NADPH Oxidases Revisited: From Function to Structure

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Publisher : Springer Nature
ISBN 13 : 3031237528
Total Pages : 583 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis NADPH Oxidases Revisited: From Function to Structure by : Edgar Pick

Download or read book NADPH Oxidases Revisited: From Function to Structure written by Edgar Pick and published by Springer Nature. This book was released on 2023-06-22 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

NADPH Oxidases Revisited: From Function to Structure

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Author :
Publisher :
ISBN 13 : 9783031237539
Total Pages : 0 pages
Book Rating : 4.2/5 (375 download)

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Book Synopsis NADPH Oxidases Revisited: From Function to Structure by : Edgar Pick

Download or read book NADPH Oxidases Revisited: From Function to Structure written by Edgar Pick and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

The Triumph of Uncertainty

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Publisher : Central European University Press
ISBN 13 : 9633866863
Total Pages : 404 pages
Book Rating : 4.6/5 (338 download)

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Book Synopsis The Triumph of Uncertainty by : Alfred I. Tauber

Download or read book The Triumph of Uncertainty written by Alfred I. Tauber and published by Central European University Press. This book was released on 2022-08-09 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tauber, a leading figure in history and philosophy of science, offers a unique autobiographical overview of how science as a discipline of thought has been characterized by philosophers and historians over the past century. He frames his account through science’s – and his own personal – quest for explanatory certainty. During the 20th century, that goal was displaced by the probabilistic epistemologies required to characterize complex systems, whether in physics, biology, economics, or the social sciences. This “triumph of uncertainty” is the inevitable outcome of irreducible chance and indeterminate causality. And beyond these epistemological limits, the interpretative faculties of the individual scientist (what Michael Polanyi called the “personal” and the “tacit”) invariably affects how data are understood. Whereas positivism had claimed radical objectivity, post-positivists have identified how a web of non-epistemic values and social forces profoundly influence the production of knowledge. Tauber presents a case study of these claims by showing how immunology has incorporated extra-curricular social elements in its theoretical development and how these in turn have influenced interpretive problems swirling around biological identity, individuality, and cognition. The correspondence between contemporary immunology and cultural notions of selfhood are strong and striking. Just as uncertainty haunts science, so too does it hover over current constructions of personal identity, self knowledge, and moral agency. Across the chasm of uncertainty, science and selfhood speak.

Physiological and Molecular Mechanisms of Important Agronomic Traits in Plants Under Various Abiotic Factors

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Publisher : Frontiers Media SA
ISBN 13 : 283255623X
Total Pages : 141 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Physiological and Molecular Mechanisms of Important Agronomic Traits in Plants Under Various Abiotic Factors by : Dongmei Li

Download or read book Physiological and Molecular Mechanisms of Important Agronomic Traits in Plants Under Various Abiotic Factors written by Dongmei Li and published by Frontiers Media SA. This book was released on 2024-10-30 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants live in environments influenced by various abiotic factors that can cause diverse stresses, for example, because of low or high temperature, deficient or excessive water, high salinity, heavy metals, and ultraviolet radiation, etc. These abiotic stresses are hostile to plant growth and development, leading to great fruit quality and crop yield penalties worldwide, especially under the global climate change. Facing the numerous abiotic stresses, plants have developed strategies to protect themselves in evolution. The elucidation of their effects and underlying mechanisms is of great significance as a fundamental principle to relieve the pressure of environmental changes and to meet the demand of human population growth Up-to-date scientific efforts are welcome to be delivered into this topic for a comprehensive understanding of the physiological and molecular effects of diverse abiotic stresses on plants ranging from model species to economically important crops. The newly identified and characterized mechanisms and genetics associated with plant adaptability to abiotic stress will provide novel insights into the physiological and molecular alterations of plants under abiotic stresses. It will assist in understanding plants’ behavior adapting to the environmental change and perspective agricultural practice including crop breeding and field management, and eventually help maintain the food security, safety, and sustainability. In addition, increasing evidence shows that the recent advancements and developments of plant biotechnologies and application of big data to the area of plant science promote the understanding of the physiological and molecular effects of diverse abiotic stresses on plants. Hence, the investigations integrated by multidisciplinary approaches are strongly encouraged, including but not limited to: CRISPR/Cas-mediated gene editing, functional genomics, phenomics, and high-throughput phenotyping etc.

