Neoplastic Hematopathology

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Neoplastic Hematopathology

Author : Dan Jones
Publisher : Springer Science & Business Media
ISBN 13 : 1607613840
Total Pages : 636 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Neoplastic Hematopathology by : Dan Jones

Download or read book Neoplastic Hematopathology written by Dan Jones and published by Springer Science & Business Media. This book was released on 2010-01-24 with total page 636 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fulfilling the void with a Hematopathology book that integrates clinical and experimental studies with diagnostic criteria, Neoplastic Hematopathology: Experimental and Clinical Approaches provides an overview of the discipline of hematopathology that connects the field with recent advances in immunology research and current clinical practice in the treatment of lymphomas and leukemias. Designed for both trainees and specialists in pathology and hematology-oncology, Neoplastic Hematopathology: Experimental and Clinical Approaches has separate sections on laboratory techniques, diagnostic hematopathology, treatment and stem cell transplantation. Expert chapter authors address both myeloid and lymphoid tumors, and provide much needed coverage in transplant biology. A study guide highlights key chapter points, making the text suitable for boards review in hematopathology and hematology-oncology.

Knowles Neoplastic Hematopathology

Author : Attilio Orazi
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 146983099X
Total Pages : 3806 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Knowles Neoplastic Hematopathology by : Attilio Orazi

Download or read book Knowles Neoplastic Hematopathology written by Attilio Orazi and published by Lippincott Williams & Wilkins. This book was released on 2013-11-14 with total page 3806 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of Knowles Neoplastic Hematopathology has been thoroughly updated by the world's experts to cover all aspects of neoplastic hematopathology, a field that covers disorders of the bone marrow, spleen, and lymphatic system. Now in full-color, this completely revised and expanded edition integrates the basic science, modern diagnostic techniques, and clinical aspects of malignant diseases affecting these organs. It is the most comprehensive, encyclopedic textbook concerning neoplastic hematopathology available on the market today.

Neoplastic Hematopathology

Author : Daniel M. Knowles
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780683302462
Total Pages : 1994 pages
Book Rating : 4.3/5 (24 download)

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Book Synopsis Neoplastic Hematopathology by : Daniel M. Knowles

Download or read book Neoplastic Hematopathology written by Daniel M. Knowles and published by Lippincott Williams & Wilkins. This book was released on 2001-01-01 with total page 1994 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated reference has been prepared by the world's leaders in neoplastic hematopathology, a field that covers disorders of the bone marrow, spleen, and lymphatic system. This is the only comprehensive, encyclopedic text that covers the three major organ systems and integrates basic science, modern diagnostic techniques, and clinical aspects of malignant diseases affecting these organs. The Second Edition features several new contributors, more full-color illustrations, updated chapters, and three new chapters--Clinical Relevance of the Revised European/American Lymphoma Classification of Non-Hodgkin's Lymphomas; Normal Histology and Immunoarchitecture of the Lymphohematopoietic System; and Application of Molecular Genetics to the Diagnosis and Classification of Acute Leukemias. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC

Atlas of Differential Diagnosis in Neoplastic Hematopathology

Author : Wojciech Gorczyca
Publisher : CRC Press
ISBN 13 : 1439806489
Total Pages : 696 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Atlas of Differential Diagnosis in Neoplastic Hematopathology by : Wojciech Gorczyca

Download or read book Atlas of Differential Diagnosis in Neoplastic Hematopathology written by Wojciech Gorczyca and published by CRC Press. This book was released on 2008-09-24 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Atlas is an essential guide to both the diagnosis and differential diagnosis of neoplastic hematopathologies, based on specific parameters. It will be an invaluable reference for all practicing hematologists, oncologists and pathologists.Atlas of Differential Diagnosis in Neoplastic Hematopathology, Second Edition discusses:basic clinical data

Neoplastic Hematopathology

Author : Cherie H. Dunphy
Publisher : Demos Medical Publishing
ISBN 13 : 1936287633
Total Pages : 303 pages
Book Rating : 4.9/5 (362 download)

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Book Synopsis Neoplastic Hematopathology by : Cherie H. Dunphy

Download or read book Neoplastic Hematopathology written by Cherie H. Dunphy and published by Demos Medical Publishing. This book was released on 2012-10-04 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dunphy (pathology and laboratory medicine, U. of North Carolina at Chapel Hill) helps practicing pathologists, hematopathologists, oncologists, internists, and trainees understand the characteristic morphologic, immunophenotypic, and cytogenic/molecular features of the hematolymphoid neoplasms listed in the current World Health Organization Classification of hematolymphoid neoplasms and arrive at definitive diagnoses. In 13 chapters, hematopathologists and pathologists from the US discuss various hematolymphoid neoplasms, rather than focusing on individual neoplasms in detail, and present summary tables and illustrations to show key pathologic and differential features. They include information on definitions, morphologic features, special stains, immunohistochemistry and flow cytometry techniques, differential diagnosis, diagnostic features, and special issues for normal findings; myeloproliferative neoplasms; neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1; myelodysplastic syndrome/myeloproliferative neoplasms; acute myeloid leukemia and related precursor neoplasms; precursor lymphoid neoplasms; mature B-cell neoplasms; mature T-cell and natural killer cell neoplasms; Hodgkin's lymphoma; histiocytic and dendritic cell neoplasms; and immunodeficiency-associated lymphoproliferative disorders. Annotation ©2012 Book News, Inc., Portland, OR (booknews.com).

Hematopathology E-Book

Author : Elaine Sarkin Jaffe
Publisher : Elsevier Health Sciences
ISBN 13 : 032338871X
Total Pages : 1564 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Hematopathology E-Book by : Elaine Sarkin Jaffe

Download or read book Hematopathology E-Book written by Elaine Sarkin Jaffe and published by Elsevier Health Sciences. This book was released on 2016-06-27 with total page 1564 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world's leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders -- both benign and malignant -- with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it's a must-have resource for both residents and practicing pathologists alike. - Authored by the chief architects of the WHO classification in neoplasms of hematopoietic and lymphoid tissue. - Covers the newest diagnostic techniques, including molecular, immunohistochemical, and genetic studies. - Confirm or challenge your diagnostic interpretations by comparing specimens to over 1,000 high-quality color images. - Boasts detailed, practical advice from world leaders in hematopathology. - Places an emphasis on pathologic diagnoses, including molecular and genetic testing. - Updated with the most current WHO classifications of hematologic disease, including lymphoma and leukemia and peripheral T-cell lymphomas. - Covers hot topics in hematopathology, such as the latest genetic insights into lymphoma and leukemia; the new nomenclature for myelodysplastic syndromes; new developments on the subject of Grey zone lymphoma; and much more. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. There's also a downloadable image bank, and Virtual Microscope Slides are featured in several chapters.

Neoplastic Diseases of the Blood

Author : Peter H. Wiernik
Publisher :
ISBN 13 :
Total Pages : 646 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neoplastic Diseases of the Blood by : Peter H. Wiernik

Download or read book Neoplastic Diseases of the Blood written by Peter H. Wiernik and published by . This book was released on 1985 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ace the Boards: Neoplastic Hematopathology

Author : Nupur Sharma
Publisher :
ISBN 13 :
Total Pages : 311 pages
Book Rating : 4.6/5 (645 download)

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Book Synopsis Ace the Boards: Neoplastic Hematopathology by : Nupur Sharma

Download or read book Ace the Boards: Neoplastic Hematopathology written by Nupur Sharma and published by . This book was released on 2020-08-28 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Ace the boards: Neoplastic hematopathology is an attempt to provide residents and fellows with a comprehensive text for hematopathology with ample illustrations. The book is written in a point-wise format with many illustrations, tables, images and flow cytometry plots to create a visual impression during memorization. Here is what the experts of Hematopathology think of our book. Julie Feldstein, MD, FCAP Director, Division of Hematopathology Mount-Sinai Hospital, New York "Ace the boards, a concise comprehensive review of a complex topic made simple, in a nutshell. Timely delivery in challenging times as an educational resource. Ace the boards will not disappoint.." Ameet Kini, MD, PhD Medical Director, Flow Cytometry, Medical Director, Hematopathology Loyola University Medical Center, Maywood, IL "This ingenious book distills the important points of hematopoietic neoplasms and presents them in a concise, easy-to-read format. An indispensable resource for residents, fellows, laboratory scientists and anyone interested in hematopathology!. Sanam Loghavi, MD Assistant Professor, Department of Hematopathology The University of Texas MD Anderson Cancer Center, Houston, TX "Neoplastic Hematopathology is an excellent resource for residents and fellows preparing for the Boards exam. The book is concise, informative, practical and provides the readers with high quality photomicrographs and illustrations." Adam Booth, MD Fellow, Beth Israel Deaconess Medical Center (Harvard med), Boston, MA "As a trainee preparing to sit for AP/CP Boards, 'Ace the Boards: Neoplastic Hematopathology' provides an outstanding resource of the diagnostic information needed to be successful. The authors have filled the book with excellent descriptions, tables, figures, and images add to that the super high-yield, to the point, 'In a Nutshell' chapter, which is perfect for quick studying."

Flow Cytometry in Neoplastic Hematology

Author : Wojciech Gorczyca
Publisher : CRC Press
ISBN 13 : 1841847445
Total Pages : 350 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Flow Cytometry in Neoplastic Hematology by : Wojciech Gorczyca

Download or read book Flow Cytometry in Neoplastic Hematology written by Wojciech Gorczyca and published by CRC Press. This book was released on 2010-02-25 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly illustrated, practical guide contains comprehensive coverage of all the important factors for clinical diagnosis with flow cytometry. It explains the general parameters and correlation with color histomorphological findings throughout, taking a systematic approach from basic cases to complicated problem areas. Hematopathologists and neoplastic hematologists will find this book an important resource for keeping up to date with developments in clinical practice. This second edition includes a chapter on antigen expression during myeloid and lymphoid differentiation.

Atlas of Differential Diagnosis in Neoplastic Hematopathology, Third Edition

Author : Wojciech Gorczyca
Publisher : CRC Press
ISBN 13 : 1482212218
Total Pages : 922 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Atlas of Differential Diagnosis in Neoplastic Hematopathology, Third Edition by : Wojciech Gorczyca

Download or read book Atlas of Differential Diagnosis in Neoplastic Hematopathology, Third Edition written by Wojciech Gorczyca and published by CRC Press. This book was released on 2014-03-21 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: Management of tumor patients now relies on new individualized approaches to treatment, requiring extensive knowledge of the molecular makeup of tumors. Updated and expanded, the third edition of Atlas of Differential Diagnosis in Neoplastic Hematopathology examines not only the differential diagnosis but also the detailed morphologic, immunophenotypic, and especially genetic characteristics of the majority of hematolymphoid malignancies. Featuring a new structure and including new chapters, the third edition updates all content and presents considerable expansion on many topics, including: Metaphase cytogenetic and FISH Flow cytometry (overview and detailed analysis of specific tumors) Acute myeloid leukemia and new classification schemes MDS, AML, and B- and T-cell lymphoproliferations Abnormal patterns in the lymph node and bone marrow with detail differential diagnosis based on histologic features and cellular composition Detailed differential diagnosis based on the expression of broad list of antigenic markers (flow cytometry and immunohistochemistry) Extranodal lymphomas Diagnosis of MDS and myeloproliferative neoplasm and their differential diagnosis based on the morphologic, flow cytometric, and chromosomal features The book also provides expanded differential diagnosis of the most common as well as most difficult and rare entities, including morphologic, immunophenotypic, and karyotypic/molecular features. This edition includes updated algorithms for most common diagnoses as well as several new algorithms. The majority of figures have been revised and are in full color.

Diagnostic Pediatric Hematopathology

Author : Maria A. Proytcheva
Publisher : Cambridge University Press
ISBN 13 : 0521881609
Total Pages : 591 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Diagnostic Pediatric Hematopathology by : Maria A. Proytcheva

Download or read book Diagnostic Pediatric Hematopathology written by Maria A. Proytcheva and published by Cambridge University Press. This book was released on 2011-02-03 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accurate and up-to-date guide to the diagnosis of benign and malignant hematologic disorders of childhood, this is an excellent reference to ensure accurate diagnoses when evaluating peripheral blood, bone marrow, and lymph node disease. It will be a valuable tool in the practice of pathologists, pediatric pathologists, and hematopathologists.

Hematopathology and Coagulation

Author : Amer Wahed
Publisher : Cambridge University Press
ISBN 13 : 131650560X
Total Pages : 147 pages
Book Rating : 4.3/5 (165 download)

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Book Synopsis Hematopathology and Coagulation by : Amer Wahed

Download or read book Hematopathology and Coagulation written by Amer Wahed and published by Cambridge University Press. This book was released on 2017-05-27 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides questions and answers to test readers' knowledge of hematopathology and coagulation, for use when preparing for the American Board of Pathology exams.

Ace The Boards

Author : Akanksha Gupta
Publisher : Ace My Path
ISBN 13 : 9781087897769
Total Pages : 278 pages
Book Rating : 4.8/5 (977 download)

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Book Synopsis Ace The Boards by : Akanksha Gupta

Download or read book Ace The Boards written by Akanksha Gupta and published by Ace My Path. This book was released on 2021-07-31 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: We envision trainees using this text to review non-neoplastic hematopathology and coagulation as they prepare for their Pathology and Hematopathology Board exams. Our book is based upon the American Board of Pathology's hematopathology exam blueprint, thereby, having all the content in one place to succeed in your exams. The highlights of the book are: -Pointwise format for easy understanding. -High-quality photomicrographs. -Numerous illustrations, tables, and charts for visual learners. Read what hematopathology experts are saying about this book! L Jeffrey Medeiros, MD Professor and Chair of Hematopathology The University of Texas MD Anderson Cancer Center, Houston, TX "Ace the Boards is an exceptional resource for residents and fellows seeking to conceptualize difficult hematopathology topics. The illustrations, images, descriptive charts, and high-yield outline format provides the reader with the tools they will need to excel both in training and on their Board exams." Julie Feldstein, MD, FCAP Professor of Pathology, Director of Hematopathology division Mount Sinai Health System, New York, NY "In a Nutshell: Simple, concise, nice graphics; a much-needed resource for our trainees. Ace the Boards: Non-Neoplastic Hematopathology and Coagulation is a must have study guide and reading resource." Genevieve Crane, MD, PhD Staff Hematopathologist Cleveland Clinic, Cleveland, OH "Stunning, illustration-rich guide to help quickly master complex and high-yield topics in hematopathology. Thoughtful artwork makes the material engaging and memorable. An awesome and much-needed resource!" Chandra Krishnan, MD Dell Children's Medical Center of Central Texas, Austin, TX @Hematogones "Ace the Boards provides a very organized and thoughtful presentation of hematopathology that would make a great reference for residents and fellows alike. The pictures and figures are very nicely done and help the reader through complex topics in hematopathology." Sanam Longhavi, MD Assistant Professor, Department of Hematopathology The University of Texas MD Anderson Cancer Center, Houston, TX "Great resource for trainees interested in broadening their knowledge of hematopathology." To provide a reference text that would assimilate all the relevant information, we attempted to create a high-yield, comprehensive book which touched on all the relevant aspects of non-neoplastic hematopathology and coagulation. In it, the reader will be able to easily navigate outlines, original illustrations, and photomicrographs that will help solidify difficult topics and provide a quick resource for revision. We sincerely hope that our passion and enthusiasm for each subject will be reflected throughout this text and that the readers will find it helpful - not only for their Board exams but also during hematopathology rotations. We welcome the input of our readers as we embark on this journey of learning and hope to incorporate their valuable feedback in our future editions. We wish you the greatest success as you study for the Boards! Ace my Path team.

Hematology Board Review

Author : Francis P. Worden, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826137830
Total Pages : 421 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis Hematology Board Review by : Francis P. Worden, MD

Download or read book Hematology Board Review written by Francis P. Worden, MD and published by Springer Publishing Company. This book was released on 2018-05-28 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematology Board Review: Blueprint Study Guide and Q&A is a concise, outline-based study guide covering all topics that appear on the Hematology Certification Exam. The book includes all topics listed in the American Board of Internal Medicine (ABIM) blueprint as essential material for the exam and highlights topic areas that are often found on the test. For hematology and oncology fellows as well as practicing clinicians needing a refresher before taking MOC, this handy study guide provides succinct overviews of all blood disorders, syndromes and diseases with practice questions on the go. Each disorder or disease-based chapter provides the same structure for ease of use beginning with the epidemiology, and followed by the etiology and risk factors, signs and symptoms, diagnostic criteria, indications for treatment, prognostic factors, treatment recommendations, and special considerations. The authors provide the most accurate and up-to-date information, including well-established treatment regimens for a variety of blood disorders, including iron disorders, bone marrow failure syndromes, platelet and megakaryocytic disorders, hemostasis, thrombosis, and hematologic malignancies. Later chapters review other major subspecialty areas found on the exam including transfusion medicine and hematopoietic cell transplantation. With 200 board-style questions and answers with detailed rationales, Hematology Board Review is the go-to, quick review for any trainee preparing for initial certification and for hematologists or oncologists preparing for recertification. Key Features: Includes 200 board-style questions and answers with rationales Provides key point summaries of each topic area for quick study and easy recall Thorough coverage of hematologic malignancies, blood disorders, transfusion medicine, hematopoietic cell transplantation, and standard treatment regimens Tables providing key data and information related to staging, treatment options, and disease classifications

Diagnostic Molecular Pathology

Author : William B. Coleman
Publisher : Academic Press
ISBN 13 : 0128229934
Total Pages : 846 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Diagnostic Molecular Pathology by : William B. Coleman

Download or read book Diagnostic Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2023-10-18 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. - Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more - Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient - Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient - Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease

Molecular Pathology in Clinical Practice

Author : Debra G.B. Leonard
Publisher : Springer Science & Business Media
ISBN 13 : 0387332278
Total Pages : 589 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Molecular Pathology in Clinical Practice by : Debra G.B. Leonard

Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer Science & Business Media. This book was released on 2007-11-25 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

A Pattern Approach to Lymph Node Diagnosis

Author : Anthony S-Y Leong
Publisher : Springer Science & Business Media
ISBN 13 : 1441971769
Total Pages : 422 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis A Pattern Approach to Lymph Node Diagnosis by : Anthony S-Y Leong

Download or read book A Pattern Approach to Lymph Node Diagnosis written by Anthony S-Y Leong and published by Springer Science & Business Media. This book was released on 2010-11-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: While a pattern approach to diagnosis is taught and practiced with almost every other tissue or organ in the body, the lymph node remains a mystery to most residents starting out in pathology and those pathologists with limited experience in the area. A Pattern Approach to Lymph Node Diagnosis demonstrates that a systematic approach to lymph node examination can be achieved through recognition of morphological patterns produced by different disease processes. It presents a combination of knowledge-based assessment and pattern recognition for diagnosis covering the major primary neoplastic and non neoplastic diseases and metastatic tumors in lymph nodes. This volume demonstrates that lymph node compartments can be recognized histologically especially with the aid of immunohistological markers and how this knowledge can be employed effectively to localize and identify pathological changes in the different compartments in order to facilitate histological diagnosis. It also defines histological features that, because of their pathological occurrence in lymph nodes, are useful pointers to specific diagnoses or disease processes. The volume is organized in accordance with the primary pattern of presentation of each diagnostic entity. Differential diagnosis is discussed and each diagnostic entity is accompanied by color illustrations that highlight the diagnostic features. Immunohistochemistry, clinical aspects, relevant cytogenetics and molecular information of each entity is provided by authors who are experts in lymphoproliferative diseases. An algorithmic approach to diagnosis is adopted at the end of each section by listing a set of questions that help to consider diagnostic entities that can present with the morphological features observed. A Pattern Approach to Lymph Node Diagnosis will be of great utility to residents and fellows in pathology and general pathologists making first hand lymph node diagnoses as well as to hematologists and physicians who treat patients with lymphoprolifeative diseases.