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Natural Compounds As Drugs
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Book Synopsis Natural Compounds as Drugs, Volume I by : Frank Petersen
Download or read book Natural Compounds as Drugs, Volume I written by Frank Petersen and published by Springer Science & Business Media. This book was released on 2007-12-27 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a real tour de force of pharmacological literature, this edited volume’s chapters highlight the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such complex chemical information, what makes them unique, as they often are, and what their characteristics are. Practical questions such as supply of natural substances and production optimization strategies are also covered.
Book Synopsis Natural Products and Drug Discovery by : Subhash C. Mandal
Download or read book Natural Products and Drug Discovery written by Subhash C. Mandal and published by Elsevier. This book was released on 2018-02-16 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout
Download or read book Natural Products written by Lixin Zhang and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
Book Synopsis Bioactive Natural Products by : Goutam Brahmachari
Download or read book Bioactive Natural Products written by Goutam Brahmachari and published by World Scientific. This book was released on 2012 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.
Book Synopsis Natural Compounds as Drugs, Volume II by : Frank Petersen
Download or read book Natural Compounds as Drugs, Volume II written by Frank Petersen and published by Springer Science & Business Media. This book was released on 2008-07-29 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.
Book Synopsis Drug Discovery and Development by : Ramarao Poduri
Download or read book Drug Discovery and Development written by Ramarao Poduri and published by Springer Nature. This book was released on 2021-02-15 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
Book Synopsis Pharmaceutical Biotechnology by : Carlos A. Guzmán
Download or read book Pharmaceutical Biotechnology written by Carlos A. Guzmán and published by Springer. This book was released on 2012-03-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives—basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens’ genomes provides opportunities that never before have been available—identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process. The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.
Book Synopsis Medicinal Natural Products by : Paul M. Dewick
Download or read book Medicinal Natural Products written by Paul M. Dewick and published by John Wiley & Sons. This book was released on 2002-01-03 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide covers classes of natural products in medicine, whether derived from plants, micro-organisms or animals. Structured according to biosynthetic pathway, it is written from a chemistry-based approach.
Book Synopsis New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity by : H.K. Wagner
Download or read book New Natural Products and Plant Drugs with Pharmacological, Biological or Therapeutical Activity written by H.K. Wagner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fact that, of the approximately 600,000 plant species existing on the earth, only some 5 % have been specifically investigated chemically or pharmacologi cally, is a challenge to chemists spezializing in na tural substances and to pharmacologists. In view of the limited number of research capacities and the ever diminishing financial means, this challenge can only be met if, together with an improvement and refinement of methods of analysis, medicinal plant research is carried out on a broader interdisciplinary basis, with comparable, scientifically recognized screening methods, and if it is better coordinated, with greater use of modern documentation means. It is thus necessary in the future to concentrate specifically on projects leading to the development of new medicinal prepara tions. The plenary lectures hold in the present symposium of the 1st International Congress for Research on Medi cinal Plants reflect these efforts and tendencies. At the same time they provide a survey of some of the fields of medicinal plant research which are at present most actual and most intensively researched. They range from plant screening, isolation and structure eluci dation of new principles, to the therapeutical opti mization of a natural product. The lectures given at this congress show clearly the necessity, in addition to national phytochemical so cieties, for a central international organisation, in which all active medicinal plant researchers in the world are included. Their aim should be to provide the impulse for more optimal, rational research, aimed at the solution of specific projects.
Book Synopsis The Role of Natural Products in Drug Discovery by : J. Mulzer
Download or read book The Role of Natural Products in Drug Discovery written by J. Mulzer and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.
Book Synopsis Natural Small Molecule Drugs from Plants by : Guan-Hua Du
Download or read book Natural Small Molecule Drugs from Plants written by Guan-Hua Du and published by Springer. This book was released on 2018-11-19 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses 120 types of natural, small-molecule drugs derived from plants. They are grouped into 7 parts according their clinical uses, such as drugs for cardiovascular diseases, for metabolic diseases, for neuropsychiatric diseases, for immune-mediated inflammatory diseases, anti-tumor drugs, and drugs for parasites and bacterial infection. Each chapter systematically summarizes one drug, including its physicochemical properties, sources, pharmacological effects and clinical applications. To help readers understand the drug better, the research and pharmacological activity for each drug is also described, which serves as a salutary lesson for future drug development. Written by frontline researchers, teachers and clinicians working in field of pharmacy and pharmacology it provides an overview of natural, small-molecule drugs derived from plants for researchers in the field.
Book Synopsis Handbook on Drugs from Natural Sources by : H. Panda
Download or read book Handbook on Drugs from Natural Sources written by H. Panda and published by ASIA PACIFIC BUSINESS PRESS Inc.. This book was released on 2010-10-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have played an important role throughout the world in treating and preventing human diseases. Natural product medicines have come from various materials including terrestrial plants, terrestrial microorganisms, organisms etc. Historical experiences with plants as therapeutic tools have helped to introduce single chemical entries in modern medicine. About 40% of the drugs used are derived from natural sources. Most are pure substances which are isolated from various organisms & used directly or after chemical modification. Natural products will continue to be important in three areas of drug discovery: as targets for production by biotechnology as a source of new lead compounds of novel chemical structure and as the active ingredients of useful treatments derived from traditional systems. Biotechnology will contribute more new natural products for medicinal use. Plants provide a fertile source of natural products many of which are clinically important medicinal agents. Natural products have traditionally provided most of the drugs in use. Despite the achievements of synthetic chemistry and the advances towards rational drug design, natural products continue to be essential in providing medicinal compounds and as starting points for the development of synthetic analogues. With the increasing power of screening programs and the increasing interest in the reservoir of untested natural products, many future drug developments will be based, at least in part, on natural products. The major contents of the book are plant products produced in cell culture , application of genetic engineering to the production of pharmaceuticals , anti transpirants and plant growth regulators based , the potential and the problems of marine natural products, marine sterols, plants as a source of anti-inflammatory substances, anti hepatotoxic principles in oriental medicinal plants, immune stimulants of fungi and higher plants, amanita muscaria in medicinal chemistry, ergot alkaloids and their derivatives in medicinal chemistry and therapy, development of drugs from cannabinoids, etc. This book contains development of new drugs from plants, work on some Thai medicinal plants, plant growth based on Jasmonates, marine sterols, bleomycin and its derivatives, drugs from cannabinoids, bioactive compounds from nature, fungi and higher plants, biological active compounds from British Marine, microbial phytotoxins as herbicides and many more. This book will be very helpful to its readers, upcoming entrepreneurs, scientists, existing industries, technical institutions, druggist etc. TAGS Drugs from Natural Sources, Plants as Source of Drugs, Plant Based Drugs and Medicines, Drugs from Natural Products, Drugs from Plants, Natural Products, Natural Products in Drugs, Sources of Drugs, Drug from Medicinal Plants, Bioactive Compounds from Natural Sources, Biologically Active Compounds from British Marine Algae, Drugs from Natural Bio Sources, Natural Products as Sources of Drugs, Medicinal Natural Products, Plant Based Natural Products, Drugs of Natural Origin, Drugs from Cannabinoids, Plant Products Produced in Cell Culture, Herbicidal Compounds, Microbes and Microbial Phytotoxins as Herbicides, Chinese Traditional Medicine, Thai Medicinal Plants, Ompounds Derived from Hormones, Indigenous Medicinal Plants, Plants as Source of Anti-Inflammatory Substances, Bleomycin and its Derivatives, Antineoplastic Structure-Activity, Oriental Medicinal Plants, Immunostimulants of Fungi and Higher Plants, Acacia, Abrus Precatorius Linn, Babul, Acacia Catechu Willd, Chyranthes Aspera Linn, Adhatoda Vasica Nees, Allium Sativum Linn, Aloe Barbadensis Mill, Argemone Mexicana Linn, Neem, Asparagus Racemosus Willd, Azadirachta Indica, Boerhaavia Chinensis Aschers & Schweinf, Boswellia Serrata Roxb, Butea Frondosa, Butea Monosperma Taub, Cassia Fistula Linn, Cassia Tora Linn, Carica Papaya Linn, Evolvulus Alsinoides, Clitoria Ternatea Linn, Clerodendron Phlomidis Linn, Cuscuta Reflexa Roxbi, Glycyrrhiza Glabra, Gmelina Arborea Roxb, Morinda Tinctoria Roxb, Melia Azedarach Linn, Pterocarpus Santalinus, Raphanus Sativces, Viola Odorata, Ashawgandha, Withania Somnifera, Muli, Lal Chandan, Raktachandan, Bakain, Bakaanaanimb, Aakaashvalli, Shankhahuli, Talmuli, Chibud, Sweet Melon, Aparajit, Arni, Quall Grass, Sufaid Murgha, Lasun, Ghungehi, Khair, Adulsa, Arusha, NPCS, Niir, Process Technology Books, Business Consultancy, Business Consultant, Startup, Business Guidance, Business Guidance to Clients, Startup Ideas, Startup Project Plan, Business Start-Up, Business Plan for Startup Business, Great Opportunity for Startup, Small Start-Up Business Project, Best Small and Cottage Scale Industries, Startup India, Stand Up India, Small Scale Industries, New Small Scale Ideas for Thai Medicinal Plants, Natural Products in Drugs Business Ideas You Can Start on Your Own, Guide to Starting and Operating Small Business, Business Ideas for Drugs From Natural Sources, How to Start Drugs from Natural Sources Business, Start Your Own Drug from Medicinal Plants Business, Natural Drugs Business Plan, Business Plan for Natural Drugs, Small Scale Industries in India, Drugs from Cannabinoids Based Small Business Ideas in India, Small Scale Industry You Can Start on Your Own, Business Plan for Small Scale Industries, Profitable Small Scale Manufacturing, How to Start Small Business in India, Free Manufacturing Business Plans, Small and Medium Scale Manufacturing, Profitable Small Business Industries Ideas, Business Ideas for Startup
Book Synopsis Drug Discovery from Nature by : S. Grabley
Download or read book Drug Discovery from Nature written by S. Grabley and published by Springer Science & Business Media. This book was released on 1998-11-26 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.
Book Synopsis Natural Products in Medicinal Chemistry by : Stephen Hanessian
Download or read book Natural Products in Medicinal Chemistry written by Stephen Hanessian and published by John Wiley & Sons. This book was released on 2013-12-18 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer
Book Synopsis Plant-derived Natural Products by : Anne E. Osbourn
Download or read book Plant-derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
Book Synopsis Discovery and Development of Antidiabetic Agents from Natural Products by : Goutam Brahmachari
Download or read book Discovery and Development of Antidiabetic Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2016-10-11 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab
Book Synopsis Novel Compounds from Natural Products in the New Millennium by : Benny K-H. Tan
Download or read book Novel Compounds from Natural Products in the New Millennium written by Benny K-H. Tan and published by World Scientific. This book was released on 2004 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is continuing interest in natural products as sources of potentially new and exciting chemical compounds. This book brings together the knowledge, perspectives and research findings of a varied group of scientists on a wide range of topics, from microarrays, genetics and bioinformatics to yeast-based technologies and enzyme studies.