Oxidative Stress Revisited - Major Role in Vascular Diseases

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Publisher : Frontiers Media SA
ISBN 13 : 2889630587
Total Pages : 158 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Oxidative Stress Revisited - Major Role in Vascular Diseases by : Cristina M. Sena

Download or read book Oxidative Stress Revisited - Major Role in Vascular Diseases written by Cristina M. Sena and published by Frontiers Media SA. This book was released on 2019-10-21 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is an underlying factor in health and disease. Reactive oxygen species are produced as a result of normal cellular metabolism. The subsequent altered redox state between the formation and the neutralization of pro-oxidants results in their increased levels and therefore leads to cellular damage. Different research disciplines have increased our knowledge of the importance of this cell redox status and the recognition of oxidative stress as a process with implications for many pathophysiological states. Genetic and environmental factors, nutrition and lifestyle may indicate a pro-oxidative and pro-inflammatory state, linked to alterations in cellular structure and function. Oxidative stress emerges as a common, unifying factor in several conditions including diabetes and cardiovascular diseases. This eBook aims to provide novel data regarding the role played by oxidative stress and inflammation in the development of chronic diseases and the different classes of therapeutics from the bench to the clinic, stressing the awareness of these concepts for the treatment of disease. In addition, articles addressing an overview of the role of oxidative stress in vascular diseases reviewing some current concepts indicating that oxidative stress and inflammation are key mechanisms linking vascular diseases and current state-of-the-art approaches to monitor, prevent and inhibit oxidative stress will be highlighted. There is a close relation between oxidative stress, inflammation and cardiovascular diseases. Despite the great amount of investigation carried out in the field, there are still uncertainties about the mechanisms by which free radicals can modify tissues such as perivascular adipose tissue that ultimately will reflect on vascular function. This eBook will focus on articles that can explore and identify these mechanisms. Concurrent with this understanding of oxidative stress milieu, it is necessary to recognize the need for new pharmacological tools effective in restoring oxidative balance. The abundance of new information and the paradigm shift in our understanding of how antioxidants and other redox-active drugs work in a wide variety of vascular diseases will be specifically highlighted. This eBook will provide a comprehensive, up-to-date source of information on the design and mechanistic, pharmacological, and medicinal aspects of redox-active therapeutics. Finally, a unique feature of the eBook is to provide a way to foster an enthralling discussion revisiting old paradigms and finding new solutions for the treatment of vascular diseases. The topic will include original research articles, hypotheses, perspectives and (mini)reviews from experts in the field. The next decade shows promise for the translation of this body of knowledge to novel human therapeutics and this eBook will enable to increment our knowledge in this field.

NADPH Oxidases

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Author :
Publisher : Humana
ISBN 13 : 9781493994236
Total Pages : 718 pages
Book Rating : 4.9/5 (942 download)

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Book Synopsis NADPH Oxidases by : Ulla G. Knaus

Download or read book NADPH Oxidases written by Ulla G. Knaus and published by Humana. This book was released on 2019-06-07 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores the NADPH oxidase family of enzymes in human physiology and genetic disease, in which early discoveries represent prime examples of the finest translational “from bed to bench and back” studies. Methods are included for testing assembly and function of multicomponent oxidase complexes and for analyzing reactive oxygen species (ROS) generation in different systems by various means, while addressing pitfalls of ROS probes currently being used, as well as protocols on NADPH oxidase regulation and their function in cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, NADPH Oxidases: Methods and Protocols will aid researchers working with the NOX/DUOX family in continuing and expanding upon their vital research.

