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Author : Yongjun Sun
Publisher : Frontiers Media SA
ISBN 13 : 2832521150
Total Pages : 314 pages
Book Rating : 4.8/5 (325 download)
Download or read book Advances in neuroprotective agents for cerebral ischemia treatment written by Yongjun Sun and published by Frontiers Media SA. This book was released on 2023-04-20 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul A. Lapchak
Publisher : Springer
ISBN 13 : 3319453459
Total Pages : 795 pages
Book Rating : 4.3/5 (194 download)
Download or read book Neuroprotective Therapy for Stroke and Ischemic Disease written by Paul A. Lapchak and published by Springer. This book was released on 2017-01-12 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.
Author :
Publisher : Academic Press
ISBN 13 : 0080857744
Total Pages : 393 pages
Book Rating : 4.0/5 (88 download)
Download or read book Neuroprotective Agents and Cerebral Ischaemia written by and published by Academic Press. This book was released on 1996-11-26 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1959, International Review of Neurobiology has been a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. This important serial is now being combined with Neuroscience Perspectives and Methods in Neurosciences. This combination results in a series that reaches a wider audience and publishes a greater number of thematic volumes. Stroke is the third major cause of death in the western world, and recent data provide hope that treatments may soon be available. Written by world experts on the mechanisms involved in neurodegeneration, Neuroprotective Agents and Cerebral Ischaemia presents an up-to-date review of current research and developing therapies. This book is essential reading for all clinicians and researchers searching for neuroprotective drugs. Describes the mechanisms involved in cell death and the biochemical changes occurring during an ischaemic episode Presents the different factors affecting the neurodegenerative process and how compounds acting on these systems may lead to novel neuroprotective agents Reviews in vitro and in vivo models of stroke and the activity of putative neuroprotective drugs Discusses the application of preclinical data to formulate approaches to a clinical problem Provides detailed reviews of both completed clinical trials and those currently underway
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
ISBN 13 : 1617790494
Total Pages : 575 pages
Book Rating : 4.6/5 (177 download)
Download or read book The Handbook of Neuroprotection written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2011-02-14 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative. The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of neurological disorders. Neuroprotective effects of older, established drugs, as well as new drugs in development, are well documented in this detailed volume, featuring the most cutting-edge and innovative methods currently in use. In-depth and authoritative, The Handbook of Neuroprotection features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.
Author : Manangos
Publisher : Springer Science & Business Media
ISBN 13 : 1468467964
Total Pages : 371 pages
Book Rating : 4.4/5 (684 download)
Download or read book Emerging Strategies in Neuroprotection written by Manangos and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: SOLOMON H. SNYDER Receptor Research Reaches Neurology: Relevance to Neurodegenerative Diseases and Stroke President George Bush has heralded the 1990s as the decade of the brain, based largely on the rapid escalation of advances in the molecular neuro sciences and the likelihood that these will bear therapeutic fruit before the turn of the century. There is little doubt that the 1970s and 1980s have witnessed more remarkable advances in the molecular neurosciences than all of the preceding hundred years. Identification of receptor sites for drugs and neurotransmitters along with simple, sensitive, and specific means of monitoring them has made it possible to elucidate the mechanism of action for many known drugs and to identify new chemical entities as potential therapeutic agents. At the same time, the numbers of distinct neurotrans mitters have multiplied. Prior to 1970 only the biogenic amines were well accepted as transmitters. The early 1970s witnessed the gradual acceptance of amino acids as major excitatory and inhibitory neurotransmitters. Identification of opiate receptors and the subsequent identification of the enkephalins as their endogenous ligands led to an appreciation of peptides as putative transmitters and the accumulation of as many as a hundred neuropeptides by the decade's end. In the 1980s the revolutions of molecular biology have been applied aggressively to the neurosciences with molecular cloning for neuropeptide precursors, many important neurochemical en zymes, and receptors for numerous transmitters.
Author : Bruno Meloni
Publisher : Frontiers Media SA
ISBN 13 : 2889717275
Total Pages : 221 pages
Book Rating : 4.8/5 (897 download)
Download or read book Therapeutic Agents and Targets to Minimize Ischemic Brain Injury written by Bruno Meloni and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: BM would like to declare that he has filed patents for the application of arginine-rich peptide as neuroprotective agents for stroke and other neurological disorders. RRR patents licensed by Neuronasal Inc., a company that he also consults for and has equity interest in. All other Topic Editors declare no competing interests with regards to the Research Topic subject.
Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0128097698
Total Pages : 492 pages
Book Rating : 4.1/5 (28 download)
Download or read book Discovery and Development of Neuroprotective Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2017-05-18 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Neuroprotective Agents from Natural Products draws together global research on medicinal agents from natural sources as starting points for the design of neuroprotective drugs. From the prediction of promising leads and identification of active agents to the extraction of complex molecules, the book explores a range of important topics to support the development of safer, more economical therapeutics for these increasingly prevalent diseases. Beginning with an overview of current developments in the field, the book goes on to explore the identification, extraction and phytochemistry of such neuroprotective agents as antioxidants, biophenols and naturally occurring anti-inflammatory steroid analogues. Specific natural sources of bioactive agents are reviewed, and the development of these agents into therapeutics for a number of specific neurological disorders, including Alzheimer’s disease, Parkinson’s disease and ischemic brain stroke, are discussed. Combining the expertise of specialists from around the world, this in the Natural Products Drug Discovery series aims to support and encourage researchers in the investigation of natural sources as starting points for the development of standardized, safe and effective neuroprotective drugs. Features chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Includes comprehensive coverage of cutting-edge research advances in the design of drugs from natural products targeted at different kinds of neurodegenerative diseases Offers a practical review of identification, isolation and extraction techniques to support medicinal chemists in the lab
Author : Matilde Otero-Losada
Publisher : Frontiers Media SA
ISBN 13 : 2889459543
Total Pages : 114 pages
Book Rating : 4.8/5 (894 download)
Download or read book Neuroprotection in Brain Hypoxia written by Matilde Otero-Losada and published by Frontiers Media SA. This book was released on 2019-08-30 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite compelling preclinical evidence from laboratory models of brain hypoxia suggesting potential neuroprotective strategies, only scattered data are available from clinical studies. A few candidate neuroprotectants have been studied regarding antioxidant, antiapoptotic, anti-excitotoxic, immunomodulatory, and neurotrophic effects. In parallel with clinical innovations, preclinical research initiatives are also identifying new animal models more closely resembling the clinical course and pathology of neurodegenerative diseases. Clarifying the specific mission of the brain cells involved in the damage/repair system in the examined animal models is important to define new therapeutic targets. Following hypoxic damage, detrimental events intermingle with the repairing events in both time- and cellular-dependent fashion. Identifying reliable post-hypoxia brain markers is mandatory to develop potential therapeutic interventions, improving translational research from the experimental observations to the clinical application. A deeper understanding of the precise participation of neurons, glia, and endothelial cells is expected to offer more clues for designing new therapeutic strategies to reduce the current gap among the experimental and the clinical data. One of the main issues should be to study the epigenetic mechanism of neuroprotective agents and their action on the genetic modification induced by hypoxia. Achieving this goal is presumed critical to obtain more conclusive results in patients that by now do not receive appropriate therapy for mitigating the several diseases generated by brain hypoxia. Although a few ongoing studies are evaluating interesting approaches, future research is necessary to come to a novel mechanism of neuroprotection. This book encompasses different chapters conveying the goals and aims of the pertaining research.
