Neurodegenerative Diseases And Metal Ions

Download Neurodegenerative Diseases And Metal Ions full books in PDF, epub, and Kindle. Read online Neurodegenerative Diseases And Metal Ions ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Metal Ions and Neurodegenerative Disorders

Author : Paolo Zatta
Publisher : World Scientific
ISBN 13 : 9812383980
Total Pages : 538 pages
Book Rating : 4.8/5 (123 download)

DOWNLOAD NOW!

Book Synopsis Metal Ions and Neurodegenerative Disorders by : Paolo Zatta

Download or read book Metal Ions and Neurodegenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on ?Metals and the Brain: From Neurochemistry to Neurodegeneration? (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.

Metal Ions in Neurological Systems

Author : Wolfgang Linert
Publisher : Springer Science & Business Media
ISBN 13 : 3709110009
Total Pages : 247 pages
Book Rating : 4.7/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Metal Ions in Neurological Systems by : Wolfgang Linert

Download or read book Metal Ions in Neurological Systems written by Wolfgang Linert and published by Springer Science & Business Media. This book was released on 2012-08 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions in the brain are a necessity as well as a poison. The presence of metal ions in the active sites of biological catalysts or metalloproteins and in the biological functioning of nucleic acids is very well documented and they are required for brain activity. On the other hand, metals are very effective in generating oxidative stress. This effect does not only play a role in immunology but also is the root of practically all neurodegenerative disorders by inducing disease via the death of neurons. Managing metal ions in the brain could therefore be an important strategy in the search for therapeutic agents used in the treatment of neurodegenerative diseases. This new title gives an overview to key topics in the area of metal ions in the brain. It focuses on the role of metal ions in neurological systems by describing their advantageous functions as well as their poisonous features. It is therefore of interest for scientists in biochemistry and biophysics, physiology, toxicology as well as for physicians focused on this topic.

Metal Ions And Neurodengenerative Disorders

Author : Paolo Zatta
Publisher : World Scientific
ISBN 13 : 9814485764
Total Pages : 538 pages
Book Rating : 4.8/5 (144 download)

DOWNLOAD NOW!

Book Synopsis Metal Ions And Neurodengenerative Disorders by : Paolo Zatta

Download or read book Metal Ions And Neurodengenerative Disorders written by Paolo Zatta and published by World Scientific. This book was released on 2003-11-03 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies have established a clear connection between neuronal oxidative stress and several neurodegenerative diseases, with consequential damages to lipids, proteins, nucleic acids, etc. In addition, several modifications indicative of oxidative stress have been described in association with neurons, neurofibrillary tangles and senile plaques in Alzheimer's disease, including advanced glycation end products and free carbonyl oxidation.Oxidative damage and antioxidant responses are now well characterized, but sources of damaging free radicals are yet to be fully understood. Evidences of alteration in metal ions metabolism have been reported in various diseases like Alzheimer's, Wilson, Menkes, Prion, Pick, Huntington disease, epilepsy and other pathological events. Thus, metal ions play a pivotal role in neurodegenerative phenomena.Chelation therapy is still in the early days of its development, but research in this area could lead to new products that could revolutionize treatment. Two international conferences on “Metals and the Brain: From Neurochemistry to Neurodegeneration” (Padova, Italy, 2000 and Fez, Morocco, 2002) were recently held to discuss the role of metal ions in neurophysiopathology. A third will be held in 2005 in Johannesburg, South Africa.This book follows the same train of thought as those conferences, in order to highlight the unquestionable importance of metal ions in the research on the neurophysiopathology of neurodegenerative diseases. The excellent reputation of the scientists who have contributed to this project ensures the quality of the chapters presented here, and hopefully this will help spur new research initiatives in the field, which is still in its infancy.

Neurodegenerative Diseases and Metal Ions

Author : Astrid Sigel
Publisher : John Wiley & Sons
ISBN 13 : 0470028106
Total Pages : 488 pages
Book Rating : 4.4/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Neurodegenerative Diseases and Metal Ions by : Astrid Sigel

Download or read book Neurodegenerative Diseases and Metal Ions written by Astrid Sigel and published by John Wiley & Sons. This book was released on 2006-07-11 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Metal-Based Neurodegeneration

Author : Robert Crichton
Publisher : John Wiley & Sons
ISBN 13 : 1118553519
Total Pages : 628 pages
Book Rating : 4.1/5 (185 download)

DOWNLOAD NOW!

Book Synopsis Metal-Based Neurodegeneration by : Robert Crichton

Download or read book Metal-Based Neurodegeneration written by Robert Crichton and published by John Wiley & Sons. This book was released on 2013-09-04 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies. Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression of neurological diseases This extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.

Metal-based Neurodegeneration

Author : Robert Crichton
Publisher : Wiley
ISBN 13 : 9780470022559
Total Pages : 248 pages
Book Rating : 4.0/5 (225 download)

DOWNLOAD NOW!

Book Synopsis Metal-based Neurodegeneration by : Robert Crichton

Download or read book Metal-based Neurodegeneration written by Robert Crichton and published by Wiley. This book was released on 2006 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.

Mechanisms and Metal Involvement in Neurodegenerative Diseases

Author : Roberta J. Ward
Publisher : Metallobiology
ISBN 13 : 9781849735889
Total Pages : 0 pages
Book Rating : 4.7/5 (358 download)

DOWNLOAD NOW!

Book Synopsis Mechanisms and Metal Involvement in Neurodegenerative Diseases by : Roberta J. Ward

Download or read book Mechanisms and Metal Involvement in Neurodegenerative Diseases written by Roberta J. Ward and published by Metallobiology. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Readily accessible information on each of the neurodegenerative diseases written by acknowledged experts in the field.

Metal Related Neurodegenerative Disease

Author :
Publisher : Academic Press
ISBN 13 : 0124105351
Total Pages : 443 pages
Book Rating : 4.1/5 (241 download)

DOWNLOAD NOW!

Book Synopsis Metal Related Neurodegenerative Disease by :

Download or read book Metal Related Neurodegenerative Disease written by and published by Academic Press. This book was released on 2013-11-07 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders An update on advances in neuroimaging and pathology of metal related disease is also presented

Metallochemistry of Neurodegeneration

Author : Henryk Kozlowski
Publisher : Royal Society of Chemistry
ISBN 13 : 1847555314
Total Pages : 295 pages
Book Rating : 4.8/5 (475 download)

DOWNLOAD NOW!

Book Synopsis Metallochemistry of Neurodegeneration by : Henryk Kozlowski

Download or read book Metallochemistry of Neurodegeneration written by Henryk Kozlowski and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinorganic chemistry has a cross disciplinary approach, applying the principles of chemistry to biological systems. Metallochemistry of Neurodegeneration: Biological, Chemical and Genetic Aspects discusses the rapidly developing area of metals in the nervous system and their role in neurodegenerative disease, such as Alzheimer's, Parkinson's and prion diseases. Written by leading experts in their fields, each chapter combines elements of genetics, biochemistry and biological inorganic chemistry in its discussion. The book highlights the differences in pathologies of neurodegenerative diseases but also discusses the mechanistic similarities. Sections include: metal ions and prion diseases; metal ions and Alzheimer disease; manganese in brain functioning; metal involvement in Parkinson disease; Cu-Zn superoxide dismutase and familial amyotrophic lateral sclerosis. This book will appeal to both chemists and biologists at the post graduate and research level.

Metals and Neurodegeneration: Restoring the Balance

Author : Anthony R. White
Publisher : Frontiers Media SA
ISBN 13 : 2889197395
Total Pages : 134 pages
Book Rating : 4.8/5 (891 download)

DOWNLOAD NOW!

Book Synopsis Metals and Neurodegeneration: Restoring the Balance by : Anthony R. White

Download or read book Metals and Neurodegeneration: Restoring the Balance written by Anthony R. White and published by Frontiers Media SA. This book was released on 2016-02-02 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many additional structural and enzymatic functions. There is now considerable evidence that abnormal biometal homeostasis is a key feature of many neurodegenerative diseases and may have an important role in the onset and progression of disorders such as Alzheimer’s, Parkinson’s, prion and motor neuron diseases. Recent studies also support biometal roles in a number of less common neurodegenerative disorders. The role of biometals in a growing list of brain disorders is supported by evidence from a wide range of sources including molecular genetics, biochemical studies and biometal imaging. These studies have spurred a growing interest in understanding the role of biometals in brain function and disease as well as the development of therapeutic approaches that may be able to restore the altered biometal chemistry of the brain. These approaches range from genetic manipulation of biometal transport to chelation of excess metals or delivery of metals where levels are deficient. A number of these approaches are offering promising results in cellular and animal models of neurodegeneration with successful translation to pre-clinical and clinical trials. At a time of aging populations and slow progress in development of neurotherapeutics to treat age-related neurodegenerative diseases, there is now a critical need to further our understanding of biometals in neurodegeneration. This issue covers a broad range of topics related to biometals and their role in neurodegeneration. It is hoped that this will inspire greater discussion and exchange of ideas in this crucial area of research and lead to positive outcomes for sufferers of these neurodegenerative diseases.

Biometals in Neurodegenerative Diseases

Author : Anthony R. White
Publisher : Academic Press
ISBN 13 : 9780128045626
Total Pages : 0 pages
Book Rating : 4.0/5 (456 download)

DOWNLOAD NOW!

Book Synopsis Biometals in Neurodegenerative Diseases by : Anthony R. White

Download or read book Biometals in Neurodegenerative Diseases written by Anthony R. White and published by Academic Press. This book was released on 2017-04-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer's Disease, Parkinson's Disease, Motor Neuron Disease, Autism and lysosomal storage disorders. This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases. Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.

Metals and Oxidative Damage in Neurological Disorders

Author : James R. Connor
Publisher : Springer Science & Business Media
ISBN 13 : 1489901973
Total Pages : 383 pages
Book Rating : 4.4/5 (899 download)

DOWNLOAD NOW!

Book Synopsis Metals and Oxidative Damage in Neurological Disorders by : James R. Connor

Download or read book Metals and Oxidative Damage in Neurological Disorders written by James R. Connor and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to bring together scientists and clinicians interested in oxidative injury in the nervous system but whose approaches to investigation and treatment design vary widely. Indeed the goal of this book is to show that the investiga tive approaches and potential therapeutic interventions perhaps do not vary as widely as some may think. I think that the readers of this book will not read it from front to back, but will pick chapters of interest. Thus, the chapters are organized to contain information that is essential to understanding basic aspects of oxidative injury, and thus have some redundancy. However, within the context of each chapter the reader should hopefully find impetus and direction to go on to another chapter. The book is divided into three seetions. The first section contains reviews of metals and their role in generating oxidative injury. lron is considered in three of these chapters because of its relative abundance in the brain and its potency in inducing free radicals. The second section focuses on mechanisms by which the brain attempts to protect itself from oxidative injury. Some of these mechanisms have the potential to be protective in some situations and potentiaIly damaging in others. The third section contains the clinicaI diseases in which oxidative injury is known to contribute to the pathogenic process. This seetion ends with a chapter on antioxidant therapeutic strate gies in neurological disorders.

Neurodegenerative Diseases and Metal Ions

Author : Astrid Sigel
Publisher : John Wiley & Sons
ISBN 13 : 9780470014882
Total Pages : 463 pages
Book Rating : 4.0/5 (148 download)

DOWNLOAD NOW!

Book Synopsis Neurodegenerative Diseases and Metal Ions by : Astrid Sigel

Download or read book Neurodegenerative Diseases and Metal Ions written by Astrid Sigel and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: About the Series... Metal Ions in Life Sciences links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic chemistry, coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry. About this Book... Volume 1, devoted solely to the vital research area concerning the role of metal ions in neurodegenerative diseases, offers in 15 stimulating chapters an authoritative and timely view of this fascinating subject. Written by 41 internationally recognized experts, Neurodegenerative Diseases and Metal Ions highlights, supported by 130 illustrations, the recent progress made in understanding the role metal ions play in diseases like transmissible spongiform encephalopathies (Creutzfeldt-Jakob and related diseases), Alzheimer's, Parkinson's, Huntington's, Wilson's and Menkes' diseases, as well as in familial amyotrophic lateral sclerosis and others. The interplay between metal ions, catecholamines and the formation of reactive oxygen species resulting in oxidative stress is considered, as is the metalloneurochemistry of zinc and the neurotoxicity of aluminum, cadmium, lead, and mercury. The need for novel drugs which manipulate metal-centered neuropathology is emphasized.

Metal Ions in Neurodegenerative Diseases

Author : Christelle Hureau
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.:/5 (932 download)

DOWNLOAD NOW!

Book Synopsis Metal Ions in Neurodegenerative Diseases by : Christelle Hureau

Download or read book Metal Ions in Neurodegenerative Diseases written by Christelle Hureau and published by . This book was released on 2012 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurotoxicity of Metals

Author : Michael Aschner
Publisher : Springer
ISBN 13 : 331960189X
Total Pages : 377 pages
Book Rating : 4.3/5 (196 download)

DOWNLOAD NOW!

Book Synopsis Neurotoxicity of Metals by : Michael Aschner

Download or read book Neurotoxicity of Metals written by Michael Aschner and published by Springer. This book was released on 2017-09-09 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

Mineral and Metal Neurotoxicology

Author : Masayuki Yasui
Publisher : CRC Press
ISBN 13 : 1439810699
Total Pages : 481 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!

Book Synopsis Mineral and Metal Neurotoxicology by : Masayuki Yasui

Download or read book Mineral and Metal Neurotoxicology written by Masayuki Yasui and published by CRC Press. This book was released on 1996-09-26 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trace minerals and metals such as zinc, copper, and magnesium are accepted as a "natural" part of the human system. Interactions of some elements and/or disturbances in trace-metal or mineral homeostasis can, however, be toxic to the central nervous system (CNS). Mineral and Metal Neurotoxicology describes a wide range of basic and clinical issues

Neurodegeneration

Author : Danilo Milardi
Publisher : Royal Society of Chemistry
ISBN 13 : 1849733015
Total Pages : 285 pages
Book Rating : 4.8/5 (497 download)

DOWNLOAD NOW!

Book Synopsis Neurodegeneration by : Danilo Milardi

Download or read book Neurodegeneration written by Danilo Milardi and published by Royal Society of Chemistry. This book was released on 2011-06-24 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed "amyloid") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitable pharmacological target. However, drugs aimed at simply removing excess metals or interfering in amyloid deposition were unsuccessful and scientists have been forced to review the classical hypothesis. The latest advances suggest that deficiencies in protein homeostasis may lead to cell dysfunction and disease. Furthermore, small molecules with the potential to control metal homeostasis, or metallostasis, are expected to provide the framework for the design of novel proteostasis regulators. This book provides an up-date on the latest developments in this fast moving field. Traditional views concerning the relationship between the physio-pathological cycles of copper, zinc, iron, aluminium and the evolution of life, are compared with emerging ideas in the neuroscience of metal ions. Topics covered emphasize the importance of metals and oxidation chemistry to neuroscientists as well as providing a wider, multidisciplinary background to chemists who are attracted by these fascinating subjects. The text starts with a chapter on chemical evolution, the brain and metallomics which describes the brain's natural defences to adverse conditions. It then goes on to cover the chemistry and biology of proteostasis, environmental factors, and the role played by membranes in protein misfolding. The remaining chapters cover the role of metals and oxidative stress in Alzheimer's Disease, Parkinsonism, ALS and other neurodegenerative diseases. The book is suitable for academics, those working in industry, and postgraduate students.