Antioxidants in Sport Nutrition

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Publisher : CRC Press
ISBN 13 : 1466567570
Total Pages : 304 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Antioxidants in Sport Nutrition by : Manfred Lamprecht

Download or read book Antioxidants in Sport Nutrition written by Manfred Lamprecht and published by CRC Press. This book was released on 2014-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

Type-B Cytochromes: Sensors and Switches

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Publisher : CRC Press
ISBN 13 : 1351094319
Total Pages : 178 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Type-B Cytochromes: Sensors and Switches by : J.L. Kiel

Download or read book Type-B Cytochromes: Sensors and Switches written by J.L. Kiel and published by CRC Press. This book was released on 2018-01-10 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes cellular level sensors that act as switches, turning on gene expression and other metabolic processes necessary for cell survival and differentiation. These responses can also initiate programmed cell death or activate latent human immunodeficiency virus or animal leukemia viruses. These redox sensors are nonspecific in sensitivity but specific in response. Unlike ligand/antiligand-type specific sensors, they respond to ionizing and ultraviolet radiations, pH gradients, heat, light, electric and magnetic fields, redox chemicals, mechanical stress, and other nonspecific stressors. The sensors are type-b cytochromes, including NADPH oxidases, NO synthases, and nitrogen oxide reductases. The intense radiation of early pre-biotic earth may have been the evolutionary driving force for the development of their common ancestor.

Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889632563
Total Pages : 281 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria by : Natalia V. Kirienko

Download or read book Beyond Antimicrobials: Non-Traditional Approaches to Combating Multidrug-Resistant Bacteria written by Natalia V. Kirienko and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Abiotic Stress Tolerance

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Publisher : Springer
ISBN 13 : 3030061183
Total Pages : 506 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Plant Abiotic Stress Tolerance by : Mirza Hasanuzzaman

Download or read book Plant Abiotic Stress Tolerance written by Mirza Hasanuzzaman and published by Springer. This book was released on 2019-04-04 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants have to manage a series of environmental stresses throughout their entire lifespan. Among these, abiotic stress is the most detrimental; one that is responsible for nearly 50% of crop yield reduction and appears to be a potential threat to global food security in coming decades. Plant growth and development reduces drastically due to adverse effects of abiotic stresses. It has been estimated that crop can exhibit only 30% of their genetic potentiality under abiotic stress condition. So, this is a fundamental need to understand the stress responses to facilitate breeders to develop stress resistant and stress tolerant cultivars along with good management practices to withstand abiotic stresses. Also, a holistic approach to understanding the molecular and biochemical interactions of plants is important to implement the knowledge of resistance mechanisms under abiotic stresses. Agronomic practices like selecting cultivars that is tolerant to wide range of climatic condition, planting date, irrigation scheduling, fertilizer management could be some of the effective short-term adaptive tools to fight against abiotic stresses. In addition, “system biology” and “omics approaches” in recent studies offer a long-term opportunity at the molecular level in dealing with abiotic stresses. The genetic approach, for example, selection and identification of major conditioning genes by linkage mapping and quantitative trait loci (QTL), production of mutant genes and transgenic introduction of novel genes, has imparted some tolerant characteristics in crop varieties from their wild ancestors. Recently research has revealed the interactions between micro-RNAs (miRNAs) and plant stress responses exposed to salinity, freezing stress and dehydration. Accordingly transgenic approaches to generate stress-tolerant plant are one of the most interesting researches to date. This book presents the recent development of agronomic and molecular approaches in conferring plant abiotic stress tolerance in an organized way. The present volume will be of great interest among research students and teaching community, and can also be used as reference material by professional researchers.

Mammalian Heme Peroxidases

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Publisher : CRC Press
ISBN 13 : 1000450635
Total Pages : 464 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Mammalian Heme Peroxidases by : Clare Hawkins

Download or read book Mammalian Heme Peroxidases written by Clare Hawkins and published by CRC Press. This book was released on 2021-10-08 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions. Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

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Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 431 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. - Presents the most advanced information regarding the role of the autophagic system in life and death - Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both - Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation - Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment - Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Mitochondria and Anaerobic Energy Metabolism in Eukaryotes

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Author :
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110612410
Total Pages : 269 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Mitochondria and Anaerobic Energy Metabolism in Eukaryotes by : William F. Martin

Download or read book Mitochondria and Anaerobic Energy Metabolism in Eukaryotes written by William F. Martin and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-12-07 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are sometimes called the powerhouses of eukaryotic cells, because mitochondria are the site of ATP synthesis in the cell. ATP is the universal energy currency, it provides the power that runs all other life processes. Humans need oxygen to survive because of ATP synthesis in mitochondria. The sugars from our diet are converted to carbon dioxide in mitochondria in a process that requires oxygen. Just like a fire needs oxygen to burn, our mitochondria need oxygen to make ATP. From textbooks and popular literature one can easily get the impression that all mitochondria require oxygen. But that is not the case. There are many groups of organismsm known that make ATP in mitochondria without the help of oxygen. They have preserved biochemical relicts from the early evolution of eukaryotic cells, which took place during times in Earth history when there was hardly any oxygen avaiable, certainly not enough to breathe. How the anaerobic forms of mitochondria work, in which organisms they occur, and how the eukaryotic anaerobes that possess them fit into the larger picture of rising atmospheric oxygen during Earth history are the topic of this book.

Cumulated Index Medicus

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Author :
Publisher :
ISBN 13 :
Total Pages : 896 pages
Book Rating : 4.M/5 ( download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1977 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent Trends in Pharmacological Treatment of Musculoskeletal Disorders

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832502261
Total Pages : 274 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Recent Trends in Pharmacological Treatment of Musculoskeletal Disorders by :

Download or read book Recent Trends in Pharmacological Treatment of Musculoskeletal Disorders written by and published by Frontiers Media SA. This book was released on 2022-10-13 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ear, Nose and Throat Diseases of the Dog and Cat

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Author :
Publisher : CRC Press
ISBN 13 : 1315355752
Total Pages : 699 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Ear, Nose and Throat Diseases of the Dog and Cat by : Richard G. Harvey

Download or read book Ear, Nose and Throat Diseases of the Dog and Cat written by Richard G. Harvey and published by CRC Press. This book was released on 2016-10-14 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ear, Nose and Throat Diseases of the Dog and Cat is the ultimate reference for veterinarians and other professionals trying to diagnose and treat both common and less frequently diagnosed diseases and conditions of the ear, nose and throat. The book is divided into four sections: The Ear, The Nose, The Throat and Surgery of the Ear, Nose and Throat. Each of the first three sections begins by discussing anatomy and physiology and then reviews a wide variety of diagnostic procedures including video-endoscopic examination of the external ear canal, nose and throat, radiography and advanced imaging, and histopathological examination of biopsy samples. Chapters in each of the three sections then provide a detailed and extensive review of the diseases of the pinna, external ear canal, middle ear and inner ear – nasal planum, nasal cavities and sinuses and nasopharynx – pharynx and larynx. The final section opens with a chapter on perioperative management with subsequent chapters that cover surgery of the ear, nose and throat. Extensively referenced, and including nearly 500 color illustrations to assist in diagnosis and treatment, the book is an invaluable resource for both veterinarians in training and in practice for the accurate diagnosis and management of diseases of the ear, nose and throat.

Women in plant science - redox biology of plant abiotic stress 2022

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832531202
Total Pages : 151 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Women in plant science - redox biology of plant abiotic stress 2022 by : Laura De Gara

Download or read book Women in plant science - redox biology of plant abiotic stress 2022 written by Laura De Gara and published by Frontiers Media SA. This book was released on 2023-08-03 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: