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Mycobacteria And The Macrophage
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Book Synopsis Mycobacteria and the Macrophage by : Suzie Hingley-Wilson
Download or read book Mycobacteria and the Macrophage written by Suzie Hingley-Wilson and published by Frontiers Media SA. This book was released on 2023-12-28 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The macrophage (or “big eater”) is often considered the first cell type to encounter the causative agent of Tuberculosis (TB), Mycobacterium tuberculosis, upon entry to the lung. Once inside the macrophage the tubercle bacillus can survive and even replicate where many other invading pathogens perish. Recent research suggests the bacilli adapts within this hostile environment, treating the macrophage like a Trojan horse. Indeed, cutting-edge techniques have revealed that the degree of bacterial heterogeneity and resistance to antibiotics changes within the macrophage. M. tuberculosis spends most of its life cycle within the macrophage and has adopted specific mechanisms to survive, egress and to recruit more of this niche cell (eg the Type VII secretion system ESX-1). Understanding the host-pathogen interaction in tuberculous infection is key to understanding TB, which remains the number one cause of death from a bacterial infection. In this research topic we aim to cover advances in understanding how the tubercle bacillus adapts and survives within the host cell. Determining the responsible mechanisms may reveal novel ways to target this deadly pathogen and halt its adaptation and transformation within these potentially destructive or permissive cells.
Book Synopsis Modulation of Macrophage Signaling Pathways during Bacterial Infections by : Supriya Shukla
Download or read book Modulation of Macrophage Signaling Pathways during Bacterial Infections written by Supriya Shukla and published by Frontiers Media SA. This book was released on 2021-08-18 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mycobacteria-Host Interactions: Genetics, Immunity, Pathology by : Alexander S. Apt
Download or read book Mycobacteria-Host Interactions: Genetics, Immunity, Pathology written by Alexander S. Apt and published by Frontiers Media SA. This book was released on 2020-12-30 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis The New Paradigm of Immunity to Tuberculosis by : Maziar Divangahi
Download or read book The New Paradigm of Immunity to Tuberculosis written by Maziar Divangahi and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed. The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthesis of the authors’ recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.
Book Synopsis Immunity to Mycobacteria by : Ian Orme
Download or read book Immunity to Mycobacteria written by Ian Orme and published by Springer. This book was released on 1995 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Macrophage-Pathogen Interactions by : Bruce S. Zwilling
Download or read book Macrophage-Pathogen Interactions written by Bruce S. Zwilling and published by CRC Press. This book was released on 1993-09-15 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Immunology series examines the complex relationships between mononuclear phagocytes and the infectious agents that live and replicate within them, describing the basic characteristics of macrophages, including their differentiation, activation, antigen processing and presentation, and antimicrobial mechanisms. It provides information on pathogens associated with HIV infection such as mycobacterium tuberculosis, mycobacterium avium, candida albicans and pneumocystis carinii.
Download or read book Macrophages written by Vijay Kumar and published by BoD – Books on Demand. This book was released on 2022-12-14 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages were first discovered in 1882 when Elia Metchnikoff recognized them as important phagocytic cells that can engulf any foreign material, including fungal spores. This discovery has proved to be a milestone in establishing the field of innate immunity. Macrophages are still ruling the area after 140 years of their discovery. This book explores the diverse role of macrophages in vertebrate immunity, parasitic, bacterial, and viral infections, regeneration, inflammation, and neurological diseases.
Book Synopsis Macrophage-Activating Factors: Advances in Research and Application: 2011 Edition by :
Download or read book Macrophage-Activating Factors: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophage-Activating Factors: Advances in Research and Application: 2011 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Macrophage-Activating Factors in a concise format. The editors have built Macrophage-Activating Factors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Macrophage-Activating Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Macrophage-Activating Factors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Recent Advancements in Microbial Diversity by : Jae Youl Cho
Download or read book Recent Advancements in Microbial Diversity written by Jae Youl Cho and published by Academic Press. This book was released on 2022-03-18 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, researchers around the globe have deep dived into the fascination world of the Macrophage and its diverse role in tissue development, angiogenesis, and wound healing, and above all the untapped mystery of the wondering immune system within our body. Macrophages and their role in inflammation includes all the latest information of macrophages and inflammation as well as it provides an in-depth understanding of this complex and rapidly progressing field of study. Outlines the role of macrophages in inflammation Contains chapters by leading authors on the basic and translational aspects of macrophage biology Deals with internal and external treats
Book Synopsis Macrophage Activation by : Khalid Hussain Bhat
Download or read book Macrophage Activation written by Khalid Hussain Bhat and published by BoD – Books on Demand. This book was released on 2020-03-25 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
Book Synopsis The Macrophage as Therapeutic Target by : J. M. Aerts
Download or read book The Macrophage as Therapeutic Target written by J. M. Aerts and published by Springer Science & Business Media. This book was released on 2003-07-10 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts
Book Synopsis Macrophage-Activating Factors—Advances in Research and Application: 2013 Edition by :
Download or read book Macrophage-Activating Factors—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophage-Activating Factors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Macrophage-Activating Factors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Macrophage-Activating Factors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis The Mononuclear Phagocyte System in Infectious Disease by : Geanncarlo Lugo-Villarino
Download or read book The Mononuclear Phagocyte System in Infectious Disease written by Geanncarlo Lugo-Villarino and published by Frontiers Media SA. This book was released on 2019-10-04 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strategy to detect 'microbial non-self' relies on MPS to recognize conserved microbial products known as 'pathogen-associated molecular pattern' (PAMPs). PAMPs recognition represents a checkpoint in the response to pathogens and relies on conserved 'pattern recognition receptors' (PRRs). Upon PRR engagement, MPS mount a cell-autonomous attack that includes the internalization and compartmentalization of intracellular pathogens into toxic compartments that promote destruction. In parallel, MPS cells launch an inflammatory response composed of a cellular arm and soluble factors to control extracellular pathogens. In cases when innate immunity fails to eliminate the invading microbe, MPS serves as a tailor to generate adaptive immunity for pathogen eradication and generation of "memory" cells, thus ensuring enhanced protection against re-infection. Indeed, MPS cell functions comprise the capture, process, migration and delivery of antigenic information to lymphoid organs, where type-1 immunity is tailored against intracellular microbes and type-2 immunity against extracellular pathogens. However, this potent adaptive immunity is also a double-edge sword that can cause aberrant inflammatory disorders, like autoimmunity or chronic inflammation. For this reason, MPS also tailors tolerance immunity against unwanted inflammation. Successful clearance of the microbe results in its destruction and proper collection of debris, resolution of inflammation and tissue healing for which MPS is essential. Reciprocally, as part of the evolutionary process taking place in all organisms, microbes evolved strategies to circumvent the actions bestowed by MPS cells. Multiple pathogens modulate the differentiation, maturation and activation programs of the MPS, as an efficient strategy to avoid a dedicated immune response. Among the most common evasion strategies are the subversion of phagocytosis, inhibition of PRR-mediated immunity, resistance to intracellular killing by reactive oxygen and nitrogen species, restriction of phagosome maturation, modulation of cellular metabolism and nutrient acquisition, regulation of cell death and autophagy, and modulation of pro-inflammatory responses and hijacking of tolerance mechanisms, among others. The tenet of this eBook is that a better understanding of MPS in infection will yield insights for development of therapeutics to enhance antimicrobial processes or dampen detrimental inflammation for the host's benefit. We believe that contributions to this topic will serve as a platform for discussion and debate about relevant issues and themes in this field. Our aim is to bring expert junior and senior scientists to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.
Book Synopsis The Effect of Macrophage Activation on Acquired Resistance in Tuberculosis by : Ronald F. Schell
Download or read book The Effect of Macrophage Activation on Acquired Resistance in Tuberculosis written by Ronald F. Schell and published by . This book was released on 1972 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism by : Jean Pieters
Download or read book Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism written by Jean Pieters and published by Springer Science & Business Media. This book was released on 2013-12-09 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
Book Synopsis Understanding Tuberculosis by : Pere-Joan Cardona
Download or read book Understanding Tuberculosis written by Pere-Joan Cardona and published by BoD – Books on Demand. This book was released on 2012-02-24 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis in an attempt to understand the extent to which the bacilli has adapted itself to the host and to its final target. On the other hand, there is a section in which other specialists discuss how to manipulate this immune response to obtain innovative prophylactic and therapeutic approaches to truncate the intimal co-evolution between Mycobacterium tuberculosis and the Homo sapiens.
Download or read book Autophagy written by Shintaro Seto and published by Elsevier Inc. Chapters. This book was released on 2013-09-03 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alveolar macrophages are the lung’s first line of defense against infection by pathogenic microbes. Despite this, Mycobacterium tuberculosis can proliferate in alveolar macrophages by inhibiting phagolysosome biogenesis. Differential recruitment of Rab GTPases, which regulate phagosome maturation, to mycobacterial phagosomes contributes to the inhibition of phagolysosome biogenesis. Recruitment of Coronin-1a, an actin binding protein, to mycobacterial phagosomes is also thought to inhibit their fusion with lysosomes. Host defense mechanisms exploit autophagy to control the proliferation of intracellular pathogens, including M. tuberculosis. On the other hand, several intracellular bacteria can evade the elimination induced by the autophagic process. M. tuberculosis also escapes being targeted for autophagosomal uptake. We have demonstrated that the depletion of Coronin-1a inhibits mycobacterial survival in macrophages, since Coronin-1a depletion facilitates the formation of autophagosomes around mycobacterial phagosomes. These results suggest that Coronin-1a inhibits autophagosome formation in regard to M. tuberculosis, thereby allowing mycobacterial survival in alveolar macrophages.
