Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders

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Publisher :
ISBN 13 : 9789811973772
Total Pages : 0 pages
Book Rating : 4.9/5 (737 download)

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Book Synopsis Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders by : Yong-Ku Kim

Download or read book Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders written by Yong-Ku Kim and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Gut Microbiota

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Publisher : BoD – Books on Demand
ISBN 13 : 1789848148
Total Pages : 115 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Gut Microbiota by : Alper Evrensel

Download or read book Gut Microbiota written by Alper Evrensel and published by BoD – Books on Demand. This book was released on 2018-12-12 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: The gut-brain axis has gained considerable attention from different branches of the scientific community in recent years. In this book, scientists from different disciplines present current scientific knowledge on the topic. The interaction between the prokaryote and eukaryote cells stimulates the evolutionary processes, and results in various systemic illnesses such as neuropsychiatric disorders and may help the continuity of health. Nature has provided us with healthy food that builds our pharmacy. This natural pharmacy store may help the body's healing processes through its effects on gut microbiota and the immune system. This book aims to provide the reader with detailed analyses of the current scientific knowledge on the gut-brain axis and its relation with health and disease. We hope that the reader benefits from the presented material.

Neurotrophic Factors

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Publisher : Springer Science & Business Media
ISBN 13 : 3642451063
Total Pages : 514 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Neurotrophic Factors by : Gary R. Lewin

Download or read book Neurotrophic Factors written by Gary R. Lewin and published by Springer Science & Business Media. This book was released on 2014-03-25 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Gut Microbiota-Brain Axis in Enteric and Central Neuronal Functions in Health and Neuropsychiatric Disorders

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889764397
Total Pages : 141 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Gut Microbiota-Brain Axis in Enteric and Central Neuronal Functions in Health and Neuropsychiatric Disorders by : Francesca Ronchi

Download or read book Gut Microbiota-Brain Axis in Enteric and Central Neuronal Functions in Health and Neuropsychiatric Disorders written by Francesca Ronchi and published by Frontiers Media SA. This book was released on 2022-06-28 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Dr. Kasper is co-founder of Symbiotix Biotherapeutics. The other Topic Editors declare no competing interests with regards to the Research Topic theme.

Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases

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Author :
Publisher : World Scientific
ISBN 13 : 9811221162
Total Pages : 396 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases by : Adrien A Eshraghi

Download or read book Gut-brain Connection, Myth Or Reality?: Role Of The Microbiome In Health And Diseases written by Adrien A Eshraghi and published by World Scientific. This book was released on 2021-11-03 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function.

Neuropsychiatric Disorders

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Publisher : Springer Science & Business Media
ISBN 13 : 4431538712
Total Pages : 346 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Neuropsychiatric Disorders by : Koho Miyoshi

Download or read book Neuropsychiatric Disorders written by Koho Miyoshi and published by Springer Science & Business Media. This book was released on 2010-08-09 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around the world societies are facing growing aging populations with the concomitant increase in neuropsychiatric disorders. Neuropsychiatric disorders are organic brain diseases with psychiatric symptoms, as in Alzheimer’s and Parkinson’s diseases, that cause cognitive impairment, including dementia, amnesic syndrome, and personality–behavioral changes. As a clinical science, neuropsychiatry aims to explore the complex interrelationship between behavior and brain function from a variety of perspectives, including those of psychology, neurology, and psychiatry. This concise and updated monograph comprises the latest findings in the field and includes chapters on delusional symptoms, mood disorders and neurotic symptoms, cognitive impairment, behavioral and personality changes, and recently, cerebral alterations revealed in PTSD patients and in endogenous psychoses through neuroimaging and neuropathology. These findings will certainly widen the realm of neuropsychiatry going forward and will prove of great value to specialists as well as to academics and trainees in neurology, psychiatry, neuropsychology, neuroradiology, neuropathology, neurophysiology, neurochemistry, and clinical genetics. Ultimately, neuropsychiatry aims to prevent and reduce the suffering of individuals with the psychiatric symptoms of cerebral disorders.

Neuroinflammation and Behaviour

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Publisher : Frontiers Media SA
ISBN 13 : 288919602X
Total Pages : 138 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Neuroinflammation and Behaviour by : Luba Sominsky

Download or read book Neuroinflammation and Behaviour written by Luba Sominsky and published by Frontiers Media SA. This book was released on 2015-07-21 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain and immune system are involved in an intricate network of bidirectional communication. This relationship is vital for optimal physiological and psychological development and functioning but can also result in unwanted outcomes. In particular, this interaction plays an important role in cognition, mood and behaviour. Neuroinflammation is known to contribute to neurological and affective disorders including impaired learning and memory, depressive, anxiety and schizoaffective symptoms, as well as pain. The development of these conditions often occurs on the backdrop of pre-existing physical illnesses which give rise to increased activation of the immune system, such as cancer, obesity, infection and autoimmune disorders. Similarly, psychological states can alter regulation of the immune system. This has been most extensively studied in the context of stress and immune function. Understanding the underlying mechanisms that lead to the onset of inflammation-induced neuropathology and stress-induced immune suppression will contribute to the development of novel and effective treatment strategies for both the disease and its neurological side effects. In this research topic we explored the relationship between the immune system and the brain throughout life. We include both original research and review papers from animal, clinical and molecular perspectives.

Gut Microbiome in Neurological Health and Disorders

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Author :
Publisher : Springer Nature
ISBN 13 : 9811945306
Total Pages : 315 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Gut Microbiome in Neurological Health and Disorders by : Amit Kumar Tripathi

Download or read book Gut Microbiome in Neurological Health and Disorders written by Amit Kumar Tripathi and published by Springer Nature. This book was released on 2022-08-03 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of bidirectional communication between gut-microbiome-brain, pathways, nutrients, and metabolites that are involved in microbiota gut-brain axis (MGBA) interactions. Further it reviews the relevance of this axis in the neurological disorders and potential therapeutic interventions, involving gut microbiome or probiotics and prebiotics which can ameliorate the neurological disorders. The book examines the role of gut microbiota in the establishment and hemostasis of innate immune response and explores the possibility of development of microbiome-targeted therapeutic interventions. Notably, the book discusses the role of the gut microbiota and immune system on the maintenance of brain functions and the development of neurological disorders. It also highlights the recent advances in improving neurological diseases by phytochemicals, prebiotics and probiotics. This book is useful for researchers working in neuropharmacology, Clinical Research, toxicology, neurodegeneration, and stroke biology.

Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders

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Author :
Publisher : Springer Nature
ISBN 13 : 9811973768
Total Pages : 564 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders by : Yong-Ku Kim

Download or read book Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders written by Yong-Ku Kim and published by Springer Nature. This book was released on 2023-03-22 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Clinical Relevance of the Immune-to-Brain and Brain-to-Immune Communications

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889457842
Total Pages : 172 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Clinical Relevance of the Immune-to-Brain and Brain-to-Immune Communications by : Julie Lasselin

Download or read book Clinical Relevance of the Immune-to-Brain and Brain-to-Immune Communications written by Julie Lasselin and published by Frontiers Media SA. This book was released on 2019-03-29 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental and clinical evidence demonstrates an intense crosstalk among the nervous, endocrine and immune systems. The central nervous system (CNS) not only has the capacity to affect peripheral immune function, but is also able to sense and process signals from the peripheral immune system. The bi-directional interaction between the CNS and the peripheral immune system has gained great interest as it can help better understand disease pathophysiology as well as improving health and treatment outcomes in patients. On the one hand, inflammatory factors are known to affect CNS functions and to induce neuropsychiatric symptoms, making immune-to-brain communication highly relevant for psychiatric diseases and their treatments. On the other hand, analyzing pathways of brain-to-immune communication will help to understand the pathophysiology of chronic inflammatory disorders and will form the basis for optimizing treatment of these diseases.

Microbial Endocrinology

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Publisher : Springer Science & Business Media
ISBN 13 : 1441955763
Total Pages : 325 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Microbial Endocrinology by : Mark Lyte

Download or read book Microbial Endocrinology written by Mark Lyte and published by Springer Science & Business Media. This book was released on 2010-04-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.

Neurodegenerative Diseases: From Gut-Brain Axis to Brain Microbiome

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Publisher : Frontiers Media SA
ISBN 13 : 2832526381
Total Pages : 159 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Neurodegenerative Diseases: From Gut-Brain Axis to Brain Microbiome by : George Tetz

Download or read book Neurodegenerative Diseases: From Gut-Brain Axis to Brain Microbiome written by George Tetz and published by Frontiers Media SA. This book was released on 2023-06-08 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there are growing line of evidence for the role of the gut microbiome in different neurodegenerative diseases, the role and even the existence of the brain microbiome is only starting to be uncovered. Indeed, the brain was long considered to be a sterile environment and only recent studies have shown the presence of bacteria and fungi in the human central nervous system, and even inhabiting brain cells. The so called “brain microbiome” is appealing and immediately drew attention, since it is highly possible that microorganisms could have profound direct effects on a variety of processes in the brain, with the non-limiting examples of neurodegenerative and neurodevelopmental diseases triggering and progression. However, the brain microbiome remains poorly understood and even despite recent technological advances, is has only began to be explored.

Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury

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Publisher : Frontiers Media SA
ISBN 13 : 2889196917
Total Pages : 286 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury by : Arthur Liesz

Download or read book Mechanisms of Neuroinflammation and Inflammatory Neurodegeneration in Acute Brain Injury written by Arthur Liesz and published by Frontiers Media SA. This book was released on 2015-11-13 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanisms of brain-immune interactions became a cutting-edge topic in systemic neurosciences over the past years. Acute lesions of the brain parenchyma, particularly, induce a profound and highly complex neuroinflammatory reaction with similar mechanistic properties between differing disease paradigms like ischemic stroke, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI). Resident microglial cells sense tissue damage and initiate inflammation, activation of the endothelial brain-immune interface promotes recruitment of systemic immune cells to the brain and systemic humoral immune mediators (e.g. complements and cytokines) enter the brain through the damaged blood-brain barrier. These cellular and humoral constituents of the neuroinflammatory reaction to brain injury contribute substantially to secondary brain damage and neurodegeneration. Diverse inflammatory cascades such as pro-inflammatory cytokine secretion of invading leukocytes and direct cell-cell-contact cytotoxicity between lymphocytes and neurons have been demonstrated to mediate the inflammatory ‘collateral damage’ in models of acute brain injury. Besides mediating neuronal cell loss and degeneration, secondary inflammatory mechanisms also contribute to functional modulation of neurons and the impact of post-lesional neuroinflammation can even be detected on the behavioral level. The contribution of several specific immune cell subpopulations to the complex orchestration of secondary neuroinflammation has been revealed just recently. However, the differential vulnerability of specific neuronal cell types and the molecular mechanisms of inflammatory neurodegeneration are still elusive. Furthermore, we are only on the verge of characterizing the control of long-term recovery and neuronal plasticity after brain damage by inflammatory pathways. Yet, a more detailed but also comprehensive understanding of the multifaceted interaction of these two supersystems is of direct translational relevance. Immunotherapeutic strategies currently shift to the center of translational research in acute CNS lesion since all clinical trials investigating direct neuroprotective therapies failed. To advance our knowledge on brain-immune communications after brain damage an interdisciplinary approach covered by cellular neuroscience as well as neuroimmunology, brain imaging and behavioral sciences is crucial to thoroughly depict the intricate mechanisms.

Neuroinflammation and Cognition

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889457605
Total Pages : 191 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Neuroinflammation and Cognition by : Ashok Kumar

Download or read book Neuroinflammation and Cognition written by Ashok Kumar and published by Frontiers Media SA. This book was released on 2019-03-22 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is one of the major risk factors for the onset and progression of various neurodegenerative diseases. Neuroinflammation is a common feature of virtually every central nervous system disease, and is acknowledged as a likely mediator of cognitive impairments. Systemic inflammation levels are augmented with advanced age and neurodegeneration. The influence of age on neuroinflammatory responses including glial activation, increased production of proinflammatory cytokines, and aberrant neuronal signaling could magnify the deterioration of the central nervous system microenvironment in disease, and may contribute to enhanced cognitive impairment. This eBook is a collection of highly informative original research articles, providing comprehensive aspect of neuroinflammation and possible therapeutic interventions in rescuing cognitive impairments.

HIV and the Brain

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Publisher : Springer Science & Business Media
ISBN 13 : 1597454346
Total Pages : 403 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis HIV and the Brain by : Robert H. Paul

Download or read book HIV and the Brain written by Robert H. Paul and published by Springer Science & Business Media. This book was released on 2009-04-20 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading experts, this book offers a picture of how HIV impairs the brain, focusing on emerging areas including genetic strains of the virus, interactions between advanced age and HIV, and the impact of HIV on the brain during antiretroviral therapy.

Paying the Price

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Author :
Publisher : King's Fund Publishing
ISBN 13 : 9781857175714
Total Pages : 143 pages
Book Rating : 4.1/5 (757 download)

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Book Synopsis Paying the Price by : Paul McCrone

Download or read book Paying the Price written by Paul McCrone and published by King's Fund Publishing. This book was released on 2008-01-01 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report concludes that the prevalence of specific mental disorders is likely to remain broadly stable over the next 20 years. However, costs are projected to increase substantially, largely because of the expected increase in the number of people with dementia. The cost of lost employment is also projected to increase, confirming the major adverse economic impact of poor mental health. The report calls for future costs to be met, a focus on employment, more evidence-based interventions, better systems of early detection and treatment of dementia, and further research into the cost-effectiveness of a range of interventions, including mental health promotion and prevention initiatives.

Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease

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Author :
Publisher : Springer
ISBN 13 : 1493908979
Total Pages : 440 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease by : Mark Lyte

Download or read book Microbial Endocrinology: The Microbiota-Gut-Brain Axis in Health and Disease written by Mark Lyte and published by Springer. This book was released on 2014-07-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.​