have been developed to address particular issues within the neurotrophic factor field. The protocols cover a broad range of biochemical, histological, and biological techniques that are often required by the modern laboratory. However, all have been written with sufficient detail to allow any laboratory to achieve proficiency without need of reference to other texts. Neurotrophin Protocols is divided into four sections dealing with p- tein, RNA, recombinant, and in vivo techniques. Protein techniques have in general been less successfully employed than those dealing with RNA or DNA. However, procedures that achieve localization and quantification of the neurotrophins are now being used more extensively. Their inclusion here should assist further studies at the protein level. Transgenic cell lines and animals are commonplace in the scientific research literature, but their inc- sion in several chapters in this book provide some novel uses that are not readily available elsewhere.
Book Synopsis Neurotrophic Factors by : Sandra E. Loughlin
Download or read book Neurotrophic Factors written by Sandra E. Loughlin and published by Elsevier. This book was released on 2012-12-02 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume clearly synthesizes current information on defined neurotrophic factors, emphasizing their localization and molecular/cellular function in the central nervous system. Brain development and aging, neurodegenerative disorders, plasticity, and memory all are closely examined within the context of this rapidly expanding field. Researchers in neurobiology, cell biology, and molecular biology will find Neurotrophic Factors an invaluable reference for their research libraries. Offers the most up-do-date synthesis of concepts on neurotrophic factors in the nervous system Integrates molecular, cellular, and neuroanatomical concepts of neurotrophic factor function Includes special chapters on primary, secondary, and tertiary messenger systems Examines brain development, differentiation, neurodegenerative disorders, and adult plasticity
Book Synopsis Neurotrophic Factors by : Franz Hefti
Download or read book Neurotrophic Factors written by Franz Hefti and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacology of neurotrophic factors is part of the general field called neuroprotection or neurodegeneration, which has emerged during the past two decades. This new broad research area has identified molecular mechanisms that regulate the morphological plasticity of the nervous system and, in con sequence, discovered novel pharmacological approaches to manipulate these processes in disease states. The new, structural neuropharmacology as de scribed in this volume attempts to regulate the anatomic aspects of the nervous system and is perhaps comparable to hardware manipulation in computer systems. In contrast, classical neuropharmacology identified multiple ways to modify the function of existing synapses or ion channels in the nervous system, comparable to software manipulations in the computer field. The pharmacol ogy of neurotrophic factor is at an early stage and has not produced any major drugs yet. However, the first quintessential clinical trials have been carried out in the past two years or are currently in progress. Rapid further advances can be expected. The discovery of nerve growth factor (NGF), the first protein known to promote survival and growth of nerve cells, led to the discovery of a family of related proteins, the neurotrophins and their receptors. This concept was generalized to incorporate many other protein families that are included in the functional definition of neurotrophic factors, i. e. , proteins able to regulate survival and differentiation of neurons.