Author : Bruce Trembly
Publisher :
ISBN 13 :
Total Pages : 368 pages
Book Rating : 4.X/5 (2 download)
Download or read book Neuroprotective Agents written by Bruce Trembly and published by . This book was released on 1995 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the use of both short- and long-term treatment of such neuroprotective agents as calcium channel antagonists, adenosine, cannabinoids, and NMDA receptor antagonists in cerebral ischaemia, hypoxia, head trauma, and neurotrauma, among other pathologic conditions. Further study is made of reactive oxygen species in neuronal degeneration and free radical mechanisms and neuroprotective antioxidants.
Author : George A. Mashour
Publisher : Oxford University Press
ISBN 13 : 0191063541
Total Pages : 351 pages
Book Rating : 4.1/5 (91 download)
Download or read book Oxford Textbook of Neuroscience and Anaesthesiology written by George A. Mashour and published by Oxford University Press. This book was released on 2019-01-10 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: The perioperative care of individuals with neurologic compromise is critically important, yet it is only one dimension of the rich relationship between anaesthesiology and the neurosciences. The mechanism of everyday therapeutic interventions such as anaesthesia and analgesia is exciting neuroscience in its own right. At the new frontier of outcomes studies lies the question of how the perioperative period might impact the brain. For example, questions related to anaesthetic neurotoxicity, delirium, and cognitive dysfunction pose critical challenges for the field. The Oxford Textbook in Neuroscience and Anaesthesiology addresses the exciting field of neuroanaesthesiology in a new and stimulating way. In twenty eight chapters, the neuroscientific basis of anaesthesiology, the full spectrum of clinical neuroanaesthesia, and the care of neurologic patients undergoing non-neurologic surgery are explored in one comprehensive textbook for the first time. The first section considers the neural mechanisms of general anaesthetics, cerebral physiology, the neurobiology of pain, and more. The second section explores the care of patients with neurologic disease in the operating room or intensive care unit. These clinical chapters systematically treat the perioperative considerations of both brain and spine surgery, and provide introductions to neurocritical care and pediatric neuroanaesthesia. The final section outlines the care of neurologic patients undergoing non-neurologic surgery. It examines key connections of neurology and anaesthesiology, examining how conditions such as dementia, stroke, or epilepsy interface with the perioperative period. Each chapter has been carefully crafted to be concise yet highly informative, reflecting the cutting edge of neuroscience and neuroanaesthesiology. This international textbook gathers the best available expertise of authors and leaders worldwide. Includes access to online-only content, including more than 20 cases and more than 90 questions that can be used in presentations and teaching sessions. By activating your unique access code, you can access and use the material.
Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author : William Slikker
Publisher :
ISBN 13 :
Total Pages : 510 pages
Book Rating : 4.F/5 ( download)
Download or read book Neuroprotective Agents written by William Slikker and published by . This book was released on 2001 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: An international group of scientists in both clinical and basic research in neuroprotective agents examine the effects of and therapy for spinal cord injury; inflammatory responses in intracerebral hemorrhage; neurotoxicity and genetic damage from amphetamine abuse; effects of marijuana abuse; cerebrovascular deficits; effects of and therapy for ischemic stroke; distribution of microglia in ageing brain and after transgenic manipulation; preconditioning gene induction for neuroprotection against oxidative stress; interaction of genes and environment in the expression and treatment of autism in an animal model; pathology and pharmacology of spreading depression. The volume also examines proposed designs and strategies for neuroprotection trials.
Author : Frank W. Marcoux
Publisher : Springer Science & Business Media
ISBN 13 : 3662062747
Total Pages : 509 pages
Book Rating : 4.6/5 (62 download)
Download or read book CNS Neuroprotection written by Frank W. Marcoux and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: "CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute and chronic human neurodegenerative conditions. While the outcomes of these trials have not been as successful as initially hoped, these were early explorations, and the pipeline of relevant ideas continues to grow in strength and depth. We predict that early in this new millennium, crippling disorders such as stroke and Alzheimer's disease will be treated effectively by therapeutic neuroprotective strategies. This volume of the Handbook of Experimental Pharmacology titled eNS Neuroprotection provides a pharmacological perspective on currently promis ing neuroprotective approaches, and a clinical perspective on the challenges involved in establishing the efficacy of these approaches through appropriate clinical trials. Section I, "Mechanistic Approaches to CNS Neuroprotection," reviews major injury mechanisms that have formed the basis for many past and present clinical trials conducted around the world. Dr. KIM and colleagues, Washington University School of Medicine, review the status of blocking excitotoxicity as an approach to CNS neuroprotection. Dr. WANG, Pfizer Global Research and Development,Ann Arbor Laboratories, outlines evidence supporting a contri bution of apoptosis to pathological neuronal or glial cell loss. Drs. BECKER and HALLENBECK, University of Washington and the National Institute on Neuro logical Diseases and Stroke, respectively, argue that inhibiting inflammatory pathways in the brain can be neuroprotective. Dr.
Author : A. Baethmann
Publisher : Springer Science & Business Media
ISBN 13 : 1468452037
Total Pages : 403 pages
Book Rating : 4.4/5 (684 download)
Download or read book Mechanisms of Secondary Brain Damage written by A. Baethmann and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: A distinction between primary and secondary brain damage of vari ous origin, particularly in acute lesions, such as head injury and ische mia is not entirely new. The concept is of practical significance, be cause it is the foremost intention of all clinical efforts to prevent, or at least attenuate the development of secondary sequelae. Primary dam age to nervous elements usually cannot be influenced by treatment. Its prevention is the objective of prophylactic measures. The current volume gathered prominent scientists and clinicians from various fields to pro vide a competent introduction and survey of the various aspects involved in secondary brain damage. It was attempted to provide criteria for the distinction between the primary and secondary phenomena on a morpho logical and functional level, on the basis of the kinetics involved and, most importantly, regarding the different specific manifestations, such as disturbances of microcirculation, aspects of the blood-brain barrier, and of cellular structure and function at a molecular level. Although it was not expected that a grand unifying hypothesis will be reached recon cilable with the many, occasionally opposing views on such a complex subject, nevertheless, the present volume attains an appropriate result. It can best be described as a mosaic of many different pieces which only as an ensemble reflect the current state of the art.
Author : Christian Alzheimer
Publisher : Springer
ISBN 13 : 9781461349341
Total Pages : 0 pages
Book Rating : 4.3/5 (493 download)
Download or read book Molecular and Cellular Biology of Neuroprotection in the CNS written by Christian Alzheimer and published by Springer. This book was released on 2012-11-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases. This book brings together leading experts from neurobiology, neurophysiology, neuropharmacology, neuroimmunology and clinical neuroscience to highlight the most recent milestones in this rapidly evolving field. The book will serve as a reference for both basic neuroscientists and clinicians interested in an authoritative update on the molecular and cellular biology of neuroprotection and its promises for new therapeutic strategies.
Author : Santhosh Penta
Publisher : Academic Press
ISBN 13 : 012803873X
Total Pages : 191 pages
Book Rating : 4.1/5 (28 download)
Download or read book Advances in Structure and Activity Relationship of Coumarin Derivatives written by Santhosh Penta and published by Academic Press. This book was released on 2015-08-07 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity. Accessible and current coverage of coumarin derivatives from structure to potential applications Application of SAR technology to predict bioactivity of the derivatives based on its chemical structure Information for researchers in medicinal chemistry, pharmaceutical sciences, and related fields
Author : Natalia N Nalivaeva
Publisher : Frontiers Media SA
ISBN 13 : 2889631176
Total Pages : 162 pages
Book Rating : 4.8/5 (896 download)
Download or read book Brain Hypoxia and Ischemia: New Insights Into Neurodegeneration and Neuroprotection written by Natalia N Nalivaeva and published by Frontiers Media SA. This book was released on 2019-11-15 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
