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Neural Grafting In The Mammalian Cns
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Book Synopsis Neural Grafting in the Mammalian CNS by : Anders Björklund
Download or read book Neural Grafting in the Mammalian CNS written by Anders Björklund and published by Elsevier Publishing Company. This book was released on 1985 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transplantation Into the Mammalian CNS by : Don M. Gash
Download or read book Transplantation Into the Mammalian CNS written by Don M. Gash and published by Elsevier. This book was released on 1988 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation into the Mammalian CNS presents a comprehensive critical overview of recent advances of basic and clinical research in neural transplantation. Special emphasis is devoted to the emerging studies on the use of clinical grafts for the treatment of parkinsonism, the extension of this technology to additional models of neurological deficits, the immunobiology of neural implants, the exploration of trophic factors, and other new directions in the field of transplantation. Due to the extensive list of contents, only content headings are given. Full details can be obtained from the Publisher upon request.
Book Synopsis Neural Transplants by : John R. Sladek
Download or read book Neural Transplants written by John R. Sladek and published by . This book was released on 2014-01-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neural Transplants by : John R. Sladek
Download or read book Neural Transplants written by John R. Sladek and published by Springer. This book was released on 2012-04-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of mammalian neural transplantation really begins eighty-one years ago. In Chicago in December of 1903, a 34-year-old physician, Elizabeth Hopkins Dunn, working as a research assistant in neurology, initiated a series of experiments to examine the ability of neonatal rat cerebral tissue to survive transplantation into the brain of matched littermates. Out of 46 attempts, four clearly successful grafts were identified. The publication of Dunn's results in 1917, the first credible report to demonstrate the feasibility of mammalian CNS transplants, generated little interest. In fact, the next significant experiment in this field did not appear until 1930. The field continued to grow slowly and quietly as investigators gradually realized the value of neural trans plantation to study problems of development and plasticity in the mammalian nervous system. With the discovery in 1979 that grafted neurons were capable of appropriate and functional interactions with the host brain, interest in neural transplantation esca lated sharply. The extraordinary opportunities created by using functional neural trans plants in investigating basic issues in neurobiology, as well as the clinical implications, excited both scientists and the public. The popularity of neural transplantation has been growing rapidly in the past five years and shows no signs of abating. The present volume was designed to meet two needs created by the rapid growth of this subdiscipline of neurobiology. The first was to provide a thorough review of the experimental foundations of neural transplantation.
Book Synopsis Functional Neural Transplantation by : Stephen B. Dunnett
Download or read book Functional Neural Transplantation written by Stephen B. Dunnett and published by Lippincott Williams & Wilkins. This book was released on 1994 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neural Grafting by : United States. Congress. Office of Technology Assessment
Download or read book Neural Grafting written by United States. Congress. Office of Technology Assessment and published by . This book was released on 1990 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Grafting in the Mammalian Central Nervous System by : Lars Olson
Download or read book Grafting in the Mammalian Central Nervous System written by Lars Olson and published by . This book was released on 1988 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Axonal Regeneration in the Mammalian Central Nervous System by : Dorothy E. Oorschot
Download or read book Axonal Regeneration in the Mammalian Central Nervous System written by Dorothy E. Oorschot and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art review links the experimental data into a cohesive and critical account of CNS regeneration. Research findings are discussed in terms of their relevance to one (or more) of thirteen hypotheses concerned with regeneration in the mammalian CNS. Research findings reviewed include: regeneration in developing mammals and in submammalian vertebrates, the use of transplants and/or pharmacological treatments, in vitro studies on neurotrophic and neurite promoting factors and their potential relevance to CNS regeneration in vivo, and in vitro studies on the types of glial cells that may be responsible for enhancing or suppressing axonal re-growth.
Book Synopsis Neural Transplantation, CNS Neuronal Injury, and Regeneration by : Joe Marwah
Download or read book Neural Transplantation, CNS Neuronal Injury, and Regeneration written by Joe Marwah and published by CRC Press. This book was released on 1994-02-23 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Author :Congress of the United States Office of Publisher :The Minerva Group, Inc. ISBN 13 :9780898759075 Total Pages :208 pages Book Rating :4.7/5 (59 download)
Book Synopsis Neural Grafting by : Congress of the United States Office of
Download or read book Neural Grafting written by Congress of the United States Office of and published by The Minerva Group, Inc.. This book was released on 2002-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Expression and Distribution of Neural Cell Adhesion and Extracellular Matrix Molecules After Injury To, and Peripheral Nerve Grafting Into, the Adult Mammalian CNS. by :
Download or read book The Expression and Distribution of Neural Cell Adhesion and Extracellular Matrix Molecules After Injury To, and Peripheral Nerve Grafting Into, the Adult Mammalian CNS. written by and published by . This book was released on 1996 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transplantation into the Mammalian CNS by :
Download or read book Transplantation into the Mammalian CNS written by and published by Elsevier. This book was released on 1988-12-01 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation into the Mammalian CNS
Book Synopsis Adult Mammalian Central Nervous System Regeneration by : Bo Peng Lear
Download or read book Adult Mammalian Central Nervous System Regeneration written by Bo Peng Lear and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: When the mammalian central nervous system (CNS), the brain and spinal cord, is damaged or degenerates, there is limited to no regeneration, leading to permanent and debilitating functional impairments resulting in high rates of mortality. Neural repair is so difficult because of both the inhibitory environment and the lack of intrinsic potential to regenerate which is further exacerbated with aging. Even with decades of scientific studies, our understanding of how to make the CNS regenerate is still unknown. Scientists have been testing different methods to increase neural repair, either exogenous or endogenous. Exogenous repair, such as transplanting induced pluripotent stem cell (iPSC)-derived or fetal tissue-derived neural progenitors into the brain or spinal cord, can be used to replace injured neurons. Separately, endogenous regeneration, such as replenishing neurons in cases of traumatic or neurodegenerative neurological diseases from stem cells in neurogenic niches lining the ventricles and the hippocampus, can be harnessed to replace from within. Additionally, when there is damage to the neuron's projections, as in the case of spinal cord injury, the neuron could be endogenously enhanced to regenerate its axon to regain function. However, many of these potential regenerative options are still clinically unproven to be effective as therapy for neural repair. To address these knowledge gaps, my thesis investigates two different avenues of enhancing mammalian CNS regeneration. In the first two chapters of my thesis, I explore the molecular drivers that result in limited human spinal cord regeneration post injury. Decades of rodent research still have not yielded a feasible therapeutic target for CNS axon regeneration. Here, I present a novel mechanism of a nucleosome remodeler protein being an important human-specific, age-related driver of endogenous axon regeneration. In the latter two chapters using mouse models, I explore molecular methods to enhance hippocampal neuronal regeneration using the brain's endogenous neural stem cell (NSC) supply. Despite having been 7 decades since the discovery of the existence of adult mammalian NSCs, we still no do not have a clinical treatment to replace neurons in the adult brain from endogenous NSCs. Here, I present a novel mechanism of using post-transcriptional regulation to encourage neurogenesis using adult mouse in vitro and in vivo model systems. Together these data provide two different perspectives on the molecular targets of neural repair, with the goals of enhancing endogenous mammalian CNS regeneration.
Book Synopsis Endogenous Stem Cell-Based Brain Remodeling in Mammals by : Marie-Pierre Junier
Download or read book Endogenous Stem Cell-Based Brain Remodeling in Mammals written by Marie-Pierre Junier and published by Springer. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury. The second part is devoted to the endogenous reparative potential of the brain, including its limitations, and articles focusing on defined pathologies (e.g. anoxia/hypoxia, epilepsy, traumatic brain injury and stress) in animal models and in humans pinpoint eventual ways these pathologies might be manipulated. The third and final focuses on the "dark side" of stem cells for brain repair or of the manipulation of spontaneous adaptive events after injury (e.g. genomic instability, sensitization to cancerous transformation and defective neural networks).
Book Synopsis Transplantation in the Mammalian CNS by :
Download or read book Transplantation in the Mammalian CNS written by and published by . This book was released on 1984 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neocortical Grafting to Newborn and Adult Rats: Developmental, Anatomical and Functional Aspects by : Afsaneh Gaillard
Download or read book Neocortical Grafting to Newborn and Adult Rats: Developmental, Anatomical and Functional Aspects written by Afsaneh Gaillard and published by Springer. This book was released on 1998-05-20 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms that govern the development of the neural circuitry are still largely unknown. Actually, it is not clearly established to what extent areal cortical differentiation depends on environmental or genetic factors. The first part of the present report deals with the findings of several transplantation studies, performed in newborn recipient rats, in which these developmental issues were addressed. In humans, the cerebral cortex can be affected by a variety of diseases and, therefore, several experimental studies have been undertaken to determine to what extent transplantation of cortical neurons could be proved as a useful treatment for cerebral cortical damage. The second part deals with the functional effects of transplantations performed in adult recipient rats.
Book Synopsis Neural Grafting by : United States. Congress. Office of Technology Assessment
Download or read book Neural Grafting written by United States. Congress. Office of Technology Assessment and published by . This book was released on 1990 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: