Myelination Of The Brain In Major Depressive Disorder

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Major Depressive Disorder

Author : Yong-Ku Kim
Publisher : Springer Nature
ISBN 13 : 9813360445
Total Pages : 555 pages
Book Rating : 4.8/5 (133 download)

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Book Synopsis Major Depressive Disorder by : Yong-Ku Kim

Download or read book Major Depressive Disorder written by Yong-Ku Kim and published by Springer Nature. This book was released on 2021-04-08 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews all aspects of major depressive disorder (MDD), casting light on its neurobiological underpinnings and describing the most recent advances in management. The book is divided into four sections, the first of which discusses MDD from a network science perspective, highlighting the alterations in functional and structural connectivity and presenting insights achieved through resting state functional MRI and the development of neuroimaging-based biomarkers. The second section examines important diagnostic and neurobiological issues, while the third considers the currently available specific treatments for MDD, including biofeedback, neurofeedback, cognitive behavioral therapy, acceptance and commitment therapy, neuromodulation therapy, psychodynamic therapy, and complementary and alternative medicine. A concluding section is devoted to promising emerging treatments, from novel psychopharmacological therapies through to virtual reality treatment, immunotherapy, biomarker-guided tailored therapy, and more. Written by leading experts from across the world, the book will be an excellent source of information for both researchers and practitioners.

Glial Neurobiology

Author : Alexei Verkhratsky
Publisher : John Wiley & Sons
ISBN 13 : 9780470513071
Total Pages : 230 pages
Book Rating : 4.5/5 (13 download)

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Book Synopsis Glial Neurobiology by : Alexei Verkhratsky

Download or read book Glial Neurobiology written by Alexei Verkhratsky and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume is a very valuable and much needed contribution." –Quarterly Review of Biology AT LAST - A comprehensive, accessible textbook on glial neurobiology! Glial cells are the most numerous cells in the human brain but for many years have attracted little scientific attention. Neurophysiologists concentrated their research efforts instead, on neurones and neuronal networks because it was thought that they were the key elements responsible for higher brain function. Recent advances, however, indicate this isn’t exactly the case. Not only are astroglial cells the stem elements from which neurones are born, but they also control the development, functional activity and death of neuronal circuits. These ground-breaking developments have revolutionized our understanding of the human brain and the complex interrelationship of glial and neuronal networks in health and disease. Features of this book: an accessible introduction to glial neurobiology including an overview of glial cell function and its active role in neural processes, brain function and nervous system pathology an exploration of all the major types of glial cells including: the astrocytes, oligodendrocytes and microglia of the ACNS and Schwann cells of the peripheral nervous system; the book also presents a broad overview of glial receptors and ion channels an investigation into the role of glial cells in various types of brain diseases including stroke, neurodegenerative diseases such as Alzheimer's, Parkinson's and Alexander's disease, brain oedema, multiple sclerosis and many more a wealth of illustrations, including unique images from the authors' own libraries of images, describing the main features of glial cells Written by two leading experts in the field, Glial Neurobiology provides a concise, authoritative introduction to glial physiology and pathology for undergraduate/postgraduate neuroscience, biomedical, medical, pharmacy, pharmacology, and neurology, neurosurgery and physiology students. It is also an invaluable resource for researchers in neuroscience, physiology, pharmacology and pharmaceutics.

Atlas of Human Brain Connections

Author : Marco Catani
Publisher : Oxford University Press, USA
ISBN 13 : 0199541167
Total Pages : 533 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Atlas of Human Brain Connections by : Marco Catani

Download or read book Atlas of Human Brain Connections written by Marco Catani and published by Oxford University Press, USA. This book was released on 2012-06-14 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major challenges of modern neuroscience is to define the complex pattern of neural connections that underlie cognition and behaviour. This atlas capitalises on novel diffusion MRI tractography methods to provide a comprehensive overview of connections derived from virtual in vivo tractography dissections of the human brain.

The Diagnosis of Psychosis

Author : Rudolf N. Cardinal
Publisher : Cambridge University Press
ISBN 13 : 1139497901
Total Pages : 402 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis The Diagnosis of Psychosis by : Rudolf N. Cardinal

Download or read book The Diagnosis of Psychosis written by Rudolf N. Cardinal and published by Cambridge University Press. This book was released on 2011-03-31 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychosis has many causes. Psychiatrists typically receive the most thorough training in its diagnosis, but the diagnosis of psychosis secondary to nonpsychiatric conditions is not often emphasized. An understanding of the underlying cause of psychosis is important for effective management. The Diagnosis of Psychosis bridges the gap between psychiatry and medicine, providing a comprehensive review of primary and secondary causes of psychosis. It covers both common and rare causes in a clinically focused guide. Useful both for teaching and reference, the text covers physical and mental state examination, describes key investigations, and summarizes the non-psychiatric features of medical conditions causing psychosis. Particularly relevant for psychiatrists and trainees in psychiatry, this volume will also assist neurologists and general physicians who encounter psychosis in their practice.

The Orbitofrontal Cortex

Author : Edmund T. Rolls
Publisher :
ISBN 13 : 0198845995
Total Pages : 318 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis The Orbitofrontal Cortex by : Edmund T. Rolls

Download or read book The Orbitofrontal Cortex written by Edmund T. Rolls and published by . This book was released on 2019 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'The Orbitofrontal Cortex' explores a part of the brain that is important in human emotion, pleasure, decision-making, valuation, and personality. The book is unique in providing a coherent multidisciplinary approach to understanding the functions of one of the most interesting regions of the human brain, in both health and in disease.

Inflammation-Associated Depression: Evidence, Mechanisms and Implications

Author : Robert Dantzer
Publisher : Springer
ISBN 13 : 3319511521
Total Pages : 357 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Inflammation-Associated Depression: Evidence, Mechanisms and Implications by : Robert Dantzer

Download or read book Inflammation-Associated Depression: Evidence, Mechanisms and Implications written by Robert Dantzer and published by Springer. This book was released on 2016-12-28 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

Advanced Neuroimaging Methods in Brain Disorders

Author : Jurong Ding
Publisher : Frontiers Media SA
ISBN 13 : 2889761274
Total Pages : 196 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Advanced Neuroimaging Methods in Brain Disorders by : Jurong Ding

Download or read book Advanced Neuroimaging Methods in Brain Disorders written by Jurong Ding and published by Frontiers Media SA. This book was released on 2022-05-05 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multiple Sclerosis

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309072859
Total Pages : 457 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Multiple Sclerosis by : Institute of Medicine

Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.

The Neurobiological Basis of Suicide

Author : Yogesh Dwivedi
Publisher : CRC Press
ISBN 13 : 143983881X
Total Pages : 485 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Quantitative Magnetic Resonance Imaging

Author : Nicole Seiberlich
Publisher : Academic Press
ISBN 13 : 0128170581
Total Pages : 1094 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Quantitative Magnetic Resonance Imaging by : Nicole Seiberlich

Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: - The basic physics behind tissue property mapping - How to implement basic pulse sequences for the quantitative measurement of tissue properties - The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* - The pros and cons for different approaches to mapping perfusion - The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor - maps and more complex representations of diffusion - How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed - How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance - Fingerprinting can be used to accelerate or improve tissue property mapping schemes - How tissue property mapping is used clinically in different organs - Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds - Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements - Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges - Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Cognitive Impairment in Major Depressive Disorder

Author : Roger S. McIntyre
Publisher : Cambridge University Press
ISBN 13 : 1107074584
Total Pages : 385 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Cognitive Impairment in Major Depressive Disorder by : Roger S. McIntyre

Download or read book Cognitive Impairment in Major Depressive Disorder written by Roger S. McIntyre and published by Cambridge University Press. This book was released on 2016-03-17 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to comprehensively assemble research, clinical, and public policy perspectives on cognitive dysfunction in major depressive disorder.

Brain and Somatization Symptoms in Psychiatric Disorders

Author : Wenbin Guo
Publisher : Frontiers Media SA
ISBN 13 : 2889458865
Total Pages : 262 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Brain and Somatization Symptoms in Psychiatric Disorders by : Wenbin Guo

Download or read book Brain and Somatization Symptoms in Psychiatric Disorders written by Wenbin Guo and published by Frontiers Media SA. This book was released on 2019-07-11 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Glutamate/GABA-Glutamine Cycle

Author : Arne Schousboe
Publisher : Springer
ISBN 13 : 3319450964
Total Pages : 420 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Glutamate/GABA-Glutamine Cycle by : Arne Schousboe

Download or read book The Glutamate/GABA-Glutamine Cycle written by Arne Schousboe and published by Springer. This book was released on 2016-11-25 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book. A number of leading experts in neuroscience including intermediary metabolism, enzymology and transporter physiology have contributed to this book which provides comprehensive discussions of these different aspects of the functional importance of the glutamate-glutamine cycle coupling homeostasis of glutamatergic, excitatory neurotransmission to basic aspects of brain energy metabolism. This book will be of particular importance for students as well as professionals interested in these fundamental processes involved in brain function and dysfunction.

Handbook of Depression in Alzheimer’s Disease

Author : G.S. Smith
Publisher : IOS Press
ISBN 13 : 1614995427
Total Pages : 396 pages
Book Rating : 4.6/5 (149 download)

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Book Synopsis Handbook of Depression in Alzheimer’s Disease by : G.S. Smith

Download or read book Handbook of Depression in Alzheimer’s Disease written by G.S. Smith and published by IOS Press. This book was released on 2015-08-05 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in healthcare have led to an extended life expectancy throughout the developed world, but cognitive impairment in later life, and Alzheimer's disease (AD) in particular, remains one of the intractable problems which can blight quality of life as we age. Depression in Alzheimer's disease is an additional factor which has a significant impact on disability, disease progression, and caregiver burden. This book, volume 4 of the Advances in Alzheimer’s Disease book series which is published in coordination with the Journal of Alzheimer’s Disease, presents papers which reflect the progress in recent years of research into depression in AD. This research has focused on several areas, including the improvement of diagnostic criteria and outcome measures for depression and depressive symptoms in AD, genetic and imaging studies to elucidate the neurobiological mechanisms, and clinical trials of antidepressants. The book is divided into sections on phenomenology, epidemiology, neuropsychology, neurobiology and neuropathology, neuroimaging, genetics, and treatment. Providing a stimulus to further research in this challenging area by engaging both basic and clinical researchers, this book will be of interest to all those whose work involves understanding and dealing with depression in those suffering from Alzheimer's disease.

Neuroprogression in Psychiatry

Author : Flávio Kapczinski
Publisher : Oxford University Press
ISBN 13 : 0191090883
Total Pages : 248 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Neuroprogression in Psychiatry by : Flávio Kapczinski

Download or read book Neuroprogression in Psychiatry written by Flávio Kapczinski and published by Oxford University Press. This book was released on 2019-03-05 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression. Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

Minding Glial Cells in the Novel Understandings of Mental Illness

Author : Takahiro A. Kato
Publisher : Frontiers Media SA
ISBN 13 : 2889451577
Total Pages : 277 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Minding Glial Cells in the Novel Understandings of Mental Illness by : Takahiro A. Kato

Download or read book Minding Glial Cells in the Novel Understandings of Mental Illness written by Takahiro A. Kato and published by Frontiers Media SA. This book was released on 2017-05-03 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, abnormalities of neurons and neuronal networks including synaptic abnormalities and disturbance of neurotransmitters have dominantly been believed to be the main causes of psychiatric disorders. Recent cellular neuroscience has revealed various unknown roles of glial cells such as astrocytes, oligodendrocytes and microglia. These glial cells have proved to continuously contact with neurons /synapses, and have been shown to play important roles in brain development, homeostasis and various brain functions. Beyond the classic neuronal doctrine, accumulating evidence has suggested that abnormalities and disturbances of neuron-glia crosstalk may induce psychiatric disorders, while these mechanisms have not been well understood. This Research Topic of the Frontiers in Cellular Neuroscience will focus on the most recent developments and ideas in the study of glial cells (astrocytes, oligodendrocytes and microglia) focusing on psychiatric disorders such as schizophrenia, mood disorders and autism. Not only molecular, cellular and pharmacological approaches using in vitro / in vivo experimental methods but also translational research approaches are welcome. Novel translational research approaches, for example, using novel techniques such as induced pluripotent stem (iPS) cells, may lead to novel solutions. We believe that investigations to clarify the correlation between glial cells and psychiatric disorders contribute to a novel understanding of the pathophysiology of these disorders and the development of effective treatment strategies.

White Matter Dementia

Author : Christopher M. Filley
Publisher : Cambridge University Press
ISBN 13 : 1107035414
Total Pages : 231 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis White Matter Dementia by : Christopher M. Filley

Download or read book White Matter Dementia written by Christopher M. Filley and published by Cambridge University Press. This book was released on 2016-04-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.